{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:25:52Z","timestamp":1792718752930,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T00:00:00Z","timestamp":1411171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s10072-014-1950-y","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T07:54:43Z","timestamp":1411113283000},"page":"275-279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The use of botulinum toxin in the treatment of sialorrhea in parkinsonian disorders"],"prefix":"10.1007","volume":"36","author":[{"given":"Mar\u00eda T.","family":"G\u00f3mez-Caravaca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"C\u00e1ceres-Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Huertas-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vargas-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Carballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,20]]},"reference":[{"key":"1950_CR1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/jnnp-2012-303135","volume":"84","author":"M Asahina","year":"2013","unstructured":"Asahina M, Vichayanrat E, Low DA, Iodice V, Mathias CJ (2013) Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology. Neurol Neurosurg Psychiatry 84:674\u2013680","journal-title":"Neurol Neurosurg Psychiatry"},{"key":"1950_CR2","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/S1353-8020(09)70820-X","volume":"15","author":"G Mostile","year":"2009","unstructured":"Mostile G, Jankovic J (2009) Treatment of dysautonomia associated with Parkinson\u2019s disease. Parkinsonism Relat Disord 15:S224\u2013S232","journal-title":"Parkinsonism Relat Disord"},{"key":"1950_CR3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mds.20189","volume":"20","author":"M Proulx","year":"2005","unstructured":"Proulx M, de Courval FP, Wiseman MA, Panisset M (2005) Salivary production in Parkinson\u2019s disease. Mov Disord 20:204\u2013207","journal-title":"Mov Disord"},{"key":"1950_CR4","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00415-009-5098-2","volume":"256","author":"JG Kalf","year":"2009","unstructured":"Kalf JG, de Swart BJ, Borm GF, Bloem BR, Munneke M (2009) Prevalence and definition of drooling in Parkinson\u2019s disease: a systematic review. J Neurol 256:1391\u20131396","journal-title":"J Neurol"},{"key":"1950_CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1468-1331.2011.03402.x","volume":"19","author":"S Perez-Lloret","year":"2012","unstructured":"Perez-Lloret S, N\u00e8gre-Pag\u00e8s L, Ojero-Senard A et al (2012) Oro-buccal symptoms (dysphagia, dysarthria, and\u00a0sialorrhea) in patients with Parkinson\u2019s disease: preliminary analysis from the French COPARK cohort. Eur J Neurol 19:28\u201337","journal-title":"Eur J Neurol"},{"key":"1950_CR6","first-page":"2306","volume":"33","author":"KL Chou","year":"2006","unstructured":"Chou KL, Evatt M, Evatt M, Hinson V, Kompoliti K (2006) Sialorrhea in Parkinson\u2019s disease: a review. Mov Disord 33:2306\u20132313","journal-title":"Mov Disord"},{"key":"1950_CR7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.mib.2012.05.012","volume":"15","author":"D Dressler","year":"2012","unstructured":"Dressler D (2012) Clinical applications of botulinum toxin. Curr Opin Microbiol 15:325\u2013336","journal-title":"Curr Opin Microbiol"},{"key":"1950_CR8","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3390\/toxins5051010","volume":"5","author":"AA Lakraj","year":"2013","unstructured":"Lakraj AA, Moghimi N, Jabbari B (2013) Sialorrhea: anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins. Toxins 5:1010\u20131031","journal-title":"Toxins"},{"key":"1950_CR9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/mds.20793","volume":"21","author":"G Lagalla","year":"2006","unstructured":"Lagalla G, Millevolte M, Capecci M, Provinciali L, Ceravolo MG (2006) Botulinum toxin type A for drooling in Parkinson\u2019s disease: a double-blind, randomized, placebo-controlled study. Mov Disord 21:704\u2013707","journal-title":"Mov Disord"},{"key":"1950_CR10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/MJT.0b013e3181e9b655","volume":"19","author":"NS Levy","year":"2012","unstructured":"Levy NS, Lowenthal DT (2012) Application of botulinum toxin to clinical therapy: advances and cautions. Am J Ther 19:281\u2013286","journal-title":"Am J Ther"},{"key":"1950_CR11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.4317\/medoral.17260","volume":"16","author":"J Silvestre-Rangil","year":"2011","unstructured":"Silvestre-Rangil J, Silvestre FJ, Puente-Sandoval A, Requeni-Bernal J, Simo-Ruiz JM (2011) Clinical-therapeutic management of drooling: review and update. Med Oral Patol Oral Cir Bucal 