{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:17:02Z","timestamp":1787987822590,"version":"build-2784847793"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s10072-020-04724-8","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T20:02:46Z","timestamp":1600977766000},"page":"1933-1940","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurological misdiagnoses of lymphoma"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-6997","authenticated-orcid":false,"given":"Chen","family":"Makranz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Arkadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Nachmias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe E.","family":"Gatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Eliahou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Atlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Mordechai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Netta","family":"Goldshmit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lossos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"3","key":"4724_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/bjh.14073","volume":"174","author":"MS Shiels","year":"2016","unstructured":"Shiels MS, Pfeiffer RM, Besson C, Clarke CA, Morton LM, Nogueira L, Pawlish K, Yanik EL, Suneja G, Engels EA (2016) Trends in primary central nervous system lymphoma incidence and survival in the U.S. Br J Haematol 174(3):417\u2013424. https:\/\/doi.org\/10.1111\/bjh.14073","journal-title":"Br J Haematol"},{"issue":"21","key":"4724_CR2","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1200\/JCO.2017.72.7602","volume":"35","author":"C Grommes","year":"2017","unstructured":"Grommes C, DeAngelis LM (2017) Primary CNS Lymphoma. J Clin Oncol 35(21):2410\u20132418. https:\/\/doi.org\/10.1200\/JCO.2017.72.7602","journal-title":"J Clin Oncol"},{"issue":"1","key":"4724_CR3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1200\/JCO.2008.16.8021","volume":"27","author":"SH Bernstein","year":"2009","unstructured":"Bernstein SH, Unger JM, Leblanc M, Friedberg J, Miller TP, Fisher RI (2009) Natural history of CNS relapse in patients with aggressive non-Hodgkin\u2019s lymphoma: a 20-year follow-up analysis of SWOG 8516 -- the Southwest Oncology Group. J Clin Oncol 27(1):114\u2013119. https:\/\/doi.org\/10.1200\/JCO.2008.16.8021","journal-title":"J Clin Oncol"},{"issue":"231","key":"4724_CR4","first-page":"699","volume":"60","author":"GM Mead","year":"1986","unstructured":"Mead GM, Kennedy P, Smith JL, Thompson J, Macbeth FR, Ryall RD, Williams CJ, Whitehouse JM (1986) Involvement of the central nervous system by non-Hodgkin\u2019s lymphoma in adults. A review of 36 cases. Q J Med 60(231):699\u2013714","journal-title":"Q J Med"},{"issue":"10","key":"4724_CR5","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1093\/annonc\/mdx515","volume":"28","author":"AJM Ferreri","year":"2017","unstructured":"Ferreri AJM (2017) Secondary CNS lymphoma: the poisoned needle in the haystack. Ann Oncol 28(10):2335\u20132337. https:\/\/doi.org\/10.1093\/annonc\/mdx515","journal-title":"Ann Oncol"},{"issue":"7","key":"4724_CR6","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1080\/02841860500256272","volume":"44","author":"IS Haldorsen","year":"2005","unstructured":"Haldorsen IS, Espeland A, Larsen JL, Mella O (2005) Diagnostic delay in primary central nervous system lymphoma. Acta Oncol 44(7):728\u2013734. https:\/\/doi.org\/10.1080\/02841860500256272","journal-title":"Acta Oncol"},{"issue":"4","key":"4724_CR7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1600-0404.1998.tb00647.x","volume":"97","author":"U Herrlinger","year":"1998","unstructured":"Herrlinger U, Schabet M, Clemens M, Kortmann R-D, Petersen D, Will BE, Meyemand R, Dichgans J (1998) Clinical presentation and therapeutic outcome in 26 patients with primary CNS lymphoma. Acta Neurol Scand 