{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:10:34Z","timestamp":1791774634232,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2023 Jiaxing Key Discipiline of Medcine, Rheumatology and Autoimmunology","award":["2023-ZC-016"],"award-info":[{"award-number":["2023-ZC-016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s10067-026-08029-7","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:19:38Z","timestamp":1773800378000},"page":"2583-2600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age-stratified treatment response in rheumatoid arthritis: a systematic review, meta-analysis, and integrated genetic and single-cell evidence implicating IL6R\/TYK2 signaling"],"prefix":"10.1007","volume":"45","author":[{"given":"Mingfeng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9535-4026","authenticated-orcid":false,"given":"Hui","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"8029_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1568-9972(03)00006-5","volume":"2","author":"GS Cooper","year":"2003","unstructured":"Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2:119\u2013125","journal-title":"Autoimmun Rev"},{"key":"8029_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.medcli.2023.07.014","volume":"161","author":"F D\u00edaz-Gonz\u00e1lez","year":"2023","unstructured":"D\u00edaz-Gonz\u00e1lez F, Hern\u00e1ndez-Hern\u00e1ndez MV (2023) Rheumatoid arthritis. Med Clin (Barc) 161:533\u2013542","journal-title":"Med Clin (Barc)"},{"key":"8029_CR3","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1080\/1744666X.2022.2106970","volume":"18","author":"AI Venetsanopoulou","year":"2022","unstructured":"Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA (2022) Epidemiology of rheumatoid arthritis: genetic and environmental influences. Expert Rev Clin Immunol 18:923\u2013931","journal-title":"Expert Rev Clin Immunol"},{"key":"8029_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102776","volume":"20","author":"FA Figus","year":"2021","unstructured":"Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A (2021) Rheumatoid arthritis: extra-articular manifestations and comorbidities. Autoimmun Rev 20:102776","journal-title":"Autoimmun Rev"},{"key":"8029_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2025.102036","volume":"39","author":"P Uke","year":"2025","unstructured":"Uke P, Maharaj A, Adebajo A (2025) A review on the epidemiology of rheumatoid arthritis: an update and trends from current literature. Best Pract Res Clin Rheumatol 39:102036","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"8029_CR6","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s00296-025-05908-1","volume":"45","author":"O Zimba","year":"2025","unstructured":"Zimba O, Baimukhamedov C, Kocyigit BF (2025) Late-onset rheumatoid arthritis: clinical features, diagnostic challenges, and treatment approaches. Rheumatol Int 45:152","journal-title":"Rheumatol Int"},{"key":"8029_CR7","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1093\/mr\/roae011","volume":"34","author":"M Kojima","year":"2024","unstructured":"Kojima M, Sugihara T, Kawahito Y, Kojima T, Kaneko Y, Ishikawa H, Abe A, Matsui K, Hirata S, Kishimoto M, Tanaka E, Morinobu A, Hashimoto M, Matsushita I, Hidaka T, Matsui T, Nishida K, Asai S, Ito H, Harada R, Harigai M (2024) Consensus statement on the management of late-onset rheumatoid arthritis. Mod Rheumatol 34:1095\u20131102","journal-title":"Mod Rheumatol"},{"key":"8029_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.31138\/mjr.290824.ada","volume":"35","author":"UP Risal","year":"2024","unstructured":"Risal UP, Bhattarai U (2024) Late-onset rheumatoid arthritis (LORA): a diagnostic and therapeutic challenge among older patients visiting a poorly resourced health-care setting. Mediterr J Rheumatol 35:573\u2013578","journal-title":"Mediterr J Rheumatol"},{"key":"8029_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0531-5565(98)00072-2","volume":"34","author":"CP Mavragani","year":"1999","unstructured":"Mavragani CP, Moutsopoulos HM (1999) Rheumatoid arthritis in the elderly. Exp Gerontol 34:463\u2013471","journal-title":"Exp Gerontol"},{"key":"8029_CR10","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/rheumatology\/38.3.228","volume":"38","author":"CT Pease","year":"1999","unstructured":"Pease CT, Bhakta BB, Devlin J, Emery P (1999) Does the age of onset of rheumatoid arthritis influence phenotype? A prospective study of outcome and prognostic factors. Rheumatology (Oxford) 38:228\u2013234","journal-title":"Rheumatology (Oxford)"},{"key":"8029_CR11","first-page":"645","volume":"31","author":"AG Greenwald","year":"2013","unstructured":"Greenwald