{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:54:34Z","timestamp":1777366474470,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s10072-018-3660-3","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T15:27:04Z","timestamp":1543678024000},"page":"385-391","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Relationship between thiol-disulphide homeostasis and visual evoked potentials in patients with multiple sclerosis"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-7273","authenticated-orcid":false,"given":"G\u00f6n\u00fcl","family":"Vural","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eadiye","family":"G\u00fcm\u00fc\u015fyayla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,1]]},"reference":[{"key":"3660_CR1","doi-asserted-by":"publisher","first-page":"20037","DOI":"10.3390\/ijms141020037","volume":"14","author":"M Tully","year":"2013","unstructured":"Tully M, Shi R (2013) New insights in the pathogenesis of multiple sclerosis\u2014role of acrolein in neuronal and myelin damage. Int J Mol Sci 14:20037\u201320047","journal-title":"Int J Mol Sci"},{"key":"3660_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/708659","volume":"2013","author":"GG Ortiz","year":"2013","unstructured":"Ortiz GG, Pacheco-Moises FP, Bitzer-Quintero OK, Ram\u00edrez-Anguiano AC, Flores-Alvarado LJ, Ram\u00edrez-Ram\u00edrez V, Macias-Islas MA, Torres-S\u00e1nchez ED (2013) Immunology and oxidative stress in multiple sclerosis: clinical and basic approach. Clin Dev Immunol 2013:1\u201314","journal-title":"Clin Dev Immunol"},{"key":"3660_CR3","first-page":"1307","volume-title":"Neurology in clinical practice","author":"GS Francis","year":"1996","unstructured":"Francis GS, Duquette P, Antel JP (1996) Inflammatory demyelinating diseases of the central nervous system. In: Bradley WG, Daroff RB, Fenickel GM, Marsden CD (eds) Neurology in clinical practice, 2nd edn. Butterworth-Heinemann, Boston, pp 1307\u20131343","edition":"2"},{"issue":"8","key":"3660_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2147\/EB.S54131","volume":"26","author":"N Kale","year":"2016","unstructured":"Kale N (2016) Optic neuritis as an early sign of multiple sclerosis. Eye Brain 26(8):195\u2013202","journal-title":"Eye Brain"},{"key":"3660_CR5","volume-title":"Ocular pathology","author":"DJ Apple","year":"1991","unstructured":"Apple DJ, Rabb MF (1991) Ocular pathology, 4th edn. Mosby Year Book, St. Louis","edition":"4"},{"key":"3660_CR6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1155\/2009\/325847","volume":"26","author":"GG Ortiz","year":"2009","unstructured":"Ortiz GG, Macias-Islas MA, Pacheco-Moises FP, Cruz-Ramos JA, Sustersik S, Barba EA, Aguayo A (2009) Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis. Dis Markers 26:35\u201339","journal-title":"Dis Markers"},{"key":"3660_CR7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","volume":"47","author":"O Erel","year":"2014","unstructured":"Erel O, Neselioglu S (2014) A novel and automated assay for thiol\/disulphide homeostasis. Clin Biochem 47:326\u2013332","journal-title":"Clin Biochem"},{"key":"3660_CR8","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749\u2013762","journal-title":"Free Radic Biol Med"},{"key":"3660_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.bcp.2005.10.044","volume":"71","author":"S Biswas","year":"2006","unstructured":"Biswas S, Chida AS, Rahman I (2006) Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 71:551\u2013564","journal-title":"Biochem Pharmacol"},{"key":"3660_CR10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.clinbiochem.2012.01.023","volume":"45","author":"I Tassed","year":"2012","unstructured":"Tassed I, Ag\u00fcera E, Sanchez-Lopez F, Feij\u00f3o M, Giraldo AI, Cruz AH, Gasc\u00f3n F, T\u00fanez I (2012) Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clin Biochem 45:440\u2013444","journal-title":"Clin Biochem"},{"key":"3660_CR11","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston A, Coles A (2008) Multiple sclerosis. Lancet 372:1502\u20131517","journal-title":"Lancet"},{"key":"3660_CR12","first-page":"164608","volume":"2011","author":"J Witherick","year":"2011","unstructured":"Witherick J, Wilkins A, Scolding N, Kemp K (2011) Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment. Autoimmune