{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:17:08Z","timestamp":1787995028915,"version":"build-2784847793"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372444"],"award-info":[{"award-number":["82372444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10067-026-08269-7","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:13:10Z","timestamp":1783595590000},"page":"5333-5348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification"],"prefix":"10.1007","volume":"45","author":[{"given":"Fuling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1778-932X","authenticated-orcid":false,"given":"Zhengxue","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"issue":"23","key":"8269_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB Mcinnes","year":"2011","unstructured":"Mcinnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365(23):2205\u20132219","journal-title":"N Engl J Med"},{"issue":"7","key":"8269_CR2","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1002\/eji.201041194","volume":"41","author":"G Alsaleh","year":"2011","unstructured":"Alsaleh G, Fran\u00e7ois A, Knapp AM et al (2011) Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF. Eur J Immunol 41(7):2113\u20132122","journal-title":"Eur J Immunol"},{"issue":"7811","key":"8269_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","volume":"582","author":"K Wei","year":"2020","unstructured":"Wei K, Korsunsky I, Marshall JL et al (2020) Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature 582(7811):259\u2013264","journal-title":"Nature"},{"issue":"10271","key":"8269_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0140-6736(20)32341-2","volume":"397","author":"F Humby","year":"2021","unstructured":"Humby F, Durez P, Buch MH et al (2021) Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. Lancet 397(10271):305\u2013317","journal-title":"Lancet"},{"key":"8269_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fphar.2020.00239","volume":"11","author":"C Han","year":"2020","unstructured":"Han C, Liu Y, Dai R, Ismail N, Su W, Li B (2020) Ferroptosis and Its Potential Role in Human Diseases. Front Pharmacol 11:239","journal-title":"Front Pharmacol"},{"issue":"9","key":"8269_CR6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","volume":"22","author":"P Li","year":"2021","unstructured":"Li P, Jiang M, Li K et al (2021) Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol 22(9):1107\u20131117","journal-title":"Nat Immunol"},{"issue":"4","key":"8269_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/ar2485","volume":"10","author":"R Huber","year":"2008","unstructured":"Huber R, Hummert C, Gausmann U et al (2008) Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther 10(4):R98","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"8269_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/ar4526","volume":"16","author":"D Woetzel","year":"2014","unstructured":"Woetzel D, Huber R, Kupfer P et al (2014) Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res Ther 16(2):R84","journal-title":"Arthritis Res Ther"},{"issue":"Database issue","key":"8269_CR9","doi-asserted-by":"publisher","first-page":"D760","DOI":"10.1093\/nar\/gkl887","volume":"35","author":"T Barrett","year":"2007","unstructured":"Barrett T, Troup DB, Wilhite SE et al (2007) NCBI GEO: mining tens of millions of expression profiles--database and tools update. Nucleic Acids Res 35(Database issue):D760-765","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"8269_CR10","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD (2012) The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28(6):882\u2013883","journal-title":"Bioinformatics"},{"issue":"1","key":"8269_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"8269_CR12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"issue":"6","key":"8269_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ygeno.2012.04.003","volume":"99","author":"X Chen","year":"2012","unstructured":"Chen X, Ishwaran H (2012) Random forests for genomic data analysis. Genomics 99(6):323\u2013329","journal-title":"Genomics"},{"issue":"12","key":"8269_CR14","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nbt1206-1565","volume":"24","author":"WS Noble","year":"2006","unstructured":"Noble WS (2006) What is a support vector machine? Nat Biotechnol 24(12):1565\u20131567","journal-title":"Nat Biotechnol"},{"key":"8269_CR15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"8269_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D et al (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"8269_CR17","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea G, Mlecnik B, Tosolini M et al (2013) Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39(4):782\u2013795","journal-title":"Immunity"},{"key":"8269_CR18","unstructured":"Telfer JF, Brock JH (2004) Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis. Med Sci Monit 10(4): 91\u201395"},{"issue":"1","key":"8269_CR19","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2024.2423759","volume":"57","author":"Q Deng","year":"2024","unstructured":"Deng Q, Peng Z, Meng F et al (2024) FOXO3 as a potential diagnostic biomarker for autophagy in rheumatoid arthritis: a bioinformatics study. Autoimmunity 57(1):2423759","journal-title":"Autoimmunity"},{"issue":"1","key":"8269_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10753-020-01338-2","volume":"44","author":"Z Xie","year":"2021","unstructured":"Xie Z, Hou H, Luo D, An R, Zhao Y, Qiu C (2021) ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: a covert clue for potential therapy. Inflammation 44(1):35\u201347","journal-title":"Inflammation"},{"key":"8269_CR21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuroscience.2024.08.025","volume":"559","author":"H Yao","year":"2024","unstructured":"Yao H, Tian J, Cheng S, Dou H, Zhu Y (2024) The mechanism of