{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:50:50Z","timestamp":1777056650831,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10067-025-07726-z","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:56:54Z","timestamp":1760551014000},"page":"4921-4930","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of plasma protein biomarkers for ankylosing spondylitis by integrating proteome with genome"],"prefix":"10.1007","volume":"44","author":[{"given":"Manli","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiadong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-9160","authenticated-orcid":false,"given":"Yingying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"issue":"7","key":"7726_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41584-021-00625-y","volume":"17","author":"D Mauro","year":"2021","unstructured":"Mauro D, Thomas R, Guggino G et al (2021) Ankylosing spondylitis: an autoimmune or autoinflammatory disease? Nat Rev Rheumatol 17(7):387\u2013404. https:\/\/doi.org\/10.1038\/s41584-021-00625-y","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"7726_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/BOR.0000000000000475","volume":"30","author":"R Wang","year":"2018","unstructured":"Wang R, Ward MM (2018) Epidemiology of axial spondyloarthritis: an update. Curr Opin Rheumatol 30(2):137\u2013143. https:\/\/doi.org\/10.1097\/BOR.0000000000000475","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"7726_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4078\/jrd.22.0023","volume":"29","author":"SR Kwon","year":"2022","unstructured":"Kwon SR, Kim TH, Kim TJ et al (2022) The epidemiology and treatment of ankylosing spondylitis in Korea. J Rheum Dis 29(4):193\u2013199. https:\/\/doi.org\/10.4078\/jrd.22.0023","journal-title":"J Rheum Dis"},{"issue":"8","key":"7726_CR4","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1007\/s10067-021-05679-7","volume":"40","author":"MC Hwang","year":"2021","unstructured":"Hwang MC, Ridley L, Reveille JD (2021) Ankylosing spondylitis risk factors: a systematic literature review. Clin Rheumatol 40(8):3079\u20133093. https:\/\/doi.org\/10.1007\/s10067-021-05679-7","journal-title":"Clin Rheumatol"},{"issue":"3","key":"7726_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00296-023-05484-2","volume":"44","author":"M Chmielinska","year":"2024","unstructured":"Chmielinska M, Olesinska M, Felis-Giemza A et al (2024) Predictors of treatment failure of non-steroidal anti-inflammatory drugs in patients with axial spondyloarthritis with focus on haptoglobin, haptoglobin polymorphism and zonulin. Rheumatol Int 44(3):483\u2013495. https:\/\/doi.org\/10.1007\/s00296-023-05484-2","journal-title":"Rheumatol Int"},{"issue":"4","key":"7726_CR6","doi-asserted-by":"publisher","DOI":"10.21037\/atm-23-195","volume":"11","author":"C Tian","year":"2023","unstructured":"Tian C, Shu J, Shao W et al (2023) Efficacy and safety of IL inhibitors, TNF-\u03b1 inhibitors, and JAK inhibitors in patients with ankylosing spondylitis: a systematic review and Bayesian network meta-analysis. Ann Transl Med 11(4):178. https:\/\/doi.org\/10.21037\/atm-23-195","journal-title":"Ann Transl Med"},{"issue":"1","key":"7726_CR7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52559","volume":"16","author":"P Agrawal","year":"2024","unstructured":"Agrawal P, Tote S, Sapkale B (2024) Diagnosis and treatment of ankylosing spondylitis. Cureus 16(1):e52559. https:\/\/doi.org\/10.7759\/cureus.52559","journal-title":"Cureus"},{"issue":"7708","key":"7726_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","volume":"558","author":"BB Sun","year":"2018","unstructured":"Sun BB, Maranville JC, Peters JE et al (2018) Genomic atlas of the human plasma proteome. Nature 558(7708):73\u201379. https:\/\/doi.org\/10.1038\/s41586-018-0175-2","journal-title":"Nature"},{"issue":"11","key":"7726_CR9","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1136\/ard-2022-223791","volume":"82","author":"F Tavasolian","year":"2023","unstructured":"Tavasolian F, Lively S, Pastrello C et al (2023) Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis. Ann Rheum Dis 