{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:10:03Z","timestamp":1756455003994,"version":"3.44.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503084","81901632","82001576"],"award-info":[{"award-number":["81503084","81901632","82001576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation of Jiangsu Province Grant","award":["BK20240371"],"award-info":[{"award-number":["BK20240371"]}]},{"name":"the Jiangsu Province College Students' Innovation and Entrepreneurship Training Program Project","award":["202410285273Y"],"award-info":[{"award-number":["202410285273Y"]}]},{"name":"Key Project of Natural Science Research in Anhui Universities","award":["2024AH040102"],"award-info":[{"award-number":["2024AH040102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10067-025-07605-7","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T10:55:04Z","timestamp":1754132104000},"page":"3525-3537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying plasma proteins and immunocyte phenotypes as risk factors in rheumatoid arthritis: The role of EPHA3 and CD28+ CD45RA+ CD8br treg cells"],"prefix":"10.1007","volume":"44","author":[{"given":"Yanqiu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longwei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-9577","authenticated-orcid":false,"given":"Jingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"issue":"11","key":"7605_CR1","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","volume":"10","author":"AF Radu","year":"2021","unstructured":"Radu AF, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells 10(11):2857. https:\/\/doi.org\/10.3390\/cells10112857","journal-title":"Cells"},{"issue":"10416","key":"7605_CR2","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/s0140-6736(23)01525-8","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo A, Bathon JM, Emery P (2023) Rheumatoid arthritis. Lancet 402(10416):2019\u20132033. https:\/\/doi.org\/10.1016\/s0140-6736(23)01525-8","journal-title":"Lancet"},{"issue":"7987","key":"7605_CR3","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","volume":"623","author":"F Zhang","year":"2023","unstructured":"Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q et al (2023) Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature 623(7987):616\u2013624. https:\/\/doi.org\/10.1038\/s41586-023-06708-y","journal-title":"Nature"},{"issue":"6","key":"7605_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","volume":"79","author":"JS Smolen","year":"2020","unstructured":"Smolen JS, Landew\u00e9 RBM, Bijlsma JWJ, Burmester GR, Dougados M, Kerschbaumer A et al (2020) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis 79(6):685\u2013699. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216655","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"7605_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.rdc.2022.02.010","volume":"48","author":"JJ Cush","year":"2022","unstructured":"Cush JJ (2022) Rheumatoid arthritis: Early diagnosis and treatment. Rheum Dis Clin North Am 48(2):537\u2013547. https:\/\/doi.org\/10.1016\/j.rdc.2022.02.010","journal-title":"Rheum Dis Clin North Am"},{"issue":"4","key":"7605_CR6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1136\/annrheumdis-2018-213678","volume":"78","author":"Y Okada","year":"2019","unstructured":"Okada Y, Eyre S, Suzuki A, Kochi Y, Yamamoto K (2019) Genetics of rheumatoid arthritis: 2018 status. Ann Rheum Dis 78(4):446\u2013453. https:\/\/doi.org\/10.1136\/annrheumdis-2018-213678","journal-title":"Ann Rheum Dis"},{"key":"7605_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","volume":"110","author":"HU Scherer","year":"2020","unstructured":"Scherer HU, H\u00e4upl T, Burmester GR (2020) The etiology of rheumatoid arthritis. J Autoimmun 110:102400. https:\/\/doi.org\/10.1016\/j.jaut.2019.102400","journal-title":"J Autoimmun"},{"key":"7605_CR8","doi-asserted-by":"publisher","first-page":"14357","DOI":"10.1038\/ncomms14357","volume":"8","author":"K Suhre","year":"2017","unstructured":"Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J et al (2017) Connecting genetic risk to disease end points through the human blood plasma proteome. Nat Commun 8:14357. https:\/\/doi.org\/10.1038\/ncomms14357","journal-title":"Nat