{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:13:12Z","timestamp":1783098792228,"version":"3.54.6"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2021-QN-A10"],"award-info":[{"award-number":["CY2021-QN-A10"]}]},{"name":"Science and Technology Program of Lanzhou city","award":["2022-ZD-101"],"award-info":[{"award-number":["2022-ZD-101"]}]},{"name":"Health Industry Scientific Research Project of Gansu Province","award":["GSWSKY2023-08"],"award-info":[{"award-number":["GSWSKY2023-08"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10067-025-07642-2","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:01:06Z","timestamp":1756468866000},"page":"4103-4118","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi-omics characterization of gut microbiota and fecal and plasma metabolites in patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"44","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Duo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-6419","authenticated-orcid":false,"given":"Haili","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"issue":"1","key":"7642_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0037-7","volume":"6","author":"JE Brandt","year":"2015","unstructured":"Brandt JE, Priori R, Valesini G, Fairweather D (2015) Sex differences in Sj\u00f6gren\u2019s syndrome: a comprehensive review of immune mechanisms. Biol Sex Differ 6(1):19. https:\/\/doi.org\/10.1186\/s13293-015-0037-7","journal-title":"Biol Sex Differ"},{"issue":"12","key":"7642_CR2","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.55563\/clinexprheumatol\/255qsx","volume":"41","author":"S Longhino","year":"2023","unstructured":"Longhino S, Chatzis LG, Dal Pozzolo R, Peretti S, Fulvio G, La Rocca G, Navarro Garcia IC, Orlandi M, Quartuccio L, Baldini C (2023) Sj\u00f6gren\u2019s syndrome: one year in review. Clin Exp Rheumatol 41(12):2343\u201356. https:\/\/doi.org\/10.55563\/clinexprheumatol\/255qsx","journal-title":"Clin Exp Rheumatol"},{"key":"7642_CR3","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1093\/rheumatology\/key330","volume":"60","author":"J Imgenberg-Kreuz","year":"2021","unstructured":"Imgenberg-Kreuz J, Rasmussen A, Sivils K, Nordmark G (2021) Genetics and epigenetics in primary Sj\u00f6gren\u2019s syndrome. Rheumatology 60:2085\u20132098. https:\/\/doi.org\/10.1093\/rheumatology\/key330","journal-title":"Rheumatology"},{"key":"7642_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5928232","volume":"2021","author":"Y Tian","year":"2021","unstructured":"Tian Y, Yang H, Liu N, Li Y, Chen J (2021) Advances in pathogenesis of Sj\u00f6gren\u2019s syndrome. J Immunol Res 2021:5928232. https:\/\/doi.org\/10.1155\/2021\/5928232","journal-title":"J Immunol Res"},{"key":"7642_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/icl.0000000000000953","volume":"49","author":"X Bai","year":"2023","unstructured":"Bai X, Xu Q, Zhang W, Wang C (2023) The gut-eye axis: correlation between the gut microbiota and autoimmune dry eye in individuals with Sj\u00f6gren syndrome. Eye Contact Lens 49:1\u20137. https:\/\/doi.org\/10.1097\/icl.0000000000000953","journal-title":"Eye Contact Lens"},{"key":"7642_CR6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088","author":"F Beghini","year":"2021","unstructured":"Beghini F, McIver LJ, Blanco-M\u00edguez A, Dubois L, Asnicar F, Maharjan S, Mailyan A, Manghi P, Scholz M, Thomas AM, Valles-Colomer M, Weingart G, Zhang Y, Zolfo M, Huttenhower C, Franzosa EA, Segata N (2021) Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife. https:\/\/doi.org\/10.7554\/eLife.65088","journal-title":"Elife"},{"key":"7642_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103050","volume":"141","author":"XM Jia","year":"2023","unstructured":"Jia XM, Wu BX, Chen BD, Li KT, Liu YD, Xu Y, Wang J (2023) Compositional and functional aberrance of the gut microbiota in treatment-na\u00efve patients with primary Sj\u00f6gren\u2019s syndrome. J Autoimmun 141:103050. https:\/\/doi.org\/10.1016\/j.jaut.2023.103050","journal-title":"J Autoimmun"},{"key":"7642_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.874021","volume":"13","author":"L Yang","year":"2022","unstructured":"Yang L, Xiang Z, Zou J, Zhang Y, Ni Y, Yang J (2022) Comprehensive analysis of the relationships between the gut microbiota and fecal metabolome in individuals with primary Sjogren\u2019s syndrome by 16S rRNA sequencing and LC-MS-based metabolomics. Front Immunol 13:874021. https:\/\/doi.org\/10.3389\/fimmu.2022.874021","journal-title":"Front Immunol"},{"issue":"1","key":"7642_CR9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2249.2005.02889.x","volume":"142","author":"M