{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:10:31Z","timestamp":1790683831215,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2016YFC1300604,2016YFC1305904, 2018YFC1314200"],"award-info":[{"award-number":["2016YFC1300604,2016YFC1305904, 2018YFC1314200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s10072-021-05038-z","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T06:59:16Z","timestamp":1610434756000},"page":"3615-3624","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The vessel density of the superficial retinal capillary plexus as a new biomarker in cerebral small vessel disease: an optical coherence tomography angiography study"],"prefix":"10.1007","volume":"42","author":[{"given":"Xiaojing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-376X","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"issue":"7","key":"5038_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","volume":"9","author":"L Pantoni","year":"2010","unstructured":"Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9(7):689\u2013701","journal-title":"Lancet Neurol"},{"issue":"7","key":"5038_CR2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1474-4422(07)70170-9","volume":"6","author":"SE Vermeer","year":"2007","unstructured":"Vermeer SE, Longstreth WJ, Koudstaal PJ (2007) Silent brain infarcts: a systematic review. Lancet Neurol 6(7):611\u2013619","journal-title":"Lancet Neurol"},{"issue":"7767","key":"5038_CR3","first-page":"288","volume":"341","author":"S Debette","year":"2010","unstructured":"Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 341(7767):288\u2013288","journal-title":"BMJ"},{"issue":"10","key":"5038_CR4","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1007\/s00415-018-9077-3","volume":"266","author":"X Chen","year":"2019","unstructured":"Chen X, Wang J, Shan Y, Cai W, Liu S, Hu M, Liao S, Huang X, Zhang B, Wang Y, Lu Z (2019) Cerebral small vessel disease: neuroimaging markers and clinical implication. J Neurol 266(10):2347\u20132362","journal-title":"J Neurol"},{"key":"5038_CR5","doi-asserted-by":"crossref","unstructured":"Montero-Odasso M, Hachinski V (2014) Preludes to brain failure: executive dysfunction and gait disturbances. Neurol Sci 35(4):601\u2013604","DOI":"10.1007\/s10072-013-1613-4"},{"issue":"7","key":"5038_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41582-018-0014-y","volume":"14","author":"AT Telgte","year":"2018","unstructured":"Telgte AT et al (2018) Cerebral small vessel disease: from a focal to a global perspective. Nat Rev Neurol 14(7):387\u2013398","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"5038_CR7","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","volume":"42","author":"PB Gorelick","year":"2011","unstructured":"Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia (2011) Vascular contributions to cognitive impairment and dementia. Stroke 42(9):2672\u20132713","journal-title":"Stroke"},{"issue":"3","key":"5038_CR8","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/01.STR.28.3.652","volume":"28","author":"L Pantoni","year":"1997","unstructured":"Pantoni L, Garcia JH (1997) Pathogenesis of leukoaraiosis: a review. Stroke 28(3):652\u2013659","journal-title":"Stroke"},{"issue":"1","key":"5038_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","volume":"9","author":"A London","year":"2013","unstructured":"London A, Benhar I, Schwartz M (2013) The retina as a window to the brain-from eye research to CNS disorders. Nat Rev Neurol 9(1):44\u201353","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"5038_CR10","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1161\/STROKEAHA.113.004166","volume":"45","author":"TC Hanff","year":"2014","unstructured":"Hanff TC, Sharrett AR, Mosley TH, Shibata D, Knopman DS, Klein R, Klein BEK, Gottesman RF (2014) Retinal microvascular abnormalities predict progression of brain microvascular disease. Stroke 45(4):1012\u20131017","journal-title":"Stroke"},{"issue":"7","key":"5038_CR11","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1212\/01.wnl.0000179177.15900.ca","volume":"65","author":"P Mitchell","year":"2005","unstructured":"Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR (2005) Retinal microvascular signs and risk of stroke and stroke mortality. Neurology 65(7):1005\u20131009","journal-title":"Neurology"},{"issue":"7","key":"5038_CR12","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1093\/brain\/awq127","volume":"133","author":"N Cheung","year":"2010","unstructured":"Cheung N, Mosley T, Islam A, Kawasaki R, Sharrett AR, Klein R, Coker LH, Knopman DS, Shibata DK, Catellier D, Wong TY (2010) Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study. Brain 133(7):1987\u20131993","journal-title":"Brain"},{"issue":"1","key":"5038_CR13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/brain\/awh688","volume":"129","author":"MK