Commun"},{"issue":"7708","key":"7605_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","volume":"558","author":"BB Sun","year":"2018","unstructured":"Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J et al (2018) Genomic atlas of the human plasma proteome. Nature 558(7708):73\u201379. https:\/\/doi.org\/10.1038\/s41586-018-0175-2","journal-title":"Nature"},{"key":"7605_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.talanta.2019.06.044","volume":"204","author":"G Nys","year":"2019","unstructured":"Nys G, Cobraiville G, Servais AC, Malaise MG, de Seny D, Fillet M (2019) Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis. Talanta 204:507\u2013517. https:\/\/doi.org\/10.1016\/j.talanta.2019.06.044","journal-title":"Talanta"},{"issue":"2","key":"7605_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020905","volume":"23","author":"S Jang","year":"2022","unstructured":"Jang S, Kwon EJ, Lee JJ (2022) Rheumatoid arthritis: pathogenic roles of diverse immune cells. Int J Mol Sci 23(2):905. https:\/\/doi.org\/10.3390\/ijms23020905","journal-title":"Int J Mol Sci"},{"issue":"4","key":"7605_CR12","doi-asserted-by":"publisher","first-page":"a041302","DOI":"10.1101\/cshperspect.a041302","volume":"12","author":"E Birney","year":"2022","unstructured":"Birney E (2022) Mendelian randomization. Cold Spring Harb Perspect Med. 12(4):a041302. https:\/\/doi.org\/10.1101\/cshperspect.a041302","journal-title":"Cold Spring Harb Perspect Med."},{"issue":"6","key":"7605_CR13","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.62347\/ecoo9552","volume":"16","author":"L Ji","year":"2024","unstructured":"Ji L, Liu Y, Wang Z, Huang Q, Cai J, Gu H et al (2024) Causal effect analysis of estrogen receptor associated breast cancer and clear cell ovarian cancer. Am J Transl Res 16(6):2699\u20132710. https:\/\/doi.org\/10.62347\/ecoo9552","journal-title":"Am J Transl Res"},{"issue":"12","key":"7605_CR14","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL et al (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53(12):1712\u20131721. https:\/\/doi.org\/10.1038\/s41588-021-00978-w","journal-title":"Nat Genet"},{"issue":"10","key":"7605_CR15","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","volume":"52","author":"V Orr\u00f9","year":"2020","unstructured":"Orr\u00f9 V, Steri M, Sidore C, Marongiu M, Serra V, Olla S et al (2020) Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet 52(10):1036\u20131045. https:\/\/doi.org\/10.1038\/s41588-020-0684-4","journal-title":"Nat Genet"},{"issue":"D1","key":"7605_CR16","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ et al (2021) Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res 49(D1):D1144\u2013D1151. https:\/\/doi.org\/10.1093\/nar\/gkaa1084","journal-title":"Nucleic Acids Res"},{"issue":"383","key":"7605_CR17","doi-asserted-by":"publisher","first-page":"eaag1166","DOI":"10.1126\/scitranslmed.aag1166","volume":"9","author":"C Finan","year":"2017","unstructured":"Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J et al (2017) The druggable genome and support for target identification and validation in drug development. Sci Transl Med 9(383):eaag1166. https:\/\/doi.org\/10.1126\/scitranslmed.aag1166","journal-title":"Sci Transl Med"},{"issue":"7","key":"7605_CR18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543\u2013552. https:\/\/doi.org\/10.1007\/s10654-015-0011-z","journal-title":"Eur J Epidemiol"},{"key":"7605_CR19","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev-genom-083117-021731","volume":"19","author":"S Burgess","year":"2018","unstructured":"Burgess S, Foley CN, Zuber V (2018) Inferring causal relationships between risk factors and outcomes from genome-wide association study data. Annu Rev Genomics Hum Genet 19:303\u2013327. https:\/\/doi.org\/10.1146\/annurev-genom-083117-021731","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"7605_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176619","volume":"976","author":"L Shi","year":"2024","unstructured":"Shi L, Li G, Hou N, Tu L, Li J, Luo J et al (2024) APOB and CCL17 as mediators in the protective effect of SGLT2 inhibition against myocardial infarction: insights from proteome-wide mendelian randomization. Eur J Pharmacol 976:176619. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176619","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"7605_CR21","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50(5):693\u2013698. https:\/\/doi.org\/10.1038\/s41588-018-0099-7","journal-title":"Nat Genet"},{"issue":"4","key":"7605_CR22","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.62347\/baaw8408","volume":"16","author":"L Ji","year":"2024","unstructured":"Ji L, Wang Y, Lu T, Jia Y, Wang L, Luo C et al (2024) Assessing the causal relationship between blood metabolites and low back pain: a Mendelian randomization study. Am J Transl Res 16(4):1366\u20131374. https:\/\/doi.org\/10.62347\/baaw8408","journal-title":"Am J Transl Res"},{"issue":"1","key":"7605_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.62347\/osua8322","volume":"13","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Zhou T, Tang Q, Feng B, Liang Y (2024) Identification of glycosyltransferase-related genes signature and integrative analyses in patients with ovarian cancer. Am J Clin Exp Immunol 13(1):12\u201325. https:\/\/doi.org\/10.62347\/osua8322","journal-title":"Am J Clin Exp Immunol"},{"key":"7605_CR24","doi-asserted-by":"publisher","first-page":"1426875","DOI":"10.3389\/fimmu.2024.1426875","volume":"15","author":"B Feng","year":"2024","unstructured":"Feng B, Zhang Y, Qiao L, Tang Q, Zhang Z, Zhang S et al (2024) Evaluating the significance of ECSCR in the diagnosis of ulcerative colitis and drug efficacy assessment. Front Immunol 15:1426875. https:\/\/doi.org\/10.3389\/fimmu.2024.1426875","journal-title":"Front Immunol"},{"issue":"3","key":"7605_CR25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.62347\/xtlj1335","volume":"13","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Feng B, Liang Y, Tang Q, Zhang S, Zhang Z et al (2024) Prognostic significance of LRPPRC and its association with immune infiltration in liver hepatocellular carcinoma. Am J Clin Exp Immunol 13(3):105\u2013116. https:\/\/doi.org\/10.62347\/xtlj1335","journal-title":"Am J Clin Exp Immunol"},{"issue":"11","key":"7605_CR26","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.joca.2022.06.010","volume":"30","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Li D, Zhu Z, Chen S, Lu M, Cao P et al (2022) Evaluating the impact of metformin targets on the risk of osteoarthritis: a mendelian randomization study. Osteoarthritis Cartilage 30(11):1506\u20131514. https:\/\/doi.org\/10.1016\/j.joca.2022.06.010","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"7605_CR27","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3390\/jcm12010286","volume":"12","author":"C Delpech","year":"2022","unstructured":"Delpech C, Laborne FX, Hilliquin P (2022) Comparison of biological agent monotherapy and associations including disease-modifying antirheumatic drugs for rheumatoid arthritis: Literature review and meta-analysis of randomized trials. J Clin Med 12(1):286. https:\/\/doi.org\/10.3390\/jcm12010286","journal-title":"J Clin Med"},{"issue":"18","key":"7605_CR28","doi-asserted-by":"publisher","first-page":"4864","DOI":"10.19540\/j.cnki.cjcmm.20230320.406","volume":"48","author":"XH Meng","year":"2023","unstructured":"Meng XH, Zhong S, Han HH, Shi Q, Sun ST, Xiao LB (2023) Effect of Juanbi Qianggu formula on biological behaviors of fibroblast-like synoviocytes in rheumatoid arthritis by regulating FGFR1 signaling pathway based on network pharmacology and cell function experiments. Zhongguo Zhong Yao Za Zhi 48(18):4864\u20134873. https:\/\/doi.org\/10.19540\/j.cnki.cjcmm.20230320.406","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"7605_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110088","volume":"759","author":"FES Mosa","year":"2024","unstructured":"Mosa FES, Alqahtani MA, El-Ghiaty MA, El-Mahrouk SR, Barakat K, El-Kadi AOS (2024) Modulation of aryl hydrocarbon receptor activity by tyrosine kinase inhibitors (ponatinib and tofacitinib). Arch Biochem Biophys 759:110088. https:\/\/doi.org\/10.1016\/j.abb.2024.110088","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"7605_CR30","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1002\/ptr.7053","volume":"35","author":"V Babu","year":"2021","unstructured":"Babu V, Binwal M, Ranjana, Kumari R, Sen S, Kumar A et al (2021) Hesperidin-rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications. Phytother Res 