{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:17:03Z","timestamp":1787995023541,"version":"build-2784847793"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hip osteoarthritis (OA) is estimated to affect 62.6 million individuals by 2050. A probable link exists between alcohol use and hip OA. However, the results are inconsistent, and the relationship between alcohol and hip OA remains speculative. To address these gaps, this study aimed to utilize the diverse, nationally representative All of Us Research Program dataset to explore the association between alcohol consumption and hip OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study utilized data from the All of Us Research Program Controlled Tier Dataset v8. 17,517 hip OA cases and 70,068 controls were identified. A 1:4 case-to-control matching ratio was applied based on age and sex. Alcohol use frequency was categorized into five levels: Never, Monthly or Less, Two to Four Times per Month, Two to Three Times per Week, and Four or More Times per Week. Multivariable logistic regression models evaluated the association between alcohol use frequency and hip OA after adjusting for demographic and clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable analysis found that alcohol use frequency was not significantly associated with hip OA. Compared to never users, participants with low (OR 0.98, 95% CI 0.93\u20131.04,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.583), moderate (OR 0.99\u20131.01, all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05), and high (OR 1.02, 95% CI 0.95\u20131.09,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.599) levels of alcohol consumption had no statistically significant differences in odds of hip OA. Female sex, Asian race, diabetes,\u00a0hypertension, hyperlipidemia, and nicotine dependence increased the odds of hip OA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Any level of alcohol consumption was not significantly associated with the odds of hip OA. This study adds valuable insight to the current body of conflicting evidence. Further prospective studies appear warranted to shed light on the long-term effects of different alcoholic beverages on different joints.\n                      <jats:table-wrap>\n                        <jats:table>\n                          <jats:tbody>\n                            <jats:tr>\n                              <jats:td align=\"left\" colspan=\"2\">\n                                <jats:bold>Key Points<\/jats:bold>\n                                \u2022\n                                <jats:italic>This study found no significant association between any degree of alcohol consumption and the odds of developing hip osteoarthritis<\/jats:italic>\n                                .\u2022\n                                <jats:italic>Utilizing data from 87,585 adults in the NIH \u201cAll of Us\" Research Program, this is the first study to analyze this relationship in a large, nationally representative population<\/jats:italic>\n                                .\u2022\n                                <jats:italic>The research provides clarity to previously conflicting literature by demonstrating that alcohol lacks a clear harmful or protective effect on the clinical course of the disease<\/jats:italic>\n                                .\u2022\n                                <jats:italic>The analysis highlights that independent risk factors such as Asian race, nicotine dependence, and components of metabolic syndrome increase the odds of hip osteoarthritis<\/jats:italic>\n                                .\n                              <\/jats:td>\n                            <\/jats:tr>\n                          <\/jats:tbody>\n                        <\/jats:table>\n                      <\/jats:table-wrap>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10067-026-08279-5","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:27:55Z","timestamp":1783751275000},"page":"5227-5235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No association between alcohol consumption and hip osteoarthritis: a diverse national analysis of 87,585 adults from the \u201cAll of Us\u201d research program"],"prefix":"10.1007","volume":"45","author":[{"given":"Shlok V.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujaa T.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smit","family":"Brahmbhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Deren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-7538","authenticated-orcid":false,"given":"Nicolas S.","family":"Piuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"issue":"1","key":"8279_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.7812\/TPP\/17-084","volume":"22","author":"MJ Lespasio","year":"2018","unstructured":"Lespasio MJ, Sultan AA, Piuzzi NS, Khlopas A, Husni ME, Muschler GF et al (2018) Hip osteoarthritis: a primer. 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Author 4 (M.E.D) reports the following conflicts of interest unrelated to the current study: Brasseler: Paid consultant. The Journal of Knee Surgery: Editorial or governing board. Author 5 (N.S.P) has the following disclosures not related to the present study: Grants or contracts \u2013 Osteal Therapeutics, Peptilogics, RegenLab, Signature Orthopedics, Zimmer, and Stryker; Consulting fees \u2013 Zimmer, Pacira Pharmaceutical, and Stryker; Editorial board member or Leadership role \u2013\n                      JBJS, American Association of Hip and Knee Surgeons, and Orthopaedic Research Society\n                      .","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}