{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:45Z","timestamp":1793424765122,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s10067-026-08417-z","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:27:31Z","timestamp":1789126051000},"page":"6521-6531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paradoxical psoriasis in axial spondyloarthritis and rheumatoid arthritis treated with b\/tsDMARDs: a retrospective cohort study"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-8730","authenticated-orcid":false,"given":"Halil","family":"Harman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-1169","authenticated-orcid":false,"given":"Tu\u011fba","family":"\u0130\u015flek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-2701","authenticated-orcid":false,"given":"Deniz","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-7788","authenticated-orcid":false,"given":"Mehmet Ali","family":"Balc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"8417_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0140-6736(16)31591-4","volume":"390","author":"J Sieper","year":"2017","unstructured":"Sieper J, Poddubnyy D (2017) Axial spondyloarthritis. Lancet 390:73\u201384","journal-title":"Lancet"},{"key":"8417_CR2","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis. Lancet 388:2023\u20132038","journal-title":"Lancet"},{"key":"8417_CR3","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1136\/annrheumdis-2016-210770","volume":"76","author":"D van der Heijde","year":"2017","unstructured":"van der Heijde D, Ramiro S, Landewe R et al (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76:978\u2013991","journal-title":"Ann Rheum Dis"},{"key":"8417_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","volume":"79","author":"JS Smolen","year":"2020","unstructured":"Smolen JS, Landewe RBM, Bijlsma JWJ et al (2020) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis 79:685\u2013699","journal-title":"Ann Rheum Dis"},{"key":"8417_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13718","volume":"30","author":"E Behrangi","year":"2024","unstructured":"Behrangi E, Moodi F, Jafarzadeh A, Goodarzi A (2024) Paradoxical and bimodal immune-mediated dermatological side effects of TNF-\u03b1 inhibitors: a comprehensive review. Skin Res Technol 30:e13718","journal-title":"Skin Res Technol"},{"key":"8417_CR6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jaad.2016.08.012","volume":"76","author":"G Brown","year":"2017","unstructured":"Brown G, Wang E, Leon A et al (2017) Tumor necrosis factor-\u03b1 inhibitor-induced psoriasis: systematic review of clinical features, histopathological findings, and management experience. J Am Acad Dermatol 76:334\u2013341","journal-title":"J Am Acad Dermatol"},{"key":"8417_CR7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41467-017-02466-4","volume":"9","author":"C Conrad","year":"2018","unstructured":"Conrad C, Di Domizio J, Mylonas A et al (2018) TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis. Nat Commun 9:25","journal-title":"Nat Commun"},{"key":"8417_CR8","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.3389\/fimmu.2018.02746","volume":"9","author":"A Mylonas","year":"2018","unstructured":"Mylonas A, Conrad C (2018) Psoriasis: classical vs. paradoxical. The Yin-Yang of TNF and type 1 interferon. Front Immunol 9:2746","journal-title":"Front Immunol"},{"key":"8417_CR9","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN (2021) Psoriasis. Lancet 397:1301\u20131315","journal-title":"Lancet"},{"key":"8417_CR10","first-page":"178","volume":"42","author":"I Sagonas","year":"2024","unstructured":"Sagonas I, Iliopoulos G, Baraliakos X, Daoussis D (2024) Anti-TNF-\u03b1 induced paradoxical psoriasis in patients with ankylosing spondylitis: a systematic review. Clin Exp Rheumatol 42:178\u2013184","journal-title":"Clin Exp Rheumatol"},{"key":"8417_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.847160","volume":"13","author":"W Xie","year":"2022","unstructured":"Xie W, Xiao S, Huang H, Zhang Z (2022) Incidence of and risk factors for paradoxical psoriasis or psoriasiform lesions in inflammatory bowel disease patients receiving anti-TNF therapy: systematic review with meta-analysis. Front Immunol 13:847160","journal-title":"Front Immunol"},{"key":"8417_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14225","volume":"33","author":"L Lian","year":"2020","unstructured":"Lian L, Fang Y, Chen M et al (2020) Tumor necrosis factor-\u03b1 inhibition-induced paradoxical psoriasis: a case series and literature review. Dermatol