{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:24:33Z","timestamp":1793413473907,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s10072-014-1630-y","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T06:21:51Z","timestamp":1392704511000},"page":"1009-1013","source":"Crossref","is-referenced-by-count":20,"title":["Betaine suppressed A\u03b2 generation by altering amyloid precursor protein processing"],"prefix":"10.1007","volume":"35","author":[{"given":"Xiu-Ping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Feng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Cui","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Qing","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"issue":"6","key":"1630_CR1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1017\/S0317167100015547","volume":"39","author":"K Honjo","year":"2012","unstructured":"Honjo K, Black SE, Verhoeff NP (2012) Alzheimer\u2019s disease, cerebrovascular disease, and the beta-amyloid cascade. Can J Neurol Sci 39(6):712\u2013728","journal-title":"Can J Neurol Sci"},{"issue":"12","key":"1630_CR2","first-page":"1651","volume":"16","author":"S Singh","year":"2012","unstructured":"Singh S, Kushwah AS, Singh R, Farswan M, Kaur R (2012) Current therapeutic strategy in Alzheimer\u2019s disease. Eur Rev Med Pharmacol Sci 16(12):1651\u20131664","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1630_CR3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/B978-0-12-394816-8.00007-6","volume":"64","author":"RF Lane","year":"2012","unstructured":"Lane RF, Shineman DW, Steele JW, Lee LB, Fillit HM (2012) Beyond amyloid: the future of therapeutics for Alzheimer\u2019s disease. Adv Pharmacol 64:213\u2013271. doi: 10.1016\/B978-0-12-394816-8.00007-6","journal-title":"Adv Pharmacol"},{"issue":"1","key":"1630_CR4","doi-asserted-by":"crossref","first-page":"e51965","DOI":"10.1371\/journal.pone.0051965","volume":"8","author":"RH Takahashi","year":"2013","unstructured":"Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK (2013) Accumulation of intraneuronal beta-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PLoS One 8(1):e51965. doi: 10.1371\/journal.pone.0051965","journal-title":"PLoS One"},{"key":"1630_CR5","author":"ME Seward","year":"2013","unstructured":"Seward ME, Swanson E, Norambuena A, Reimann A, Cochran JN, Li R, Roberson ED, Bloom GS (2013) Amyloid-beta signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer\u2019s disease. J Cell Sci. doi: 10.1242\/jcs.1125880","journal-title":"J Cell Sci"},{"issue":"Suppl 1","key":"1630_CR6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1471-4159.2011.07505.x","volume":"120","author":"P St George-Hyslop","year":"2012","unstructured":"St George-Hyslop P, Fraser PE (2012) Assembly of the presenilin gamma-\/epsilon-secretase complex. J Neurochem 120(Suppl 1):84\u201388. doi: 10.1111\/j.1471-4159.2011.07505.x","journal-title":"J Neurochem"},{"key":"1630_CR7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-394816-8.00004-0","volume":"64","author":"MS Wolfe","year":"2012","unstructured":"Wolfe MS (2012) gamma-Secretase as a target for Alzheimer\u2019s disease. Adv Pharmacol 64:127\u2013153. doi: 10.1016\/B978-0-12-394816-8.00004-0","journal-title":"Adv Pharmacol"},{"issue":"1","key":"1630_CR8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1172\/JCI64516","volume":"123","author":"PT Ly","year":"2013","unstructured":"Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W (2013) Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest 123(1):224\u2013235. doi: 10.1172\/JCI64516","journal-title":"J Clin Invest"},{"issue":"49","key":"1630_CR9","doi-asserted-by":"crossref","first-page":"41245","DOI":"10.1074\/jbc.M112.409110","volume":"287","author":"F Jeppsson","year":"2012","unstructured":"Jeppsson F, Eketjall S, Janson J, Karlstrom S, Gustavsson S, Olsson LL, Radesater AC, Ploeger B, Cebers G, Kolmodin K, Swahn BM, von Berg S, Bueters T, Falting J (2012) Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem 287(49):41245\u201341257. doi: 10.1074\/jbc.M112.409110","journal-title":"J Biol Chem"},{"issue":"5","key":"1630_CR10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/jn\/133.5.1302","volume":"133","author":"SH