97(4):257\u2013264. https:\/\/doi.org\/10.1111\/j.1600-0404.1998.tb00647.x","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"4724_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/bf00833908","volume":"239","author":"DF Braus","year":"1992","unstructured":"Braus DF, Schwechheimer K, M\u00fcller-Hermelink HK, Schwarzkopf G, Volk B, Mundinger F (1992) Primary cerebral malignant non-Hodgkin\u2019s lymphomas: a retrospective clinical study. J Neurol 239(3):117\u2013124. https:\/\/doi.org\/10.1007\/bf00833908","journal-title":"J Neurol"},{"issue":"3-4","key":"4724_CR9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/10428199509107892","volume":"19","author":"M Krough-Jensen","year":"1995","unstructured":"Krough-Jensen M, Amore FD, Jensen MK, Christensen BE, Thorling K, Pedersen M, Johansen P, Boesen AM, Andersen E (1995) Clinicopathological features, survival and prognostic factors of primary central nervous system lymphomas: trends in incidence of primary central nervous system lymphomas and primary malignant brain tumors in a well-defined geographical area; Population-Based Data from the Danish Lymphoma Registry, Lyfo, And the Danish Cancer Reistry. Leuk Lymphoma 19(3-4):223\u2013233. https:\/\/doi.org\/10.3109\/10428199509107892","journal-title":"Leuk Lymphoma"},{"issue":"21","key":"4724_CR10","doi-asserted-by":"publisher","first-page":"E807","DOI":"10.1097\/BRS.0b013e31818441be","volume":"33","author":"P Khong","year":"2008","unstructured":"Khong P, Pitham T, Owler B (2008) Isolated neurolymphomatosis of the cauda equina and filum terminale: case report. Spine (Phila Pa 1976) 33(21):E807\u2013E811. https:\/\/doi.org\/10.1097\/BRS.0b013e31818441be","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"4724_CR11","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1212\/wnl.42.6.1136","volume":"42","author":"R Diaz-Arrastia","year":"1992","unstructured":"Diaz-Arrastia R, Younger DS, Hair L, Inghirami G, Hays AP, Knowles DM, Odel JG, Fetell MR, Lovelace RE, Rowland LP (1992) Neurolymphomatosis: a clinicopathologic syndrome re-emerges. Neurology 42(6):1136\u20131141. https:\/\/doi.org\/10.1212\/wnl.42.6.1136","journal-title":"Neurology"},{"key":"4724_CR12","doi-asserted-by":"crossref","unstructured":"Avila JD, Vivar C (2017) Neurolymphomatosis: a review of 82 cases (P5.141). Neurology 88(16 Supplement)","DOI":"10.1212\/WNL.88.16_supplement.P5.141"},{"issue":"3-4","key":"4724_CR13","first-page":"349","volume":"76","author":"H Nakashima","year":"2014","unstructured":"Nakashima H, Imagama S, Ito Z, Ando K, Kobayashi K, Ukai J, Muramoto A, Shinjyo R, Matsumoto T, Yamauchi I, Satou A, Ishiguro N (2014) Primary cauda equina lymphoma: case report and literature review. Nagoya J Med Sci 76(3-4):349\u2013354","journal-title":"Nagoya J Med Sci"},{"issue":"8","key":"4724_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1212\/WNL.0b013e31822b00b9","volume":"77","author":"EP Flanagan","year":"2011","unstructured":"Flanagan EP, O'Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM (2011) Primary intramedullary spinal cord lymphoma. Neurology 77(8):784\u2013791. https:\/\/doi.org\/10.1212\/WNL.0b013e31822b00b9","journal-title":"Neurology"},{"issue":"3","key":"4724_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s11060-011-0781-4","volume":"107","author":"EP Flanagan","year":"2012","unstructured":"Flanagan EP, O'Neill BP, Habermann TM, Porter AB, Keegan BM (2012) Secondary intramedullary spinal cord non-Hodgkin's lymphoma. J Neuro-Oncol 107(3):575\u2013580. https:\/\/doi.org\/10.1007\/s11060-011-0781-4","journal-title":"J Neuro-Oncol"},{"issue":"4","key":"4724_CR16","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1227\/01.NEU.0000053223.77641.5E","volume":"52","author":"AA Cohen-Gadol","year":"2003","unstructured":"Cohen-Gadol AA, Zikel OM, Miller GM, Aksamit AJ, Scheithauer BW, Krauss WE (2003) Spinal Cord Biopsy: A Review of 38 Cases. Neurosurgery 