{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:18:26Z","timestamp":1780636706656,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s10072-014-1877-3","type":"journal-article","created":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T10:14:33Z","timestamp":1405246473000},"page":"1983-1990","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between angiotensin converting enzyme gene insertion\/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis"],"prefix":"10.1007","volume":"35","author":[{"given":"A.","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vivekanandhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V. P.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"issue":"2","key":"1877_CR1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(07)70031-5","volume":"6","author":"K Strong","year":"2007","unstructured":"Strong K, Mathers C, Bonita R (2007) Preventing stroke: saving lives around the world. Lancet Neurol 6(2):182\u2013187","journal-title":"Lancet Neurol"},{"issue":"4","key":"1877_CR2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(09)70025-0","volume":"8","author":"VL Feigin","year":"2009","unstructured":"Feigin VL, Lawes CMM, Bennett DA, Barker-Collo SL, Parag V (2009) Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 8(4):355\u2013369","journal-title":"Lancet Neurol"},{"issue":"24","key":"1877_CR3","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1073\/pnas.85.24.9386","volume":"85","author":"F Soubrier","year":"1988","unstructured":"Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G et al (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 85(24):9386\u20139390","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1877_CR4","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/nar\/20.6.1433-a","volume":"20","author":"B Rigat","year":"1992","unstructured":"Rigat B, Hubert C, Corvol P, Soubrier F (1992) PCR detection of the insertion\/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 20(6):1433","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1877_CR5","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","volume":"86","author":"B Rigat","year":"1990","unstructured":"Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86(4):1343\u20131346","journal-title":"J Clin Invest"},{"issue":"2","key":"1877_CR6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.ATV.20.2.484","volume":"20","author":"B Agerholm-Larsen","year":"2000","unstructured":"Agerholm-Larsen B, Nordestgaard BG, Tybjaerg-Hansen A (2000) ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler Thromb Vasc Biol 20(2):484\u2013492","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"1877_CR7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.gene.2013.03.076","volume":"522","author":"Y Chen","year":"2013","unstructured":"Chen Y, Dong S, He M, Qi T, Zhu W (2013) Angiotensin-converting enzyme insertion\/deletion polymorphism and risk of myocardial infarction in an updated meta-analysis based on 34993 participants. Gene 522(2):196\u2013205","journal-title":"Gene"},{"issue":"4","key":"1877_CR8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1470320308097499","volume":"9","author":"V Ramachandran","year":"2008","unstructured":"Ramachandran V, Ismail P, Stanslas J, Shamsudin N, Moin S, Jas RM (2008) Association of insertion\/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. J Renin Angiotensin Aldosterone Syst 9(4):208\u2013214","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"12","key":"1877_CR9","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.1007\/s11033-012-1875-6","volume":"39","author":"X Li","year":"2012","unstructured":"Li X, Li Y, Jia N, Guo S, Chu S, Niu W (2012) Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis. Mol Biol Rep 39(12):10063\u201310075","journal-title":"Mol Biol Rep"},{"issue":"2","key":"1877_CR10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2990.2007.00885.x","volume":"34","author":"JS Miners","year":"2008","unstructured":"Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S et al (2008) Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer\u2019s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 34(2):181\u2013193","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"1877_CR11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/1470320311434240","volume":"13","author":"YH Lee","year":"2012","unstructured":"Lee YH, Choi SJ, Ji JD, Song GG (2012) Associations between the angiotensin-converting enzyme insertion\/deletion polymorphism and susceptibility to vasculitis: a meta-analysis. J Renin Angiotensin Aldosterone Syst 13(1):196\u2013201","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"6","key":"1877_CR12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1179\/1743132813Y.0000000184","volume":"35","author":"H Qin","year":"2013","unstructured":"Qin H, Zhang L, Xu G, Pan X (2013) Association of angiotensin-converting enzyme insertion\/deletion polymorphism (rs4646994) with the risk of primary intracerebral hemorrhage. Neurol Res 35(6):545\u2013552","journal-title":"Neurol