Zeisel","year":"2003","unstructured":"Zeisel SH, Mar MH, Howe JC, Holden JM (2003) Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133(5):1302\u20131307","journal-title":"J Nutr"},{"issue":"16","key":"1630_CR11","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1212\/WNL.0b013e3181f88162","volume":"75","author":"B Hooshmand","year":"2010","unstructured":"Hooshmand B, Solomon A, Kareholt I, Leiviska J, Rusanen M, Ahtiluoto S, Winblad B, Laatikainen T, Soininen H, Kivipelto M (2010) Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study. Neurology 75(16):1408\u20131414. doi: 10.1212\/WNL.0b013e3181f8816275\/16\/1408","journal-title":"Neurology"},{"issue":"2","key":"1630_CR12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jhep.2006.08.024","volume":"46","author":"KK Kharbanda","year":"2007","unstructured":"Kharbanda KK, Mailliard ME, Baldwin CR, Beckenhauer HC, Sorrell MF, Tuma DJ (2007) Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol 46(2):314\u2013321. doi: 10.1016\/j.jhep.2006.08.024","journal-title":"J Hepatol"},{"issue":"3","key":"1630_CR13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jnc.12094","volume":"124","author":"GS Chai","year":"2013","unstructured":"Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124(3):388\u2013396. doi: 10.1111\/jnc.12094","journal-title":"J Neurochem"},{"issue":"9","key":"1630_CR14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/glia.22347","volume":"60","author":"XP Liu","year":"2012","unstructured":"Liu XP, Zheng HY, Qu M, Zhang Y, Cao FY, Wang Q, Ke D, Liu GP, Wang JZ (2012) Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice. Glia 60(9):1279\u20131288. doi: 10.1002\/glia.22347","journal-title":"Glia"},{"key":"1630_CR15","author":"YQ Lu","year":"2013","unstructured":"Lu YQ, Luo Y, He ZF, Chen J, Yan BL, Wang Y, Yu Q (2013) Hydroxysafflor Yellow A ameliorates homocysteine induced Alzheimer-like pathologic dysfunction and memory\/synaptic disorder. Rejuvenation Res. doi: 10.1089\/rej.2013.1451","journal-title":"Rejuvenation Res"},{"issue":"2","key":"1630_CR16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3233\/JAD-2007-11209","volume":"11","author":"AA Boldyrev","year":"2007","unstructured":"Boldyrev AA, Johnson P (2007) Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer\u2019s disease. J Alzheimers Dis 11(2):219\u2013228","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"1630_CR17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","volume":"48","author":"F Dam Van","year":"2009","unstructured":"Van Dam F, Van Gool WA (2009) Hyperhomocysteinemia and Alzheimer\u2019s disease: a systematic review. Arch Gerontol Geriatr 48(3):425\u2013430. doi: 10.1016\/j.archger.2008.03.009","journal-title":"Arch Gerontol Geriatr"},{"issue":"11","key":"1630_CR18","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","volume":"55","author":"R Clarke","year":"1998","unstructured":"Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM (1998) Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55(11):1449\u20131455","journal-title":"Arch Neurol"},{"issue":"76","key":"1630_CR19","first-page":"189","volume":"14","author":"C Zhang","year":"2012","unstructured":"Zhang C (2012) Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer\u2019s disease. Discov Med 14(76):189\u2013197","journal-title":"Discov Med"},{"key":"1630_CR20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1742-2094-9-62","volume":"9","author":"MT Ferretti","year":"2012","unstructured":"Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC (2012) Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer\u2019s disease-like amyloid pathology. J Neuroinflammation 9:62. doi: 10.1186\/1742-2094-9-62","journal-title":"J Neuroinflammation"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1630-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-014-1630-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1630-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:39:19Z","timestamp":1565188759000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-014-1630-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["1630"],"URL":"https:\/\/doi.org\/10.1007\/s10072-014-1630-y","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]}}}