AG, Zakerzadeh A, Laxer RM, Schneider R, Cameron B, Feldman B, Spiegel L, Tse SM, Silverman ED (2013) Later-onset rheumatoid factor negative polyarticular juvenile idiopathic arthritis (JIA): a unique patient group? Clin Exp Rheumatol 31:645\u2013652","journal-title":"Clin Exp Rheumatol"},{"key":"8029_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.archger.2005.07.003","volume":"42","author":"N Turkcapar","year":"2006","unstructured":"Turkcapar N, Demir O, Atli T, Kopuk M, Turgay M, Kinikli G, Duman M (2006) Late onset rheumatoid arthritis: clinical and laboratory comparisons with younger onset patients. Arch Gerontol Geriatr 42:225\u2013231","journal-title":"Arch Gerontol Geriatr"},{"key":"8029_CR13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/tan.12521","volume":"85","author":"CM Mariaselvam","year":"2015","unstructured":"Mariaselvam CM, Chaaben AB, Salah S, Charron D, Krishnamoorthy R, Tamouza R, Negi VS (2015) Human leukocyte antigen-G polymorphism influences the age of onset and autoantibody status in rheumatoid arthritis. Tissue Antigens 85:182\u2013189","journal-title":"Tissue Antigens"},{"key":"8029_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-022-00322-7","volume":"6","author":"M Kojima","year":"2022","unstructured":"Kojima M, Kawahito Y, Sugihara T, Kojima T, Harada R, Hirata S, Hashimoto M, Hidaka T, Ishikawa H, Ito H, Kishimoto M, Kaneko Y, Matsui K, Matsui T, Matsushita I, Morinobu A, Nishida K, Tanaka E, Abe A, Ishitoku M, Asai S, Kida T, Onishi A, Takanashi S, Harigai M (2022) Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design. BMC Rheumatol 6:90","journal-title":"BMC Rheumatol"},{"key":"8029_CR15","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1093\/mr\/roae006","volume":"34","author":"T Matsui","year":"2024","unstructured":"Matsui T, Yoshida T, Nishino T, Yoshizawa S, Sawada T, Tohma S (2024) Trends in treatment for patients with late-onset rheumatoid arthritis in Japan: data from the Ninja study. Mod Rheumatol 34:881\u2013891","journal-title":"Mod Rheumatol"},{"key":"8029_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.13235","volume":"25","author":"S Keskin Demircan","year":"2025","unstructured":"Keskin Demircan S, Kahveci A (2025) The disease burden of earlier and late-onset rheumatoid arthritis on depression and related geriatric syndromes. Psychogeriatrics 25:e13235","journal-title":"Psychogeriatrics"},{"key":"8029_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.hrtlng.2005.03.007","volume":"35","author":"BA Cunha","year":"2006","unstructured":"Cunha BA, Syed U, Hamid N (2006) Fever of unknown origin caused by late-onset rheumatoid arthritis. Heart Lung 35:70\u201373","journal-title":"Heart Lung"},{"key":"8029_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02952-1","volume":"24","author":"X Li","year":"2022","unstructured":"Li X, Cesta A, Movahedi M, Bombardier C (2022) Late-onset rheumatoid arthritis has a similar time to remission as younger-onset rheumatoid arthritis: results from the Ontario Best Practices Research Initiative. Arthritis Res Ther 24:255","journal-title":"Arthritis Res Ther"},{"key":"8029_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s40266-025-01195-4","volume":"42","author":"M Harigai","year":"2025","unstructured":"Harigai M, Sugihara T (2025) Management of late-onset rheumatoid arthritis with treat-to-target strategy. Drugs Aging 42:413\u2013433","journal-title":"Drugs Aging"},{"key":"8029_CR20","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.cgh.2018.12.032","volume":"17","author":"NZ Borren","year":"2019","unstructured":"Borren NZ, Ananthakrishnan AN (2019) Safety of biologic therapy in older patients with immune-mediated diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 17:1736\u20131743","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8029_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003160","volume":"9","author":"K Ebina","year":"2023","unstructured":"Ebina K, Etani Y, Maeda Y et al (2023) Drug retention of biologics and Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study. RMD Open 9:e003160","journal-title":"RMD Open"},{"key":"8029_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/ar4540","volume":"16","author":"L Innala","year":"2014","unstructured":"Innala L, Berglin E, M\u00f6ller B et al (2014) Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study. Arthritis Res Ther 16:R94","journal-title":"Arthritis Res Ther"},{"key":"8029_CR23","first-page":"1987","volume":"40","author":"S Jinno","year":"2020","unstructured":"Jinno S, Onishi A, Dubreuil M et al (2020) Comparison of the efficacy and safety of biologic agents between elderly-onset and young-onset RA