{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:30:16Z","timestamp":1775514616628,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013318","name":"ShanXi Science and Technology Department","doi-asserted-by":"publisher","award":["201704D13111584"],"award-info":[{"award-number":["201704D13111584"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s10072-021-05166-6","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T09:12:30Z","timestamp":1615453950000},"page":"4657-4666","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fasciculation score: a sensitive biomarker in amyotrophic lateral sclerosis"],"prefix":"10.1007","volume":"42","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueli","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"issue":"4","key":"5166_CR1","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.clinph.2014.06.052","volume":"126","author":"A Grimm","year":"2015","unstructured":"Grimm A, Prell T, D\u00e9card BF, Schumacher U, Witte OW, Axer H, Grosskreutz J (2015) Muscle ultrasonography as an additional diagnostic tool for the diagnosis of amyotrophic lateral sclerosis. Clin Neurophysiol 126(4):820\u2013827. https:\/\/doi.org\/10.1016\/j.clinph.2014.06.052","journal-title":"Clin Neurophysiol"},{"issue":"16","key":"5166_CR2","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1212\/WNL.0b013e318233b36a","volume":"77","author":"S Misawa","year":"2011","unstructured":"Misawa S, Noto Y, Shibuya K, Isose S, Sekiguchi Y, Nasu S, Kuwabara S (2011) Ultrasonographic detection of fasciculations markedly increases diagnostic sensitivity of ALS. Neurology 77(16):1532\u20131537. https:\/\/doi.org\/10.1212\/WNL.0b013e318233b36a","journal-title":"Neurology"},{"key":"5166_CR3","doi-asserted-by":"crossref","unstructured":"Benjamin R, Brooks (1994) \u201cEl escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis,\u201d J Neurol Sci","DOI":"10.1016\/0022-510X(94)90191-0"},{"issue":"6","key":"5166_CR4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1080\/01616412.2020.1738100","volume":"42","author":"W Juan","year":"2020","unstructured":"Juan W, Fang L, Qi W, Jing M, Shan H, Jing Z, Xueli C, Wei Z, Junhong G (2020) Muscle ultrasonography in the diagnosis of amyotrophic lateral sclerosis. Neurol Res 42(6):458\u2013462. https:\/\/doi.org\/10.1080\/01616412.2020.1738100","journal-title":"Neurol Res"},{"issue":"3","key":"5166_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","volume":"119","author":"M de Carvalho","year":"2008","unstructured":"de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura J, Mills K, Mitsumoto H, Nodera H, Shefner J, Swash M (2008) Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol 119(3):497\u2013503. https:\/\/doi.org\/10.1016\/j.clinph.2007.09.143","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"5166_CR6","doi-asserted-by":"publisher","first-page":"III1","DOI":"10.1007\/BF03161081","volume":"246","author":"A Chi\u00f2","year":"1999","unstructured":"Chi\u00f2 A (1999) ISIS Survey: an international study on the diagnostic process and its implications in amyotrophic lateral sclerosis. J Neurol 246(3):III1\u2013III5","journal-title":"J Neurol"},{"key":"5166_CR7","doi-asserted-by":"crossref","unstructured":"Hardiman et al. (2011) \u201cClinical diagnosis and management of amyotrophic lateral sclerosis.,\u201d Nat Rev Neurol","DOI":"10.1007\/978-1-84996-011-3_7"},{"issue":"9","key":"5166_CR8","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1136\/jnnp-2017-315574","volume":"88","author":"M De Carvalho","year":"2017","unstructured":"De Carvalho M, Kiernan MC, Swash M (2017) Fasciculation in amyotrophic lateral sclerosis: origin and pathophysiological relevance. J Neurol Neurosurg Psychiatry 88(9):773\u2013779. https:\/\/doi.org\/10.1136\/jnnp-2017-315574","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"5166_CR9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/(sici)1097-4598(199803)21:3<336::aid-mus7>3.3.co;2-5","volume":"21","author":"M