{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:15:03Z","timestamp":1772565303827,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s10072-018-3647-0","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T21:58:14Z","timestamp":1542837494000},"page":"357-362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["MR evaluation of encephalic leukoaraiosis in sudden sensorineural hearing loss (SSNHL) patients"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-6346","authenticated-orcid":false,"given":"Franca","family":"Dicuonzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Purciariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Dimauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Laura","family":"Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lepore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"3647_CR1","volume-title":"Encyclopedia of otolaryngology, head and neck surgery","author":"RA Georgopoulos","year":"2013","unstructured":"Georgopoulos RA, Schessel DA (2013) Sudden sensorineural hearing loss. In: Kountakis SE (ed) Encyclopedia of otolaryngology, head and neck surgery. Springer, Berlin"},{"issue":"2","key":"3647_CR2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.atherosclerosis.2012.10.024","volume":"225","author":"MM Ciccone","year":"2012","unstructured":"Ciccone MM, Cortese F, Pinto M, Di Teo C, Fornarelli F, Gesualdo M et al (2012) Endothelial function and cardiovascular risk in patients with idiopathic sudden sensorineural hearing loss. Atherosclerosis 225(2):511\u2013516","journal-title":"Atherosclerosis"},{"key":"3647_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1177\/019459988309100612","volume":"91","author":"WR Wilson","year":"1983","unstructured":"Wilson WR, Veltri RW, Laird N, Sprinkle PM (1983) Viral and epidemiologic studies of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 91:653\u2013658","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5 Pt 1","key":"3647_CR4","first-page":"647","volume":"94","author":"FM Byl Jr","year":"1984","unstructured":"Byl FM Jr (1984) Sudden hearing loss: eight years\u2019 experience and suggested prognostic table. Laryngoscope 94(5 Pt 1):647\u2013661","journal-title":"Laryngoscope"},{"issue":"4","key":"3647_CR5","first-page":"529","volume":"17","author":"BL Fetterman","year":"1996","unstructured":"Fetterman BL, Saunders JE, Luxford WM (1996) Prognosis and treatment of sudden sensorineural hearing loss. Am J Otolaryngol 17(4):529\u2013536","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"3647_CR6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0030-6665(20)30362-5","volume":"29","author":"GB Hughes","year":"1996","unstructured":"Hughes GB, Freedman MA, Haberkamp TJ, Guay ME (1996) Sudden sensorineural hearing loss. Otolaryngol Clin N Am 29(3):393\u2013405","journal-title":"Otolaryngol Clin N Am"},{"issue":"11","key":"3647_CR7","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1080\/00016480701242477","volume":"127","author":"R Nosrati-Zarenoe","year":"2007","unstructured":"Nosrati-Zarenoe R, Arlinger S, Hultcrantz E (2007) Idiopathic sudden sensorineural hearing loss: results drawn from the Swedish national database. Acta Otolaryngol 127(11):1168\u20131175","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"3647_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1288\/00005537-197603000-00008","volume":"86","author":"FT Shaia","year":"1976","unstructured":"Shaia FT, Sheehy JL (1976) Sudden sensori-neural hearing impairment: a report of 1,220 cases. Laryngoscope 86(3):389\u2013398","journal-title":"Laryngoscope"},{"issue":"5","key":"3647_CR9","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1097\/01.mao.0000185071.35328.6d","volume":"26","author":"PT Huy","year":"2005","unstructured":"Huy PT, Sauvaget E (2005) Idiopathic sudden sensorineural hearing loss is not an otologic emergency. Otol Neurotol 26(5):896\u2013902","journal-title":"Otol Neurotol"},{"issue":"3","key":"3647_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/00129492-200205000-00012","volume":"23","author":"DL Tucci","year":"2002","unstructured":"Tucci DL, Farmer JC Jr, Kitch RD, Witsell DL (2002) Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir. Otol Neurotol 23(3):301\u2013308","journal-title":"Otol Neurotol"},{"key":"3647_CR11","first-page":"Doc05","volume":"16","author":"SK Plontke","year":"2018","unstructured":"Plontke SK (2018) Diagnostics and therapy of sudden hearing loss. GMS Curr Top Otorhinolaryngol Head Neck Surg 