{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:57:44Z","timestamp":1773035864930,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T00:00:00Z","timestamp":1530316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10072-018-3480-5","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T12:01:12Z","timestamp":1530360072000},"page":"1691-1695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyperhomocysteinemia influenced malnutrition in Parkinson\u2019s disease patients"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1613-3831","authenticated-orcid":false,"given":"Svetlana","family":"Tomic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlasta","family":"Pekic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljka","family":"Popijac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomislav","family":"Pucic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Petek","family":"Vinkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tihana Gilman","family":"Kuric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvonimir","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"key":"3480_CR1","volume-title":"Biochemistry","author":"PC Champe","year":"2008","unstructured":"Champe PC, Harvey RA (2008) Biochemistry. Lippincott Williams and Wilkins, Philadelphia"},{"key":"3480_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0002-9343(94)90149-X","volume":"96","author":"DG Savage","year":"1994","unstructured":"Savage DG, Lindebaum J, Stabler SP et al (1994) Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin deficiencies. Am J Med 96:239\u2013246","journal-title":"Am J Med"},{"issue":"12","key":"3480_CR3","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1046\/j.1365-2362.2000.00746.x","volume":"30","author":"W Herrmann","year":"2000","unstructured":"Herrmann W, Schorr H, Bodis M et al (2000) Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects. Eur J Clin Investig 30(12):1083\u20131089","journal-title":"Eur J Clin Investig"},{"issue":"6 Suppl","key":"3480_CR4","doi-asserted-by":"publisher","first-page":"1731S","DOI":"10.1093\/jn\/136.6.1731S","volume":"136","author":"H Refsum","year":"2006","unstructured":"Refsum H, Nurk E, Smith AD et al (2006) The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 136(6 Suppl):1731S\u20131740S","journal-title":"J Nutr"},{"issue":"6","key":"3480_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/01.WNF.0000236763.16032.60","volume":"29","author":"S Hassin-Baer","year":"2006","unstructured":"Hassin-Baer S, Cohen O, Vakil E et al (2006) Plasma homocysteine levels and Parkinson disease: disease progression, carotid intima-media thickness and neuropsychiatric complications. Clin Neuropharmacol 29(6):305\u2013311","journal-title":"Clin Neuropharmacol"},{"issue":"1\u20132","key":"3480_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jns.2007.01.028","volume":"257","author":"E Martignoni","year":"2007","unstructured":"Martignoni E, Tassorelli C, Nappi G, Zangaglia R, Pacchetti C, Blandini F (2007) Homocysteine and Parkinson\u2019s disease: a dangerous liaison? J Neurol Sci 257(1\u20132):31\u201337","journal-title":"J Neurol Sci"},{"issue":"3","key":"3480_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/092986710790149774","volume":"17","author":"S Zoccolella","year":"2010","unstructured":"Zoccolella S, dell'Aquila C, Specchio LM, Logroscino G, Lamberti P (2010) Elevated homocysteine levels in Parkinson\u2019s disease: is there anything besides L-dopa treatment? Curr Med Chem 17(3):213\u2013221","journal-title":"Curr Med Chem"},{"issue":"9","key":"3480_CR8","doi-asserted-by":"publisher","first-page":"7197","DOI":"10.3390\/nu7095333","volume":"7","author":"L Shen","year":"2015","unstructured":"Shen L (2015) Associations between B vitamins and Parkinson\u2019s disease. Nutrients 7(9):7197\u20137208. \n                    https:\/\/doi.org\/10.3390\/nu7095333","journal-title":"Nutrients"},{"issue":"3","key":"3480_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0166-2236(03)00032-8","volume":"26","author":"MP Mattson","year":"2003","unstructured":"Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26(3):137\u2013146","journal-title":"Trends Neurosci"},{"issue":"1","key":"3480_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","volume":"80","author":"W Duan","year":"2002","unstructured":"Duan W, Ladenheim B, Cutler RG, Kruman II, Cadet JL, Mattson MP (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson\u2019s disease. J Neurochem 80(1):101\u2013110","journal-title":"J Neurochem"},{"issue":"1","key":"3480_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2174\/187152708783885101","volume":"7","author":"GA Qureshi","year":"2008","unstructured":"Qureshi GA, Qureshi AA, Devrajani BR, Chippa MA, Syed SA (2008) Is the deficiency of vitamin B12 related to oxidative stress and neurotoxicity in Parkinson\u2019s patients? CNS Neurol Disord Drug Targets 7(1):20\u201327","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"3480_CR12","first-page":"181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease. A clinico-pathological study of 100 cases. JNNP 