Res"},{"issue":"1","key":"1877_CR13","first-page":"113","volume":"58","author":"K Aho","year":"1980","unstructured":"Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov VE, Strasser T (1980) Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ 58(1):113\u2013130","journal-title":"Bull World Health Organ"},{"key":"1877_CR14","doi-asserted-by":"crossref","unstructured":"Kumar A, Vivekanandhan S, Srivastava A, Tripathi M, Padma Srivastava MV, Saini N et al. (2014) Association between angiotensin converting enzyme gene insertion\/deletion polymorphism and ischemic stroke in north Indian population: a case-control study and meta-analysis. Neurol Res [Epub ahead of print]","DOI":"10.1179\/1743132814Y.0000000335"},{"issue":"1","key":"1877_CR15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-2377-13-136","volume":"13","author":"A Kumar","year":"2013","unstructured":"Kumar A, Sagar R, Kumar P, Sahu JK, Grover A, Srivastava AK et al (2013) Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design (Study protocol). BMC Neurol 13(1):136","journal-title":"BMC Neurol"},{"issue":"7\u20138","key":"1877_CR16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cca.2010.12.022","volume":"412","author":"J Kalita","year":"2011","unstructured":"Kalita J, Somarajan BI, Kumar B, Mittal B, Misra UK (2011) A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke. Clin Chim Acta 412(7\u20138):642\u2013646","journal-title":"Clin Chim Acta"},{"issue":"6 Pt 1","key":"1877_CR17","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/clinchem\/44.6.1353","volume":"44","author":"FT Chiang","year":"1998","unstructured":"Chiang FT, Hsu KL, Chen WM, Tseng CD, Tseng YZ (1998) Determination of angiotensin-converting enzyme gene polymorphisms: stepdown PCR increases detection of heterozygotes. Clin Chem 44(6 Pt 1):1353\u20131356","journal-title":"Clin Chem"},{"issue":"10","key":"1877_CR18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/00207454.2011.591513","volume":"121","author":"S Nirmal","year":"2011","unstructured":"Nirmal S, Tripathi M, Shastri SS, Sagar R, S V (2011) Association of Angiotensin-converting enzyme insertion(I)\/deletion (D) genotype in Alzheimer\u2019s disease patients of north Indian population. Int J Neurosci 121(10):557\u2013561","journal-title":"Int J Neurosci"},{"issue":"1","key":"1877_CR19","first-page":"197","volume":"51","author":"L Tiret","year":"1992","unstructured":"Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F et al (1992) Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51(1):197\u2013205","journal-title":"Am J Hum Genet"},{"issue":"6 Pt 2","key":"1877_CR20","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/0002-8703(94)90255-0","volume":"128","author":"B Pitt","year":"1994","unstructured":"Pitt B (1994) Angiotensin-converting enzyme inhibitors in patients with coronary atherosclerosis. Am Heart J 128(6 Pt 2):1328\u20131332","journal-title":"Am Heart J"},{"issue":"6","key":"1877_CR21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0008-6363(96)00170-8","volume":"32","author":"E Villard","year":"1996","unstructured":"Villard E, Soubrier F (1996) Molecular biology and genetics of the angiotensin-I-converting enzyme: potential implications in cardiovascular diseases. Cardiovasc Res 32(6):999\u20131007","journal-title":"Cardiovasc Res"},{"key":"1877_CR22","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1073\/pnas.92.4.1137","volume":"92","author":"R Moncada","year":"1995","unstructured":"Moncada R, Pulmer R, Higgs E (1995) Generation of prostacyclin and endothelium derived relaxing factor from endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 92:1137\u20131141","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1877_CR23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1177\/1470320310395799","volume":"12","author":"SK Nawaz","year":"2011","unstructured":"Nawaz SK, Hasnain S (2011) Effect of ACE polymorphisms on the association between noise and hypertension in a Pakistani population. J Renin Angiotensin Aldosterone Syst 12(4):516\u2013520","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"5 Pt 1","key":"1877_CR24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0895-7061(97)00036-8","volume":"10","author":"JR Jeng","year":"1997","unstructured":"Jeng JR, Harn HJ, Jeng CY, Yueh KC, Shieh SM (1997) Angiotensin I converting enzyme gene polymorphism in Chinese patients with hypertension. Am J Hypertens 10(5 Pt 1):558\u2013561","journal-title":"Am J Hypertens"},{"issue":"9","key":"1877_CR25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10815-012-9800-4","volume":"29","author":"M Zhu","year":"2012","unstructured":"Zhu M, Zhang J, Nie S, Yan W (2012) Associations of ACE I\/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis. J Assist Reprod Genet 29(9):921\u2013932","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"1877_CR26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/FPC.0b013e328343ab15","volume":"21","author":"E Dardiotis","year":"2011","unstructured":"Dardiotis E, Jagiella