Ikram","year":"2006","unstructured":"Ikram MK, de Jong FJ, van Dijk EJ, Prins ND, Hofman A, Breteler MMB, de Jong PTVM (2006) Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study. Brain 129(1):182\u2013188","journal-title":"Brain"},{"key":"5038_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neulet.2014.06.024","volume":"577","author":"S Hilal","year":"2014","unstructured":"Hilal S, Ong YT, Cheung CY, Tan CS, Venketasubramanian N, Niessen WJ, Vrooman H, Anuar AR, Chew M, Chen C, Wong TY, Ikram MK (2014) Microvascular network alterations in retina of subjects with cerebral small vessel disease. Neurosci Lett 577:95\u2013100","journal-title":"Neurosci Lett"},{"issue":"7","key":"5038_CR15","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.041","volume":"27","author":"OM Dumitrascu","year":"2018","unstructured":"Dumitrascu OM, Demaerschalk BM, Valencia Sanchez C, Almader-Douglas D, O'Carroll CB, Aguilar MI, Lyden PD, Kumar G (2018) Retinal microvascular abnormalities as surrogate markers of cerebrovascular ischemic disease: a meta-analysis. J Stroke Cerebrovasc Dis 27(7):1960\u20131968","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"5038_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","volume":"64","author":"RF Spaide","year":"2018","unstructured":"Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G (2018) Optical coherence tomography angiography. Prog Retin Eye Res 64:1\u201355","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"5038_CR17","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3233\/JAD-180738","volume":"66","author":"L Lahme","year":"2018","unstructured":"Lahme L, Esser EL, Mihailovic N, Schubert F, Lauermann J, Johnen A, Eter N, Duning T, Alnawaiseh M (2018) Evaluation of ocular perfusion in Alzheimer\u2019s disease using optical coherence tomography angiography. J Alzheimers Dis 66(4):1745\u20131752","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"5038_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1136\/bjophthalmol-2017-310476","volume":"102","author":"M Bulut","year":"2018","unstructured":"Bulut M, Kurtulu\u015f F, G\u00f6zkaya O, Erol MK, Cengiz A, Ak\u0131dan M, Yaman A (2018) Evaluation of optical coherence tomography angiographic findings in Alzheimer\u2019s type dementia. Br J Ophthalmol 102(2):233\u2013237","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"5038_CR19","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3928\/23258160-20191031-06","volume":"50","author":"SP Yoon","year":"2019","unstructured":"Yoon SP, Thompson AC, Polascik BW, Calixte C, Burke JR, Petrella JR, Grewal DS, Fekrat S (2019) Correlation of OCTA and volumetric MRI in mild cognitive impairment and Alzheimer\u2019s disease. Ophthalmic Surg Lasers Imaging Retina 50(11):709\u2013718","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"13","key":"5038_CR20","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1177\/1352458517729463","volume":"24","author":"R Lanzillo","year":"2018","unstructured":"Lanzillo R, Cennamo G, Criscuolo C, Carotenuto A, Velotti N, Sparnelli F, Cianflone A, Moccia M, Brescia Morra V (2018) Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis. Mult Scler 24(13):1706\u20131714","journal-title":"Mult Scler"},{"issue":"2","key":"5038_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1177\/1352458517750009","volume":"25","author":"N Feucht","year":"2019","unstructured":"Feucht N, Maier M, Lepennetier G, Pettenkofer M, Wetzlmair C, Daltrozzo T, Scherm P, Zimmer C, Hoshi MM, Hemmer B, Korn T, Knier B (2019) Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis. Mult Scler 25(2):224\u2013234","journal-title":"Mult Scler"},{"issue":"10","key":"5038_CR22","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1136\/bjophthalmol-2013-304547","volume":"98","author":"X Wang","year":"2014","unstructured":"Wang X, Jia Y, Spain R, Potsaid B, Liu JJ, Baumann B, Hornegger J, Fujimoto JG, Wu Q, Huang D (2014) Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. Br J Ophthalmol 98(10):1368\u20131373","journal-title":"Br J Ophthalmol"},{"key":"5038_CR23","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3389\/fneur.2020.00542","volume":"11","author":"G Cennamo","year":"2020","unstructured":"Cennamo G, Carotenuto A, Montorio D, Petracca M, Moccia M, Melenzane A, Tranfa F, Lamberti A, Spiezia AL, Servillo G, de Angelis M, Petruzzo M, Criscuolo C, Lanzillo R, Brescia Morra V (2020) Peripapillary vessel density as early biomarker in multiple sclerosis. Front Neurol 11:542","journal-title":"Front Neurol"},{"issue":"1","key":"5038_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13195-020-00638-x","volume":"12","author":"JY Lee","year":"2020","unstructured":"Lee JY, Kim JP, Jang H, Kim J, Kang SH, Kim JS, Lee J, Jung YH, Na DL, Seo