16:Doc05","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"issue":"8","key":"3647_CR12","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1002\/lary.26394","volume":"127","author":"NG Sabbagh El","year":"2017","unstructured":"El Sabbagh NG, Sewitch MJ, Bezdjian A, Daniel SJ (2017) Intratympanic dexamethasone in sudden sensorineural hearing loss: a systematic review and meta-analysis. Laryngoscope 127(8):1897\u20131908","journal-title":"Laryngoscope"},{"issue":"2","key":"3647_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1001\/jamaoto.2017.2569","volume":"144","author":"JY Kim","year":"2018","unstructured":"Kim JY, Hong JY, Kim DK (2018) JAMA association of sudden sensorineural hearing loss with risk of cardiocerebrovascular disease: a study using data from the Korea National Health Insurance Service. Otolaryngol Head Neck Surg 144(2):129\u2013135. https:\/\/doi.org\/10.1001\/jamaoto.2017.2569","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"3647_CR14","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1161\/STROKEAHA.108.519090","volume":"39","author":"HC Lin","year":"2008","unstructured":"Lin HC, Chao PZ, Lee HC (2008) Sudden sensorineural hearing loss increases the risk of stroke: a 5-year follow-up study. Stroke 39(10):2744\u20132748","journal-title":"Stroke"},{"issue":"36","key":"3647_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004841","volume":"95","author":"CL Kuo","year":"2016","unstructured":"Kuo CL, Shiao AS, Wang SJ, Chang WP, Lin YY (2016) Risk of sudden sensorineural hearing loss in stroke patients: a 5-year nationwide investigation of 44,460 patients. Medicine (Baltimore) 95(36):e4841","journal-title":"Medicine (Baltimore)"},{"key":"3647_CR16","volume-title":"Encyclopedia of clinical neuropsychology","author":"Y Suchy","year":"2018","unstructured":"Suchy Y, Eastvold A (2018) Leukoaraiosis. In: Kreutzer JS, DeLuca J, Caplan B (eds) Encyclopedia of clinical neuropsychology. Springer, Cham"},{"issue":"4 Suppl","key":"3647_CR17","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1017\/S0317167100037264","volume":"13","author":"VC Hachinski","year":"1986","unstructured":"Hachinski VC, Potter P, Merskey H (1986) Leuko-araiosis: an ancient term for a new problem. Can J Neurol Sci 13(4 Suppl):533\u2013534","journal-title":"Can J Neurol Sci"},{"key":"3647_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/brain\/awg040","volume":"126","author":"A Hassan","year":"2003","unstructured":"Hassan A, Hunt BJ, O\u2019Sullivan M, Parmar K, Bamford JM, Briley D et al (2003) Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 126:424\u2013432","journal-title":"Brain"},{"key":"3647_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1148\/radiol.2371041496","volume":"237","author":"A Murray","year":"2005","unstructured":"Murray A, Staff RT, Shenkin SD, Deary IJ, Starr JM, Whalley LJ (2005) Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people. Radiology 237:251\u2013257","journal-title":"Radiology"},{"key":"3647_CR20","doi-asserted-by":"publisher","first-page":"c3666","DOI":"10.1136\/bmj.c3666","volume":"341","author":"S Debette","year":"2010","unstructured":"Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 341:c3666. https:\/\/doi.org\/10.1136\/bmj.c3666","journal-title":"BMJ"},{"key":"3647_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3109\/00016489309126213","volume":"501","author":"T Shiraishi","year":"1993","unstructured":"Shiraishi T, Kubo T, Okumura S, Naramura H, Nishimur M, Okusa M, Matsunaga T (1993) Hearing recovery in sudden deafness patients using a modified defibrinogenation therapy. Acta Otolaryngol Suppl 501:46\u201350","journal-title":"Acta Otolaryngol Suppl"},{"issue":"9","key":"3647_CR22","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","volume":"43","author":"F Fazekas","year":"1993","unstructured":"Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43(9):1683\u20131689","journal-title":"Neurology"},{"key":"3647_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer \u2018s dementia and normal aging. AJR Am J Roentgenol 149:351\u2013356","journal-title":"AJR Am J Roentgenol"},{"key":"3647_CR24","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1001\/archneur.1992.00530320049011","volume":"49","author":"R Schmidt","year":"1992","unstructured":"Schmidt R, Fazekas F, Kleinert G, Offenbacher H, Gindl K, Payer F et al (1992) Magnetic resonance imaging signal hyperintensities in the deep and subcortical white matter. A comparative study between stroke patients and normal volunteers. Arch Neurol 49:825\u2013827","journal-title":"Arch