{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:50:04Z","timestamp":1760403004720,"version":"build-2065373602"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH229"],"award-info":[{"award-number":["ZR2021QH229"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10067-025-07596-5","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T06:25:28Z","timestamp":1754461528000},"page":"4263-4273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for calcium pyrophosphate deposition disease"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8756-9334","authenticated-orcid":false,"given":"Ri-peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"7596_CR1","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1056\/NEJMra1511117","volume":"374","author":"AK Rosenthal","year":"2016","unstructured":"Rosenthal AK, Ryan LM (2016) Calcium pyrophosphate deposition disease. N Engl J Med 374:2575\u20132584. https:\/\/doi.org\/10.1056\/NEJMra1511117","journal-title":"N Engl J Med"},{"key":"7596_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/ard.62.6.513","volume":"62","author":"RL Neame","year":"2003","unstructured":"Neame RL, Carr AJ, Muir K, Doherty M (2003) UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte. Ann Rheum Dis 62:513\u2013518. https:\/\/doi.org\/10.1136\/ard.62.6.513","journal-title":"Ann Rheum Dis"},{"key":"7596_CR3","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/art.1780300811","volume":"30","author":"DT Felson","year":"1987","unstructured":"Felson DT, Naimark A, Anderson J et al (1987) The prevalence of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum 30:914\u2013918. https:\/\/doi.org\/10.1002\/art.1780300811","journal-title":"Arthritis Rheum"},{"key":"7596_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1136\/ard.42.3.280","volume":"42","author":"E Wilkins","year":"1983","unstructured":"Wilkins E, Dieppe P, Maddison P, Evison G (1983) Osteoarthritis and articular chondrocalcinosis in the elderly. Ann Rheum Dis 42:280\u2013284. https:\/\/doi.org\/10.1136\/ard.42.3.280","journal-title":"Ann Rheum Dis"},{"key":"7596_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","volume":"18","author":"Y Hasin","year":"2017","unstructured":"Hasin Y, Seldin M, Lusis A (2017) Multi-omics approaches to disease. Genome Biol 18:83. https:\/\/doi.org\/10.1186\/s13059-017-1215-1","journal-title":"Genome Biol"},{"key":"7596_CR6","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nature06758","volume":"452","author":"V Emilsson","year":"2008","unstructured":"Emilsson V, Thorleifsson G, Zhang B et al (2008) Genetics of gene expression and its effect on disease. Nature 452:423\u2013428. https:\/\/doi.org\/10.1038\/nature06758","journal-title":"Nature"},{"key":"7596_CR7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nature18270","volume":"534","author":"JM Chick","year":"2016","unstructured":"Chick JM, Munger SC, Simecek P et al (2016) Defining the consequences of genetic variation on a proteome-wide scale. Nature 534:500\u2013505. https:\/\/doi.org\/10.1038\/nature18270","journal-title":"Nature"},{"key":"7596_CR8","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0362","volume":"368","author":"AC Nica","year":"2013","unstructured":"Nica AC, Dermitzakis ET (2013) Expression quantitative trait loci: present and future. Philos Trans R Soc Lond B Biol Sci 368:20120362. https:\/\/doi.org\/10.1098\/rstb.2012.0362","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"7596_CR9","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1222794","volume":"337","author":"MT Maurano","year":"2012","unstructured":"Maurano MT, Humbert R, Rynes E et al (2012) Systematic localization of common disease-associated variation in regulatory DNA. Science 337:1190\u20131195. https:\/\/doi.org\/10.1126\/science.1222794","journal-title":"Science"},{"key":"7596_CR10","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1166","volume":"9","author":"C Finan","year":"2017","unstructured":"Finan C, Gaulton A, Kruger FA et al (2017) The druggable genome and support for target identification and validation in drug development. Sci Transl Med 9:eaag1166. https:\/\/doi.org\/10.1126\/scitranslmed.aag1166","journal-title":"Sci Transl Med"},{"key":"7596_CR11","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrd892","volume":"1","author":"AL Hopkins","year":"2002","unstructured":"Hopkins AL, Groom CR (2002) The druggable genome. Nat Rev Drug Discov 1:727\u2013730. https:\/\/doi.org\/10.1038\/nrd892","journal-title":"Nat Rev Drug Discov"},{"key":"7596_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/ije\/dyh048","volume":"33","author":"DC Thomas","year":"2004","unstructured":"Thomas DC, Conti DV (2004) Commentary: the concept of \u201cMendelian Randomization.