{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:24:33Z","timestamp":1790126673966,"version":"4.0.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10067-026-08103-0","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:44:48Z","timestamp":1776530688000},"page":"3799-3807","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cell immunotherapy in autoimmune rheumatic diseases: a paradigm shift in the therapy of autoimmune inflammatory rheumatic diseases"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8602-0958","authenticated-orcid":false,"given":"Ian C.","family":"Chikanza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-3314","authenticated-orcid":false,"given":"Lazaros I.","family":"Sakkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"issue":"3","key":"8103_CR1","first-page":"145","volume":"12","author":"J Smith","year":"2023","unstructured":"Smith J, Martinez L, Patel R (2023) Advances in cell therapy for autoimmune diseases. Autoimmune Res J 12(3):145\u2013160","journal-title":"Autoimmune Res J"},{"issue":"2","key":"8103_CR2","first-page":"98","volume":"18","author":"A Doe","year":"2022","unstructured":"Doe A, Kim S, Wang L (2022) Mesenchymal stem cells in rheumatic disease treatment. Immunol Today 18(2):98\u2013110","journal-title":"Immunol Today"},{"issue":"4","key":"8103_CR3","first-page":"211","volume":"29","author":"K Brown","year":"2021","unstructured":"Brown K, White H, Roberts M (2021) Clinical trials of MSC therapy in rheumatoid arthritis. J Rheumatol 29(4):211\u2013225","journal-title":"J Rheumatol"},{"issue":"1","key":"8103_CR4","first-page":"67","volume":"15","author":"P Green","year":"2022","unstructured":"Green P, Collins R, Hughes D (2022) MSC therapy and synovial repair in arthritis. Stem Cell Res 15(1):67\u201380","journal-title":"Stem Cell Res"},{"issue":"5","key":"8103_CR5","first-page":"303","volume":"20","author":"R Wilson","year":"2023","unstructured":"Wilson R, Zhao M, Lee S (2023) Challenges in MSC therapy standardization. Regen Med 20(5):303\u2013318","journal-title":"Regen Med"},{"issue":"2","key":"8103_CR6","first-page":"55","volume":"10","author":"H Lee","year":"2020","unstructured":"Lee H, Thompson A, Rodriguez P (2020) Treg cells and their role in autoimmune diseases. Immunol Rev 10(2):55\u201370","journal-title":"Immunol Rev"},{"issue":"3","key":"8103_CR7","first-page":"125","volume":"14","author":"M Johnson","year":"2022","unstructured":"Johnson M, Evans L, Carter B (2022) Regulatory T cell therapy in SLE patients. Lupus 14(3):125\u2013140","journal-title":"Lupus"},{"issue":"6","key":"8103_CR8","first-page":"345","volume":"21","author":"L Davis","year":"2023","unstructured":"Davis L, Chang E, Foster N (2023) Optimizing treg therapy for autoimmune disease. J Immunother 21(6):345\u2013360","journal-title":"J Immunother"},{"issue":"2","key":"8103_CR9","first-page":"89","volume":"19","author":"B Carter","year":"2021","unstructured":"Carter B, Adams T, Reed O (2021) Cost and technical challenges of treg therapy. Autoimmun Ther 19(2):89\u2013105","journal-title":"Autoimmun Ther"},{"issue":"4","key":"8103_CR10","first-page":"221","volume":"31","author":"Y Wang","year":"2023","unstructured":"Wang Y, Simmons R, Park J (2023) CAR-T therapy for autoimmune conditions: a new frontier. Hematol Immunother 31(4):221\u2013236","journal-title":"Hematol Immunother"},{"issue":"5","key":"8103_CR11","first-page":"401","volume":"16","author":"S Kim","year":"2024","unstructured":"Kim S, Miller V, Harper J (2024) Targeting B cells in autoimmune disease with CAR-T therapy. Nat Immunol 16(5):401\u2013417","journal-title":"Nat Immunol"},{"issue":"1","key":"8103_CR12","first-page":"77","volume":"27","author":"E Roberts","year":"2023","unstructured":"Roberts E, Anderson D, Tran M (2023) Safety considerations in CAR-T therapy for autoimmune disorders. Clin Immunol 27(1):77\u201392","journal-title":"Clin Immunol"},{"issue":"3","key":"8103_CR13","first-page":"143","volume":"25","author":"S Patel","year":"2022","unstructured":"Patel S, Yang B, Nelson A (2022) Exosomes in immune modulation and autoimmune diseases. Clin Immunol 25(3):143\u2013158","journal-title":"Clin Immunol"},{"issue":"6","key":"8103_CR14","first-page":"312","volume":"22","author":"T Zhang","year":"2023","unstructured":"Zhang T, Murphy C, Daniels F (2023) MSC-derived exosomes in rheumatoid arthritis therapy. J Cell Immunother 22(6):312\u2013329","journal-title":"J Cell Immunother"},{"issue":"2","key":"8103_CR15","first-page":"98","volume":"30","author":"V Hughes","year":"2024","unstructured":"Hughes V, Simmons L, Foster R (2024) Advantages of exosome therapy over MSC therapy. Precis Med 30(2):98\u2013113","journal-title":"Precis Med"},{"issue":"4","key":"8103_CR16","first-page":"275","volume":"18","author":"S Parker","year":"2024","unstructured":"Parker S, Wright J, Thompson L (2024) Exosome therapy in synovial inflammation and cartilage repair. Autoimmun Horiz 18(4):275\u2013290","journal-title":"Autoimmun Horiz"},{"key":"8103_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/B978-0-443-13947-5.00007-5","volume-title":"Regulatory T cells and autoimmune diseases","author":"IC Chikanza","year":"2024","unstructured":"Chikanza IC, Trollip S, Sakkas LI (2024) Regulatory T cells and autoimmunity. In: Dwivedi MK, Fairweather D (eds) Regulatory T cells and autoimmune diseases. Academic Press, pp 41\u201356"},{"issue":"22","key":"8103_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216040","volume":"24","author":"LN Zaripova","year":"2023","unstructured":"Zaripova LN, Midgley A, Christmas SE et al (2023) Mesenchymal stem cells in the pathogenesis and therapy of autoimmune and autoinflammatory diseases. Int J Mol Sci 24(22)","journal-title":"Int J Mol Sci"},{"key":"8103_CR19","doi-asserted-by":"crossref","unstructured":"Pittenger MF, Mackay AM, Beck SC et al (1999) Multilineage potential of adult human mesenchymalstem cells. Science 284(5411):143\u2013147","DOI":"10.1126\/science.284.5411.143"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08103-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08103-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08103-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:27:09Z","timestamp":1783398429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-026-08103-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["8103"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08103-0","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"19 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}