82(11):1429\u20131443. https:\/\/doi.org\/10.1136\/ard-2022-223791","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"7726_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03044-4","volume":"25","author":"M Hwang","year":"2023","unstructured":"Hwang M, Assassi S, Zheng J (2023) Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis. Arthritis Res Ther 25(1):57. https:\/\/doi.org\/10.1186\/s13075-023-03044-4","journal-title":"Arthritis Res Ther"},{"key":"7726_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.838891","volume":"13","author":"Z Yu","year":"2022","unstructured":"Yu Z, Hong X, Zhang X et al (2022) Global proteomic analyses reveals abnormal immune regulation in patients with new onset ankylosing spondylitis. Front Immunol 13:838891. https:\/\/doi.org\/10.3389\/fimmu.2022.838891","journal-title":"Front Immunol"},{"issue":"7","key":"7726_CR12","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543\u2013552. https:\/\/doi.org\/10.1007\/s10654-015-0011-z","journal-title":"Eur J Epidemiol"},{"issue":"12","key":"7726_CR13","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA (2021) Large-scale integration of the plasma proteome with genetics and disease. Nat Genet 53(12):1712\u20131721. https:\/\/doi.org\/10.1038\/s41588-021-00978-w","journal-title":"Nat Genet"},{"issue":"7944","key":"7726_CR14","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613(7944):508\u2013518. https:\/\/doi.org\/10.1038\/s41586-022-05473-8","journal-title":"Nature"},{"key":"7726_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601","volume":"362","author":"NM Davies","year":"2018","unstructured":"Davies NM, Holmes MV, Davey Smith G (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ (Clinical research ed) 362:k601. https:\/\/doi.org\/10.1136\/bmj.k601","journal-title":"BMJ (Clinical research ed)"},{"issue":"11","key":"7726_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330967","volume":"73","author":"S Li","year":"2024","unstructured":"Li S, Gong M (2024) Drug targets for haemorrhoidal disease: proteome-wide Mendelian randomisation and colocalisation analyses. Gut 73(11):e31. https:\/\/doi.org\/10.1136\/gutjnl-2023-330967","journal-title":"Gut"},{"key":"7726_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1161817","volume":"14","author":"Z Wu","year":"2023","unstructured":"Wu Z, Yang KG, Lam TP et al (2023) Genetic insight into the putative causal proteins and druggable targets of osteoporosis: a large-scale proteome-wide mendelian randomization study. Front Genet 14:1161817. https:\/\/doi.org\/10.3389\/fgene.2023.1161817","journal-title":"Front Genet"},{"key":"7726_CR18","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000000920","author":"A Harroud","year":"2021","unstructured":"Harroud A, Richards JB, Baranzini SE (2021) Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS. Neurol Neuroimmunol Neuroinflamm. https:\/\/doi.org\/10.1212\/nxi.0000000000000920","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"7726_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106395","volume":"191","author":"W Cao","year":"2023","unstructured":"Cao W, Xing M, Liang S et al (2023) Causal relationship of gut microbiota and metabolites on cognitive performance: a mendelian randomization analysis. Neurobiol Dis 191:106395. https:\/\/doi.org\/10.1016\/j.nbd.2023.106395","journal-title":"Neurobiol Dis"},{"issue":"2","key":"7726_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1161\/circulationaha.118.035905","volume":"139","author":"MK Georgakis","year":"2019","unstructured":"Georgakis MK, Gill D, Rannikm\u00e4e K et al (2019) Genetically determined levels of circulating cytokines and risk of stroke. Circulation 139(2):256\u2013268. https:\/\/doi.org\/10.1161\/circulationaha.118.035905","journal-title":"Circulation"},{"issue":"3","key":"7726_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0962280210394459","volume":"21","author":"TM Palmer","year":"2012","unstructured":"Palmer TM, Lawlor DA, Harbord RM et al (2012) Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Med Res 21(3):223\u2013242. https:\/\/doi.org\/10.1177\/0962280210394459","journal-title":"Stat Med