SW, Oh SY, Kim HJ (2020) Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases. Alzheimers Res Ther 12(1):73","journal-title":"Alzheimers Res Ther"},{"issue":"18","key":"5038_CR25","doi-asserted-by":"publisher","first-page":"E2395","DOI":"10.1073\/pnas.1500185112","volume":"112","author":"Y Jia","year":"2015","unstructured":"Jia Y, Bailey ST, Hwang TS, McClintic SM, Gao SS, Pennesi ME, Flaxel CJ, Lauer AK, Wilson DJ, Hornegger J, Fujimoto JG, Huang D (2015) Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A 112(18):E2395\u2013E2402","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5038_CR26","doi-asserted-by":"crossref","unstructured":"Di Maio LG et al (2020) Optical coherence tomography angiography findings in Huntington\u2019s disease. Neurol Sci","DOI":"10.1007\/s10072-020-04611-2"},{"key":"5038_CR27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40942-017-0068-9","volume":"3","author":"M Al-Sheikh","year":"2017","unstructured":"Al-Sheikh M et al (2017) Impact of image quality on OCT angiography based quantitative measurements. Int J Retina Vitreous 3:13","journal-title":"Int J Retina Vitreous"},{"issue":"7","key":"5038_CR28","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.1161\/01.STR.0000075768.91709.E4","volume":"34","author":"M Hiroki","year":"2003","unstructured":"Hiroki M, Miyashita K, Yoshida H, Hirai S, Fukuyama H (2003) Central retinal artery Doppler flow parameters reflect the severity of cerebral small-vessel disease. Stroke 34(7):e92\u2013e94","journal-title":"Stroke"},{"issue":"14","key":"5038_CR29","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1212\/WNL.0b013e3181d7d8b4","volume":"74","author":"FN Doubal","year":"2010","unstructured":"Doubal FN, MacGillivray TJ, Patton N, Dhillon B, Dennis MS, Wardlaw JM (2010) Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke. Neurology 74(14):1102\u20131107","journal-title":"Neurology"},{"issue":"10","key":"5038_CR30","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1212\/WNL.0000000000003080","volume":"87","author":"U Mutlu","year":"2016","unstructured":"Mutlu U, Cremers LGM, de Groot M, Hofman A, Niessen WJ, van der Lugt A, Klaver CCW, Ikram MA, Vernooij MW, Ikram MK (2016) Retinal microvasculature and white matter microstructure. Neurology 87(10):1003\u20131010","journal-title":"Neurology"},{"issue":"1","key":"5038_CR31","doi-asserted-by":"publisher","first-page":"6320","DOI":"10.1038\/s41598-019-42534-x","volume":"9","author":"S McGrory","year":"2019","unstructured":"McGrory S, Ballerini L, Doubal FN, Staals J, Allerhand M, Valdes-Hernandez MC, Wang X, MacGillivray T, Doney ASF, Dhillon B, Starr JM, Bastin ME, Trucco E, Deary IJ, Wardlaw JM (2019) Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study. Sci Rep 9(1):6320","journal-title":"Sci Rep"},{"issue":"6 Pt 2","key":"5038_CR32","first-page":"H2498","volume":"267","author":"DY Yu","year":"1994","unstructured":"Yu DY et al (1994) Intraretinal oxygen distribution in rats as a function of systemic blood pressure. Am J Phys 267(6 Pt 2):H2498\u2013H2507","journal-title":"Am J Phys"},{"key":"5038_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","volume":"69","author":"M Chen","year":"2019","unstructured":"Chen M, Luo C, Zhao J, Devarajan G, Xu H (2019) Immune regulation in the aging retina. Prog Retin Eye Res 69:159\u2013172","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"5038_CR34","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1136\/jnnp.2006.103549","volume":"78","author":"U Khan","year":"2007","unstructured":"Khan U et al (2007) Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry 78(7):702\u2013706","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"5038_CR35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1161\/str.33.1.297","volume":"33","author":"Y Yamamoto","year":"2002","unstructured":"Yamamoto Y, Akiguchi I, Oiwa K, Hayashi M, Kasai T, Ozasa K (2002) Twenty-four-hour blood pressure and MRI as predictive factors for different outcomes in patients with lacunar infarct. Stroke 33(1):297\u2013305","journal-title":"Stroke"},{"issue":"3","key":"5038_CR36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","volume":"34","author":"JM Wardlaw","year":"2003","unstructured":"Wardlaw JM, Sandercock PAG, Dennis MS, Starr J (2003) Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 34(3):806\u2013812","journal-title":"Stroke"},{"issue":"15","key":"5038_CR37","doi-asserted-by":"publisher","first-page":"e1669","DOI":"10.1212\/WNL.0000000000007263","volume":"92","author":"SM Wong","year":"2019","unstructured":"Wong SM, Jansen JFA, Zhang CE, Hoff EI, Staals J, van Oostenbrugge RJ, Backes WH (2019) Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease. Neurology 92(15):e1669\u2013e1677","journal-title":"Neurology"},{"issue":"6","key":"5038_CR38","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.preteyeres.2008.09.003","volume":"27","author":"C