{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:14:14Z","timestamp":1787656454456,"version":"build-2736575974"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s10072-020-04725-7","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T21:02:21Z","timestamp":1600635741000},"page":"1879-1886","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adult brainstem glioma: a multicentre retrospective analysis of 47 Italian patients"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-4205","authenticated-orcid":false,"given":"Andrea","family":"Rigamonti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Silvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rud\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Franchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Merli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Servida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Picca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Berzero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cerase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivano","family":"Chiarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannantonio","family":"Spena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salmaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the neurooncology group of SNO (Society of Hospital Neurosciences, Italy)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"issue":"suppl 4","key":"4725_CR1","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/nov189","volume":"17","author":"QT Ostrom","year":"2015","unstructured":"Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2015) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro-Oncology 17(suppl 4):iv1\u2013iv62","journal-title":"Neuro-Oncology"},{"key":"4725_CR2","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1093\/brain\/124.12.2528","volume":"124","author":"JS Guillamo","year":"2001","unstructured":"Guillamo JS, Monjour A, Taillandier L, Devaux B, Varlet P, Haie-Meder C, Defer GL, Maison P, Mazeron JJ, Cornu P, Delattre JY, Association des Neuro-Oncologues d'Expression Fran\u00e7aise (ANOCEF) (2001) Brainstem gliomas in adults: prognostic factors and classification. Brain 124:2528\u20132539","journal-title":"Brain"},{"issue":"1","key":"4725_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11060-019-03134-x","volume":"143","author":"KC Schreck","year":"2019","unstructured":"Schreck KC, Ranjan S, Skorupan N, Bettegowda C, Eberhart CG, Ames HM, Holdhoff M (2019) Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas. Neurooncol 143(1):87\u201393","journal-title":"Neurooncol"},{"issue":"8","key":"4725_CR4","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1093\/neuonc\/now274","volume":"19","author":"D Meyronet","year":"2017","unstructured":"Meyronet D, Esteban-Mader M, Bonnet C, Joly MO, Uro-Coste E, Amiel-Benouaich A, Forest F, Rousselot-Denis C, Burel-Vandenbos F, Bourg V, Guyotat J, Fenouil T, Jouvet A, Honnorat J, Ducray F (2017) Characteristics of H3 K27M-mutant gliomas in adults. Neuro-Oncology 19(8):1127\u20131134","journal-title":"Neuro-Oncology"},{"issue":"3","key":"4725_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s11060-019-03313-w","volume":"145","author":"J Doyle","year":"2019","unstructured":"Doyle J, Khalafallah AM, Yang W, Sun Y, Bettegowda C, Mukherjee D (2019) Association between extent of resection on survival in adult brainstem high-grade glioma patients. J Neuro-Oncol 145(3):479\u2013486","journal-title":"J Neuro-Oncol"},{"key":"4725_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00415-008-0589-0","volume":"255","author":"A Salmaggi","year":"2008","unstructured":"Salmaggi A, Fariselli L, Milanesi I, Lamperti E, Silvani A, Bizzi A, Maccagnano E, Trevisan E, Laguzzi E, Rud\u00e0 R, Boiardi A, Soffietti R, Associazione Italiana di Neuro-oncologia (2008) Natural history and management of brainstem gliomas in adults. A retrospective italian study. J Neurol 255:171\u2013177","journal-title":"J Neurol"},{"issue":"2","key":"4725_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11060-016-2363-y","volume":"132","author":"SEM Veldhuijzen van Zanten","year":"2017","unstructured":"Veldhuijzen van Zanten SEM, Baugh J, Chaney B, De Jongh D, Sanchez Aliaga E, Barkhof F, Noltes J, De Wolf R, Van Dijk J, Cannarozzo A, Damen-Korbijn CM, Lieverst JA, Colditz N, Hoffmann M, Warmuth-Metz M, Bison B, Jones DTW, Sturm D, Gielen GH, Jones C, Hulleman E, Calmon R, Castel D, Varlet P, Giraud G, Slavc I, Van Gool S, Jacobs S, Jadrijevic-Cvrlje F, Sumerauer