{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:46Z","timestamp":1792425706878,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s10072-021-05326-8","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T03:47:25Z","timestamp":1621568845000},"page":"435-440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predictive value of admission neutrophil\/lymphocyte ratio in symptomatic intracranial hemorrhage after stroke thrombolysis"],"prefix":"10.1007","volume":"43","author":[{"given":"O\u011fuz","family":"\u00d6ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemile","family":"Haki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melih","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"issue":"4","key":"5326_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.emc.2017.07.007","volume":"35","author":"CR Cassella","year":"2017","unstructured":"Cassella CR, Jagoda A (2017) Ischemic stroke: advances in diagnosis and management. Emerg Med Clin North Am 35(4):911\u2013930","journal-title":"Emerg Med Clin North Am"},{"issue":"3","key":"5326_CR2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/MBC.0000000000000227","volume":"26","author":"E Baysal","year":"2015","unstructured":"Baysal E, Cetin M, Yaylak B, Altntas B, Altndag R, Adyaman S et al (2015) Roles of the red cell distribution width and neutrophil\/lymphocyte ratio in predicting thrombolysis failure in patients with an ST-segment elevation myocardial infarction. Blood Coagul Fibrinolysis 26(3):274\u2013278","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"5326_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12974-016-0680-x","volume":"13","author":"Z Guo","year":"2016","unstructured":"Guo Z, Yu S, Xiao L, Chen X, Ye R, Zheng P, Dai Q, Sun W, Zhou C, Wang S, Zhu W, Liu X (2016) Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke. J Neuroinflammation 13(1):199","journal-title":"J Neuroinflammation"},{"issue":"2","key":"5326_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.5152\/eajem.2016.39974","volume":"15","author":"U Lok","year":"2016","unstructured":"Lok U, Gulacti U (2016) The predictive effect of the neutrophil-to-lymphocyte ratio (NLR) on the mortality of acute ischemic stroke and its subtypes: a retrospective cross-sectional study. Eur J Emerg Med 15(2):69\u201372","journal-title":"Eur J Emerg Med"},{"issue":"8","key":"5326_CR5","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1007\/s10072-020-04324-6","volume":"41","author":"A Ying","year":"2020","unstructured":"Ying A, Cheng Y, Lin Y, Yu J, Wu X, Lin Y (2020) Dynamic increase in neutrophil levels predicts parenchymal hemorrhage and function outcome of ischemic stroke with r-tPA thrombolysis. Neurol Sci 41(8):2215\u20132223","journal-title":"Neurol Sci"},{"issue":"13","key":"5326_CR6","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, D\u00e1valos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359(13):1317\u20131329","journal-title":"N Engl J Med"},{"issue":"10","key":"5326_CR7","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1212\/WNL.0b013e31822dc795","volume":"77","author":"HC Koennecke","year":"2011","unstructured":"Koennecke HC, Belz W, Berfelde D, Endres M, Fitzek S, Hamilton F, Kreitsch P, Mackert BM, Nabavi DG, Nolte CH, Pohls W, Schmehl I, Schmitz B, von Brevern M, Walter G, Heuschmann PU, For the Berlin Stroke Register Investigators (2011) Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology. 77(10):965\u2013972","journal-title":"Neurology."},{"issue":"4","key":"5326_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1212\/WNL.0b013e31824367ab","volume":"78","author":"M Knoflach","year":"2012","unstructured":"Knoflach M, Matosevic B, R\u00fccker M, Furtner M, Mair A, Wille G et al (2012) Functional recovery after ischemic stroke--a matter of age: data from the Austrian Stroke Unit Registry. Neurology. 78(4):279\u2013285","journal-title":"Neurology."},{"issue":"6","key":"5326_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.7326\/M16-1754","volume":"166","author":"J Weiss","year":"2017","unstructured":"Weiss J, Freeman M, Low A, Fu R, Kerfoot A, Paynter R, Motu'apuaka M, Kondo K, Kansagara D (2017) Benefits and harms of intensive blood pressure treatment in adults aged 60 years or older: a systematic review and meta-analysis. Ann Intern Med 166(6):419\u2013429","journal-title":"Ann Intern Med"},{"issue":"3","key":"5326_CR10","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s12640-017-9707-z","volume":"31","author":"S Qun","year":"2017","unstructured":"Qun S, Tang Y, Sun J, Liu Z, Wu J, Zhang J, Guo J, Xu Z, Zhang D, Chen Z, Hu F, Xu X, Ge W (2017) Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke. Neurotox Res 31(3):444\u2013452","journal-title":"Neurotox