{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:27:47Z","timestamp":1787023667302,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202600"],"award-info":[{"award-number":["82202600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10067-026-08203-x","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:42:18Z","timestamp":1783060938000},"page":"4977-4991","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum exosomal tRNA-derived small RNAs as diagnostic biomarkers for primary Sj\u00f6gren\u2018s syndrome: a combined model with autoantibodies"],"prefix":"10.1007","volume":"45","author":[{"given":"Ning","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-856X","authenticated-orcid":false,"given":"Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"8","key":"8203_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41584-024-01135-3","volume":"20","author":"C Baldini","year":"2024","unstructured":"Baldini C, Fulvio G, La Rocca G, Ferro F (2024) Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome. Nat Rev Rheumatol 20(8):473\u2013491","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"8203_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41584-021-00634-x","volume":"17","author":"R Seror","year":"2021","unstructured":"Seror R, Nocturne G, Mariette X (2021) Current and future therapies for primary Sjogren syndrome. Nat Rev Rheumatol 17(8):475\u2013486","journal-title":"Nat Rev Rheumatol"},{"issue":"10320","key":"8203_CR3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0140-6736(21)02644-1","volume":"399","author":"A Saraux","year":"2022","unstructured":"Saraux A, Devauchelle-Pensec V (2022) Primary Sjogren\u2019s syndrome: new beginning for evidence-based trials. Lancet 399(10320):121\u2013122","journal-title":"Lancet"},{"key":"8203_CR4","doi-asserted-by":"publisher","first-page":"1127417","DOI":"10.3389\/fimmu.2023.1127417","volume":"14","author":"Q Zhan","year":"2023","unstructured":"Zhan Q, Zhang J, Lin Y, Chen W, Fan X, Zhang D (2023) Pathogenesis and treatment of Sjogren\u2019s syndrome: review and update. Front Immunol 14:1127417","journal-title":"Front Immunol"},{"key":"8203_CR5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180076","author":"D Fairweather","year":"2024","unstructured":"Fairweather D, Beetler DJ, McCabe EJ, Lieberman SM (2024) Mechanisms underlying sex differences in autoimmunity. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI180076","journal-title":"J Clin Invest"},{"issue":"5","key":"8203_CR6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41584-023-00932-6","volume":"19","author":"GE Thorlacius","year":"2023","unstructured":"Thorlacius GE, Bjork A, Wahren-Herlenius M (2023) Genetics and epigenetics of primary Sjogren syndrome: implications for future therapies. Nat Rev Rheumatol 19(5):288\u2013306","journal-title":"Nat Rev Rheumatol"},{"key":"8203_CR7","unstructured":"Bombardieri M, Argyropoulou OD, Ferro F, Coleby R, Pontarini E, Governato G, et al (2020) One year in review 2020: pathogenesis of primary Sjogren\u2019s syndrome. Clin Exp Rheumatol 38 Suppl 126(4):3\u20139"},{"issue":"11","key":"8203_CR8","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/j.ard.2025.07.021","volume":"84","author":"E Pontarini","year":"2025","unstructured":"Pontarini E, Lucchesi D, Sciacca E, Cavallaro G, Song Q, Galbraith D et al (2025) Transcriptomic profiling of Sj\u00f6gren\u2019s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La\/SSB seropositivity. Ann Rheum Dis 84(11):1822\u201335","journal-title":"Ann Rheum Dis"},{"key":"8203_CR9","doi-asserted-by":"publisher","first-page":"103035","DOI":"10.1016\/j.jaut.2023.103035","volume":"138","author":"X Wang","year":"2023","unstructured":"Wang X, Zhu L, Ying S, Liao X, Zheng J, Liu Z et al (2023) Increased RNA editing sites revealed as potential novel biomarkers for diagnosis in primary Sj\u00f6gren\u2019s syndrome. J Autoimmun 138:103035. https:\/\/doi.org\/10.1016\/j.jaut.2023.103035","journal-title":"J