Res"},{"issue":"7","key":"7726_CR22","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37(7):658\u2013665. https:\/\/doi.org\/10.1002\/gepi.21758","journal-title":"Genet Epidemiol"},{"issue":"1","key":"7726_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02736-7","volume":"21","author":"B Liu","year":"2023","unstructured":"Liu B, Lyu L, Zhou W et al (2023) Associations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study. BMC Med 21(1):39. https:\/\/doi.org\/10.1186\/s12916-023-02736-7","journal-title":"BMC Med"},{"issue":"4","key":"7726_CR24","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey Smith G, Haycock PC et al (2016) Consistent estimation in Mendelian Randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304\u2013314. https:\/\/doi.org\/10.1002\/gepi.21965","journal-title":"Genet Epidemiol"},{"issue":"5","key":"7726_CR25","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1177\/0962280215597579","volume":"26","author":"S Burgess","year":"2017","unstructured":"Burgess S, Small DS, Thompson SG (2017) A review of instrumental variable estimators for Mendelian randomization. Stat Med Res 26(5):2333\u20132355. https:\/\/doi.org\/10.1177\/0962280215597579","journal-title":"Stat Med Res"},{"issue":"5","key":"7726_CR26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen CY, Neale B et al (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50(5):693\u2013698. https:\/\/doi.org\/10.1038\/s41588-018-0099-7","journal-title":"Nat Genet"},{"issue":"5","key":"7726_CR27","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48(5):481\u2013487. https:\/\/doi.org\/10.1038\/ng.3538","journal-title":"Nat Genet"},{"issue":"12","key":"7726_CR28","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1136\/ard-2023-224459","volume":"82","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xie J, Wen S (2023) Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits. Ann Rheum Dis 82(12):1606\u20131617. https:\/\/doi.org\/10.1136\/ard-2023-224459","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"7726_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01229-9","volume":"15","author":"J Sun","year":"2023","unstructured":"Sun J, Zhao J, Jiang F et al (2023) Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome. Genome Med 15(1):75. https:\/\/doi.org\/10.1186\/s13073-023-01229-9","journal-title":"Genome Med"},{"issue":"1","key":"7726_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04919-z","volume":"22","author":"L Zhang","year":"2024","unstructured":"Zhang L, Xiong Y, Zhang J et al (2024) Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma. J Transl Med 22(1):330. https:\/\/doi.org\/10.1186\/s12967-024-04919-z","journal-title":"J Transl Med"},{"issue":"5","key":"7726_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE et al (2014) Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet 10(5):e1004383. https:\/\/doi.org\/10.1371\/journal.pgen.1004383","journal-title":"PLoS Genet"},{"key":"7726_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366736","volume":"15","author":"W Zhao","year":"2024","unstructured":"Zhao W, Fang P, Lai C et al (2024) Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis. Front Immunol 15:1366736. https:\/\/doi.org\/10.3389\/fimmu.2024.1366736","journal-title":"Front Immunol"},{"key":"7726_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.molimm.2023.07.010","volume":"161","author":"C Zanchi","year":"2023","unstructured":"Zanchi C, Locatelli M, Corna D et al (2023) Liver factor B silencing to cure C3 glomerulopathy: evidence from a mouse model of complement dysregulation. Mol Immunol 161:25\u201332. https:\/\/doi.org\/10.1016\/j.molimm.2023.07.010","journal-title":"Mol Immunol"},{"key":"7726_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117238","volume":"289","author":"MC Nakhla","year":"2025","unstructured":"Nakhla MC, Comita J, Shapiro AB et al (2025) Small molecule inhibitors of mannan-binding lectin-associated serine proteases-2 and-3. Eur J Med Chem 289:117238. https:\/\/doi.org\/10.1016\/j.ejmech.2025.117238","journal-title":"Eur J Med Chem"},{"issue":"6","key":"7726_CR35","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrrheum.2017.56","volume":"13","author":"V