Dis 2011:164608","journal-title":"Autoimmune Dis"},{"key":"3660_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bbadis.2010.06.011","volume":"1812","author":"J vanHorssen","year":"2011","unstructured":"vanHorssen J, Witte ME, Schreibelt G, de Vries HE (2011) Radical changes in multiple sclerosis pathogenesis. Biochim Biophys Acta 1812:141\u2013150","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"3660_CR14","doi-asserted-by":"publisher","first-page":"e65184","DOI":"10.1371\/journal.pone.0065184","volume":"8","author":"A Fiorini","year":"2013","unstructured":"Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schinin\u00e0 ME, DiDomenico F, De Marco F, Perluigi M (2013) Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis. PLoS One 8(6):e65184","journal-title":"PLoS One"},{"issue":"1","key":"3660_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jns.2008.06.029","volume":"274","author":"RE Gonsette","year":"2008","unstructured":"Gonsette RE (2008) Neurodegeneration in multiplesclerosis: the role of oxidative stress and excitotoxicity. J Neurol Sci 274(1):48\u201353","journal-title":"J Neurol Sci"},{"issue":"1\u20132","key":"3660_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clinbiochem.2011.09.021","volume":"45","author":"E Miller","year":"2012","unstructured":"Miller E, Walczak A, Saluk J, Ponczek MB, Majsterek I (2012) Oxidative modification of patient\u2019s plasma proteins and its role in pathogenesis of multiple sclerosis. Clin Biochem 45(1\u20132):26\u201330","journal-title":"Clin Biochem"},{"key":"3660_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.clinbiochem.2014.09.023","volume":"48","author":"M Karlik","year":"2015","unstructured":"Karlik M, Valokovic P, Hancinova V, Krizova L, Tothova L, Celec P (2015) Markers of oxidative stress in plasma and saliva in patients with multiple sclerosis. Clin Biochem 48:24\u201328","journal-title":"Clin Biochem"},{"issue":"1","key":"3660_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mvr.2011.04.012","volume":"83","author":"PV Usatyuk","year":"2012","unstructured":"Usatyuk PV, Natarajan V (2012) Hydroxy alkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc Res 83(1):45\u201355","journal-title":"Microvasc Res"},{"key":"3660_CR19","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.1016\/j.febslet.2011.08.004","volume":"585","author":"H Lassman","year":"2011","unstructured":"Lassman H, van Horssen J (2011) The molecular basis of neurodegeneration in multiple sclerosis. FEBS Lett 585:3715\u20133723","journal-title":"FEBS Lett"},{"key":"3660_CR20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2008.04.038","volume":"45","author":"MA Ansari","year":"2008","unstructured":"Ansari MA, Roberts KN, Scheff SW (2008) Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med 45:443\u2013452","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"3660_CR21","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s11064-011-0442-1","volume":"36","author":"E Miller","year":"2011","unstructured":"Miller E, Mrowicka M, Saluk-Juszczak J, Ireneusz M (2011) The level of isoprostanes as a non-invasive marker for in vivo lipid peroxidation in secondary progressive multiple sclerosis. Neurochem Res 36(6):1012\u20131016","journal-title":"Neurochem Res"},{"key":"3660_CR22","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","volume":"271","author":"JS Beckman","year":"1996","unstructured":"Beckman JS, Koppenol WH (1996) Nitricoxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Phys 271:1424\u20131437","journal-title":"Am J Phys"},{"issue":"4","key":"3660_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrneurol.2014.37","volume":"10","author":"MA Friese","year":"2014","unstructured":"Friese MA, Schattling B, Fugger L (2014) Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat Rev Neurol 10(4):225\u2013238","journal-title":"Nat Rev Neurol"},{"key":"3660_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1468-1331.2007.01739.x","volume":"14","author":"M Koch","year":"2007","unstructured":"Koch M, Mostert J, Arutjunyan AV, Stepanov M, Teelken A, Heersema D, De Keyser J (2007) Plasma lipid peroxidation and progression of disability in multiple sclerosis. Eur J Neurol 14:529\u2013533","journal-title":"Eur J