52(4):806\u2013816. https:\/\/doi.org\/10.1227\/01.NEU.0000053223.77641.5E","journal-title":"Neurosurgery"},{"issue":"3","key":"4724_CR17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/neuonc\/4.3.187","volume":"4","author":"S Schwarz","year":"2002","unstructured":"Schwarz S, Zoubaa S, Knauth M, Sommer C, Storch-Hagenlocher B (2002) Intravascular lymphomatosis presenting with a conus medullaris syndrome mimicking disseminated encephalomyelitis. Neuro-Oncology 4(3):187\u2013191. https:\/\/doi.org\/10.1093\/neuonc\/4.3.187","journal-title":"Neuro-Oncology"},{"key":"4724_CR18","doi-asserted-by":"publisher","unstructured":"Kumar N, Keegan BM, Rodriguez FJ, Hammack JE, Kantarci OH Intravascular lymphoma presenting as a longitudinally-extensive myelitis: diagnostic challenges and etiologic clues. J Neurol Sci 303(1):146\u2013149. https:\/\/doi.org\/10.1016\/j.jns.2010.12.016","DOI":"10.1016\/j.jns.2010.12.016"},{"issue":"1","key":"4724_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1136\/practneurol-2014-000849","volume":"15","author":"K Ali","year":"2015","unstructured":"Ali K, Morris HR (2015) Parkinson\u2019s disease: chameleons and mimics. Pract Neurol 15(1):14\u201325. https:\/\/doi.org\/10.1136\/practneurol-2014-000849","journal-title":"Pract Neurol"},{"issue":"1","key":"4724_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s002340000451","volume":"43","author":"M Sanchez-Guerra","year":"2001","unstructured":"Sanchez-Guerra M, Cerezal L, Leno C, Diez C, Figols J, Berciano J (2001) Primary brain lymphoma presenting as Parkinson\u2019s disease. Neuroradiology 43(1):36\u201340","journal-title":"Neuroradiology"},{"issue":"3-4","key":"4724_CR21","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/BF00687019","volume":"65","author":"R Gherardi","year":"1985","unstructured":"Gherardi R, Roualdes B, Fleury J, Prost C, Poirier J, Degos JD (1985) Parkinsonian syndrome and central nervous system lymphoma involving the substantia nigra. A case report. Acta Neuropathol 65(3-4):338\u2013343","journal-title":"Acta Neuropathol"},{"issue":"10","key":"4724_CR22","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s004150050485","volume":"246","author":"PP Pramstaller","year":"1999","unstructured":"Pramstaller PP, Salerno A, Bhatia KP, Prugger M, Marsden CD (1999) Primary central nervous system lymphoma presenting with a parkinsonian syndrome of pure akinesia. J Neurol 246(10):934\u2013938","journal-title":"J Neurol"},{"issue":"12","key":"4724_CR23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11910-013-0403-y","volume":"13","author":"AJ Solomon","year":"2013","unstructured":"Solomon AJ, Weinshenker BG (2013) Misdiagnosis of multiple sclerosis: frequency, causes, effects, and prevention. Curr Neurol Neurosci Rep 13(12):403. https:\/\/doi.org\/10.1007\/s11910-013-0403-y","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"24","key":"4724_CR24","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1212\/WNL.0b013e318259e2e2","volume":"78","author":"RA Rudick","year":"2012","unstructured":"Rudick RA, Miller AE (2012) Multiple sclerosis or multiple possibilities: the continuing problem of misdiagnosis. Neurology 78(24):1904\u20131906. https:\/\/doi.org\/10.1212\/WNL.0b013e318259e2e2","journal-title":"Neurology"},{"issue":"24","key":"4724_CR25","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1212\/WNL.0b013e318259e1b2","volume":"78","author":"AJ Solomon","year":"2012","unstructured":"Solomon AJ, Klein EP, Bourdette D (2012) \u201cUndiagnosing\u201d multiple sclerosis: the challenge of misdiagnosis in MS. Neurology 78(24):1986\u20131991. https:\/\/doi.org\/10.1212\/WNL.0b013e318259e1b2","journal-title":"Neurology"},{"issue":"7","key":"4724_CR26","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1212\/01.wnl.0000178894.51436.54","volume":"65","author":"W Kuker","year":"2005","unstructured":"Kuker W, Nagele T, Thiel E, Weller M, Herrlinger U (2005) Primary central nervous system lymphomas (PCNSL): MRI response criteria