{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:43:41Z","timestamp":1784180621122,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Reaserach funds Pisa University Medical School"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and rationale<\/jats:title>\n                <jats:p>Histopathological studies revealed degeneration of the dorsal motor nucleus of the vagus nerve (VN) early in the course of idiopathic Parkinson\u2019s disease (IPD). Degeneration of VN axons should be detectable by high-resolution ultrasound (HRUS) as a thinning of the nerve trunk. In order to establish if the VN exhibits sonographic signs of atrophy in IPD, we examined patients with IPD compared with age-matched controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>We measured the caliber (cross-sectional area, CSA) and perimeter of the VN in 20 outpatients with IPD (8 females and 12 males; mean age 73.0 <jats:underline>+<\/jats:underline> 8.6 years) and in age-matched controls using HRUS. Evaluation was performed by blinded raters using an Esaote MyLab Gamma device in conventional B-Mode with an 8\u201319 MHz probe.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In both sides, the VN CSA was significantly smaller in IPD outpatients than in controls (right 2.37 <jats:underline>+<\/jats:underline> 0.91, left 1.87 <jats:underline>+<\/jats:underline> 1.35 mm<jats:sup>2<\/jats:sup> versus 6.0 <jats:underline>+<\/jats:underline> 1.33, 5.6 <jats:underline>+<\/jats:underline> 1.26 mm<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic> &lt;0.001), as well as the perimeter (right 5.06 <jats:underline>+<\/jats:underline> 0.85, left 4.78 <jats:underline>+<\/jats:underline> 1.74 mm versus 8.87 <jats:underline>+<\/jats:underline> 0.86, 8.58 + 0.97 mm; <jats:italic>p<\/jats:italic> &lt;0.001). There were no significant correlations between VN CSA and age, the Hoehn and Yahr scale, L-dopa therapy, and disease duration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our findings provide evidence of atrophy of the VNs in IPD patients by HRUS. Moreover, HRUS of the VN represent a non-invasive easy imaging modality of screening in IPD patients independent of disease stage and duration and an interesting possible additional index of disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-021-05183-5","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T20:02:29Z","timestamp":1617652949000},"page":"5205-5211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High-resolution ultrasound changes of the vagus nerve in idiopathic Parkinson\u2019s disease (IPD): a possible additional index of disease"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-679X","authenticated-orcid":false,"given":"F.","family":"Sartucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Santin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bongioanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"5183_CR1","doi-asserted-by":"crossref","unstructured":"Xu L., Pu J. 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