{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:13:31Z","timestamp":1763140411111},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1007\/s10072-009-0145-4","type":"journal-article","created":{"date-parts":[[2009,10,31]],"date-time":"2009-10-31T06:50:41Z","timestamp":1256971841000},"page":"171-173","source":"Crossref","is-referenced-by-count":21,"title":["Cyclophosphamide as second-line therapy in multiple sclerosis: benefits and risks"],"prefix":"10.1007","volume":"30","author":[{"given":"Luciano","family":"Rinaldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Perini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"issue":"2","key":"145_CR1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1191\/1352458502ms790oa","volume":"8","author":"HL Weiner","year":"2002","unstructured":"Weiner HL, Cohen JA (2002) Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects. Mult Scler 8(2):142\u2013154","journal-title":"Mult Scler"},{"issue":"6","key":"145_CR2","first-page":"345","volume":"215","author":"G Aimard","year":"1966","unstructured":"Aimard G, Girard PF, Raveau J (1966) Multiple sclerosis and the autoimmunization process. Treatment by antimitotics. Lyon Med 215(6):345\u2013352","journal-title":"Lyon Med"},{"issue":"19","key":"145_CR3","first-page":"967","volume":"75","author":"PF Girard","year":"1967","unstructured":"Girard PF, Aimard G, Pellet H (1967) Immunodepressive therapy in neurology. Presse Med 75(19):967\u2013968","journal-title":"Presse Med"},{"issue":"4","key":"145_CR4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1056\/NEJM198301273080401","volume":"308","author":"SL Hauser","year":"1983","unstructured":"Hauser SL et al (1983) Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med 308(4):173\u2013180","journal-title":"N Engl J Med"},{"issue":"5","key":"145_CR5","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1212\/WNL.43.5.910","volume":"43","author":"HL Weiner","year":"1993","unstructured":"Weiner HL et al (1993) Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 43(5):910\u2013918","journal-title":"Neurology"},{"issue":"8739","key":"145_CR6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0140-6736(91)93389-Q","volume":"337","author":"The Canadian Cooperative Multiple Sclerosis Study Group","year":"1991","unstructured":"The Canadian Cooperative Multiple Sclerosis Study Group (1991) The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. Lancet 337(8739):441\u2013446","journal-title":"Lancet"},{"issue":"12","key":"145_CR7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/jnnp.54.12.1055","volume":"54","author":"WH Likosky","year":"1991","unstructured":"Likosky WH et al (1991) Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg Psychiatry 54(12):1055\u20131060","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"145_CR8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0165-5728(99)00039-9","volume":"99","author":"MI Gobbini","year":"1999","unstructured":"Gobbini MI et al (1999) Effect of open label pulse cyclophosphamide therapy on MRI measures of disease activity in five patients with refractory relapsing-remitting multiple sclerosis. J Neuroimmunol 99(1):142\u2013149","journal-title":"J Neuroimmunol"},{"issue":"7","key":"145_CR9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00415-003-1089-x","volume":"250","author":"P Perini","year":"2003","unstructured":"Perini P, Gallo P (2003) Cyclophosphamide is effective in stabilizing rapidly deteriorating secondary progressive multiple sclerosis. J Neurol 250(7):834\u2013838","journal-title":"J Neurol"},{"issue":"8","key":"145_CR10","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s00415-006-0154-7","volume":"253","author":"P Perini","year":"2006","unstructured":"Perini P et al (2006) Mitoxantrone versus cyclophosphamide in secondary-progressive multiple sclerosis: a comparative study. J Neurol 253(8):1034\u20131040","journal-title":"J Neurol"},{"key":"145_CR11","doi-asserted-by":"crossref","unstructured":"La Mantia L et al (2002) Cyclophosphamide for multiple sclerosis. Cochrane Database Syst Rev (4):CD002819","DOI":"10.1002\/14651858.CD002819"},{"issue":"5","key":"145_CR12","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1191\/1352458503ms926oa","volume":"9","author":"E Portaccio","year":"2003","unstructured":"Portaccio E et al (2003) Safety and tolerability of cyclophosphamide \u2018pulses\u2019 in multiple sclerosis: a prospective study in a clinical cohort. Mult Scler 9(5):446\u2013450","journal-title":"Mult Scler"},{"issue":"3","key":"145_CR13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/1097-0142(19880201)61:3<451::AID-CNCR2820610308>3.0.CO;2-G","volume":"61","author":"TJ Stillwell","year":"1988","unstructured":"Stillwell TJ, Benson RC Jr (1988) Cyclophosphamide-induced hemorrhagic cystitis. A review of 100 patients. Cancer 61(3):451\u2013457","journal-title":"Cancer"},{"issue":"5","key":"145_CR14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.7326\/0003-4819-124-5-199603010-00003","volume":"124","author":"C Talar-Williams","year":"1996","unstructured":"Talar-Williams C et al (1996) Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Ann Intern Med 124(5):477\u2013484","journal-title":"Ann Intern Med"},{"issue":"8","key":"145_CR15","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/art.1780380815","volume":"38","author":"CD Radis","year":"1995","unstructured":"Radis CD et al (1995) Effects of cyclophosphamide on the development of malignancy and on long-term survival of patients with rheumatoid arthritis. A 20-year followup study. Arthritis Rheum 38(8):1120\u20131127","journal-title":"Arthritis Rheum"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-009-0145-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-009-0145-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-009-0145-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T05:11:41Z","timestamp":1559106701000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-009-0145-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":15,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["145"],"URL":"https:\/\/doi.org\/10.1007\/s10072-009-0145-4","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}