Pertovaara","year":"2005","unstructured":"Pertovaara M, Raitala A, Uusitalo H, Pukander J, Helin H, Oja SS, Hurme M (2005) Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sj\u00f6gren\u2019s syndrome. Clin Exp Immunol 142(1):155\u201361. https:\/\/doi.org\/10.1111\/j.1365-2249.2005.02889.x","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"7642_CR10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/labmed\/lmac084","volume":"54","author":"H Apayd\u0131n","year":"2023","unstructured":"Apayd\u0131n H, Koca Bicer C, Feyza Yurt E, Abdulkadir Serdar M, Dogan \u0130, Erten S (2023) Elevated kynurenine levels in patients with primary Sj\u00f6gren\u2019s syndrome. Laborat Med 54(2):166\u201372. https:\/\/doi.org\/10.1093\/labmed\/lmac084","journal-title":"Laborat Med"},{"key":"7642_CR11","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/s41423-022-00943-5","volume":"19","author":"Y Wei","year":"2022","unstructured":"Wei Y, Peng N, Deng C, Zhao F, Tian J, Tang Y, Yu S, Chen Y, Xue Y, Xiao F, Zhou Y, Li X, Zou H, Rui K, Lin X, Lu L (2022) Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjo\u0308gren\u2019s syndrome. Cell Mol Immunol 19:1361\u20131372. https:\/\/doi.org\/10.1038\/s41423-022-00943-5","journal-title":"Cell Mol Immunol"},{"key":"7642_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jtos.2019.10.006","volume":"18","author":"CM Trujillo-Vargas","year":"2020","unstructured":"Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Ade BR, Paiva CS (2020) The gut-eye-lacrimal gland-microbiome axis in Sj\u00f6gren syndrome. Ocul Surf 18:335\u2013344. https:\/\/doi.org\/10.1016\/j.jtos.2019.10.006","journal-title":"Ocul Surf"},{"key":"7642_CR13","first-page":"7378","volume":"14","author":"J Han","year":"2022","unstructured":"Han J, Zeng A, Hou Z, Xu Y, Zhao H, Wang B, Guan W, An Y, Liang S, Ma Y (2022) Identification of diagnostic markers related to fecal and plasma metabolism in primary Sj\u00f6gren\u2019s syndrome. Am J Transl Res 14:7378\u20137390","journal-title":"Am J Transl Res"},{"issue":"Suppl 133","key":"7642_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.55563\/clinexprheumatol\/ylte6v","volume":"39","author":"T Xu","year":"2021","unstructured":"Xu T, Guo Y, Lu J, Shan J, Lin L, Qian W, Chen W, Wang J, Lv X, Ke M, Kong D, Shen Q, Zhu Y, Liu P, Su J, Lu W, Li Y, Gao P, Liu S (2021) Untargeted serum metabolomics and potential biomarkers for Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol 39(Suppl 133):23\u201329. https:\/\/doi.org\/10.55563\/clinexprheumatol\/ylte6v","journal-title":"Clin Exp Rheumatol"},{"key":"7642_CR15","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1007\/s10067-024-07165-2","volume":"43","author":"R Feng","year":"2024","unstructured":"Feng R, Xiao X, Wang Y, Huang B, Chen J, Cheng G, Jin Y (2024) Metabolic impact of low dose IL-2 therapy for primary Sj\u00f6gren\u2019s syndrome in a double-blind, randomized clinical trial. Clin Rheumatol 43:3789\u20133798. https:\/\/doi.org\/10.1007\/s10067-024-07165-2","journal-title":"Clin Rheumatol"},{"key":"7642_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112999","volume":"179","author":"\u00c1 Fern\u00e1ndez-Ochoa","year":"2020","unstructured":"Fern\u00e1ndez-Ochoa \u00c1, Borr\u00e1s-Linares I, Quirantes-Pin\u00e9 R, Alarc\u00f3n-Riquelme ME, Beretta L, Segura-Carretero A (2020) Discovering new metabolite alterations in primary Sj\u00f6gren\u2019s syndrome in urinary and plasma samples using an HPLC-ESI-QTOF-MS methodology. J Pharm Biomed Anal 179:112999. https:\/\/doi.org\/10.1016\/j.jpba.2019.112999","journal-title":"J Pharm Biomed Anal"},{"key":"7642_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2023.152722","volume":"228","author":"J Zhang","year":"2023","unstructured":"Zhang J, Tang Z, Liu Z, Wang G, Yang X (2023) Metabolomic and proteomic analyses of primary Sjogren\u2019s syndrome. Immunobiology 228:152722. https:\/\/doi.org\/10.1016\/j.imbio.2023.152722","journal-title":"Immunobiology"},{"key":"7642_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0837-1","volume":"15","author":"F Franceschini","year":"2017","unstructured":"Franceschini F, Cavazzana I, Andreoli L, Tincani A (2017) The 2016 classification criteria for primary Sjogren\u2019s syndrome: what\u2019s new? BMC Med 15:69. https:\/\/doi.org\/10.1186\/s12916-017-0837-1","journal-title":"BMC Med"},{"key":"7642_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204315","author":"X Xiang","year":"2023","unstructured":"Xiang X, Chen J, Zhu M, Gao H, Liu X (2023) Multiomics revealed the multi-dimensional effects of late