Ther 33:e13718","journal-title":"Dermatol Ther"},{"key":"8417_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000239","volume":"2","author":"E Toussirot","year":"2016","unstructured":"Toussirot E, Aubin F (2016) Paradoxical reactions under TNF-\u03b1 blocking agents and other biological agents given for chronic immune-mediated diseases: an analytical and comprehensive overview. RMD Open 2:e000239","journal-title":"RMD Open"},{"key":"8417_CR14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, van der Heijde D, Landewe R et al (2009) The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68:777\u2013783","journal-title":"Ann Rheum Dis"},{"key":"8417_CR15","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569\u20132581","journal-title":"Arthritis Rheum"},{"key":"8417_CR16","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21:2286\u20132291","journal-title":"J Rheumatol"},{"key":"8417_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van \u2019t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Arthritis Rheum 38:44\u20138","journal-title":"Arthritis Rheum"},{"key":"8417_CR18","first-page":"238","volume":"157","author":"T Fredriksson","year":"1978","unstructured":"Fredriksson T, Pettersson U (1978) Severe psoriasis \u2014 oral therapy with a new retinoid. Dermatologica 157:238\u2013244","journal-title":"Dermatologica"},{"key":"8417_CR19","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/sim.1047","volume":"21","author":"G Heinze","year":"2002","unstructured":"Heinze G, Schemper M (2002) A solution to the problem of separation in logistic regression. Stat Med 21:2409\u20132419","journal-title":"Stat Med"},{"key":"8417_CR20","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/bjd.12670","volume":"170","author":"AW Armstrong","year":"2014","unstructured":"Armstrong AW, Harskamp CT, Dhillon JS, Armstrong EJ (2014) Psoriasis and smoking: a systematic review and meta-analysis. Br J Dermatol 170:304\u2013314","journal-title":"Br J Dermatol"},{"key":"8417_CR21","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1365-2133.2011.10526.x","volume":"165","author":"AW Armstrong","year":"2011","unstructured":"Armstrong AW, Armstrong EJ, Fuller EN, Sockolov ME, Voyles SV (2011) Smoking and pathogenesis of psoriasis: a review of oxidative, inflammatory and genetic mechanisms. Br J Dermatol 165:1162\u20131168","journal-title":"Br J Dermatol"},{"key":"8417_CR22","first-page":"110","volume":"154","author":"N Dand","year":"2024","unstructured":"Dand N, Mahil SK, Capon F et al (2024) A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis. J Allergy Clin Immunol 154:110\u2013121","journal-title":"J Allergy Clin Immunol"},{"key":"8417_CR23","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1111\/j.1365-2133.2005.06977.x","volume":"153","author":"G Michaelsson","year":"2005","unstructured":"Michaelsson G, Kajermo U, Michaelsson A, Hagforsen E (2005) Infliximab can precipitate as well as worsen palmoplantar pustulosis: possible linkage to the expression of tumour necrosis factor-alpha in the normal palmar eccrine sweat duct. Br J Dermatol 153:1243\u20131244","journal-title":"Br J Dermatol"},{"key":"8417_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2026.103592","volume":"162","author":"A Tonutti","year":"2026","unstructured":"Tonutti A, Voiculescu V, Trunfio F, Abacar K, Altaie A, Macleod T, Vandevelde C, Meridor K, Shams K, Zabotti A, Quartuccio L, Selmi C, Marzo-Ortega H, McGonagle D (2026) Description and therapy of palmoplantar pustular psoriasis under IL-17A or dual IL-17A\/F inhibition. J Autoimmun 162:103592","journal-title":"J Autoimmun"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08417-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08417-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-026-08417-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:05:45Z","timestamp":1793423145000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-026-08417-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["8417"],"URL":"https:\/\/doi.org\/10.1007\/s10067-026-08417-z","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"12 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the institutional ethics committee and conducted in accordance with the 1964 Declaration of Helsinki and its later amendments.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Informed consent was waived by the ethics committee due to the retrospective nature of the study.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":3,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}