patients: the ANSWER cohort study. Rheumatology (Oxford) 40:1987\u20131995","journal-title":"Rheumatology (Oxford)"},{"key":"8029_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1928","volume":"22","author":"H Jeries","year":"2024","unstructured":"Jeries H, Daood R, Hijazi B et al (2024) Drug survival on first biologic therapy among late-onset rheumatoid arthritis patients compared to early-onset patients: a population-based cohort study. Musculoskelet Care 22:e1928","journal-title":"Musculoskelet Care"},{"key":"8029_CR25","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3899\/jrheum.201135","volume":"48","author":"S Ochi","year":"2021","unstructured":"Ochi S, Mizoguchi F, Nakano K, Tanaka Y (2021) Similarity of response to biologics between elderly-onset rheumatoid arthritis (EORA) and non-EORA elderly patients: from the FIRST registry. J Rheumatol 48:847\u2013854","journal-title":"J Rheumatol"},{"key":"8029_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13075-023-03251-z","volume":"26","author":"T Fujii","year":"2024","unstructured":"Fujii T, Murata K, Onizawa H et al (2024) Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort. Arthritis Res Ther 26:16","journal-title":"Arthritis Res Ther"},{"key":"8029_CR27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.reuma.2023.10.004","volume":"20","author":"N P\u00e9rez","year":"2024","unstructured":"P\u00e9rez N, Gargiulo MdLA, Khoury M et al (2024) Elderly-onset rheumatoid arthritis receives less aggressive therapies than young-onset rheumatoid arthritis in an Argentinian cohort. Reumatol Clin 20:136\u2013141","journal-title":"Reumatol Clin"},{"key":"8029_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02496-w","volume":"23","author":"S Jinno","year":"2021","unstructured":"Jinno S, Onishi A, Dubreuil M et al (2021) Comparison of the drug retention and reasons for discontinuation of tumor necrosis factor inhibitors and interleukin-6 inhibitors in Japanese patients with elderly-onset rheumatoid arthritis\u2014the ANSWER cohort study. Arthritis Res Ther 23:116","journal-title":"Arthritis Res Ther"},{"key":"8029_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02952-1","volume":"24","author":"X Li","year":"2022","unstructured":"Li X, Cesta A, Movahedi M et al (2022) Late-onset rheumatoid arthritis has a similar time to remission as younger-onset rheumatoid arthritis: results from the Ontario Best Practices Research Initiative. Arthritis Res Ther 24:255","journal-title":"Arthritis Res Ther"},{"key":"8029_CR30","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.3899\/jrheum.201135","volume":"48","author":"S Ochi","year":"2021","unstructured":"Ochi S, Mizoguchi F, Nakano K, Tanaka Y (2021) Similarity of response to biologics between elderly-onset rheumatoid arthritis (EORA) and non-EORA elderly patients: from the FIRST Registry. J Rheumatol 48:1655\u20131662","journal-title":"J Rheumatol"},{"key":"8029_CR31","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10067-015-3031-x","volume":"35","author":"TN Ruban","year":"2016","unstructured":"Ruban TN, Jacob B, Pope JE, Keystone EC, Bombardier C, Kuriya B (2016) The influence of age at disease onset on disease activity and disability: results from the Ontario Best Practices Research Initiative. Clin Rheumatol 35:759\u2013763","journal-title":"Clin Rheumatol"},{"key":"8029_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa450","author":"G Butler-Laporte","year":"2020","unstructured":"Butler-Laporte G, Kreuzer D, Nakanishi T, Harroud A, Forgetta V, Richards JB (2020) Genetic determinants of antibody-mediated immune responses to infectious diseases agents: a genome-wide and HLA association study. Open Forum Infect Dis. https:\/\/doi.org\/10.1093\/ofid\/ofaa450","journal-title":"Open Forum Infect Dis"},{"key":"8029_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG, CRP CHD Genetics Collaboration (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40:755\u2013764","journal-title":"Int J Epidemiol"},{"key":"8029_CR34","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.molcel.2017.01.023","volume":"65","author":"C Ziegenhain","year":"2017","unstructured":"Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W (2017) Comparative analysis of single-cell RNA sequencing methods. Mol Cell 65:631\u2013643","journal-title":"Mol Cell"},{"key":"8029_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0071-8","volume":"50","author":"B Hwang","year":"2018","unstructured":"Hwang B, Lee JH, Bang D (2018) Single-cell RNA sequencing technologies and bioinformatics pipelines. Exp Mol Med 50:1\u201314","journal-title":"Exp Mol Med"},{"key":"8029_CR36","first-page":"242","volume":"352\u2013353","author":"Y