sleep on gut microbiota and metabolites in children in northwest China. Nutrients. https:\/\/doi.org\/10.3390\/nu15204315","journal-title":"Nutrients"},{"key":"7642_CR20","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1080\/00365521.2022.2065888","volume":"57","author":"A Hedstr\u00f6m","year":"2022","unstructured":"Hedstr\u00f6m A, Kvarnstr\u00f6m M, Lindberg G, Alsabeah S, Alsabeah H, Ndegwa N, L\u00f6hr JM, Haas SL, Vujasinovic M (2022) High prevalence of gastrointestinal symptoms in patients with primary Sj\u00f6gren\u2019s syndrome cannot be attributed to pancreatic exocrine insufficiency. Scand J Gastroenterol 57:1250\u20131256. https:\/\/doi.org\/10.1080\/00365521.2022.2065888","journal-title":"Scand J Gastroenterol"},{"key":"7642_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-020-01348-7","volume":"19","author":"R Mendez","year":"2020","unstructured":"Mendez R, Watane A, Farhangi M, Cavuoto KM, Leith T, Budree S, Galor A, Banerjee S (2020) Gut microbial dysbiosis in individuals with Sj\u00f6gren\u2019s syndrome. Microb Cell Fact 19:90. https:\/\/doi.org\/10.1186\/s12934-020-01348-7","journal-title":"Microb Cell Fact"},{"key":"7642_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2025.110444","volume":"273","author":"X Yuan","year":"2025","unstructured":"Yuan X, Wang J, Wang W, Song Y, Wu J, Du R (2025) Microbiome alterations in primary Sj\u00f6gren\u2019s syndrome: regional dysbiosis and microbiome-targeted therapeutic strategies. Clin Immunol 273:110444. https:\/\/doi.org\/10.1016\/j.clim.2025.110444","journal-title":"Clin Immunol"},{"key":"7642_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-021-02173-7","author":"CH Yoon","year":"2021","unstructured":"Yoon CH, Ryu JS, Moon J, Kim MK (2021) Association between aging-dependent gut microbiome dysbiosis and dry eye severity in C57BL\/6 male mouse model: a pilot study. BMC Microbiol. https:\/\/doi.org\/10.1186\/s12866-021-02173-7","journal-title":"BMC Microbiol"},{"key":"7642_CR24","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2298246","volume":"16","author":"G Gargari","year":"2024","unstructured":"Gargari G, Mantegazza G, Cremon C, Taverniti V, Valenza A, Barbaro MR, Marasco G, Duncan R, Fiore W, Ferrari R, De Vitis V, Barbara G, Guglielmetti S (2024) Collinsella aerofaciens as a predictive marker of response to probiotic treatment in non-constipated irritable bowel syndrome. Gut Microbes 16:2298246. https:\/\/doi.org\/10.1080\/19490976.2023.2298246","journal-title":"Gut Microbes"},{"key":"7642_CR25","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1099\/ijs.0.045823-0","volume":"63","author":"T Takada","year":"2013","unstructured":"Takada T, Kurakawa T, Tsuji H, Nomoto K (2013) Fusicatenibacter saccharivorans gen. nov., sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 63:3691\u20133696. https:\/\/doi.org\/10.1099\/ijs.0.045823-0","journal-title":"Int J Syst Evol Microbiol"},{"issue":"1","key":"7642_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01620-3","volume":"11","author":"E Medawar","year":"2021","unstructured":"Medawar E, Haange SB, Rolle-Kampczyk U, Engelmann B, Dietrich A, Thieleking R, Wiegank C, Fries C, Horstmann A, Villringer A, von Bergen M (2021) Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior. Transl Psychiatry 11(1):500. https:\/\/doi.org\/10.1038\/s41398-021-01620-3","journal-title":"Transl Psychiatry"},{"key":"7642_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.802493","volume":"9","author":"SE Firmani","year":"2022","unstructured":"Firmani SE, Maples HD, Balamohan A (2022) Lactococcus species central line-associated bloodstream infection in pediatrics: a case series. Front Med 9:802493. https:\/\/doi.org\/10.3389\/fmed.2022.802493","journal-title":"Front Med"},{"key":"7642_CR28","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s10067-024-07294-8","volume":"44","author":"F Pang","year":"2025","unstructured":"Pang F, Jiang Q, Tang X, Li K (2025) Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sj\u00f6gren\u2019s syndrome. Clin Rheumatol 44:1209\u20131223. https:\/\/doi.org\/10.1007\/s10067-024-07294-8","journal-title":"Clin Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07642-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07642-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:25:29Z","timestamp":1760365529000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07642-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["7642"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07642-2","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"10 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}