{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:40Z","timestamp":1793424760844,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Ganzhou Science and Technology\u2013Healthcare Joint Program Project","award":["2022-YB1424"],"award-info":[{"award-number":["2022-YB1424"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s10067-026-08408-0","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:29:36Z","timestamp":1788877776000},"page":"7015-7029","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic effects of hUC-MSCs on collagen-induced arthritis are associated with immune rebalancing and systemic metabolic changes"],"prefix":"10.1007","volume":"45","author":[{"given":"Zhi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6097-5747","authenticated-orcid":false,"given":"Hailang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"6","key":"8408_CR1","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.chest.2024.02.016","volume":"165","author":"GC McDermott","year":"2024","unstructured":"McDermott GC, Sparks JA (2024) Rheumatoid arthritis and bronchiectasis risk: additional evidence linking autoimmunity and airways disease. Chest 165(6):1276\u20131277","journal-title":"Chest"},{"issue":"12","key":"8408_CR2","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1001\/jama.2022.0786","volume":"327","author":"MH Smith","year":"2022","unstructured":"Smith MH, Berman JR (2022) What is rheumatoid arthritis? JAMA 327(12):1194","journal-title":"JAMA"},{"issue":"9285","key":"8408_CR3","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","volume":"358","author":"DM Lee","year":"2001","unstructured":"Lee DM, Weinblatt ME (2001) Rheumatoid arthritis. Lancet 358(9285):903\u2013911","journal-title":"Lancet"},{"issue":"13","key":"8408_CR4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2310178","volume":"390","author":"EM Gravallese","year":"2024","unstructured":"Gravallese EM, Firestein GS, Koscal N, Ling E, Longo DL, Messenger LA et al (2024) What is rheumatoid arthritis? N Engl J Med 390(13):e32","journal-title":"N Engl J Med"},{"issue":"9","key":"8408_CR5","first-page":"1725","volume":"41","author":"FM Mariani","year":"2023","unstructured":"Mariani FM, Martelli I, Pistone F, Chericoni E, Puxeddu I, Alunno A (2023) Pathogenesis of rheumatoid arthritis: one year in review 2023. Clin Exp Rheumatol 41(9):1725\u20131734","journal-title":"Clin Exp Rheumatol"},{"key":"8408_CR6","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.molimm.2025.06.008","volume":"184","author":"S Ganeshalingam","year":"2025","unstructured":"Ganeshalingam S, Wilson NJ, Ciciriello S, Antonipillai J, Achuthan AA (2025) Cellular interactions in maintaining an inflammatory microenvironment in rheumatoid arthritis. Mol Immunol 184:112\u2013122","journal-title":"Mol Immunol"},{"issue":"1","key":"8408_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03343-4","volume":"26","author":"H Qian","year":"2024","unstructured":"Qian H, Deng C, Chen S, Zhang X, He Y, Lan J et al (2024) Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis. Arthritis Res Ther 26(1):103","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"8408_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13075-023-03224-2","volume":"25","author":"Y Huang","year":"2023","unstructured":"Huang Y, Peng Y, Li H, Li C, Wu Y, Wang X et al (2023) Wilforine inhibits rheumatoid arthritis pathology through the Wnt11\/beta-catenin signaling pathway axis. Arthritis Res Ther 25(1):243","journal-title":"Arthritis Res Ther"},{"key":"8408_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.555245","volume":"11","author":"A Rodriguez-Trillo","year":"2020","unstructured":"Rodriguez-Trillo A, Mosquera N, Pena C, Rivas-Tobio F, Mera-Varela A, Gonzalez A et al (2020) Non-canonical WNT5A signaling through RYK contributes to aggressive phenotype of the rheumatoid fibroblast-like synoviocytes. Front Immunol 11:555245","journal-title":"Front Immunol"},{"issue":"5","key":"8408_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052688","volume":"25","author":"M Yang","year":"2024","unstructured":"Yang M, Zhu L (2024) Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis. Int J Mol Sci 25(5):2688","journal-title":"Int J Mol Sci"},{"issue":"1","key":"8408_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s10020-024-00788-w","volume":"30","author":"H Zheng","year":"2024","unstructured":"Zheng H, Liu Y, Deng Y, Li Y, Liu S, Yang Y et al (2024) Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets. Mol Med 30(1):20","journal-title":"Mol Med"},{"key":"8408_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.962969","volume":"9","author":"R Sakthiswary","year":"2022","unstructured":"Sakthiswary R, Uma Veshaaliini R, Chin KY, Das S, Sirasanagandla SR (2022) Pathomechanisms of bone loss in rheumatoid arthritis. Front Med (Lausanne) 9:962969","journal-title":"Front Med (Lausanne)"},{"key":"8408_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103488","volume":"88","author":"R