{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:17:10Z","timestamp":1787995030751,"version":"build-2784847793"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Kunming Health Science and Technology Talent Project 10 Projects of China","award":["2023-SW (GUIDE)-07"],"award-info":[{"award-number":["2023-SW (GUIDE)-07"]}]},{"name":"Spring City Famous Medical Special Project","award":["N08901329"],"award-info":[{"award-number":["N08901329"]}]},{"name":"the Science Fund of the Yunnan Provincial Department of Education","award":["2026Y0376"],"award-info":[{"award-number":["2026Y0376"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10067-026-08267-9","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:42:12Z","timestamp":1783917732000},"page":"5729-5739","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral blood immunoglobulin A level is independently negatively correlated with renal involvement in newly diagnosed childhood systemic lupus erythematosus: a single-center cross-sectional study based on 380 pediatric lupus nephritis patients in southwest China"],"prefix":"10.1007","volume":"45","author":[{"given":"Hongye","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingJing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Zhouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YangCui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-4732","authenticated-orcid":false,"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"8267_CR1","unstructured":"Dou L, et al. Role of Traditional Chinese medicine for the treatment of lupus nephritis: mechanisms and applications. Alternative therapies in health and medicine. 2024;"},{"key":"8267_CR2","unstructured":"E M, et al. Establishment of a multidisciplinary pediatric lupus care clinic at a tertiary center. Journal of multidisciplinary healthcare. 2025;"},{"issue":"11","key":"8267_CR3","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.4103\/0366-6999.232809","volume":"131","author":"DN Chen","year":"2018","unstructured":"Chen DN, Fan L, Wu YX, Zhou Q, Chen W, Yu XQ (2018) A predictive model for estimation risk of proliferative lupus nephritis. Chin Med J 131(11):1275\u20131281","journal-title":"Chin Med J"},{"key":"8267_CR4","doi-asserted-by":"crossref","unstructured":"Fang Y, et al. Age-dependent distribution of IgA and IgG antibody-secreting cells in the pharyngeal tonsil of the Bactrian camel. Veterinary journal (London, England\u202f: 1997). 2024;5.","DOI":"10.1016\/j.tvjl.2024.106131"},{"key":"8267_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/742535","author":"J Xie","year":"2015","unstructured":"Xie J et al (2015) Expansion of circulating T follicular helper cells in children with acute Henoch-Sch\u00f6nlein purpura. J Immunol Res. https:\/\/doi.org\/10.1155\/2015\/742535","journal-title":"J Immunol Res"},{"issue":"1_Supplement","key":"8267_CR6","doi-asserted-by":"publisher","first-page":"0032_4970","DOI":"10.4049\/jimmunol.212.supp.0032.4970","volume":"212","author":"Q Li","year":"2024","unstructured":"Li Q, Wei J, Luo H, Zhu H, Zhu C (2024) Autoreactive IgA antibodies are high prevalent and associated with clinical manifestations in systemic lupus erythematosus, systemic scleroderma and idiopathic inflammatory myositis. J Immunol 212(1_Supplement):0032_4970","journal-title":"J Immunol"},{"key":"8267_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/289316","volume":"2013","author":"L Hongyan","year":"2013","unstructured":"Hongyan L, Yi Z, Bao D, Yuewu L, Juan M (2013) A study on clinical and pathologic features in lupus nephritis with mainly IgA deposits and a literature review. Clin Dev Immunol 2013:289316","journal-title":"Clin Dev Immunol"},{"issue":"6","key":"8267_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.15586\/aei.v53i6.1472","volume":"53","author":"EY G\u00fcng\u00f6ren","year":"2025","unstructured":"G\u00fcng\u00f6ren EY, \u00c7al\u0131\u015fkan N, \u00d6zkalkan B, Karada\u0123 IK, \u00d6z\u00e7eker D, \u00c7imen SS (2025) Insights into the clinical spectrum of selective IgA deficiency: data from two centers. Allergol Immunopathol 53(6):32\u201337","journal-title":"Allergol Immunopathol"},{"issue":"1","key":"8267_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12016-019-08756-7","volume":"58","author":"DD Odineal","year":"2020","unstructured":"Odineal DD, Gershwin ME (2020) The epidemiology and clinical manifestations of autoimmunity in selective IgA deficiency. Clin Rev Allergy Immunol 58(1):107\u2013133","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"8267_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13223-023-00826-y","volume":"19","author":"A Vosughimotlagh","year":"2023","unstructured":"Vosughimotlagh A, Rasouli SE, Rafiemanesh H, Safarirad M, Sharifinejad N, Madanipour A et al (2023) Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis. Allergy, asthma, and clinical immunology\u202f: official journal of the Canadian Society of Allergy and Clinical Immunology 19(1):75","journal-title":"Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology"},{"issue":"9","key":"8267_CR11","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/art.40930","volume":"71","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R et al (2019) 2019 European League Against Rheumatism\/American College of Rheumatology Classification criteria for systemic lupus Erythematosus. Arthritis & Rheumatology (Hoboken, NJ) 71(9):1400\u20131412","journal-title":"Arthritis & Rheumatology (Hoboken, NJ)"},{"key":"8267_CR12","unstructured":"The Subspecialty Group of Nephrology CMA the Society of Pediatrics. Evidence-based guidelines for diagnosis and treatment of lupus nephritis (2016). Chinese Journal of Pediatrics. 2018;56(2):88\u201394."},{"key":"8267_CR13","doi-asserted-by":"publisher","first-page":"11357","DOI":"10.2147\/JIR.S496138","volume":"17","author":"H Zhang","year":"2024","unstructured":"Zhang H, Li S, Deng Z, Wang Y (2024) Molecular differences in glomerular compartment to distinguish immunoglobulin A nephropathy and lupus nephritis. J Inflamm Res 17:11357\u201311373","journal-title":"J Inflamm Res"},{"issue":"2","key":"8267_CR14","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.amjms.2020.11.032","volume":"363","author":"LL Li","year":"2022","unstructured":"Li LL, Chu H, Tao J, Song D, Tan M, Wang SX et al (2022) Lupus nephritis with obvious IgA deposits in the kidneys. Am J Med Sci 363(2):174\u2013184","journal-title":"Am J Med Sci"},{"issue":"1","key":"8267_CR15","first-page":"31","volume":"22","author":"B Pasquier","year":"2005","unstructured":"Pasquier B, Launay P, Kanamaru Y, Moura IC, Pfirsch S, Ruffi\u00e9 C et al (2005) Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22(1):31\u201342","journal-title":"Immunity"},{"issue":"4","key":"8267_CR16","first-page":"2669","volume":"180","author":"Y Kanamaru","year":"1950","unstructured":"Kanamaru Y, Pfirsch S, Aloulou M, Vrtovsnik F, Essig M, Loirat C et al (1950) Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. J Invest Med 180(4):2669\u20132678","journal-title":"J Invest Med"},{"key":"8267_CR17","doi-asserted-by":"crossref","unstructured":"Rossato E, Ben Mkaddem S, Kanamaru Y, Hurtado\u2010Nedelec M, Hayem G, Descatoire V, et al. Reversal of arthritis by human monomeric IgA through the receptor\u2010mediated SH2 domain-containing phosphatase 1 inhibitory pathway. Arthritis & Rheumatology [Internet]. 2015 Jun;67(7):1766\u20131777. Available from:","DOI":"10.1002\/art.39142"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08267-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08267-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08267-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:35:10Z","timestamp":1787992510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-026-08267-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["8267"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08267-9","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"7 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of Kunming Children\u2019s Hospital  (Kunming Medical University Affiliated Children\u2019s Hospital) (approval No. 2023-03 371-K01). All procedures followed the ethical standards of the responsible committee on  human experimentation and the Helsinki Declaration. Given the cross-sectional design  with retrospective collection of de-identified clinical data from routine practice, and  because no additional interventions or procedures were performed beyond standard  clinical care, the requirement for written informed consent was waived by the Ethics  Committee.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":3,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}}]}}