35(6):3325\u201336. https:\/\/doi.org\/10.1002\/ptr.7053","journal-title":"Phytother Res"},{"issue":"18","key":"7605_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184646","volume":"15","author":"ME Vail","year":"2023","unstructured":"Vail ME, Farnsworth RH, Hii L, Allen S, Arora S, Anderson RL et al (2023) Inhibition of EphA3 expression in tumour stromal cells suppresses tumour growth and progression. Cancers (Basel) 15(18):4646. https:\/\/doi.org\/10.3390\/cancers15184646","journal-title":"Cancers (Basel)"},{"issue":"4","key":"7605_CR32","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrm.2015.16","volume":"17","author":"A Kania","year":"2016","unstructured":"Kania A, Klein R (2016) Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nat Rev Mol Cell Biol 17(4):240\u2013256. https:\/\/doi.org\/10.1038\/nrm.2015.16","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7605_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01473","volume":"10","author":"TK Darling","year":"2019","unstructured":"Darling TK, Lamb TJ (2019) Emerging roles for EPh receptors and Ephrin ligands in immunity. Front Immunol 10:1473. https:\/\/doi.org\/10.3389\/fimmu.2019.01473","journal-title":"Front Immunol"},{"issue":"1","key":"7605_CR34","doi-asserted-by":"publisher","first-page":"C189","DOI":"10.1152\/ajpcell.00314.2007","volume":"294","author":"T Kitamura","year":"2008","unstructured":"Kitamura T, Kabuyama Y, Kamataki A, Homma MK, Kobayashi H, Aota S et al (2008) Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis. Am J Physiol Cell Physiol 294(1):C189\u2013C196. https:\/\/doi.org\/10.1152\/ajpcell.00314.2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"7605_CR35","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.immuni.2016.04.020","volume":"44","author":"JH Esensten","year":"2016","unstructured":"Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA (2016) CD28 costimulation: from mechanism to therapy. Immunity 44(5):973\u2013988. https:\/\/doi.org\/10.1016\/j.immuni.2016.04.020","journal-title":"Immunity"},{"issue":"1","key":"7605_CR36","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nrrheum.2012.149","volume":"9","author":"EJ Wehrens","year":"2013","unstructured":"Wehrens EJ, Prakken BJ, van Wijk F (2013) T cells out of control\u2013impaired immune regulation in the inflamed joint. Nat Rev Rheumatol 9(1):34\u201342. https:\/\/doi.org\/10.1038\/nrrheum.2012.149","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"7605_CR37","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.yexcr.2003.08.021","volume":"292","author":"LM Smith","year":"2004","unstructured":"Smith LM, Walsh PT, R\u00fcdiger T, Cotter TG, Mc Carthy TV, Marx A et al (2004) EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res 292(2):295\u2013303. https:\/\/doi.org\/10.1016\/j.yexcr.2003.08.021","journal-title":"Exp Cell Res"},{"issue":"6590","key":"7605_CR38","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9591","volume":"376","author":"J Li","year":"2022","unstructured":"Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V et al (2022) KIR(+)CD8(+) T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science 376(6590):eabi9591. https:\/\/doi.org\/10.1126\/science.abi9591","journal-title":"Science"},{"issue":"2","key":"7605_CR39","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1189\/jlb.0513297","volume":"95","author":"J Ma","year":"2014","unstructured":"Ma J, Liu Y, Li Y, Gu J, Liu J, Tang J et al (2014) Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells. J Leukoc Biol 95(2):275\u2013283. https:\/\/doi.org\/10.1189\/jlb.0513297","journal-title":"J Leukoc Biol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07605-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07605-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:50:19Z","timestamp":1756453819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07605-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,2]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["7605"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07605-7","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"type":"print","value":"0770-3198"},{"type":"electronic","value":"1434-9949"}],"subject":[],"published":{"date-parts":[[2025,8,2]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}