\u201d Int J Epidemiol 33:21\u201325. https:\/\/doi.org\/10.1093\/ije\/dyh048","journal-title":"Int J Epidemiol"},{"key":"7596_CR13","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1136\/jnnp-2023-331142","volume":"94","author":"W-M Su","year":"2023","unstructured":"Su W-M, Gu X-J, Dou M et al (2023) Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatry 94:954\u2013961. https:\/\/doi.org\/10.1136\/jnnp-2023-331142","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"7596_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3899\/jrheum.111476","volume":"41","author":"M Uzuki","year":"2014","unstructured":"Uzuki M, Sawai T, Ryan LM et al (2014) Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. J Rheumatol 41:65\u201374. https:\/\/doi.org\/10.3899\/jrheum.111476","journal-title":"J Rheumatol"},{"key":"7596_CR15","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1002\/art.11133","volume":"48","author":"CJ Williams","year":"2003","unstructured":"Williams CJ, Pendleton A, Bonavita G et al (2003) Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 48:2627\u20132631. https:\/\/doi.org\/10.1002\/art.11133","journal-title":"Arthritis Rheum"},{"key":"7596_CR16","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1136\/annrheumdis-2013-205149","volume":"74","author":"YFM Ramos","year":"2015","unstructured":"Ramos YFM, Bos SD, van der Breggen R et al (2015) A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis. Ann Rheum Dis 74:1756\u20131762. https:\/\/doi.org\/10.1136\/annrheumdis-2013-205149","journal-title":"Ann Rheum Dis"},{"key":"7596_CR17","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR et al (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement. JAMA 326:1614\u20131621. https:\/\/doi.org\/10.1001\/jama.2021.18236","journal-title":"JAMA"},{"key":"7596_CR18","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour SL, Kiwala S, Cotto KC et al (2021) Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res 49:D1144\u2013D1151. https:\/\/doi.org\/10.1093\/nar\/gkaa1084","journal-title":"Nucleic Acids Res"},{"key":"7596_CR19","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","volume":"53","author":"U V\u00f5sa","year":"2021","unstructured":"V\u00f5sa U, Claringbould A, Westra H-J et al (2021) Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet 53:1300\u20131310. https:\/\/doi.org\/10.1038\/s41588-021-00913-z","journal-title":"Nat Genet"},{"key":"7596_CR20","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA et al (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53:1712\u20131721. https:\/\/doi.org\/10.1038\/s41588-021-00978-w","journal-title":"Nat Genet"},{"key":"7596_CR21","doi-asserted-by":"publisher","unstructured":"GTEx Consortium, Laboratory, Data Analysis &Coordinating Center (LDACC)\u2014Analysis Working Group, Statistical Methods groups\u2014Analysis Working Group, et al (2017) Genetic effects on gene expression across human tissues. Nature 550:204\u2013213. https:\/\/doi.org\/10.1038\/nature24277","DOI":"10.1038\/nature24277"},{"issue":"1","key":"7596_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/ije\/dyr233","volume":"41","author":"CL Relton","year":"2012","unstructured":"Relton CL, Davey Smith G (2012) Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol 41(1):161\u2013176. https:\/\/doi.org\/10.1093\/ije\/dyr233","journal-title":"Int J Epidemiol"},{"key":"7596_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-publhealth-032315-021402","volume":"37","author":"TJ VanderWeele","year":"2016","unstructured":"VanderWeele TJ (2016) Mediation analysis: a practitioner\u2019s guide. Annu Rev Public Health 37:17\u201332. https:\/\/doi.org\/10.1146\/annurev-publhealth-032315-021402","journal-title":"Annu