Ranganathan","year":"2017","unstructured":"Ranganathan V, Gracey E, Brown MA et al (2017) Pathogenesis of ankylosing spondylitis - recent advances and future directions. Nat Rev Rheumatol 13(6):359\u2013367. https:\/\/doi.org\/10.1038\/nrrheum.2017.56","journal-title":"Nat Rev Rheumatol"},{"key":"7726_CR36","first-page":"378","volume":"29","author":"H Li","year":"2023","unstructured":"Li H, He Z, Deng B et al (2023) Cytokines and chemokines involved in HLA-B27-positive ankylosing spondylitis-associated acute anterior uveitis. Mol Vis 29:378\u2013385","journal-title":"Mol Vis"},{"issue":"2","key":"7726_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/ejh.14422","volume":"115","author":"RP de Latour","year":"2025","unstructured":"de Latour RP, Kulasekararaj A, Dingli D et al (2025) Anchored indirect treatment comparison finds comparable effects of pegcetacoplan and iptacopan in paroxysmal nocturnal haemoglobinuria. Eur J Haematol 115(2):125\u2013133. https:\/\/doi.org\/10.1111\/ejh.14422","journal-title":"Eur J Haematol"},{"key":"7726_CR38","doi-asserted-by":"publisher","unstructured":"Barratt J, Perkovic V, Rizk DV (2025) Alternative complement pathway, iptacopan, and IgA nephropathy. Reply. The New England journal of medicine 392(19):1976. https:\/\/doi.org\/10.1056\/NEJMc2503117","DOI":"10.1056\/NEJMc2503117"},{"issue":"1","key":"7726_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/08923973.2022.2112220","volume":"45","author":"M Ahangari Maleki","year":"2023","unstructured":"Ahangari Maleki M, Malek Mahdavi A, Soltani-Zangbar MS et al (2023) Randomized double-blinded controlled trial on the effect of synbiotic supplementation on IL-17\/IL-23 pathway and disease activity in patients with axial spondyloarthritis. Immunopharmacol Immunotoxicol 45(1):43\u201351. https:\/\/doi.org\/10.1080\/08923973.2022.2112220","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"3","key":"7726_CR40","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3233\/jad-200406","volume":"76","author":"SY Wang","year":"2020","unstructured":"Wang SY, Gong PY, E Y (2020) The role of TREML2 in Alzheimer\u2019s disease. J Alzheimers Dis 76(3):799\u2013806. https:\/\/doi.org\/10.3233\/jad-200406","journal-title":"J Alzheimers Dis"},{"key":"7726_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.gene.2018.05.057","volume":"668","author":"Y Feng","year":"2018","unstructured":"Feng Y, Hong Y, Zhang X et al (2018) Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis. Gene 668:121\u2013128. https:\/\/doi.org\/10.1016\/j.gene.2018.05.057","journal-title":"Gene"},{"issue":"30","key":"7726_CR42","doi-asserted-by":"publisher","first-page":"10495","DOI":"10.1073\/pnas.0802423105","volume":"105","author":"M Hashiguchi","year":"2008","unstructured":"Hashiguchi M, Kobori H, Ritprajak P et al (2008) Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7\u2013H3 and enhances T cell responses. Proc Natl Acad Sci U S A 105(30):10495\u201310500. https:\/\/doi.org\/10.1073\/pnas.0802423105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"7726_CR43","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1007\/s10753-014-0103-z","volume":"38","author":"R Yan","year":"2015","unstructured":"Yan R, Hu Y, Yu P et al (2015) Reduced serum B7\u2013H3 levels in patients with ankylosing spondylitis. Inflammation 38(3):1322\u20131328. https:\/\/doi.org\/10.1007\/s10753-014-0103-z","journal-title":"Inflammation"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07726-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07726-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07726-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:13:32Z","timestamp":1762776812000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07726-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["7726"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07726-z","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"3 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Previous datasets have been approved by their respective ethical approval committees.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}