Xiao","year":"2025","unstructured":"Xiao R, Tang P, Zhou J, Zheng W, Cao Y, Zhu Y et al (2025) Safety of TNF-alpha inhibitors therapy in patients with rheumatoid arthritis: an umbrella review. EClinicalMedicine 88:103488","journal-title":"EClinicalMedicine"},{"issue":"1","key":"8408_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13075-024-03456-w","volume":"26","author":"N Maharaj","year":"2024","unstructured":"Maharaj N, Uppada DR, Reddy N, Reddy P, Batalov A, Lvanova D et al (2024) Comparing immunogenicity and safety following transition from reference rituximab to biosimilar rituximab (DRL_RI) in patients with rheumatoid arthritis: a randomized, double-blind, phase 3 study. Arthritis Res Ther 26(1):225","journal-title":"Arthritis Res Ther"},{"key":"8408_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152498","volume":"68","author":"L Zeng","year":"2024","unstructured":"Zeng L, Yang K, Yu G, Chen J, Long Z, Xiang W et al (2024) Efficacy and safety of culture-expanded mesenchymal stromal cell therapy in the treatment of 4 types of inflammatory arthritis: a systematic review and meta-analysis of 36 randomized controlled trials. Semin Arthritis Rheum 68:152498","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"8408_CR16","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41598-020-58127-y","volume":"10","author":"M Dimitrijevic","year":"2020","unstructured":"Dimitrijevic M, Arsenovic-Ranin N, Kosec D, Bufan B, Nacka-Aleksic M, Pilipovic I et al (2020) Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis. Sci Rep 10(1):1214","journal-title":"Sci Rep"},{"issue":"1","key":"8408_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13075-015-0548-y","volume":"17","author":"A Andersson","year":"2015","unstructured":"Andersson A, Stubelius A, Karlsson MN, Engdahl C, Erlandsson M, Grahnemo L et al (2015) Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther 17(1):32","journal-title":"Arthritis Res Ther"},{"key":"8408_CR18","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.bbi.2018.11.311","volume":"76","author":"M Dimitrijevic","year":"2019","unstructured":"Dimitrijevic M, Arsenovic-Ranin N, Kosec D, Bufan B, Nacka-Aleksic M, Pilipovic I et al (2019) Sexual dimorphism in Th17\/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis. Brain Behav Immun 76:198\u2013214","journal-title":"Brain Behav Immun"},{"issue":"5","key":"8408_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/ar2319","volume":"9","author":"JJ Inglis","year":"2007","unstructured":"Inglis JJ, Criado G, Medghalchi M, Andrews M, Sandison A, Feldmann M et al (2007) Collagen-induced arthritis in C57BL\/6 mice is associated with a robust and sustained T-cell response to type II collagen. Arthritis Res Ther 9(5):R113","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"8408_CR20","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nprot.2008.19","volume":"3","author":"JJ Inglis","year":"2008","unstructured":"Inglis JJ, Simelyte E, McCann FE, Criado G, Williams RO (2008) Protocol for the induction of arthritis in C57BL\/6 mice. Nat Protoc 3(4):612\u2013618","journal-title":"Nat Protoc"},{"issue":"6","key":"8408_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196048","volume":"13","author":"G Moroncini","year":"2018","unstructured":"Moroncini G, Paolini C, Orlando F, Capelli C, Grieco A, Tonnini C et al (2018) Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice. PLoS One 13(6):e0196048","journal-title":"PLoS One"},{"issue":"7","key":"8408_CR22","first-page":"1134","volume":"13","author":"Y Yu","year":"2019","unstructured":"Yu Y, Yoon KA, Kang TW, Jeon HJ, Sim YB, Choe SH et al (2019) Therapeutic effect of long-interval repeated intravenous administration of human umbilical cord blood-derived mesenchymal stem cells in DBA\/1 mice with collagen-induced arthritis. J Tissue Eng Regen Med 13(7):1134\u20131142","journal-title":"J Tissue Eng Regen Med"},{"key":"8408_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720965896","author":"L Liu","year":"2020","unstructured":"Liu L, Farhoodi HP, Han M, Liu G, Yu J, Nguyen L et al (2020) Preclinical evaluation of a single intravenous infusion of hUC-MSC (BX-U001) in rheumatoid arthritis. Cell Transplant. https:\/\/doi.org\/10.1177\/0963689720965896","journal-title":"Cell Transplant"},{"key":"8408_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00441","volume":"11","author":"Q Meng","year":"2020","unstructured":"Meng Q, Qiu B (2020) Exosomal microRNA-320a derived from mesenchymal stem cells regulates rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing CXCL9 expression. Front Physiol 11:441","journal-title":"Front Physiol"},{"issue":"1","key":"8408_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s42358-024-00382-y","volume":"64","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Zhang J, Liu Y, Ren S, Tao N, Meng F et al (2024) High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community. Adv Rheumatol 64(1):44","journal-title":"Adv