D, Nysom K, Pentikainen V, Kivivuori SM, Leblond P, Entz-Werle N, von Bueren AO, Kattamis A, Hargrave DR, Hauser P, Garami M, Thorarinsdottir HK, Pears J, Gandola L, Rutkauskiene G, Janssens GO, Torsvik IK, Perek-Polnik M, Gil-da-Costa MJ, Zheludkova O, Shats L, Deak L, Kitanovski L, Cruz O, Morales La Madrid A, Holm S, Gerber N, Kebudi R, Grundy R, Lopez-Aguilar E, Zapata-Tarres M, Emmerik J, Hayden T, Bailey S, Biassoni V, Massimino M, Grill J, Vandertop WP, Kaspers GJL, Fouladi M, Kramm CM, van Vuurden DG, Members of the SIOPE DIPG Network (2017) Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neuro-Oncol 132(2):255\u2013266","journal-title":"J Neuro-Oncol"},{"issue":"9","key":"4725_CR8","first-page":"1279","volume":"19","author":"T Cooney","year":"2017","unstructured":"Cooney T, Lane A, Bartels U, Bouffet E, Goldman S, Leary SES, Foreman NK, Packer RJ, Broniscer A, Minturn JE, Shih CS, Chintagumpala M, Hassall T, Gottardo NG, Dholaria H, Hoffman L, Chaney B, Baugh J, Doughman R, Leach JL, Jones BV, Fouladi M, Warren KE, Monje M (2017) Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study.Neuro. Oncol 19(9):1279\u20131280","journal-title":"Oncol"},{"issue":"18","key":"4725_CR9","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1002\/cncr.29920","volume":"122","author":"SC Eisele","year":"2016","unstructured":"Eisele SC, Reardon DA (2016) Adult brainstem gliomas. Cancer 122(18):2799\u20132809","journal-title":"Cancer"},{"key":"4725_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s11060-008-9545-1","volume":"88","author":"S Kesari","year":"2008","unstructured":"Kesari S, Kim RS, Markos V, Drappatz J, Wen PY, Pruitt AA (2008) Prognostic factors in adult brainstem gliomas: a multicenter, retrospective analysis of 101 cases. J Neuro-Oncol 88:175\u2013183","journal-title":"J Neuro-Oncol"},{"key":"4725_CR11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11060-014-1434-1","volume":"118","author":"T Hundsberger","year":"2014","unstructured":"Hundsberger T, Tonder M, Hottinger A, Br\u00fcgge D, Roelcke U, Putora PM, Stupp R, Weller M (2014) Clinical management and outcome of histologically verified adult brainstem gliomas in Switzerland: a retrospective analysis of 21 patients. J Neuro-Oncol 118:321\u2013328","journal-title":"J Neuro-Oncol"},{"key":"4725_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jns.2015.04.014","volume":"353","author":"BJ Theeler","year":"2015","unstructured":"Theeler BJ, Ellezam B, Melguizo-Gavilanes I, de Groot JF, Mahajan A, Aldape KD, Bruner JM, Puduvalli VK (2015) Adult brainstem gliomas: correlation of clinical and molecular features. J Neurol Sci 353:92\u201397","journal-title":"J Neurol Sci"},{"key":"4725_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1471-2407-14-115","volume":"14","author":"T Reithmeier","year":"2014","unstructured":"Reithmeier T, Kuzeawu A, Hentschel B, Loeffler M, Trippel M, Nikkhah G (2014) Retrospective analysis of 104 proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors. BMC Cancer 14:115\u2013122","journal-title":"BMC Cancer"},{"key":"4725_CR14","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/sj.bjc.6603402","volume":"95","author":"S Wagner","year":"2006","unstructured":"Wagner S, Benesch M, Berthold F, Gnekow AK, Rutkowski S, Strater R, Warmuth-Metz M, Kortmann RD, Pitsch T, Wolff JEA (2006) Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas. Br J Cancer 95:991\u2013997","journal-title":"Br J Cancer"},{"issue":"1","key":"4725_CR15","doi-asserted-by":"publisher","first-page":"E9","DOI":"10.3171\/2019.9.FOCUS19699","volume":"48","author":"TD Azad","year":"2020","unstructured":"Azad TD, Jin MC, Bernhardt LJ, Bettegowda C (2020) Liquid biopsy for pediatric diffuse midline glioma: a review of circulating tumor DNA and cerebrospinal fluid tumor DNA. Neurosurg Focus 48(1):E9. https:\/\/doi.org\/10.3171\/2019.9.FOCUS19699","journal-title":"Neurosurg Focus"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04725-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-020-04725-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04725-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T21:26:10Z","timestamp":1632173170000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-020-04725-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["4725"],"URL":"https:\/\/doi.org\/10.1007\/s10072-020-04725-7","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"21 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by an Internal Insitutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}