de Carvalho","year":"1998","unstructured":"de Carvalho M, Swash M (1998) Fasciculation potentials: a study of amyotrophic lateral sclerosis and other neurogenic disorders. Muscle Nerve 21(3):336\u2013344. https:\/\/doi.org\/10.1002\/(sici)1097-4598(199803)21:3<336::aid-mus7>3.3.co;2-5","journal-title":"Muscle Nerve"},{"issue":"9","key":"5166_CR10","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1136\/jnnp-2012-304545","volume":"84","author":"M De Carvalho","year":"2013","unstructured":"De Carvalho M, Swash M (2013) Fasciculation potentials and earliest changes in motor unit physiology in ALS. J Neurol Neurosurg Psychiatry 84(9):963\u2013968. https:\/\/doi.org\/10.1136\/jnnp-2012-304545","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"12","key":"5166_CR11","first-page":"1741","volume":"57","author":"Traynor","year":"2000","unstructured":"Traynor (2000) Clinical features of amyotrophic lateral sclerosis according to the El Escorial and Airlie house diagnostic criteria: a population-based study (vol 57, pg 1171, 2000). JAMA Neurol 57(12):1741","journal-title":"JAMA Neurol"},{"issue":"5","key":"5166_CR12","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/mus.20748","volume":"35","author":"AA Makki","year":"2007","unstructured":"Makki AA, Benatar M (2007) The electromyographic diagnosis of amyotrophic lateral sclerosis: does the evidence support the El Escorial criteria? Muscle Nerve 35(5):614\u2013619","journal-title":"Muscle Nerve"},{"issue":"5","key":"5166_CR13","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.clinph.2013.10.052","volume":"125","author":"T Shimizu","year":"2014","unstructured":"Shimizu T, Fujimaki Y, Nakatani-Enomoto S, Matsubara S, Watabe K, Rossini PM, Ugawa Y (2014) Complex fasciculation potentials and survival in amyotrophic lateral sclerosis. Clin Neurophysiol 125(5):1059\u20131064","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"5166_CR14","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/BF00900945","volume":"243","author":"CD Reimers","year":"1996","unstructured":"Reimers CD, Ziemann U, Scheel A, Rieckmann P, Kurth C (1996) Fasciculations: clinical, electromyographic, and ultrasonographic assessment. J Neurol 243(8):579\u2013584","journal-title":"J Neurol"},{"issue":"1","key":"5166_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.clinph.2019.08.017","volume":"131","author":"K Bokuda","year":"2020","unstructured":"Bokuda K, Shimizu T, Kimura H, Morishima R, Kamiyama T, Kawata A, Nakayama Y, Isozaki E (2020) Relationship between EMG-detected and ultrasound-detected fasciculations in amyotrophic lateral sclerosis: a prospective cohort study. Clin Neurophysiol 131(1):259\u2013264. https:\/\/doi.org\/10.1016\/j.clinph.2019.08.017","journal-title":"Clin Neurophysiol"},{"issue":"7\u20138","key":"5166_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3109\/21678421.2014.913636","volume":"15","author":"L Tremolizzo","year":"2014","unstructured":"Tremolizzo L, Susani E, Aliprandi A, Salmaggi A, Ferrarese C, Appollonio I (2014) Muscle ultrasonography for detecting fasciculations in frontotemporal dementia. Amyotroph Lateral Scler Front Degener 15(7\u20138):546\u2013550. https:\/\/doi.org\/10.3109\/21678421.2014.913636","journal-title":"Amyotroph Lateral Scler Front Degener"},{"issue":"1","key":"5166_CR17","first-page":"29","volume":"1","author":"D Carvalho","year":"1999","unstructured":"Carvalho D, Bentes C, Teresinh, Mamede (1999) Fibrillation and sharp-waves: do we need them to diagnose ALS? Amyotroph Lateral Scler Other Mot Neuron Disord 1(1):29\u201332","journal-title":"Amyotroph Lateral Scler Other Mot Neuron Disord"},{"issue":"6","key":"5166_CR18","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/mus.25676","volume":"56","author":"CM O\u2019gorman","year":"2017","unstructured":"O\u2019gorman CM et al (2017) Detecting fasciculations in cranial nerve innervated