55:181\u2013184","journal-title":"JNNP"},{"key":"3480_CR13","first-page":"147","volume":"9","author":"JS Garrow","year":"1985","unstructured":"Garrow JS, Webster J (1985) Quetelet\u2019s index (W\/H2) as a measure of fatness. Int J Obes 9:147\u2013153","journal-title":"Int J Obes"},{"key":"3480_CR14","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0261-5614(03)00098-0","volume":"22","author":"J Kondrup","year":"2003","unstructured":"Kondrup J, Allison SP, Elia M, Vellas B, Plauth M, Educational and Clinical Practice Committee, European Society of Parenteral and Enteral Nutrition (ESPEN) (2003) ESPEN guidelines for nutrition screening 2002. Clin Nutr 22:415\u2013421","journal-title":"Clin Nutr"},{"key":"3480_CR15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0899-9007(98)00171-3","volume":"15","author":"B Vellas","year":"1999","unstructured":"Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, Albarede JL (1999) The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly. Nutrition 15:116\u2013122","journal-title":"Nutrition"},{"issue":"5","key":"3480_CR16","first-page":"319","volume":"30","author":"OO Ojo","year":"2011","unstructured":"Ojo OO, Oladipo OO, Ojini FI, Sanya EO, Danesi MA, Okubadejo NU (2011) Plasma homocysteine level and its relationship to clinical profile in Parkinson\u2019s disease patients at the Lagos University Teaching Hospital. West Afr J Med 30(5):319\u2013324","journal-title":"West Afr J Med"},{"issue":"3","key":"3480_CR17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000012827","volume":"44","author":"M Krajcovicov\u00e1-Kudl\u00e1ckov\u00e1","year":"2000","unstructured":"Krajcovicov\u00e1-Kudl\u00e1ckov\u00e1 M, Blaz\u00edcek P, Kopcov\u00e1 J, B\u00e9derov\u00e1 A, Babinsk\u00e1 K (2000) Homocysteine levels in vegetarians versus omnivores. Ann Nutr Metab 44(3):135\u2013138","journal-title":"Ann Nutr Metab"},{"issue":"6","key":"3480_CR18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1001\/archneur.61.6.865","volume":"61","author":"PE O'Suilleabhain","year":"2004","unstructured":"O'Suilleabhain PE, Sung V, Hernandez C et al (2004) Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol 61(6):865\u2013868","journal-title":"Arch Neurol"},{"key":"3480_CR19","doi-asserted-by":"publisher","unstructured":"Kamberi B, Kamberi G (2012) Traditional eating habits and level of homocysteine in the acute first-ever ischaemic stroke. Maced J Med Sci 5(2). \n                    https:\/\/doi.org\/10.3889\/MJMS.1857-5773.2012.0231","DOI":"10.3889\/MJMS.1857-5773.2012.0231"},{"key":"3480_CR20","first-page":"673","volume":"3","author":"S Missoni","year":"2006","unstructured":"Missoni S (2006) Nutritional studies in Croatia\u2014a century of research. Coll Antropol 3:673\u2013696","journal-title":"Coll Antropol"},{"key":"3480_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2017.08.005","volume":"44","author":"Nicole Licking","year":"2017","unstructured":"Licking N, Murchison C, Cholerton B et al (2017) Homocysteine and cognitive function in Parkinson\u2019s disease. Parkinsonism Relat Disord. \n                    https:\/\/doi.org\/10.1016\/j.parkreldis.2017.08.005","journal-title":"Parkinsonism & Related Disorders"},{"issue":"2","key":"3480_CR22","first-page":"257","volume":"14","author":"S Alajbegovi\u0107","year":"2017","unstructured":"Alajbegovi\u0107 S, Lepara O, Had\u017eovi\u0107-D\u017euvo A et al (2017) Serum homocysteine levels in patients with probable vascular dementia. Med Glas (Zenica) 14(2):257\u2013261","journal-title":"Med Glas (Zenica)"},{"key":"3480_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/819528","volume":"2014","author":"Zhanjie Zheng","year":"2014","unstructured":"Zheng Z, Wang J, Yi L, Yu H, Kong L, Cui W, Chen H, Wang C (2014) Correlation between behavioural and psychological symptoms of Alzheimer type dementia and plasma homocysteine concentration. Biomed Res Int:383494. \n                    https:\/\/doi.org\/10.1155\/2014\/383494","journal-title":"BioMed Research International"},{"issue":"3","key":"3480_CR24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2174\/157016106777698414","volume":"4","author":"S Zoccolella","year":"2006","unstructured":"Zoccolella S, Martino D, Defazio G, Lamberti P, Livrea P (2006) Hyperhomocysteinemia in movement disorders: current evidence and hypotheses. Curr Vasc Pharmacol 4(3):237\u2013243","journal-title":"Curr Vasc Pharmacol"},{"issue":"4","key":"3480_CR25","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/ejcn.2016.224","volume":"71","author":"LE Elstgeest","year":"2017","unstructured":"Elstgeest LE, Brouwer IA, Penninx BW, van Schoor NM, Visser M (2017) Vitamin B12, homocysteine and depressive symptoms: a longitudinal study among older adults. Eur J Clin Nutr 71(4):468\u2013475","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"3480_CR26","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/mds.22227","volume":"24","author":"RM Camicioli","year":"2009","unstructured":"Camicioli RM, Bouchard TP, Somerville MJ (2009) Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson\u2019s disease patients. Mov Disord 