Rheumatol"},{"issue":"6","key":"8408_CR26","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1136\/annrheumdis-2020-219247","volume":"80","author":"S Hayer","year":"2021","unstructured":"Hayer S, Vervoordeldonk MJ, Denis MC, Armaka M, Hoffmann M, Backlund J et al (2021) \u201cSMASH\u201d recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models. Ann Rheum Dis 80(6):714\u201326","journal-title":"Ann Rheum Dis"},{"issue":"113","key":"8408_CR27","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adm7800","volume":"10","author":"M Zoccheddu","year":"2025","unstructured":"Zoccheddu M, Suga K, Seng A, Svensson MND, Dutta P, Panahandeh S et al (2025) T(H)17 cells converted into exT(H)17 cells sustain rheumatoid-like IL-17-independent inflammatory arthritis. Sci Immunol 10(113):eadm7800","journal-title":"Sci Immunol"},{"issue":"1","key":"8408_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03071-2","volume":"19","author":"HK Min","year":"2021","unstructured":"Min HK, Kim S, Lee JY, Kim KW, Lee SH, Kim HR (2021) IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell \/ regulatory T cell imbalance in rheumatoid arthritis. J Transl Med 19(1):392","journal-title":"J Transl Med"},{"issue":"1","key":"8408_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60928-4","volume":"14","author":"S Kurawaki","year":"2024","unstructured":"Kurawaki S, Nakashima A, Ishiuchi N, Kanai R, Maeda S, Sasaki K et al (2024) Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction. Sci Rep 14(1):10251","journal-title":"Sci Rep"},{"key":"8408_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.607585","volume":"8","author":"W Shi","year":"2021","unstructured":"Shi W, Zheng Y, Luo S, Li X, Zhang Y, Meng X et al (2021) METTL3 Promotes activation and inflammation of FLSs through the NF-kappaB signaling pathway in rheumatoid arthritis. Front Med (Lausanne) 8:607585","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"8408_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.376","volume":"11","author":"R Wang","year":"2021","unstructured":"Wang R, Li M, Wu W, Qiu Y, Hu W, Li Z et al (2021) NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt\/beta-catenin signaling pathway in rheumatoid arthritis. Clin Transl Med 11(4):e376","journal-title":"Clin Transl Med"},{"key":"8408_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4186102","volume":"2021","author":"X Li","year":"2021","unstructured":"Li X, Zhang L, Xu Y, Zhao D, Mu L, Zhang B et al (2021) Therapeutic effect of matrine on collagen-induced arthritis rats and its regulatory effect on RANKL and OPG expression. J Immunol Res 2021:4186102","journal-title":"J Immunol Res"},{"issue":"3","key":"8408_CR33","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/bph.16227","volume":"181","author":"AH Schneider","year":"2024","unstructured":"Schneider AH, Taira TM, Publio GA, da Silva PD, Donate Yabuta PB, Dos Santos JC et al (2024) Neutrophil extracellular traps mediate bone erosion in rheumatoid arthritis by enhancing RANKL-induced osteoclastogenesis. Br J Pharmacol 181(3):429\u2013446","journal-title":"Br J Pharmacol"},{"key":"8408_CR34","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.matbio.2025.11.001","volume":"142","author":"AM Knapinska","year":"2025","unstructured":"Knapinska AM, Tokmina-Roszyk D, Haag S, Lauer-Fields JK, Singh C, Stawikowska R et al (2025) Matrix metalloproteinase 13 (MMP-13) processing of type II collagen is altered by antibodies and citrullination found in the early stages of rheumatoid arthritis. Matrix Biol 142:46\u201357","journal-title":"Matrix Biol"},{"issue":"1","key":"8408_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03290-0","volume":"26","author":"G Li","year":"2024","unstructured":"Li G, Fang Y, Xu N, Ding Y, Liu D (2024) Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes. Arthritis Res Ther 26(1):56","journal-title":"Arthritis Res Ther"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08408-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08408-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08408-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:05:38Z","timestamp":1793423138000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08408-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["8408"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08408-0","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"12 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal study was approved by the Animal Ethics Committee of Jiangsu Huachuang Yutong Medical Laboratory Co., Ltd. (Approval No. HC25010-P001-01). All animal procedures were performed in strict accordance with institutional guidelines and the approved protocol, following the 3R principles and relevant regulations for laboratory animal care and use. Human umbilical cord-derived mesenchymal stem cells were commercially obtained, and donor informed consent and source ethics approval were provided by the supplier.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}