Res"},{"issue":"3","key":"5326_CR11","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s12640-017-9707-z","volume":"31","author":"S Qun","year":"2017","unstructured":"Qun S, Tang Y, Sun J, Liu Z, Wu J, Zhang J, Guo J, Xu Z, Zhang D, Chen Z, Hu F, Xu X, Ge W (2017) Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke. Neurotox Res 31(3):444\u2013452","journal-title":"Neurotox Res"},{"issue":"2","key":"5326_CR12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000339675","volume":"34","author":"RC Seet","year":"2012","unstructured":"Seet RC, Rabinstein AA (2012) Symptomatic intracranial hemorrhage following intravenous thrombolysis for acute ischemic stroke: a critical review of case definitions. Cerebrovasc Dis 34(2):106\u2013114","journal-title":"Cerebrovasc Dis"},{"issue":"9","key":"5326_CR13","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.04.027","volume":"27","author":"X Xu","year":"2018","unstructured":"Xu X, Wang D, Wang F, Norton C, Liu X, Selim M (2018) The risk of hemorrhagic transformation after thrombolysis for acute ischemic stroke in Chinese versus North Americans: a comparative study. J Stroke Cerebrovasc Dis 27(9):2381\u20132387","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"10","key":"5326_CR14","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1161\/01.STR.27.10.1739","volume":"27","author":"SE Akopov","year":"1996","unstructured":"Akopov SE, Simonian NA, Grigorian GS (1996) Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage. Stroke. 27(10):1739\u20131743","journal-title":"Stroke."},{"issue":"1","key":"5326_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/jcla.21639","volume":"28","author":"A Celikbilek","year":"2014","unstructured":"Celikbilek A, Ismailogullari S, Zararsiz G (2014) Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal 28(1):27\u201331","journal-title":"J Clin Lab Anal"},{"key":"5326_CR16","doi-asserted-by":"crossref","unstructured":"Goyal N, Tsivgoulis G, Chang JJ, Malhotra K, Pandhi A, Ishfaq MF, Alsbrook D, Arthur AS, Elijovich L, Alexandrov AV (2018) Admission Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker of Outcomes in Large Vessel Occlusion Strokes. Stroke 49(8):1985\u20131987","DOI":"10.1161\/STROKEAHA.118.021477"},{"issue":"8","key":"5326_CR17","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1136\/neurintsurg-2013-010780","volume":"6","author":"SD Brooks","year":"2014","unstructured":"Brooks SD, Spears C, Cummings C, VanGilder RL, Stinehart KR, Gutmann L et al (2014) Admission neutrophil-lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy. J Neurointerv Surg 6(8):578\u2013583","journal-title":"J Neurointerv Surg"},{"issue":"16","key":"5326_CR18","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1212\/WNL.0000000000002029","volume":"85","author":"I Maestrini","year":"2015","unstructured":"Maestrini I, Strbian D, Gautier S, Haapaniemi E, Moulin S, Sairanen T, Dequatre-Ponchelle N, Sibolt G, Cordonnier C, Melkas S, Leys D, Tatlisumak T, Bordet R (2015) Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes. Neurology 85(16):1408\u201316","journal-title":"Neurology"},{"issue":"11","key":"5326_CR19","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1161\/STROKEAHA.112.665331","volume":"43","author":"WN Whiteley","year":"2012","unstructured":"Whiteley WN, Slot KB, Fernandes P, Sandercock P, Wardlaw J (2012) Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies. Stroke. 43(11):2904\u20132909","journal-title":"Stroke."}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05326-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-021-05326-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05326-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T18:30:06Z","timestamp":1641234606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-021-05326-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["5326"],"URL":"https:\/\/doi.org\/10.1007\/s10072-021-05326-8","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]},"assertion":[{"value":"12 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors obtained approval from the ethics committee of the Bursa Y\u00fcksek \u0130htisas Training and Research Hospital with the protocol number 2011-KAEK-25 2018\/06-42.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This is a retrospective study and, therefore, the ethical board of our institution did not require an informed consent of the patients to perform this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were performed in accordance with the 1964 Helsinki Declaration. Reported patients were conducted in accordance with good clinical practice respectful of any human rights.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"This article does not contain any studies with animals.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and\/or animal studies"}}]}}