revised. Neurology 65(7):1129\u20131131. https:\/\/doi.org\/10.1212\/01.wnl.0000178894.51436.54","journal-title":"Neurology"},{"issue":"1","key":"4724_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1017\/S0317167100012610","volume":"39","author":"L Husseini","year":"2012","unstructured":"Husseini L, Saleh A, Reifenberger G, Hartung HP, Kieseier BC (2012) Inflammatory demyelinating brain lesions heralding primary CNS lymphoma. Can J Neurol Sci 39(1):6\u201310","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"4724_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1136\/jnnp.70.2.259","volume":"70","author":"T Kuhlmann","year":"2001","unstructured":"Kuhlmann T, Schroter A, Dechent P, Weber F, Rustenbeck HH, Fuzesi L, Bruck W, Ehrenreich H, Frahm J (2001) Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy. J Neurol Neurosurg Psychiatry 70(2):259\u2013262","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4724_CR29","doi-asserted-by":"crossref","unstructured":"Lin X, Tan K, Liauw L, Tin AS, Soon W, Eileen YSR, Zhu TBP, Lee HY, Yu W-Y (2014) Distinguishing clinico-radiological features in patients with central nervous system tumefactive white matter lesions (P5.177). Neurology 82(10 Supplement)","DOI":"10.1212\/WNL.82.10_supplement.P5.177"},{"issue":"4","key":"4724_CR30","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nrneurol.2018.14","volume":"14","author":"R Geraldes","year":"2018","unstructured":"Geraldes R, Ciccarelli O, Barkhof F, De Stefano N, Enzinger C, Filippi M, Hofer M, Paul F, Preziosa P, Rovira A, GC DL, Kappos L, Yousry T, Fazekas F, Frederiksen J, Gasperini C, Sastre-Garriga J, Evangelou N, Palace J, Group MS (2018) The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nat Rev Neurol 14(4):199\u2013213. https:\/\/doi.org\/10.1038\/nrneurol.2018.14","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"4724_CR31","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/00019052-199912000-00005","volume":"12","author":"LM DeAngelis","year":"1999","unstructured":"DeAngelis LM (1999) Primary central nervous system lymphoma. Curr Opin Neurol 12(6):687\u2013691","journal-title":"Curr Opin Neurol"},{"issue":"sup1","key":"4724_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/10428190802311441","volume":"49","author":"J Rubenstein","year":"2008","unstructured":"Rubenstein J, Ferreri AJM, Pittaluga S (2008) Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment. Leuk Lymphoma 49(sup1):43\u201351. https:\/\/doi.org\/10.1080\/10428190802311441","journal-title":"Leuk Lymphoma"},{"issue":"11","key":"4724_CR33","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1080\/17474086.2016.1242405","volume":"9","author":"M Nowosielski","year":"2016","unstructured":"Nowosielski M, Pardo-Moreno J, Penalver FJ, Buda G, Bennani H, Costopoulos M, Le Garff-Tavernier M, Soussain C, Schmid M, Orfao JA, Glantz M (2016) How to facilitate early diagnosis of CNS involvement in malignant lymphoma AU - Korfel, Agnieszka. Expert Rev Hematol 9(11):1081\u20131091. https:\/\/doi.org\/10.1080\/17474086.2016.1242405","journal-title":"Expert Rev Hematol"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04724-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-020-04724-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04724-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T19:36:30Z","timestamp":1723664190000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-020-04724-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["4724"],"URL":"https:\/\/doi.org\/10.1007\/s10072-020-04724-8","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"assertion":[{"value":"25 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study followed the principles of the Declaration of Helsinki. Approval from the ethical standards committee of Hadassah Medical Center has been received to conduct this study, and it is IRB-approved.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}