Neurol"},{"key":"3660_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/10284150290029205","volume":"5","author":"HT Besler","year":"2002","unstructured":"Besler HT, Como\u011flu S, Ok\u00e7u Z (2002) Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutr Neurosci 5:215\u2013220","journal-title":"Nutr Neurosci"},{"key":"3660_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/1028415031000115945","volume":"6","author":"HT Besler","year":"2003","unstructured":"Besler HT, Como\u011flu S (2003) Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci 6:189\u2013196","journal-title":"Nutr Neurosci"},{"key":"3660_CR27","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00415-005-0037-3","volume":"253","author":"M Koch","year":"2006","unstructured":"Koch M, Ramsaransing GS, Arutjunyan AV, Stepanov M, Teelken A, Heersema DJ, De Keyser J (2006) Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis. J Neurol 253:483\u2013487","journal-title":"J Neurol"},{"key":"3660_CR28","first-page":"112","volume":"71","author":"C Syburra","year":"1999","unstructured":"Syburra C, Passi S (1999) Oxidative stress in patients with multiple sclerosis. Ukr Biokhim Zh 71:112\u2013115","journal-title":"Ukr Biokhim Zh"},{"key":"3660_CR29","first-page":"677","volume":"11","author":"G Ferretti","year":"2005","unstructured":"Ferretti G, Bacchetti T, Principi F, DiLudovico F, Viti B, Angeleri VA, Danni M, Provinciali L (2005) Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity. MultScler 11:677\u2013682","journal-title":"MultScler"},{"key":"3660_CR30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.2152\/jmi.57.168","volume":"57","author":"E Miller","year":"2010","unstructured":"Miller E, Mrowicka M, Malinowska K, Zolynski K, Kedziora J (2010) Effects of the whole-body cryotherapy on a total antioxidative status and activities of some antioxidative enzymes in blood of patients with multiple sclerosis-preliminary study. J Med Investig 57:168\u2013173","journal-title":"J Med Investig"},{"issue":"1\u20132","key":"3660_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jns.2012.07.045","volume":"321","author":"SR Oliveira","year":"2012","unstructured":"Oliveira SR, Kallaur AP, Sim\u00e3o AN, Morimoto HK, Lopes J, Panis C, Petenucci DL, da Silva E, Cecchini R, Kaimen-Maciel DR, Reiche EM (2012) Oxidative stress in multiple sclerosis patients in clinical remission: association with the expanded disability status scale. J Neurol Sci 321(1\u20132):49\u201353","journal-title":"J Neurol Sci"},{"issue":"7","key":"3660_CR32","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuint.2013.02.025","volume":"62","author":"S Ljubisavljevic","year":"2013","unstructured":"Ljubisavljevic S, Stojanovic I, Vojinovic S, Stojanov D, Stojanovic S, Cvetkovic T, Savic D, Pavlovic D (2013) The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF. Neurochem Int 62(7):988\u2013997","journal-title":"Neurochem Int"},{"key":"3660_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.clinbiochem.2014.09.024","volume":"48","author":"L Pasquali","year":"2015","unstructured":"Pasquali L, Pecori C, Lucchesi C, LoGerfo A, Iudice A, Siciliano G, Bonuccelli U (2015) Plasmatic oxidative stress biomarkers in multiple sclerosis: relation with clinical and demographic characteristics. Clin Biochem 48:19\u201323","journal-title":"Clin Biochem"},{"key":"3660_CR34","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neuropharm.2007.05.002","volume":"53","author":"A Mirshafiey","year":"2007","unstructured":"Mirshafiey A (2007) Venom therapy in multiple sclerosis. Neuropharmacology 53:353\u2013361","journal-title":"Neuropharmacology"},{"key":"3660_CR35","first-page":"125","volume":"24","author":"V Calabrese","year":"1998","unstructured":"Calabrese V, Bella R, Testa D, Spadaro F, Scrofani A, Rizza V, Pennisi G (1998) Increased cerebrospinal fluid and plasma levels of ultra weak chemiluminescence are associated with changes in the thiol pool and lipid soluble fluorescence in MS: the pathogenic role of oxidative stress. Drugs Exp Clin Res 24:125\u2013131","journal-title":"Drugs Exp Clin Res"},{"key":"3660_CR36","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/S1388-2457(01)00687-3","volume":"112","author":"P Fuhr","year":"2001","unstructured":"Fuhr P, Kappos L (2001) Evoked potentials for evaluation of multiple