Rev Public Health"},{"key":"7596_CR24","doi-asserted-by":"publisher","first-page":"l1855","DOI":"10.1136\/bmj.l1855","volume":"365","author":"AR Carter","year":"2019","unstructured":"Carter AR, Gill D, Davies NM et al (2019) Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study. BMJ 365:l1855. https:\/\/doi.org\/10.1136\/bmj.l1855","journal-title":"BMJ"},{"key":"7596_CR25","doi-asserted-by":"publisher","first-page":"D799","DOI":"10.1093\/nar\/gku1202","volume":"43","author":"JD Eicher","year":"2015","unstructured":"Eicher JD, Landowski C, Stackhouse B et al (2015) GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes. Nucleic Acids Res 43:D799-804. https:\/\/doi.org\/10.1093\/nar\/gku1202","journal-title":"Nucleic Acids Res"},{"key":"7596_CR26","doi-asserted-by":"publisher","first-page":"k601","DOI":"10.1136\/bmj.k601","volume":"362","author":"NM Davies","year":"2018","unstructured":"Davies NM, Holmes MV, Davey Smith G (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601. https:\/\/doi.org\/10.1136\/bmj.k601","journal-title":"BMJ"},{"key":"7596_CR27","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1038\/s41467-020-16969-0","volume":"11","author":"AF Schmidt","year":"2020","unstructured":"Schmidt AF, Finan C, Gordillo-Mara\u00f1\u00f3n M et al (2020) Genetic drug target validation using Mendelian randomisation. Nat Commun 11:3255. https:\/\/doi.org\/10.1038\/s41467-020-16969-0","journal-title":"Nat Commun"},{"key":"7596_CR28","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512\u2013525. https:\/\/doi.org\/10.1093\/ije\/dyv080","journal-title":"Int J Epidemiol"},{"key":"7596_CR29","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s11064-016-2070-2","volume":"42","author":"JV Andersen","year":"2017","unstructured":"Andersen JV, Christensen SK, Aldana BI et al (2017) Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe\/PSEN1dE9 mouse model of Alzheimer\u2019s disease. Neurochem Res 42:1589\u20131598. https:\/\/doi.org\/10.1007\/s11064-016-2070-2","journal-title":"Neurochem Res"},{"key":"7596_CR30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693\u2013698. https:\/\/doi.org\/10.1038\/s41588-018-0099-7","journal-title":"Nat Genet"},{"key":"7596_CR31","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, Tilling K, Davey Smith G (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13:e1007081. https:\/\/doi.org\/10.1371\/journal.pgen.1007081","journal-title":"PLoS Genet"},{"key":"7596_CR32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1681\/ASN.0000000000000379","volume":"35","author":"C Tang","year":"2024","unstructured":"Tang C, Chen P, Xu L-L et al (2024) Circulating proteins and IgA nephropathy: a multiancestry proteome-wide Mendelian randomization study. J Am Soc Nephrol 35:1045\u20131057. https:\/\/doi.org\/10.1681\/ASN.0000000000000379","journal-title":"J Am Soc Nephrol"},{"key":"7596_CR33","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/s41588-018-0184-y","volume":"50","author":"W Zhou","year":"2018","unstructured":"Zhou W, Nielsen JB, Fritsche LG et al (2018) Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nat Genet 50:1335\u20131341. https:\/\/doi.org\/10.1038\/s41588-018-0184-y","journal-title":"Nat Genet"},{"key":"7596_CR34","doi-asserted-by":"publisher","first-page":"e00175","DOI":"10.1002\/prp2.175","volume":"3","author":"MG Rolf","year":"2015","unstructured":"Rolf MG, Curwen JO, Veldman-Jones M et al (2015) In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib. Pharmacol Res Perspect 3:e00175. https:\/\/doi.org\/10.1002\/prp2.175","journal-title":"Pharmacol Res Perspect"},{"key":"7596_CR35","doi-asserted-by":"publisher","first-page":"30929","DOI":"10.1074\/jbc.M704009200","volume":"282","author":"PE Row","year":"2007","unstructured":"Row PE, Liu H, Hayes S et al (2007) The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem 282:30929\u201330937. https:\/\/doi.org\/10.1074\/jbc.M704009200","journal-title":"J Biol Chem"},{"key":"7596_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","volume":"19","author":"I Dikic","year":"2018","unstructured":"Dikic I, Elazar Z (2018) Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol 19:349\u2013364. https:\/\/doi.org\/10.1038\/s41580-018-0003-4","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7596_CR37","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41580-021-00392-4","volume":"22","author":"YG Zhao","year":"2021","unstructured":"Zhao YG, Codogno P, Zhang H (2021) Machinery, regulation and pathophysiological implications of autophagosome maturation. Nat Rev Mol Cell Biol 22:733\u2013750. https:\/\/doi.org\/10.1038\/s41580-021-00392-4","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7596_CR38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41580-020-0241-0","volume":"21","author":"H Nakatogawa","year":"2020","unstructured":"Nakatogawa H (2020) Mechanisms governing autophagosome biogenesis. Nat Rev Mol Cell Biol 21:439\u2013458. https:\/\/doi.org\/10.1038\/s41580-020-0241-0","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7596_CR39","doi-asserted-by":"publisher","first-page":"13028","DOI":"10.1074\/jbc.M114.630558","volume":"290","author":"AK Rosenthal","year":"2015","unstructured":"Rosenthal AK, Gohr CM, Mitton-Fitzgerald E et al (2015) Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. J Biol Chem 290:13028\u201313038. https:\/\/doi.org\/10.1074\/jbc.M114.630558","journal-title":"J Biol Chem"},{"key":"7596_CR40","doi-asserted-by":"publisher","first-page":"C902","DOI":"10.1152\/ajpcell.00296.2020","volume":"320","author":"TJ Zheng","year":"2021","unstructured":"Zheng TJ, Lofurno ER, Melrose AR et al (2021) Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function. Am J Physiol Cell Physiol 320:C902\u2013C915. https:\/\/doi.org\/10.1152\/ajpcell.00296.2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"7596_CR41","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.bbrc.2004.09.171","volume":"324","author":"R Roskoski","year":"2004","unstructured":"Roskoski R (2004) Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun 324:1155\u20131164. https:\/\/doi.org\/10.1016\/j.bbrc.2004.09.171","journal-title":"Biochem Biophys Res Commun"},{"key":"7596_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2005.03.012","volume":"331","author":"R Roskoski","year":"2005","unstructured":"Roskoski R (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 331:1\u201314. https:\/\/doi.org\/10.1016\/j.bbrc.2005.03.012","journal-title":"Biochem Biophys Res Commun"},{"key":"7596_CR43","doi-asserted-by":"publisher","first-page":"10364","DOI":"10.1073\/pnas.92.22.10364","volume":"92","author":"M Lotz","year":"1995","unstructured":"Lotz M, Rosen F, McCabe G et al (1995) Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad Sci U S A 92:10364\u201310368. https:\/\/doi.org\/10.1073\/pnas.92.22.10364","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7596_CR44","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/art.1780340717","volume":"34","author":"AK Rosenthal","year":"1991","unstructured":"Rosenthal AK, Cheung HS, Ryan LM (1991) Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. Arthritis Rheum 34:904\u2013911. https:\/\/doi.org\/10.1002\/art.1780340717","journal-title":"Arthritis Rheum"},{"key":"7596_CR45","unstructured":"Distinct processing of lncRNAs contributes to non-conserved functions in stem cells - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/32259487\/. Accessed 16 Dec 2024"},{"key":"7596_CR46","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.1158\/0008-5472.CAN-15-1824","volume":"76","author":"S Di Cecilia","year":"2016","unstructured":"Di Cecilia S, Zhang F, Sancho A et al (2016) RBM5-AS1 is critical for self-renewal of colon cancer stem-like cells. Cancer Res 76:5615\u20135627. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-1824","journal-title":"Cancer Res"},{"key":"7596_CR47","unstructured":"Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt\/\u03b2-catenin signalling pathway via suppression of activator protein 2\u03b1 - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/25994219\/. Accessed 16 Dec 2024"},{"key":"7596_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2021.101718","volume":"35","author":"CJ Williams","year":"2021","unstructured":"Williams CJ, Rosenthal AK (2021) Pathogenesis of calcium pyrophosphate deposition disease. Best Pract Res Clin Rheumatol 