hypoxia-inducible factor-1\u03b1 enhancing the transcriptional activity of transferrin ferroportin 1 and regulating the Nrf2\/HO-1 pathway in ferroptosis after cerebral ischemic injury. Neuroscience 559:26\u201338","journal-title":"Neuroscience"},{"key":"8269_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117464","volume":"289","author":"Y Wang","year":"2025","unstructured":"Wang Y, Wang X, Wu Q (2025) T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1\u03b1\/p53\/p21 pathway. Ecotoxicol Environ Saf 289:117464","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"8269_CR23","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","volume":"12","author":"U Fearon","year":"2016","unstructured":"Fearon U, Canavan M, Biniecka M, Veale DJ (2016) Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol 12(7):385\u2013397","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"8269_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nrrheum.2009.179","volume":"5","author":"WB Van Den Berg","year":"2009","unstructured":"Van Den Berg WB, Miossec P (2009) IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol 5(10):549\u2013553","journal-title":"Nat Rev Rheumatol"},{"issue":"Pt 3","key":"8269_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113560","volume":"143","author":"C Deng","year":"2024","unstructured":"Deng C, Sun S, Zhang H et al (2024) Sappanone A attenuates rheumatoid arthritis via inhibiting PI3K\/AKT\/NF-\u03baB and JAK2\/STAT3 signaling pathways in vivo and in vitro. Int Immunopharmacol 143(Pt 3):113560","journal-title":"Int Immunopharmacol"},{"issue":"Pt 3","key":"8269_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113558","volume":"143","author":"X Gu","year":"2024","unstructured":"Gu X, Weng R, Deng Q et al (2024) Interleukin-17D accelerates atherosclerosis through promoting endothelial cells ferroptosis via CD93\/miR-181a-5p\/SLC7A11 signaling. Int Immunopharmacol 143(Pt 3):113558","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"8269_CR27","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1002\/art.34342","volume":"64","author":"CF Spurlock","year":"2012","unstructured":"Spurlock CF 3rd, Tossberg JT, Fuchs HA, Olsen NJ, Aune TM (2012) Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum 64(6):1780\u20131789","journal-title":"Arthritis Rheum"},{"issue":"3","key":"8269_CR28","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.celrep.2017.12.077","volume":"22","author":"A Tarangelo","year":"2018","unstructured":"Tarangelo A, Magtanong L, Bieging-Rolett KT et al (2018) p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep 22(3):569\u2013575","journal-title":"Cell Rep"},{"key":"8269_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114006","volume":"433","author":"Y Yu","year":"2022","unstructured":"Yu Y, Li Y, Qi K, Xu W, Wei Y (2022) Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF\/Nrf2 signaling and autophagy pathway. Behav Brain Res 433:114006","journal-title":"Behav Brain Res"},{"issue":"1","key":"8269_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15010041","volume":"15","author":"S Qi","year":"2025","unstructured":"Qi S, Zhang C, Yan J et al (2025) Ethyl acetate extract of Cichorium glandulosum activates the P21\/Nrf2\/HO-1 pathway to alleviate oxidative stress in a mouse model of alcoholic liver disease. Metabolites 15(1):41","journal-title":"Metabolites"},{"issue":"1","key":"8269_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/cei.13256","volume":"196","author":"P Wehr","year":"2019","unstructured":"Wehr P, Purvis H, Law S, Thomas R (2019) Dendritic cells, T cells and their interaction in rheumatoid arthritis. Clin Exp Immunol 196(1):12\u201327","journal-title":"Clin Exp Immunol"},{"key":"8269_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.708186","volume":"12","author":"EA Ross","year":"2021","unstructured":"Ross EA, Devitt A, Johnson JR (2021) Macrophages: the good, the bad, and the gluttony. Front Immunol 12:708186","journal-title":"Front Immunol"},{"key":"8269_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156171","volume":"165","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Li R (2023) HMGB1 is a promising therapeutic target for asthma. Cytokine 165:156171","journal-title":"Cytokine"},{"issue":"3","key":"8269_CR34","doi-asserted-by":"publisher","first-page":"R536","DOI":"10.1186\/ar1706","volume":"7","author":"RJ Berckmans","year":"2005","unstructured":"Berckmans RJ, Nieuwland R, Kraan MC et al (2005) Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes. Arthritis Res Ther 7(3):R536-544","journal-title":"Arthritis Res Ther"},{"key":"8269_CR35","doi-asserted-by":"crossref","unstructured":"Gang X, Xu H, Si L et al (2018) Treatment effect of CDKN1A on rheumatoid arthritis by mediating proliferation and invasion of fibroblast-like synoviocytes cells. Clin Exp Immuno l194(2):220-230","DOI":"10.1111\/cei.13161"},{"key":"8269_CR36","doi-asserted-by":"crossref","unstructured":"Zhou N, Bao J (2020) FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations. Database (Oxford) 2020:baaa021","DOI":"10.1093\/database\/baaa021"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08269-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08269-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08269-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:35:48Z","timestamp":1787992548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-026-08269-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["8269"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08269-7","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The clinical study protocols were approved by the Ethics Committee of the Honghui Hospital, Xi'an Jiaotong University, and informed consent was obtained from all participating patients (Approval\u00a0NO.202402001).","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}