Kaur","year":"2008","unstructured":"Kaur C, Foulds WS, Ling EA (2008) Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res 27(6):622\u2013647","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"5038_CR39","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","volume":"206","author":"N Patton","year":"2005","unstructured":"Patton N, Aslam T, MacGillivray T, Pattie A, Deary IJ, Dhillon B (2005) Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat 206(4):319\u2013348","journal-title":"J Anat"},{"issue":"40","key":"5038_CR40","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.2174\/1381612825666190115122622","volume":"24","author":"R Lenin","year":"2018","unstructured":"Lenin R, Thomas SM, Gangaraju R (2018) Endothelial activation and oxidative stress in neurovascular defects of the retina. Curr Pharm Des 24(40):4742\u20134754","journal-title":"Curr Pharm Des"},{"issue":"13","key":"5038_CR41","doi-asserted-by":"publisher","first-page":"e1158","DOI":"10.1212\/WNL.0000000000005205","volume":"90","author":"JA Deal","year":"2018","unstructured":"Deal JA, Sharrett AR, Rawlings AM, Gottesman RF, Bandeen-Roche K, Albert M, Knopman D, Selvin E, Wasserman BA, Klein B, Klein R (2018) Retinal signs and 20-year cognitive decline in the Atherosclerosis Risk in Communities Study. Neurology 90(13):e1158\u2013e1166","journal-title":"Neurology"},{"issue":"1","key":"5038_CR42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.09.002","volume":"23","author":"CY Cheung","year":"2014","unstructured":"Cheung CY, Ong SY, Ikram MK, Ong YT, Chen CP, Venketasubramanian N, Wong TY (2014) Retinal vascular fractal dimension is associated with cognitive dysfunction. J Stroke Cerebrovasc Dis 23(1):43\u201350","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"4","key":"5038_CR43","doi-asserted-by":"publisher","first-page":"e0214685","DOI":"10.1371\/journal.pone.0214685","volume":"14","author":"YS Zhang","year":"2019","unstructured":"Zhang YS, Zhou N, Knoll BM, Samra S, Ward MR, Weintraub S, Fawzi AA (2019) Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer\u2019s disease on optical coherence tomography angiography. PLoS One 14(4):e0214685","journal-title":"PLoS One"},{"issue":"1\u20132","key":"5038_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1900\/RDS.2015.12.159","volume":"12","author":"AJ Jenkins","year":"2015","unstructured":"Jenkins AJ, Joglekar MV, Hardikar AA, Keech AC, O'Neal DN, Januszewski AS (2015) Biomarkers in diabetic retinopathy. Rev Diabet Stud 12(1\u20132):159\u2013195","journal-title":"Rev Diabet Stud"},{"issue":"6","key":"5038_CR45","doi-asserted-by":"publisher","first-page":"e0233975","DOI":"10.1371\/journal.pone.0233975","volume":"15","author":"C Criscuolo","year":"2020","unstructured":"Criscuolo C, Cennamo G, Montorio D, Carotenuto A, Strianese A, Salvatore E, Tranfa F, Cennamo G, Lanzillo R, Brescia Morra V (2020) Assessment of retinal vascular network in amnestic mild cognitive impairment by optical coherence tomography angiography. PLoS One 15(6):e0233975","journal-title":"PLoS One"},{"key":"5038_CR46","doi-asserted-by":"publisher","first-page":"42201","DOI":"10.1038\/srep42201","volume":"7","author":"JP Campbell","year":"2017","unstructured":"Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, Huang D (2017) Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography. Sci Rep 7:42201","journal-title":"Sci Rep"},{"issue":"4","key":"5038_CR47","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/IJG.0000000000000900","volume":"27","author":"L Zhu","year":"2018","unstructured":"Zhu L, Zong Y, Yu J, Jiang C, He Y, Jia Y, Huang D, Sun X (2018) Reduced retinal vessel density in primary angle closure glaucoma. J Glaucoma 27(4):322\u2013327","journal-title":"J Glaucoma"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05038-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-021-05038-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05038-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T03:03:19Z","timestamp":1674874999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-021-05038-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["5038"],"URL":"https:\/\/doi.org\/10.1007\/s10072-021-05038-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"4 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies involving human participants were in accordance with the Scientific Research Projects Approval Determination of Ethics Committee of The First Affiliated Hospital of Anhui Medical University, with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All the experiments were conducted with the consent of the patient and his\/her family, and written informed consent was obtained in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}