sclerosis. Clin Neurophysiol 112:2185\u20132189","journal-title":"Clin Neurophysiol"},{"key":"3660_CR37","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","volume":"391","author":"AJ Thompson","year":"2018","unstructured":"Thompson AJ, Baranzini SE, Geurts J, Hemmer B, Ciccarelli O (2018) Multiple sclerosis. Lancet 391:1622\u20131636","journal-title":"Lancet"},{"issue":"71","key":"3660_CR38","first-page":"1","volume":"15","author":"M Dietrich","year":"2018","unstructured":"Dietrich M, Helling N, Hilla A, Heskamp A, Issberner A, Hildebrandt T, Kohne Z, K\u00fcry P, Berndt C, Aktas O, Fischer D, Hartung HP, Albrecht P (2018) Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental auto immune encephalomyelitis-optic neuritis model. J Neuroinflammation 15(71):1\u201313","journal-title":"J Neuroinflammation"},{"key":"3660_CR39","doi-asserted-by":"publisher","first-page":"214","DOI":"10.4236\/wjns.2016.63026","volume":"6","author":"G Vural","year":"2016","unstructured":"Vural G, Gumusyayla S, Bektas H, Deniz O, Ergin M, Erel O (2016) Dynamic thiol-disulphide homeostasis in patients with multiple sclerosis. WJNS 6:214\u2013219","journal-title":"WJNS"},{"key":"3660_CR40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.15586\/codon.multiplesclerosis.2017.ch10","volume-title":"Multiple sclerosis: perspectives in treatment and pathogenesis","author":"B Adamczyk","year":"2017","unstructured":"Adamczyk B, Niedziela N, Adamczyk-Sowa M (2017) Novel approaches of oxidative stress mechanisms in the multiple sclerosis pathophysiology and therapy. In: Zagon IS, McLaughlin PJ (eds) Multiple sclerosis: perspectives in treatment and pathogenesis. Codon Publications, Brisbane, pp 155\u2013172"},{"issue":"11","key":"3660_CR41","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1007\/s10072-017-3087-2","volume":"38","author":"B Elmas","year":"2017","unstructured":"Elmas B, Erel \u00d6, Ersava\u015f D, Y\u00fcr\u00fcmez Y (2017) Thiol\/disulfide homeostasis as a novel indicator of oxidative stress in children with simple febrile seizures. Neurol Sci 38(11):1969\u20131975","journal-title":"Neurol Sci"},{"issue":"8","key":"3660_CR42","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s10072-017-3004-8","volume":"38","author":"ANC Kurt","year":"2017","unstructured":"Kurt ANC, Ayd\u0131n A, Demir H, Erel \u00d6 (2017) Headache in children and dynamic thiol\/disulfide balance evaluation with a new method. Neurol Sci 38(8):1495\u20131499","journal-title":"Neurol Sci"},{"issue":"3","key":"3660_CR43","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1080\/01616412.2018.1428522","volume":"40","author":"G Vural","year":"2018","unstructured":"Vural G, Bektas H, Gumusyayla S, Deniz O, Al\u0131\u015f\u0131k M, Erel O (2018) Impaired thiol-disulphide homeostasis in patients with axonal polyneuropathy. Neurol Res 40(3):166\u2013172","journal-title":"Neurol Res"},{"issue":"8","key":"3660_CR44","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s10072-016-2592-z","volume":"37","author":"S Gumusyayla","year":"2016","unstructured":"Gumusyayla S, Vural G, Bektas H, Neselioglu S, Deniz O, Erel O (2016) A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis. Neurol Sci 37(8):1311\u20131317","journal-title":"Neurol Sci"},{"key":"3660_CR45","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.clineuro.2016.12.009","volume":"153","author":"G Vural","year":"2017","unstructured":"Vural G, Gumusyayla S, Bektas H, Deniz O, Al\u0131\u015f\u0131k M, Erel O (2017) Impairment of dynamic thiol-disulphide homeostasis in patients with idiopathic Parkinson\u2019s disease and its relationship with clinical stage of disease. Clin Neurol Neurosurg 153:50\u201355","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10072-018-3660-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3660-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-018-3660-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T08:12:17Z","timestamp":1575274337000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10072-018-3660-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3660"],"URL":"https:\/\/doi.org\/10.1007\/s10072-018-3660-3","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,1]]},"assertion":[{"value":"3 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}