24(2):176\u2013182","journal-title":"Mov Disord"},{"issue":"2","key":"3480_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1479-8301.2011.00356.x","volume":"11","author":"CM Nascimento","year":"2011","unstructured":"Nascimento CM, Stella F, Garlipp CR, Santos RF, Gobbi S, Gobbi LT (2011) Serum homocysteine and physical exercise in patients with Parkinson\u2019s disease. Psychogeriatrics 11(2):105\u2013112","journal-title":"Psychogeriatrics"},{"issue":"8","key":"3480_CR28","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s00726-014-1741-z","volume":"46","author":"S Silva Ade de","year":"2014","unstructured":"de Silva Ade S, da Mota MP (2014) Effects of physical activity and training programs on plasma homocysteine levels: a systematic review. Amino Acids 46(8):1795\u20131804","journal-title":"Amino Acids"},{"issue":"1","key":"3480_CR29","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2190\/HX7L-4B40-PQNY-2A4P","volume":"35","author":"MA Kiraly","year":"2005","unstructured":"Kiraly MA, Kiraly SJ (2005) The effect of exercise on hippocampal integrity: review of recent research. Int J Psychiatry Med 35(1):75\u201389","journal-title":"Int J Psychiatry Med"},{"key":"3480_CR30","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1753-4887.2011.00413.x","volume":"69","author":"JM Sheard","year":"2011","unstructured":"Sheard JM, Ash S, Silburn PA, Kerr GK (2011) Prevalence of malnutrition in Parkinson\u2019s disease: a systematic review. Nutr Rev 69:520\u2013532","journal-title":"Nutr Rev"},{"key":"3480_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jns.2017.01.070","volume":"375","author":"S Tomic","year":"2017","unstructured":"Tomic S, Pekic V, Popijac Z et al (2017) What increases the risk of malnutrition in Parkinson\u2019s disease? J Neurol Sci 375:235\u2013238","journal-title":"J Neurol Sci"},{"key":"3480_CR32","first-page":"84","volume":"5","author":"A Kistner","year":"2014","unstructured":"Kistner A, Lhommee E, Krack P (2014) Mechanisms of body weight fluctuations in Parkinson\u2019s disease. Front Neurol 5:84","journal-title":"Front Neurol"},{"issue":"4","key":"3480_CR33","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.2337\/db16-0755","volume":"66","author":"RH Anderberg","year":"2017","unstructured":"Anderberg RH, Richard JE, Eerola K, L\u00f3pez-Ferreras L, Banke E, Hansson C, Nissbrandt H, Berqquist F, Gribble FM, Reimann F, Wernstedt Asterholm I, Lamy CM, Skibicka KP (2017) Glucagon-like peptide 1 and its analogs act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight. Diabetes 66(4):1062\u20131073","journal-title":"Diabetes"},{"issue":"5","key":"3480_CR34","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/0031-9384(95)00156-D","volume":"58","author":"SM Gospe","year":"1995","unstructured":"Gospe SM, Gietzen DW, Summers PJ, Lunetta JM, Miller JW, Selhub J, Ellis WG, Clifford AJ (1995) Behavioral and neurochemical changes in folate-deficient mice. Physiol Behav 58(5):935\u2013941","journal-title":"Physiol Behav"},{"key":"3480_CR35","doi-asserted-by":"publisher","first-page":"e57986","DOI":"10.1371\/journal.pone.0057986","volume":"8","author":"JM Sheard","year":"2013","unstructured":"Sheard JM, Ash S, Mellick GD, Silburn PA, Kerr GK (2013) Markers of disease severity are associated with malnutrition in Parkinson\u2019s disease. PLoS One 8:e57986","journal-title":"PLoS One"},{"issue":"9","key":"3480_CR36","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.bbagen.2016.06.018","volume":"1860","author":"R Paul","year":"2016","unstructured":"Paul R, Borah A (2016) L-DOPA-induced hyperhomocysteinemia in Parkinson\u2019s disease: elephant in the room. Biochim Biophys Acta 1860(9):1989\u20131997","journal-title":"Biochim Biophys Acta"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-018-3480-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3480-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3480-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T19:10:44Z","timestamp":1561835444000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-018-3480-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,30]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["3480"],"URL":"https:\/\/doi.org\/10.1007\/s10072-018-3480-5","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,30]]},"assertion":[{"value":"14 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Tomic Svetlana received honoraria from Medis Adris d.o.o., Krka d.o.o., and Pliva Teva d.o.o. and has been sponsored for congress participations by Medis Adria d.o.o., Ewopharma d.o.o., Abbvie d.o.o., Makpharm d.o.o., and Alkaloid d.o.o.Tihana Gilman Kuric has been sponsored for congress participations by Abbvie d.o.o., Pliva Teva d.o.o., and Shire d.o.o.Zvonimir Popovic has been sponsored for congress participations from Pliva Teva d.o.o., Abbvie d.o.o., and Shire d.o.o.Vlasta Pekic and Zeljka Popijac have been sponsored for congress participations by Abbvie d.o.o.Marta Petek Vinkovic has been sponsored for congress participations by Pliva Teva d.o.o.Tomislav Pucic has no declaration of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}