Autoimmun"},{"issue":"4","key":"8203_CR10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"G van Niel","year":"2018","unstructured":"van Niel G, D\u2019Angelo G, Raposo G (2018) Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 19(4):213\u2013228","journal-title":"Nat Rev Mol Cell Biol"},{"key":"8203_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01074-2","author":"DW Greening","year":"2025","unstructured":"Greening DW, Xu R, Rai A, Suwakulsiri W, Chen M, Simpson RJ (2025) Clinical relevance of extracellular vesicles in cancer-therapeutic and diagnostic potential. Nat Rev Clin Oncol. https:\/\/doi.org\/10.1038\/s41571-025-01074-2","journal-title":"Nat Rev Clin Oncol"},{"key":"8203_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","author":"R Kalluri","year":"6478","unstructured":"Kalluri R, LeBleu VS (6478) The biology, function, and biomedical applications of exosomes. Science. https:\/\/doi.org\/10.1126\/science.aau6977","journal-title":"Science"},{"issue":"6393","key":"8203_CR13","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1126\/science.aar4142","volume":"360","author":"Q Cai","year":"2018","unstructured":"Cai Q, Qiao L, Wang M, He B, Lin FM, Palmquist J et al (2018) Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science 360(6393):1126\u20131129","journal-title":"Science"},{"issue":"37","key":"8203_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504064","volume":"12","author":"K Xu","year":"2025","unstructured":"Xu K, Shen R, Zhang L, Gao X, Wang X, Zhang C et al (2025) Pancreatic cancer-derived extracellular vesicles enriched with miR-223-5p promote skeletal muscle wasting associated with cachexia. Adv Sci (Weinh) 12(37):e04064","journal-title":"Adv Sci (Weinh)"},{"issue":"28","key":"8203_CR15","doi-asserted-by":"publisher","first-page":"eadr5635","DOI":"10.1126\/sciadv.adr5635","volume":"11","author":"F Chen","year":"2025","unstructured":"Chen F, He Z, Guo R, Li M, Li J, Wang Y, He X, He Q et al (2025) Extracellular vesicle-hitchhiking nanoliposomes for cancer-associated fibroblast phenotype modulation impede metastasis progression. Sci Adv 11(28):eadr5635","journal-title":"Sci Adv"},{"issue":"10","key":"8203_CR16","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.tibs.2021.05.001","volume":"46","author":"Q Chen","year":"2021","unstructured":"Chen Q, Zhang X, Shi J, Yan M, Zhou T (2021) Origins and evolving functionalities of tRNA-derived small RNAs. Trends Biochem Sci 46(10):790\u2013804","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"8203_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41392-020-00217-4","volume":"5","author":"Y Xie","year":"2020","unstructured":"Xie Y, Yao L, Yu X, Ruan Y, Li Z, Guo J (2020) Action mechanisms and research methods of tRNA-derived small RNAs. Signal Transduct Target Ther 5(1):109","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"8203_CR18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.7150\/thno.102650","volume":"15","author":"H Jia","year":"2025","unstructured":"Jia H, Zhang L (2025) tRNA-derived small RNAs in disease immunity. Theranostics 15(1):245\u2013257","journal-title":"Theranostics"},{"issue":"5","key":"8203_CR19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41580-023-00690-z","volume":"25","author":"S Muthukumar","year":"2024","unstructured":"Muthukumar S, Li CT, Liu RJ, Bellodi C (2024) Roles and regulation of tRNA-derived small RNAs in animals. Nat Rev Mol Cell Biol 25(5):359\u2013378","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"8203_CR20","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1038\/s12276-023-01038-5","volume":"55","author":"S Lee","year":"2023","unstructured":"Lee S, Kim J, Valdmanis PN, Kim HK (2023) Emerging roles of tRNA-derived small RNAs in cancer biology. Exp Mol Med 55(7):1293\u20131304","journal-title":"Exp Mol Med"},{"issue":"6763","key":"8203_CR21","doi-asserted-by":"publisher","first-page":"eadp5384","DOI":"10.1126\/science.adp5384","volume":"389","author":"G Li","year":"2025","unstructured":"Li G, Sun L, Xin C, Hao T, Kharel P, Manning