16:763\u2013766","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"1950_CR12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.toxicon.2008.11.013","volume":"54","author":"J Jankovic","year":"2009","unstructured":"Jankovic J (2009) Disease-oriented approach to botulinum toxin use. Toxicon 54:614\u2013623","journal-title":"Toxicon"},{"key":"1950_CR13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1212\/01.WNL.0000101713.81253.4C","volume":"62","author":"WG Ondo","year":"2004","unstructured":"Ondo WG, Hunter C, Moore W (2004) A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson\u2019s disease. Neurology 62:37\u201340","journal-title":"Neurology"},{"key":"1950_CR14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.parkreldis.2007.01.007","volume":"13","author":"JG Kalf","year":"2004","unstructured":"Kalf JG, Smita AM, Bloemb BR, Zwartsb MJ, Mullenersc WM, Munnekeb M (2004) Botulinum toxin A for drooling in Parkinson\u2019s disease: a pilot study to compare submandibular to parotid gland injections. Parkinsonism Relat Disord 13:532\u2013534","journal-title":"Parkinsonism Relat Disord"},{"key":"1950_CR15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.anorl.2010.12.010","volume":"128","author":"R Breheret","year":"2011","unstructured":"Breheret R, Bizon A, Jeufroy C, Laccourreye L (2011) Ultrasound-guided botulinum toxin injections for treatment of drooling. Eur Ann Otorhinolaryngol Head Neck Dis 128:224\u2013229","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"1950_CR16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.parkreldis.2006.05.005","volume":"13","author":"MF Contarino","year":"2007","unstructured":"Contarino MF, Pompili M, Tittoto P et al (2007) Botulinum toxin B ultrasound-guided injections for sialorrhea in amyotrophic lateral sclerosis and Parkinson\u2019s disease. Parkinsonism Relat Disord 13:299\u2013303","journal-title":"Parkinsonism Relat Disord"},{"key":"1950_CR17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clineuro.2003.10.012","volume":"106","author":"O Dogu","year":"2004","unstructured":"Dogu O, Apaydin D, Sevim S, Talas DU, Aral M (2004) Ultrasound-guided versus \u2018blind\u2019 intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson\u2019s disease. Clin Neurol Neurosurg 106:93\u201396","journal-title":"Clin Neurol Neurosurg"},{"key":"1950_CR18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/mds.10420","volume":"18","author":"F Mancini","year":"2003","unstructured":"Mancini F, Zangaglia R, Cristina S et al (2003) Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism. Mov Disord 18:685\u2013688","journal-title":"Mov Disord"},{"key":"1950_CR19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00005537-200301000-00020","volume":"113","author":"PH Jongerius","year":"2003","unstructured":"Jongerius PH, Joosten F, Hoogen FJ, Gabreels FJ, Rotteveel JJ (2003) The treatment of drooling by ultrasound-guided intraglandular injections of botulinum toxin type A into the salivary glands. Laryngoscope 113:107\u2013111","journal-title":"Laryngoscope"},{"key":"1950_CR20","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/jnnp.70.4.538","volume":"70","author":"M Porta","year":"2001","unstructured":"Porta M, Gamba M, Bertacchi G, Vaj P (2001) Treatment of sialorrhoea with ultrasound guided botulinum toxin type A injection in patients with neurological disorders. J Neurol Neurosurg Psychiatry 70:538\u2013540","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1950_CR21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.clineuro.2008.12.007","volume":"111","author":"AC N\u00f3brega","year":"2009","unstructured":"N\u00f3brega AC, Rodrigues B, Melo A (2009) Clinical does botulinum toxin injection in parotid glands interfere with the swallowing dynamics of Parkinson\u2019s disease patients? Clin Neurol Neurosurg 111:430\u2013432","journal-title":"Clin Neurol Neurosurg"},{"key":"1950_CR22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1345\/aph.1H381","volume":"41","author":"J Benson","year":"2007","unstructured":"Benson J, Daugherty KK (2007) Botulinum toxin A in the treatment of sialorrhea. Ann Pharmacother 41:79\u201385","journal-title":"Ann Pharmacother"},{"key":"1950_CR23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MOO.0b013e32835328ec","volume":"20","author":"N Squires","year":"2012","unstructured":"Squires N, Wills A, Rowson J (2012) The management of drooling in adults with neurological conditions. Curr Opin Otolaryngol Head Neck Surg 20:171\u2013176","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"1950_CR24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/0194599812465059","volume":"148","author":"R