{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:20:30Z","timestamp":1765423230901,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10072-020-04967-5","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T04:39:18Z","timestamp":1610512758000},"page":"3625-3630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians"],"prefix":"10.1007","volume":"42","author":[{"given":"Nour","family":"Hamad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-5099","authenticated-orcid":false,"given":"Karem H.","family":"Alzoubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer F.","family":"Swedan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar F.","family":"Khabour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"El-Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"4967_CR1","unstructured":"Migraine (2017). https:\/\/www.mayoclinic.org\/diseases-conditions\/migraine-headache\/symptoms-causes\/syc-20360201. (Accessed 5 November 2017 2017)"},{"issue":"17","key":"4967_CR2","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","volume":"35","author":"R Burstein","year":"2015","unstructured":"Burstein R, Noseda R, Borsook D (2015) Migraine: multiple processes, complex pathophysiology. J Neurosci 35(17):6619\u20136629","journal-title":"J Neurosci"},{"issue":"suppl 2","key":"4967_CR3","first-page":"ii10","volume":"72","author":"G Elrington","year":"2002","unstructured":"Elrington G (2002) Migraine: diagnosis and management. Journal of Neurology, Neurosurgery & Psychiatry 72(suppl 2):ii10\u2013ii15","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"4967_CR4","first-page":"226","volume":"4","author":"B Shah","year":"2017","unstructured":"Shah B, Dipesh RP (2017) Migraine review article. European J Biomed Pharm Sci 4:226\u2013230","journal-title":"European J Biomed Pharm Sci"},{"key":"4967_CR5","doi-asserted-by":"crossref","unstructured":"Woldeamanuel YW, Cowan RP (2017) Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants. J Neurol Sci 5(372)307\u2013315","DOI":"10.1016\/j.jns.2016.11.071"},{"issue":"3","key":"4967_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/2040622315579627","volume":"6","author":"MW Weatherall","year":"2015","unstructured":"Weatherall MW (2015) The diagnosis and treatment of chronic migraine. Ther Adv Chronic Dis 6(3):115\u2013123","journal-title":"Ther Adv Chronic Dis"},{"issue":"8","key":"4967_CR7","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/head.12150","volume":"53","author":"DC Buse","year":"2013","unstructured":"Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, Serrano D, Lipton RB (2013) Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache 53(8):1278\u20131299","journal-title":"Headache"},{"key":"4967_CR8","unstructured":"Chawla J (2017) Migraine Headache. https:\/\/emedicine.medscape.com\/article\/1142556-overview. (Accessed 3 November 2017 2017)."},{"issue":"14","key":"4967_CR9","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1177\/0333102414531157","volume":"34","author":"CD Chong","year":"2014","unstructured":"Chong CD, Dodick DW, Schlaggar BL, Schwedt TJ (2014) Atypical age-related cortical thinning in episodic migraine. Cephalalgia 34(14):1115\u20131124","journal-title":"Cephalalgia"},{"key":"4967_CR10","unstructured":"Hu F, Qian ZW (2016) Characteristic analysis of white matter lesions in migraine patients with MRI. Eur Rev Med Pharmacol Sci 20(6):1032\u20131036"},{"key":"4967_CR11","unstructured":"Shankar SV (2009) Effect of homoeopathicmedicines in the treatment ofmigraine, homoeopathic materia medica, DR. M.G.R. Medical University"},{"key":"4967_CR12","unstructured":"Teixido MCJ (2014) Migraine \u2013 More than a headache, John Hopkin's otolaryngology, Baltimore, Maryland"},{"key":"4967_CR13","unstructured":"Epidemiology and impact of headache and migraine (2016) https:\/\/americanheadachesociety.org\/wp-content\/uploads\/2016\/07\/NAP_for_Web_-_Epidemiology___Impact_of_Headache___Migraine.pdf. (Accessed 3 November 2017 2017)"},{"key":"4967_CR14","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1146\/annurev-physiol-030212-183717","volume":"75","author":"D Pietrobon","year":"2013","unstructured":"Pietrobon D, Moskowitz MA (2013) Pathophysiology of migraine. Annu Rev Physiol 75:365\u2013391","journal-title":"Annu Rev Physiol"},{"issue":"4","key":"4967_CR15","doi-asserted-by":"publisher","first-page":"a016279","DOI":"10.1101\/cshperspect.a016279","volume":"7","author":"J