Neurol"},{"key":"3647_CR25","doi-asserted-by":"publisher","first-page":"308","DOI":"10.2310\/7070.2003.11288","volume":"32","author":"A Koc","year":"2003","unstructured":"Koc A, Sanisoglu O (2003) Sudden sensorineural hearing loss: literature survey on recent studies. J Otolaryngol 32:308\u2013313","journal-title":"J Otolaryngol"},{"issue":"1","key":"3647_CR26","doi-asserted-by":"publisher","DOI":"10.4081\/audiores.2016.151","volume":"6","author":"N Quaranta","year":"2016","unstructured":"Quaranta N, De Ceglie V, D'Elia A (2016) Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiol Res 6(1):151","journal-title":"Audiol Res"},{"issue":"6","key":"3647_CR27","doi-asserted-by":"publisher","first-page":"001140","DOI":"10.1161\/JAHA.114.001140","volume":"4","author":"JM Wardlaw","year":"2015","unstructured":"Wardlaw JM, Vald\u00e9s Hern\u00e1ndez MC, Mu\u00f1oz-Maniega S (2015) What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc 4(6):001140. https:\/\/doi.org\/10.1161\/JAHA.114.001140 Review","journal-title":"J Am Heart Assoc"},{"key":"3647_CR28","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10162-013-0381-4","volume":"14","author":"MA Eckert","year":"2013","unstructured":"Eckert MA, Kuchinsky SE, Vaden KI, Cute SL, Spampinato MV, Dubno JR (2013) White matter hyperintensities predict low frequency hearing in older adults. JARO 14:425\u2013433. https:\/\/doi.org\/10.1007\/s10162-013-0381-4","journal-title":"JARO"},{"key":"3647_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/brain\/awq343","volume":"134","author":"KF Laat De","year":"2011","unstructured":"De Laat KF, Tuladhar AM, van Norden AGW, Norris DG, Zwiers MP, de Leeuw F-E (2011) Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 134:73\u201383","journal-title":"Brain"},{"key":"3647_CR30","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1212\/01.wnl.0000305959.46197.e6","volume":"70","author":"H Baezner","year":"2008","unstructured":"Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Hennerici MG, On behalf of the LADIS Study Group (2008) Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70:935\u2013942","journal-title":"Neurology"},{"key":"3647_CR31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fneur.2017.00241","volume":"8","author":"N Cerchiai","year":"2017","unstructured":"Cerchiai N, Mancuso M, Navari E, Giannini N, Casani AP (2017) Aging with Cerebral Small Vessel Disease and Dizziness: The importance of undiagnosed peripheral vestibular disorders. Front Neurol 8:241","journal-title":"Front Neurol"},{"issue":"2","key":"3647_CR32","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1136\/jnnp.2009.204685","volume":"82","author":"AA Gouw","year":"2011","unstructured":"Gouw AA, Seewann A, Van Der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ (2011) Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry 82(2):126\u2013135","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"3647_CR33","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/01677063.2011.591462","volume":"25","author":"Y Uchida","year":"2017","unstructured":"Uchida Y, Sugiura S, Nakashima T, Ando F, Shimokata H (2017) Contribution of 1425G\/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study. J Neurogenet 25(3):82\u201387","journal-title":"J Neurogenet"},{"issue":"1","key":"3647_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3174\/ajnr.A3714","volume":"35","author":"F Fazekas","year":"2014","unstructured":"Fazekas F (2014) Incidental periventricular white matter hyperintensities revisited: what detailed morphological image analyses can tell us. AJNR Am J Neuroradiol 35(1):63\u201364","journal-title":"AJNR Am J Neuroradiol"},{"key":"3647_CR35","unstructured":"Pascucci M, Loacono C, Tortorelli D\u2019Ambrosio MG et al (2010) La leucoaraiosi cerebrale (classificazione, eziologia, correlati funzionali ed istopatologici). Geriatria XXI(13\u201318) XXII n. 1 Jan\/Feb 2010"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-018-3647-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3647-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3647-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T18:41:45Z","timestamp":1605465705000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-018-3647-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,21]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3647"],"URL":"https:\/\/doi.org\/10.1007\/s10072-018-3647-0","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,21]]},"assertion":[{"value":"16 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}