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The actual prevalence of ILD in SSc cohort was estimated between 10.5% and 47.3%. The most common form was usual interstitial pneumonitis (UIP). The total lung capacity (TLC)\/diffusion capacity of carbon monoxide (DLCO), renal function, and CRP were poorer in the SSc\u2013ILD who smoked less than the counterpart without ILD. A weighted score incorporated from essential parameters (risk of ILD\u2009=\u2009TLC\u2009\u2212\u20090.1\u2009\u00d7\u2009ESR\u2009\u2212\u20091.5\u2009\u00d7\u2009CRP) has modest power (ROC AUC 0.7242) to predict ILD. The main causes of death in the SSc\u2013ILD were infections (72.7%), pulmonary hypertension (PH, OR\u2009=\u200918.81, 95% CI\u2009=\u20092.11\u2013167.70), and renal failure (OR\u2009=\u200933.6, 95% CI\u2009=\u20092.00\u2013546.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The SSc\u2013ILD have lower TLC\/DLCO, higher CRP, and poorer renal function than the SSc without ILD. Early-onset dyspnea, PH, and renal failure may be independent risk factors for mortality in SSc\u2013ILD.\n                      <jats:table-wrap>\n                        <jats:table>\n                          <jats:tbody>\n                            <jats:tr>\n                              <jats:td colspan=\"2\">\n                                <jats:bold>Key Points<\/jats:bold>\n                                \u2022\n                                <jats:italic>110 SSc (M: F=26:84) were retrospectively analyzed for ILD, with 10.5\u201347.3% presenting with ILD (UIP the most).<\/jats:italic>\n                                \u2022\n                                <jats:italic>Risk of ILD in SSc\u2009=\u2009TLC \u2013 0.1\u2009\u00d7\u2009 ESR\u2009\u2212\u20091.5\u2009\u00d7\u2009CRP can apply in this cohort.<\/jats:italic>\n                                \u2022\n                                <jats:italic>Death originated from infections, PH, and renal failure in addition to early-onset dyspnea in this cohort.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                          <\/jats:tbody>\n                        <\/jats:table>\n                      <\/jats:table-wrap>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10067-025-07913-y","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T09:46:25Z","timestamp":1767779185000},"page":"1011-1022","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interstitial lung disease in systemic sclerosis\u2014a retrospective cross-sectional study in Taiwan"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-1766","authenticated-orcid":false,"given":"Chih-Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7370-3769","authenticated-orcid":false,"given":"Yen-An","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-0400","authenticated-orcid":false,"given":"Chia-Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-2608","authenticated-orcid":false,"given":"Hung-Cheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3906-0345","authenticated-orcid":false,"given":"I.-Cheng","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Syuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-4840","authenticated-orcid":false,"given":"Hsien-Tzung","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-4018","authenticated-orcid":false,"given":"Chang-Youh","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"7913_CR1","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/art.38702","volume":"66","author":"EL Herzog","year":"2014","unstructured":"Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J (2014) Review - interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? 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