muscles with ultrasound in amyotrophic lateral sclerosis. Muscle Nerve 56(6):1072\u20131076. https:\/\/doi.org\/10.1002\/mus.25676","journal-title":"Muscle Nerve"},{"issue":"6","key":"5166_CR19","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/mus.25607","volume":"56","author":"YI Noto","year":"2017","unstructured":"Noto YI, Shibuya K, Shahrizaila N, Huynh W, Matamala JM, Dharmadasa T, Kiernan MC (2017) Detection of fasciculations in amyotrophic lateral sclerosis: the optimal ultrasound scan time. Muscle Nerve 56(6):1068\u20131071. https:\/\/doi.org\/10.1002\/mus.25607","journal-title":"Muscle Nerve"},{"issue":"2","key":"5166_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/mus.26487","volume":"60","author":"LD Hobson-Webb","year":"2019","unstructured":"Hobson-Webb LD, Simmons Z (2019) Ultrasound in the diagnosis and monitoring of amyotrophic lateral sclerosis: a review. Muscle Nerve 60(2):114\u2013123. https:\/\/doi.org\/10.1002\/mus.26487","journal-title":"Muscle Nerve"},{"issue":"12","key":"5166_CR21","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1016\/j.clinph.2014.04.009","volume":"125","author":"HH Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer HH, Vlazak A, D\u00f6ring K, Tanislav C, Allend\u00f6rfer J, Kaps M (2014) Excellent interrater agreement for the differentiation of fasciculations and artefacts \u2013 a dynamic myosonography study. Clin Neurophysiol 125(12):2441\u20132445","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"5166_CR22","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.clinph.2018.01.061","volume":"129","author":"Y-i Noto","year":"2018","unstructured":"Noto Y-i et al (2018) Ectopic impulse generation in peripheral nerve hyperexcitability syndromes and amyotrophic lateral sclerosis. Clin Neurophysiol 129(5):974\u2013980. https:\/\/doi.org\/10.1016\/j.clinph.2018.01.061","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"5166_CR23","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1016\/j.clinph.2017.08.031","volume":"128","author":"MT Johansson","year":"2017","unstructured":"Johansson MT, Ellegaard HR, Tankisi H, Fuglsang-Frederiksen A, Qerama E (2017) Fasciculations in nerve and muscle disorders \u2013 a prospective study of muscle ultrasound compared to electromyography. Clin Neurophysiol 128(11):2250\u20132257. https:\/\/doi.org\/10.1016\/j.clinph.2017.08.031","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"5166_CR24","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.clinph.2017.02.015","volume":"128","author":"Y Tsuji","year":"2017","unstructured":"Tsuji Y, Noto Y-i, Shiga K, Teramukai S, Nakagawa M, Mizuno T (2017) A muscle ultrasound score in the diagnosis of amyotrophic lateral sclerosis. Clin Neurophysiol 128(6):1069\u20131074. https:\/\/doi.org\/10.1016\/j.clinph.2017.02.015","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"5166_CR25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 1(5):293\u2013299. https:\/\/doi.org\/10.1080\/146608200300079536","journal-title":"Amyotroph Lateral Scler"},{"key":"5166_CR26","doi-asserted-by":"crossref","unstructured":"Labra J, Menon P, Byth K et al. (2015) \u201cRate of disease progression: a prognostic biomarker in ALS,\u201d J Neurol Neurosurg Psychiatry, vol. jnnp-2015-","DOI":"10.1136\/jnnp-2015-310998"},{"issue":"10","key":"5166_CR27","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.clinph.2018.07.015","volume":"129","author":"J Tsugawa","year":"2018","unstructured":"Tsugawa J, Dharmadasa T, Ma Y, Huynh W, Vucic S, Kiernan MC (2018) Fasciculation intensity and disease progression in amyotrophic lateral sclerosis. Clin Neurophysiol 129(10):2149\u20132154. https:\/\/doi.org\/10.1016\/j.clinph.2018.07.015","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"5166_CR28","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1093\/brain\/awq290","volume":"133","author":"KR Mills","year":"2010","unstructured":"Mills KR (2010) Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome. Brain 133(11):3458\u20133469","journal-title":"Brain"},{"key":"5166_CR29","doi-asserted-by":"crossref","unstructured":"Rana SS, Schramke CJ, Sangha A, Karpinski AC (2009) \u201cComparison of psychosocial factors between patients with benign fasciculations and those with amyotrophic lateral sclerosis,\u201d Ann Indian Acad Neurol, vol. 12, no. 2","DOI":"10.4103\/0972-2327.53079"},{"key":"5166_CR30","unstructured":"Shibuya K (2019) \u201c[Split hand: characteristic neurological symptoms in ALS].,\u201d Brain Nerve, vol. Nov, no. 71(11), pp. 1145\u20131151"},{"key":"5166_CR31","doi-asserted-by":"crossref","unstructured":"Seok HY, Park J, Kim YH et al. (2018) \u201cSplit hand muscle echo intensity index as a reliable imaging marker for differential diagnosis of amyotrophic lateral sclerosis,\u201d J Neurol Neurosurg Psychiatry, vol. jnnp-2017-","DOI":"10.1136\/jnnp-2017-317917"},{"issue":"16","key":"5166_CR32","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1212\/WNL.0b013e318233b3c4","volume":"77","author":"M Swash","year":"2011","unstructured":"Swash M, De Carvalho M (2011) Muscle ultrasound detects fasciculations and facilitates diagnosis in ALS. Neurology 77(16):1508\u20131509. https:\/\/doi.org\/10.1212\/WNL.0b013e318233b3c4","journal-title":"Neurology"},{"issue":"1\u20132","key":"5166_CR33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3109\/17482960903062137","volume":"11","author":"J Fermont","year":"2010","unstructured":"Fermont J, Arts IMP, Overeem S, Kleine BU, Schelhaas HJ, Zwarts MJ (2010) Prevalence and distribution of fasciculations in healthy adults: effect of age, caffeine consumption and exercise. Amyotroph Lateral Scler Other Mot Neuron Disord 11(1\u20132):181\u2013186","journal-title":"Amyotroph Lateral Scler Other Mot Neuron Disord"},{"key":"5166_CR34","doi-asserted-by":"crossref","unstructured":"De Carvalho M, Swash M (2016) \u201cLower motor neuron dysfunction in ALS,\u201d Clin Neurophysiol, p. S1388245716300062","DOI":"10.1016\/j.clinph.2016.03.024"},{"issue":"5","key":"5166_CR35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neurol.2017.04.002","volume":"173","author":"AM Grapperon","year":"2017","unstructured":"Grapperon AM, Attarian S (2017) Disorders of motor neurons manifested by hyperactivity. Rev Neurol (Paris) 173(5):345\u2013351. https:\/\/doi.org\/10.1016\/j.neurol.2017.04.002","journal-title":"Rev Neurol (Paris)"},{"issue":"12","key":"5166_CR36","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1007\/s10072-016-2692-9","volume":"37","author":"K Bokuda","year":"2016","unstructured":"Bokuda K, Shimizu T, Kimura H, Yamazaki T, Kamiyama T, Watabe K, Kawata A, Hayashi M, Isozaki E (2016) Quantitative analysis of the features of fasciculation potentials and their relation with muscle strength in amyotrophic lateral sclerosis. Neurol Sci 37(12):1939\u20131945","journal-title":"Neurol Sci"}],"updated-by":[{"DOI":"10.1007\/s10072-024-07807-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000}}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05166-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-021-05166-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05166-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T09:06:52Z","timestamp":1729588012000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-021-05166-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["5166"],"URL":"https:\/\/doi.org\/10.1007\/s10072-021-05166-6","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10072-024-07807-y","asserted-by":"object"}]},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"13 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10072-024-07807-y","URL":"https:\/\/doi.org\/10.1007\/s10072-024-07807-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was preliminarily obtained from all patients and controls before their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}