J, Xiromerisiou G, Dardioti M, Vogiatzi C, Urbanik A et al (2011) Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage. Pharmacogenet Genomics 21(3):136\u2013141","journal-title":"Pharmacogenet Genomics"},{"issue":"2","key":"1877_CR27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/bbrc.1993.1231","volume":"191","author":"K Higashimori","year":"1993","unstructured":"Higashimori K, Zhao Y, Higaki J, Kamitani A, Katsuya T, Nakura J et al (1993) Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophys Res Commun 191(2):399\u2013404","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"1877_CR28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0895-7061(95)00449-1","volume":"9","author":"S Vassilikioti","year":"1996","unstructured":"Vassilikioti S, Doumas M, Douma S, Petidis K, Karagiannis A, Balaska K et al (1996) Angiotensin converting enzyme gene polymorphism is not related to essential hypertension in a Greek population. Am J Hypertens 9(7):700\u2013702","journal-title":"Am J Hypertens"},{"issue":"2","key":"1877_CR29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0895-7061(96)00345-7","volume":"10","author":"FT Chiang","year":"1997","unstructured":"Chiang FT, Lai ZP, Chern TH, Tseng CD, Hsu KL, Lo HM et al (1997) Lack of association of the angiotensin converting enzyme polymorphism with essential hypertension in a Chinese population. Am J Hypertens 10(2):197\u2013201","journal-title":"Am J Hypertens"},{"issue":"3","key":"1877_CR30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/jnnp-2011-300371","volume":"83","author":"N Samarasekera","year":"2012","unstructured":"Samarasekera N, Smith C, Al-Shahi SR (2012) The association between cerebral amyloid angiopathy and intracerebral haemorrhage: systematic review and meta-analysis. J Neurol Neurosurg Psychiatr 83(3):275\u2013281","journal-title":"J Neurol Neurosurg Psychiatr"},{"issue":"3","key":"1877_CR31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1042-3680(18)30651-X","volume":"3","author":"BA Cohen","year":"1992","unstructured":"Cohen BA, Biller J (1992) Hemorrhagic stroke due to cerebral vasculitis and the role of immunosuppressive therapy. Neurosurg Clin N Am 3(3):611\u2013624","journal-title":"Neurosurg Clin N Am"},{"key":"1877_CR32","doi-asserted-by":"crossref","unstructured":"Song GG, Kim J-H, Lee YH (2013) Associations between the insertion\/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: a meta-analysis. J Renin Angiotensin Aldosterone Syst [Epub ahead of print]","DOI":"10.1177\/1470320313485897"},{"issue":"5","key":"1877_CR33","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10072-011-0903-y","volume":"33","author":"UK Misra","year":"2012","unstructured":"Misra UK, Kalita J, Somarajan BI, Kumar B, Das M, Mittal B (2012) Do ACE (rs4646994) and \u03b1ADDUCIN (rs4961) gene polymorphisms predict the recurrence of hypertensive intracerebral hemorrhage? Neurol Sci 33(5):1071\u20131077","journal-title":"Neurol Sci"},{"issue":"1","key":"1877_CR34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0028-3886.76856","volume":"59","author":"J Kalita","year":"2011","unstructured":"Kalita J, Misra UK, Bindu IS, Kumar B, Mittal B (2011) Angiotensin-converting enzyme (rs4646994) and \u03b1 ADDUCIN (rs4961) gene polymorphisms\u2019 study in primary spontaneous intracerebral hemorrhage. Neurol India 59(1):41\u201346","journal-title":"Neurol India"},{"key":"1877_CR35","doi-asserted-by":"crossref","unstructured":"Huang Y, Li G, Lan H, Zhao G, Huang C (2014) Angiotensin-converting enzyme insertion\/deletion gene polymorphisms and risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies. J Renin Angiotensin Aldosterone Syst 15(1):32\u201338","DOI":"10.1177\/1470320313481838"},{"issue":"2","key":"1877_CR36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/01.WNL.0000130200.12993.0C","volume":"63","author":"A Slowik","year":"2004","unstructured":"Slowik A, Turaj W, Dziedzic T, Haefele A, Pera J, Malecki MT et al (2004) DD genotype of ACE gene is a risk factor for intracerebral hemorrhage. Neurology 63(2):359\u2013361","journal-title":"Neurology"},{"issue":"6","key":"1877_CR37","doi-asserted-by":"crossref","first-page":"e67402","DOI":"10.1371\/journal.pone.0067402","volume":"8","author":"Y Sun","year":"2013","unstructured":"Sun Y, Liu Y, Watts LT, Sun Q, Zhong Z, Yang G-Y et al (2013) Genetic associations of angiotensin-converting enzyme with primary intracerebral hemorrhage: a meta-analysis. PLoS One 8(6):e67402","journal-title":"PLoS One"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1877-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-014-1877-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1877-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T06:43:24Z","timestamp":1598078604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-014-1877-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,14]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1877"],"URL":"https:\/\/doi.org\/10.1007\/s10072-014-1877-3","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,14]]}}}