35:101718. https:\/\/doi.org\/10.1016\/j.berh.2021.101718","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"7596_CR49","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/acr.23160","volume":"69","author":"C KleiberBalderrama","year":"2017","unstructured":"KleiberBalderrama C, Rosenthal AK, Lans D et al (2017) Calcium pyrophosphate deposition disease and associated medical comorbidities: a national cross-sectional study of US veterans. Arthritis Care Res (Hoboken) 69:1400\u20131406. https:\/\/doi.org\/10.1002\/acr.23160","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"7596_CR50","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00428-013-1372-x","volume":"462","author":"L Koens","year":"2013","unstructured":"Koens L, Heyning FH, Szepesi A et al (2013) Nuclear factor-\u03baB activation in primary lymphoma of bone. Virchows Arch 462:349\u2013354. https:\/\/doi.org\/10.1007\/s00428-013-1372-x","journal-title":"Virchows Arch"},{"key":"7596_CR51","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000345630","volume":"91","author":"H Cai","year":"2013","unstructured":"Cai H, Sun L, Cui L et al (2013) A functional insertion\/deletion polymorphism (-94 ins\/del ATTG) in the promoter region of the NFKB1 gene is related to the risk of renal cell carcinoma. Urol Int 91:206\u2013212. https:\/\/doi.org\/10.1159\/000345630","journal-title":"Urol Int"},{"key":"7596_CR52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm2083","volume":"8","author":"ND Perkins","year":"2007","unstructured":"Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8:49\u201362. https:\/\/doi.org\/10.1038\/nrm2083","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7596_CR53","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.1038\/ncomms7818","volume":"6","author":"CL Wilson","year":"2015","unstructured":"Wilson CL, Jurk D, Fullard N et al (2015) NF\u03baB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun 6:6818. https:\/\/doi.org\/10.1038\/ncomms7818","journal-title":"Nat Commun"},{"key":"7596_CR54","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jhep.2010.03.025","volume":"53","author":"AM Elsharkawy","year":"2010","unstructured":"Elsharkawy AM, Oakley F, Lin F et al (2010) The NF-\u03baB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J Hepatol 53:519\u2013527. https:\/\/doi.org\/10.1016\/j.jhep.2010.03.025","journal-title":"J Hepatol"},{"key":"7596_CR55","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.4049\/jimmunol.174.8.5016","volume":"174","author":"R Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Pritzker K, Firestein GS, Terkeltaub R (2005) TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol 174:5016\u20135023. https:\/\/doi.org\/10.4049\/jimmunol.174.8.5016","journal-title":"J Immunol"},{"key":"7596_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/03008200109014244","volume":"42","author":"PM Reuben","year":"2001","unstructured":"Reuben PM, Wenger L, Cruz M, Cheung HS (2001) Induction of matrix metalloproteinase-8 in human fibroblasts by basic calcium phosphate and calcium pyrophosphate dihydrate crystals: effect of phosphocitrate. Connect Tissue Res 42:1\u201312. https:\/\/doi.org\/10.3109\/03008200109014244","journal-title":"Connect Tissue Res"},{"key":"7596_CR57","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.21037\/atm-22-4471","volume":"10","author":"W Wang","year":"2022","unstructured":"Wang W, Ou Z, Peng J et al (2022) A transcriptome-wide association study provides new insights into the etiology of osteoarthritis. Ann Transl Med 10:1116. https:\/\/doi.org\/10.21037\/atm-22-4471","journal-title":"Ann Transl Med"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07596-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07596-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07596-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:26:11Z","timestamp":1760365571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07596-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["7596"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07596-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"type":"print","value":"0770-3198"},{"type":"electronic","value":"1434-9949"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"3 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}