AC, Li H et al (2025) A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy. Science 389(6763):eadp5384","journal-title":"Science"},{"issue":"2","key":"8203_CR22","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/jcsm.13187","volume":"14","author":"L Shen","year":"2023","unstructured":"Shen L, Liao T, Chen Q, Lei Y, Wang L, Gu H, Chen L, Wang J et al (2023) TRNA-derived small RNA, 5\u2032tiRNA-Gly-CCC, promotes skeletal muscle regeneration through the inflammatory response. J Cachexia Sarcopenia Muscle 14(2):1033\u201345","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"8203_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2018.01.015","volume":"419","author":"L Zhu","year":"2018","unstructured":"Zhu L, Liu X, Pu W, Peng Y (2018) tRNA-derived small non-coding RNAs in human disease. Cancer Lett 419:1\u20137","journal-title":"Cancer Lett"},{"issue":"1","key":"8203_CR24","doi-asserted-by":"publisher","first-page":"2459132","DOI":"10.1080\/22221751.2025.2459132","volume":"14","author":"Z Huang","year":"2025","unstructured":"Huang Z, Luo Q, Xiong C, Zhu H, Yu C, Xu J et al (2025) Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis. Emerg Microbes Infect 14(1):2459132","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"8203_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13045-023-01466-w","volume":"16","author":"Q Xiong","year":"2023","unstructured":"Xiong Q, Zhang Y (2023) Small RNA modifications: regulatory molecules and potential applications. J Hematol Oncol 16(1):64","journal-title":"J Hematol Oncol"},{"key":"8203_CR26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ejca.2022.11.033","volume":"180","author":"K Panoutsopoulou","year":"2023","unstructured":"Panoutsopoulou K, Magkou P, Dreyer T, Dorn J, Obermayr E, Mahner S et al (2023) TRNA-derived small RNA 3\u2032U-tRF(ValCAC) promotes tumour migration and early progression in ovarian cancer. Eur J Cancer 180:134\u201345","journal-title":"Eur J Cancer"},{"issue":"6456","key":"8203_CR27","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1126\/science.aav8907","volume":"365","author":"B Ren","year":"2019","unstructured":"Ren B, Wang X, Duan J, Ma J (2019) Rhizobial tRNA-derived small RNAs are signal molecules regulating plant nodulation. Science 365(6456):919\u2013922","journal-title":"Science"},{"issue":"7683","key":"8203_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature25005","volume":"552","author":"HK Kim","year":"2017","unstructured":"Kim HK, Fuchs G, Wang S, Wei W, Zhang Y, Park H, Zhang F, Zhang QC et al (2017) A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature 552(7683):57\u201362","journal-title":"Nature"},{"issue":"14","key":"8203_CR29","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1177\/09612033211061482","volume":"30","author":"Y Liang","year":"2021","unstructured":"Liang Y, Zhang J, Qiu W, Chen B, Zhou Y, Chen X et al (2021) Dysregulation of tRNA-derived small RNAs and their potential roles in lupus nephritis. Lupus 30(14):2248\u20132255","journal-title":"Lupus"},{"issue":"1","key":"8203_CR30","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/s12964-024-01730-7","volume":"22","author":"YM Chen","year":"2024","unstructured":"Chen YM, Tang KT, Liu HJ, Huang ST, Liao TL (2024) tRF-His-GTG-1 enhances NETs formation and interferon-alpha production in lupus by extracellular vesicle. Cell Commun Signal 22(1):354","journal-title":"Cell Commun Signal"},{"key":"8203_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.735105","volume":"12","author":"P Yang","year":"2021","unstructured":"Yang P, Zhang X, Chen S, Tao Y, Ning M, Zhu Y et al (2021) A novel serum tsRNA for diagnosis and prediction of nephritis in SLE. Front Immunol 12:735105","journal-title":"Front Immunol"},{"key":"8203_CR32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.molimm.2021.08.015","volume":"139","author":"R Dou","year":"2021","unstructured":"Dou R, Zhang X, Xu X, Wang P, Yan B (2021) Mesenchymal stem cell exosomal tsRNA-21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization. Mol