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Reduced levels of EPCs during pregnancy have been associated with preeclampsia and miscarriage. Women with multiple sclerosis (MS) are not at increased risk of preeclampsia nor of general adverse obstetric outcome, in contrast with some other autoimmune diseases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aim of this study was to evaluate circulating EPCs levels in pregnant patients with MS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>CD34+ and CD133+ were longitudinally detected by flow cytometry in the maternal plasma of 29 healthy controls and 9 MS patients and in the cord blood of their newborns.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>EPCs were affected by pregnancy with the same trend in both groups (CD34+ <jats:italic>p<\/jats:italic>\u00a0=\u20090.0342; CD133+ <jats:italic>p<\/jats:italic>\u00a0=\u20090.0347). EPCs during pregnancy were increased in MS (mean \u00b1 SD: CD34+ cells 0.038\u2009\u00b1\u20090.010; CD133+ 0.024\u2009\u00b1\u20090.009) with respect to healthy controls (mean\u2009\u00b1\u2009SD: CD34+ cells 0.022\u2009\u00b1\u20090.006; CD133+ 0.016\u2009\u00b1\u20090.004), CD34+ <jats:italic>p<\/jats:italic>\u00a0=\u20090.0004; CD133+ <jats:italic>p<\/jats:italic>\u00a0=\u20090.0109. EPCs levels of the cord blood of MS patients' newborns mild correlated with maternal EPC levels at delivery (CD34+: spearman\u2019s Rho 0.658, <jats:italic>p<\/jats:italic>\u00a0=\u20090.054; CD133+: spearman\u2019s Rho 0.758, <jats:italic>p<\/jats:italic>\u00a0=\u20090.018).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This work identified increased circulating EPC levels during pregnancy, following the same trend both in MS patients and healthy controls. Despite the similar trend, the levels of circulating EPCs were significantly higher in MS patients with respect to the control population. A correlation was also found in MS patients between cord blood EPCs and circulating EPCs at delivery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-020-04648-3","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T15:04:12Z","timestamp":1597676652000},"page":"1443-1451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating endothelial progenitor cells during pregnancy in multiple sclerosis"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-9594","authenticated-orcid":false,"given":"Giulia","family":"Mallucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausta","family":"Beneventi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bizzotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cavagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"De Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Bellingeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Viarengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsenio","family":"Spinillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"4648_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.02.003","volume":"127\u2013128","author":"G Mallucci","year":"2015","unstructured":"Mallucci G, Peruzzotti-Jametti L, Bernstock JD, Pluchino S (2015) The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis. 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