{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:03:57Z","timestamp":1790996637066,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["643706"],"award-info":[{"award-number":["643706"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s10072-018-3522-z","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T12:28:03Z","timestamp":1534249683000},"page":"1971-1976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Disease progression in Parkinson subtypes: the PPMI dataset"],"prefix":"10.1007","volume":"39","author":[{"given":"Darko","family":"Aleksovski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Miljkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-2807","authenticated-orcid":false,"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"3522_CR1","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/npjparkd.2016.18","volume":"2","author":"R Biundo","year":"2016","unstructured":"Biundo R, Weis L, Antonini A (2016) Cognitive decline in Parkinson's disease: the complex picture. NPJ Parkinsons Dis 2:16018","journal-title":"NPJ Parkinsons Dis"},{"issue":"6","key":"3522_CR2","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1136\/jnnp-2011-301874","volume":"83","author":"M Poletti","year":"2012","unstructured":"Poletti M, Frosini D, Pagni C, Baldacci F, Nicoletti V, Tognoni G, Lucetti C, del Dotto P, Ceravolo R, Bonuccelli U (2012) Mild cognitive impairment and cognitive-motor relationships in newly diagnosed drug-naive patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 83(6):601\u2013606","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"3522_CR3","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.parkreldis.2015.04.002","volume":"21","author":"VE Kelly","year":"2015","unstructured":"Kelly VE, Johnson CO, McGough EL et al (2015) Association of cognitive domains with postural instability\/gait disturbance in Parkinson\u2019s disease. Parkinsonism Relat Disord 21(7):692\u2013697","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"3522_CR4","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/mds.20897","volume":"21","author":"G Alves","year":"2006","unstructured":"Alves G, Larsen JP, Emre M, Wentzel-Larsen T, Aarsland D (2006) Changes in motor subtype and risk for incident dementia in Parkinson's disease. Mov Disord 21(8):1123\u20131130","journal-title":"Mov Disord"},{"issue":"5","key":"3522_CR5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1136\/jnnp.2005.081711","volume":"77","author":"DJ Burn","year":"2006","unstructured":"Burn DJ, Rowan EN, Allan LM, Molloy S, O'Brien JT, McKeith I (2006) Motor subtype and cognitive decline in Parkinson\u2019s disease, Parkinson\u2019s disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 77(5):585\u2013589","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"3522_CR6","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1474-4422(15)00178-7","volume":"14","author":"MA Nalls","year":"2015","unstructured":"Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, van Deerlin V, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB, Parkinson\u2019s Disease Biomarkers Program and Parkinson\u2019s Progression Marker Initiative investigators (2015) Diagnosis of Parkinson\u2019s disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol 14(10):1002\u20131009","journal-title":"Lancet Neurol"},{"issue":"5","key":"3522_CR7","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/mds.25383","volume":"28","author":"GT Stebbins","year":"2013","unstructured":"Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC (2013) How to identify tremor dominant and postural instability\/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. Mov Disord 28(5):668\u2013670","journal-title":"Mov Disord"},{"key":"3522_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.parkreldis.2016.04.027","volume":"28","author":"T Simuni","year":"2016","unstructured":"Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Tanner C, Marek K, PPMI Investigators (2016) How stable are Parkinson's disease subtypes in de novo patients: analysis of the PPMI cohort? Parkinsonism Relat Disord 28:62\u201367","journal-title":"Parkinsonism Relat Disord"},{"issue":"4","key":"3522_CR9","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH (1982) Random-effects models for longitudinal data. Biometrics 38(4):963\u2013974","journal-title":"Biometrics"},{"issue":"2","key":"3522_CR10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/PL00007856","volume":"249","author":"T Foltynie","year":"2002","unstructured":"Foltynie T, Brayne C, Barker RA (2002) The heterogeneity of idiopathic Parkinson\u2019s disease. J Neurol 249(2):138\u2013145","journal-title":"J Neurol"},{"issue":"6","key":"3522_CR11","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s10072-014-2060-6","volume":"36","author":"G Abbruzzese","year":"2015","unstructured":"Abbruzzese G, Barone P, Ceravolo R et al (2015) Clinical variables associated with treatment changes in Parkinson\u2019s disease: results from the longitudinal phase of the REASON study. Neurol Sci 36(6):935\u2013943","journal-title":"Neurol Sci"},{"issue":"5","key":"3522_CR12","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/jnnp.2010.222042","volume":"82","author":"SA Factor","year":"2011","unstructured":"Factor SA, Steenland NK, Higgins DS, Molho ES, Kay DM, Montimurro J, Rosen AR, Zabetian CP, Payami H (2011) Postural instability\/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis. J Neurol Neurosurg Psychiatry 82(5):564\u2013568","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"3522_CR13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/mds.23346","volume":"26","author":"SM Rooden van","year":"2011","unstructured":"van Rooden SM, Colas F, Mart\u00ednez-Mart\u00edn P, Visser M, Verbaan D, Marinus J, Chaudhuri RK, Kok JN, van Hilten JJ (2011) Clinical subtypes of Parkinson's disease. Mov Disord 26(1):51\u201358","journal-title":"Mov Disord"},{"issue":"4","key":"3522_CR14","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J (2008) Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368\u2013376","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"3522_CR15","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1093\/brain\/awx118","volume":"140","author":"SM Fereshtehnejad","year":"2017","unstructured":"Fereshtehnejad SM, Zeighami Y, Dagher A, Postuma RB (2017) Clinical criteria for subtyping Parkinson\u2019s disease: biomarkers and longitudinal progression. Brain 140(7):1959\u20131976","journal-title":"Brain"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-018-3522-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3522-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3522-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T17:45:40Z","timestamp":1569001540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-018-3522-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,14]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["3522"],"URL":"https:\/\/doi.org\/10.1007\/s10072-018-3522-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,14]]},"assertion":[{"value":"3 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was funded by EU Framework Programme for Research and Innovation Horizon 2020, under grant number 643706. Data used in the preparation of this article were obtained from the Parkinson\u2019s Progression Markers Initiative (PPMI) database (\n            \n            ).Angelo Antonini has received consultancy fees from AbbVie, Lundbeck and speaker honoraria from AbbVie, Boehringer Ingelheim, Sunovion, Lundbeck, Mundipharma, GE, UCB, Zambon, Ever Neuro Pharma, Movement Disorders Society. Daniele Bravi is an employee of Lundbeck. Darko Aleksovski and Dragana Miljkovic have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}