Sedy","year":"2014","unstructured":"Sedy J, Bekiaris V, Ware CF (2014) Tumor necrosis factor superfamily in innate immunity and inflammation. Cold Spring Harb Perspect Biol 7(4):a016279","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1-2","key":"4967_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jns.2014.11.009","volume":"348","author":"MS Fawzi","year":"2015","unstructured":"Fawzi MS, El-Shal AS, Rashad NM, Fathy HA (2015) Influence of tumor necrosis factor alpha gene promoter polymorphisms and its serum level on migraine susceptibility in Egyptian patients. J Neurol Sci 348(1-2):74\u201380","journal-title":"J Neurol Sci"},{"issue":"10","key":"4967_CR17","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1111\/j.1526-4637.2011.01200.x","volume":"12","author":"O Ates","year":"2011","unstructured":"Ates O, Kurt S, Altinisik J, Karaer H, Sezer S (2011) Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility. Pain Med 12(10):1464\u20131469","journal-title":"Pain Med"},{"issue":"2","key":"4967_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s00415-009-0961-8","volume":"256","author":"C Asuni","year":"2009","unstructured":"Asuni C, Stochino ME, Cherchi A, Manchia M, Congiu D, Manconi F, Squassina A, Piccardi MP, Del Zompo M (2009) Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample. J Neurol 256(2):194\u2013197","journal-title":"J Neurol"},{"issue":"7","key":"4967_CR19","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1111\/j.1526-4610.2007.00847.x","volume":"47","author":"KA Lee","year":"2007","unstructured":"Lee KA, Jang SY, Sohn KM, Won HH, Kim MJ, Kim JW, Chung CS (2007) Association between a polymorphism in the lymphotoxin-a promoter region and migraine. Headache 47(7):1056\u20131062","journal-title":"Headache"},{"key":"4967_CR20","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition, Cephalalgia 38(1), 1-211","DOI":"10.1177\/0333102417738202"},{"key":"4967_CR21","doi-asserted-by":"publisher","first-page":"821827","DOI":"10.1155\/2015\/821827","volume":"2015","author":"AH Arab","year":"2015","unstructured":"Arab AH, Elhawary NA (2015) Association between ANKK1 (rs1800497) and LTA (rs909253) genetic variants and risk of schizophrenia. Biomed Res Int 2015:821827","journal-title":"Biomed Res Int"},{"issue":"12","key":"4967_CR22","doi-asserted-by":"publisher","first-page":"9159","DOI":"10.1007\/s13277-015-3593-x","volume":"36","author":"JG de Oliveira","year":"2015","unstructured":"de Oliveira JG, Rossi AF, Nizato DM, Cadamuro AC, Jorge YC, Valsechi MC, Venancio LP, Rahal P, Pavarino EC, Goloni-Bertollo EM, Silva AE (2015) Influence of functional polymorphisms in TNF-alpha, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumour Biol 36(12):9159\u20139170","journal-title":"Tumour Biol"},{"issue":"8","key":"4967_CR23","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/abbs\/gms046","volume":"44","author":"B Qiu","year":"2012","unstructured":"Qiu B, Wang X, Zhang P, Shi C, Zhang J, Qiu W, Wang W, Li D (2012) Association of TNF-\u03b1 promoter polymorphisms with the outcome of persistent HBV infection in a northeast Chinese Han population. Acta Biochim Biophys Sin 44(8):712\u2013718","journal-title":"Acta Biochim Biophys Sin"},{"issue":"6","key":"4967_CR24","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1007\/s00415-009-5430-x","volume":"257","author":"J Ghosh","year":"2010","unstructured":"Ghosh J, Joshi G, Pradhan S, Mittal B (2010) Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol 257(6):898\u2013904","journal-title":"J Neurol"},{"issue":"11","key":"4967_CR25","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrneurol.2013.192","volume":"9","author":"AC Charles","year":"2013","unstructured":"Charles AC, Baca SM (2013) Cortical spreading depression and migraine. Nat Rev Neurol 9(11):637\u2013644","journal-title":"Nat Rev Neurol"},{"key":"4967_CR26","doi-asserted-by":"crossref","unstructured":"U\u00e7ar Karabulut K, Ugur Egercioglu T, Uyar M, U\u00e7ar Y (2016) The Change of Neutrophils\/Lymphocytes Ratio in Migraine Attacks","DOI":"10.1016\/j.amsu.2016.07.023"},{"key":"4967_CR27","doi-asserted-by":"crossref","unstructured":"Peng Y-F, Wei Y, Qin Y-H, Wei Y-S, Teng Y-J, (2016) A relationship between absolute monocyte count and C-reactive protein in patients with migraine undergoing no pharmacological therapy, Clinical Chemistry and Laboratory Medicine (CCLM), p. e249","DOI":"10.1515\/cclm-2015-1196"},{"issue":"4","key":"4967_CR28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/j.1526-4637.2009.00791.x","volume":"11","author":"IA Y\u0131lmaz","year":"2010","unstructured":"Y\u0131lmaz IA, \u00d6zge A, Erdal ME, Edg\u00fcnl\u00fc TG, \u00c7akmak SE, Yal\u0131n O\u00d6 (2010) Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med 11(4):492\u2013497","journal-title":"Pain Med"},{"issue":"5","key":"4967_CR29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1046\/j.1526-4610.2002.02104.x","volume":"42","author":"S Trabace","year":"2002","unstructured":"Trabace S, Brioli G, Lulli P, Morellini M, Giacovazzo M, Cicciarelli G, Martelletti P (2002) Tumor necrosis factor gene polymorphism in migraine, headache. The Journal of Head and Face Pain 42(5):341\u2013345","journal-title":"The Journal of Head and Face Pain"},{"issue":"1","key":"4967_CR30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1212\/01.WNL.0000101717.16799.8F","volume":"62","author":"I Rainero","year":"2004","unstructured":"Rainero I, Grimaldi LME, Salani G, Valfr\u00e8 W, Rivoiro C, Savi L, Pinessi L (2004) Association between the tumor necrosis factor-\u03b1 \u2212308 G\/A gene polymorphism and migraine. Neurology 62(1):141\u2013143","journal-title":"Neurology"},{"issue":"3","key":"4967_CR31","doi-asserted-by":"publisher","first-page":"430","DOI":"10.5114\/aoms.2010.14267","volume":"6","author":"S Pappa","year":"2010","unstructured":"Pappa S, Hatzistilianou M, Kouvatsi A, Pantzartzi C, Sakellaropoulou A, Pavlou E, Mavromichales I, Athanassiadou F (2010) Tumour necrosis factor gene polymorphisms and migraine in Greek children. Arch Med Sci 6(3):430\u2013437","journal-title":"Arch Med Sci"},{"key":"4967_CR32","doi-asserted-by":"crossref","unstructured":"Lee K-A, Yeon Jang S, Sohn K-M, Won H-H, Ji Kim M, Kim J-W, Chung C-S (2007) Association between a polymorphism in the lymphotoxin ? A Promoter Region and Migraine","DOI":"10.1111\/j.1526-4610.2007.00847.x"},{"issue":"6","key":"4967_CR33","doi-asserted-by":"publisher","first-page":"e100189","DOI":"10.1371\/journal.pone.0100189","volume":"9","author":"R Liu","year":"2014","unstructured":"Liu R, Ma M, Cui M, Dong Z, Wang X, Zhang W, Yang M, Yu S (2014) Effects of tumor necrosis factor-beta (TNF-beta) 252A>G polymorphism on the development of migraine: a meta-analysis. PLoS One 9(6):e100189","journal-title":"PLoS One"},{"issue":"7","key":"4967_CR34","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jpain.2009.01.326","volume":"10","author":"M Schurks","year":"2009","unstructured":"Schurks M, Kurth T, Buring JE, Zee RY (2009) A candidate gene association study of 77 polymorphisms in migraine. J Pain 10(7):759\u2013766","journal-title":"J Pain"},{"issue":"13","key":"4967_CR35","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1177\/0333102411419022","volume":"31","author":"M Schurks","year":"2011","unstructured":"Schurks M, Rist PM, Zee RY, Chasman DI, Kurth T (2011) Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis. Cephalalgia 31(13):1381\u20131404","journal-title":"Cephalalgia"},{"issue":"12","key":"4967_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11916-018-0735-z","volume":"22","author":"A Vgontzas","year":"2018","unstructured":"Vgontzas A, Burch R (2018) Episodic migraine with and without aura: key differences and implications for pathophysiology, management, and assessing risks. Curr Pain Headache Rep 22(12):78","journal-title":"Curr Pain Headache Rep"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04967-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-020-04967-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-020-04967-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:36:13Z","timestamp":1630694173000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-020-04967-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["4967"],"URL":"https:\/\/doi.org\/10.1007\/s10072-020-04967-5","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"assertion":[{"value":"3 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The protocol of this study was approved by the Institutional Review Board (IRB) of Jordan University of Science and Technology, Irbid, Jordan.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent were obtained from all study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"N\/A.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}