{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:46:08Z","timestamp":1771926368425,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Keele"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>The coronavirus disease (COVID-19) pandemic has changed routine clinical practice worldwide with major impacts on the provision of care and treatment for stroke patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective observational study included all patients admitted to the Royal Stoke University Hospital in Stoke-on-Trent, UK, with a stroke or transient ischaemic attack between March 15th and April 14th, 2020 (COVID). Patient demographics, characteristics of the stroke, treatment details and logistics were compared with patients admitted in the corresponding weeks in the year before (2019).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was a 39.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009101 vs <jats:italic>n<\/jats:italic>\u2009=\u2009167) reduction in admissions in the COVID cohort compared with 2019 with more severe strokes (median National Institutes of Health Stroke Scale (NIHSS) 7 vs 4, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), and fewer strokes with no visible acute pathology (21.8 vs 37.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) on computed tomography. There was no statistically significant difference in the rates of thrombolysis (10.9 vs 13.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.72) and\/or thrombectomy (5.9 vs 4.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.90) and no statistically significant difference in time from stroke onset to arrival at hospital (734 vs 576\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.34), door-to-needle time for thrombolysis (54 vs 64\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.43) and door-to-thrombectomy time (181 vs 445\u00a0min, p\u2009=\u20090.72). Thirty-day mortality was not significantly higher in the COVID year (10.9 vs 8.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.77). None of the 7 stroke patients infected with COVID-19 died.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>During the COVID-19 pandemic, the number of stroke admissions fell, and stroke severity increased. There was no statistically significant change in the delivery of thrombolysis and mechanical thrombectomy and no increase in mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-020-04775-x","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T13:02:42Z","timestamp":1601989362000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Impact of COVID-19 on stroke admissions, treatments, and outcomes at a comprehensive stroke centre in the United Kingdom"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-7980","authenticated-orcid":false,"given":"Nishita","family":"Padmanabhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Gunston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Raseta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Roffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"4775_CR1","unstructured":"World Health Organisation. 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Data for this project were collected as part of the Sentinel Stroke Audit Programme (SSNAP), which is approved by the NHS Health Research Authority (HRA). All data included are anonymized. Patients were not asked to give informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}