Vashishta","year":"2013","unstructured":"Vashishta R, Nguyen SA, White DR, Gillespie MB (2013) Botulinum toxin for the treatment of sialorrhea: a meta-analysis. Otolaryngol Head Neck Surg 148:191\u2013196","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1950_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.toxicon.2012.10.020","volume":"67","author":"M Naumann","year":"2013","unstructured":"Naumann M, Dressler D, Hallett M et al (2013) Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon 67:141\u2013152","journal-title":"Toxicon"},{"key":"1950_CR26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/00016357.2010.545035","volume":"69","author":"E Moller","year":"2011","unstructured":"Moller E, Karlsborg M, Bardow A, Lykkeaa J, Nissen FH, Bakke M (2011) Treatment of severe drooling with botulinum toxin in amyotrophic lateral sclerosis and Parkinson\u2019s disease: efficacy and possible mechanisms. Acta Odontol Scand 69:151\u2013157","journal-title":"Acta Odontol Scand"},{"key":"1950_CR27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/mds.23473","volume":"26","author":"A Guidubaldi","year":"2011","unstructured":"Guidubaldi A, Fasano A, Ialongo T et al (2011) Botulinum Toxin A Versus B in Sialorrhea: a prospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson\u2019s disease. Mov Disord 26:313\u2013319","journal-title":"Mov Disord"},{"key":"1950_CR28","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1212\/WNL.61.9.1279","volume":"61","author":"A Lipp","year":"2003","unstructured":"Lipp A, Trottenberg T, Schink T, Kupsch A, Arnold G (2003) A randomized trial of botulinum toxin A for treatment of drooling. Neurology 61:1279\u20131281","journal-title":"Neurology"},{"key":"1950_CR29","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/1531-8257(199911)14:6<1057::AID-MDS1033>3.0.CO;2-4","volume":"14","author":"WH Jost","year":"1999","unstructured":"Jost WH (1999) Treatment of drooling in Parkinson\u2019s disease with botulinum toxin. Mov Disord 14:1057","journal-title":"Mov Disord"},{"key":"1950_CR30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mds.23929","volume":"27","author":"R Chinnapongse","year":"2012","unstructured":"Chinnapongse R, Gullo K, Nemeth P, Zhang Y, Griggs L (2012) Safety and efficacy of botulinum toxin type B for treatment of sialorrhea in Parkinson\u2019s Disease: a prospective double-blind trial. Mov Disord 27:219\u2013226","journal-title":"Mov Disord"},{"key":"1950_CR31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mds.25327","volume":"28","author":"G Respondek","year":"2013","unstructured":"Respondek G, Roeber S, Kretzschmar H et al (2013) Accuracy of the national institute for neurological disorders and stroke\/society for progressive supranuclear palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy. Mov Disord 28:504\u2013509","journal-title":"Mov Disord"},{"key":"1950_CR32","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S1474-4422(09)70288-1","volume":"8","author":"N Stefanova","year":"2009","unstructured":"Stefanova N, B\u00fccke P, Duerr S, Wenning GK (2009) Multiple system atrophy: an update. Lancet Neurol 8:1172\u20131178","journal-title":"Lancet Neurol"},{"key":"1950_CR33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/ene.12022","volume":"20","author":"A Berardelli","year":"2013","unstructured":"Berardelli A, Wenning GK, Antonini A et al (2013) EFNS\/MDS-ES\/ENS [corrected] recommendations for the\u00a0diagnosis\u00a0of Parkinson\u2019s disease. Eur J Neurol 20:16\u201334","journal-title":"Eur J Neurol"},{"key":"1950_CR34","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"80","author":"MJ Armstrong","year":"2013","unstructured":"Armstrong MJ, Litvan I, Lang AE et al (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 80:496\u2013503","journal-title":"Neurology"},{"key":"1950_CR35","first-page":"23","volume":"35","author":"A Friedman","year":"2001","unstructured":"Friedman A, Potulska A (2001) Botulinum toxin for treatment of parkinsonian sialorrhea. Neurol Neurochir Pol 35:23\u201327","journal-title":"Neurol Neurochir Pol"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1950-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-014-1950-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-014-1950-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T09:19:00Z","timestamp":1559121540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-014-1950-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,20]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["1950"],"URL":"https:\/\/doi.org\/10.1007\/s10072-014-1950-y","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,20]]}}}