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Marcello Moccia has received research grants from ECTRIMS-MAGNIMS, UK MS Society and Merck; honoraria from Biogen, Merck, Novartis and Roche; and consulting fees from Veterans Evaluation Services. Roberta Lanzillo received personal compensations for speaking or consultancy from Biogen, Teva, Genzyme, Merck, Novartis, Almirall. Maria Petracca received travel grant from Novartis. Vincenzo Brescia Morra received personal compensations for speaking or consultancy from Biogen, Teva, Genzyme, Merck, Novartis, Almirall. Chiodi Alessandro, Laura Rosa, Bianchi Maurizio, Francesca Lauro, Ilaria Ferrante and Ianniello Antonio declare no potential conflicts of interest with respect to the research, authorship and\/or publication of this abstract. Carlo Pozzilli received consulting and lecture fees and research funding and travel grants from Almirall, Bayer, Biogen, Genzyme, Merck Serono, Novartis, Roche and Teva. Laura Del Giglio received speaking honoraria from Genzyme and Novartis; travel grants from Biogen, Merk and Teva; and consulting fees from Genzyme, Merk, and Novartis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Institutional Review Board of the University of Naples \u2018Federico II\u2019 and of the \u2018S. Andrea\u2019 Hospital in Rome and all investigators adhered to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consents were obtained from all subjects enrolled in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}