Shuasheva","year":"2024","unstructured":"Shuasheva Y, Buleshov M, Kemelbekov K (2024) Clinical, immunological and thesio-graphic characteristics rheumatoid arthritis and chronic rheumatic heart disease. Georgian Med News 352\u2013353:242\u2013248","journal-title":"Georgian Med News"},{"key":"8029_CR37","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/1756-185X.12861","volume":"20","author":"TC Tan","year":"2017","unstructured":"Tan TC, Gao X, Thong BY, Leong KP, Lian TY, Law WG, Kong KO, Howe HS, Chng HH, Koh ET, TTSH Rheumatoid Arthritis Study Group (2017) Comparison of elderly- and young-onset rheumatoid arthritis in an Asian cohort. Int J Rheum Dis 20:737\u2013745","journal-title":"Int J Rheum Dis"},{"key":"8029_CR38","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.2169\/internalmedicine.3288-23","volume":"63","author":"S Takanashi","year":"2024","unstructured":"Takanashi S, Kaneko Y, Kawahito Y, Kida T, Sugihara T, Kojima T, Harada R, Ishitoku M, Hirata S, Hashimoto M, Hidaka T, Abe A, Ishikawa H, Ito H, Kishimoto M, Matsui K, Matsui T, Matsushita I, Morinobu A, Nishida K, Tanaka E, Abe A, Ishitoku M, Asai S, Kida T, Onishi A, Takanashi S, Harigai M (2024) A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan. Intern Med 63:3299\u20133306","journal-title":"Intern Med"},{"key":"8029_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101878","volume":"59","author":"S Pavlov-Dolijanovic","year":"2023","unstructured":"Pavlov-Dolijanovic S, Bogojevic M, Nozica-Radulovic T, Radunovic G, Mujovic N (2023) Elderly-onset rheumatoid arthritis: characteristics and treatment options. Medicina Kaunas 59:1878","journal-title":"Medicina Kaunas"},{"key":"8029_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102528","volume":"19","author":"L Serhal","year":"2020","unstructured":"Serhal L, Lwin MN, Holroyd C, Edwards CJ (2020) Rheumatoid arthritis in the elderly: characteristics and treatment considerations. Autoimmun Rev 19:102528","journal-title":"Autoimmun Rev"},{"key":"8029_CR41","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1007\/s12325-020-01435-6","volume":"37","author":"R Caporali","year":"2020","unstructured":"Caporali R, Fakhouri WKH, Nicolay C, Longley HJ, Losi S, Rogai V (2020) New rheumatoid arthritis treatments for \u2018old\u2019 patients: results of a systematic review. Adv Ther 37:3676\u20133691","journal-title":"Adv Ther"},{"key":"8029_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152607","volume":"71","author":"SPM Truijen","year":"2025","unstructured":"Truijen SPM, Schreurs JPR, Boonen A, van Onna M (2025) The operational definition of old age and impact on outcomes in DMARD-treated patients with rheumatoid arthritis: a systematic literature review. Semin Arthritis Rheum 71:152607","journal-title":"Semin Arthritis Rheum"},{"key":"8029_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1928","volume":"22","author":"H Jeries","year":"2024","unstructured":"Jeries H, Daood R, Hijazi B, Golan-Cohen A, Green I, Merzon E, Naffaa ME, Hassan F (2024) Drug survival on first biologic therapy among late-onset rheumatoid arthritis patients compared to early-onset patients: a population-based cohort study. Musculoskelet Care 22:e1928","journal-title":"Musculoskelet Care"},{"key":"8029_CR44","first-page":"51","volume":"17","author":"AA Zulfiqar","year":"2019","unstructured":"Zulfiqar AA, Niazi R, Pennaforte JL, Andres E (2019) Polyarthrite rhumato\u00efde \u00e0 r\u00e9v\u00e9lation tardive: caract\u00e9ristiques cliniques, biologiques et th\u00e9rapeutiques \u00c0 propos d\u2019une \u00e9tude r\u00e9trospective. Geriatr Psychol Neuropsychiatr Vieil 17:51\u201362","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"8029_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152607","volume":"71","author":"SPM Truijen","year":"2025","unstructured":"Truijen SPM, Schreurs JPR, Boonen A, van Onna M (2025) The operational definition of old age and impact on outcomes in DMARD-treated patients with rheumatoid arthritis: a systematic literature review. Semin Arthritis Rheum 71:152607","journal-title":"Semin Arthritis Rheum"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08029-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08029-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08029-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:02:41Z","timestamp":1775797361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-026-08029-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["8029"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08029-7","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"15 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}