Immunol 139:106\u2013114","journal-title":"Mol Immunol"},{"key":"8203_CR33","doi-asserted-by":"publisher","first-page":"1077645","DOI":"10.3389\/fimmu.2023.1077645","volume":"14","author":"S Chen","year":"2023","unstructured":"Chen S, Zhang X, Meng K, Sun Y, Shu R, Han Y et al (2023) Urinary exosome tsRNAs as novel markers for diagnosis and prediction of lupus nephritis. Front Immunol 14:1077645","journal-title":"Front Immunol"},{"issue":"5","key":"8203_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1677","volume":"14","author":"P Yang","year":"2024","unstructured":"Yang P, Sun Y, Wang C, Li Z, Han Y, Gong J, Wang J, Wang Y et al (2024) Serum exosomal tsRNA biomarkers: a novel strategy for identifying lupus nephritis. Clin Transl Med 14(5):e1677","journal-title":"Clin Transl Med"},{"issue":"1","key":"8203_CR35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM et al (2017) 2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for primary Sjogren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol 69(1):35\u201345","journal-title":"Arthritis Rheumatol"},{"key":"8203_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103243","volume":"147","author":"J Ritter","year":"2024","unstructured":"Ritter J, Szelinski F, Aue A, Stefanski AL, Rincon-Arevalo H, Chen Y et al (2024) Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjogren\u2019s syndrome: novel biomarkers for disease activity and subsets. J Autoimmun 147:103243","journal-title":"J Autoimmun"},{"key":"8203_CR37","doi-asserted-by":"publisher","first-page":"106992","DOI":"10.1016\/j.intimp.2020.106992","volume":"88","author":"L Ye","year":"2020","unstructured":"Ye L, Shi H, Yu C, Fu J, Chen C, Wu S et al (2020) LncRNA Neat1 positively regulates MAPK signaling and is involved in the pathogenesis of Sj\u00f6gren\u2019s syndrome. Int Immunopharmacol 88:106992. https:\/\/doi.org\/10.1016\/j.intimp.2020.106992","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"8203_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1228","volume":"13","author":"Y Sun","year":"2023","unstructured":"Sun Y, Nascimento Da Conceicao V, Chauhan A, Sukumaran P, Chauhan P, Ambrus JL et al (2023) Targeting alarmin release reverses Sjogren\u2019s syndrome phenotype by revitalizing Ca(2+) signalling. Clin Transl Med 13(4):e1228","journal-title":"Clin Transl Med"},{"issue":"2","key":"8203_CR39","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/rheumatology\/kez269","volume":"59","author":"J Fernandez-Torres","year":"2020","unstructured":"Fernandez-Torres J, Perez-Hernandez N, Hernandez-Molina G, Martinez-Nava GA, Garrido-Rodriguez D, Lopez-Reyes A et al (2020) Risk of Wnt\/\u03b2-catenin signalling pathway gene polymorphisms in primary Sj\u00f6gren\u2019s syndrome. Rheumatology (Oxford) 59(2):418\u2013425","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"8203_CR40","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/annrheumdis-2016-210167","volume":"76","author":"A Charras","year":"2017","unstructured":"Charras A, Konsta OD, Le Dantec C, Bagacean C, Kapsogeorgou EK, Tzioufas AG et al (2017) Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjogren\u2019s syndrome. Ann Rheum Dis 76(3):625\u20138","journal-title":"Ann Rheum Dis"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08203-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08203-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08203-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:28Z","timestamp":1787022928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-026-08203-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["8203"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08203-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"22 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The studies involving humans were approved by The Ethics Committee of the Affiliated Drum Tower Hospital of Nanjing University Medical School (Ethics code 2024\u2013422-03). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}