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Diagnostic properties of assessments for this specific ADL impairment are sparsely investigated in PD. The ability of the Functional Activities Questionnaire (FAQ) for differentiating between PD patients with normal cognition and with mild cognitive impairment (PD-MCI), according to informant and self-reports, was examined. Global cognitive function in groups with and without mild ADL impairment was compared according to different cut-offs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Multicenter data of 589 patients of an international cohort (CENTRE-PD) were analyzed. Analyses were run separately for informant-rated and self-rated FAQ. Receiver operating characteristic (ROC) analysis was conducted to define the optimal FAQ cut-off for PD-MCI (\u2265\u20091), and groups were additionally split according to reported FAQ cut-offs for PD-MCI in the literature (\u2265\u20093,\u2009\u2265\u20095). Binary logistic regressions examined the effect of the Montreal Cognitive Assessment (MoCA) score in PD patients with and without mild ADL impairment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Two hundred and twenty-five (38.2%) patients were classified as PD-MCI. For all three cut-off values, sensitivity was moderate to low (&lt;\u20090.55), but specificity was moderately high (&gt;\u20090.54) with a tendency of higher values for self-reported deficits. For the self-report, the cut-off\u2009\u2265\u20093 showed a significant effect of the MoCA (<jats:italic>B<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.31, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), where FAQ\u2009\u2265\u20093 patients had worse cognition. No effect for group differences based on informant ratings was detected.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our data argue that self-reported ADL impairments assessed by the FAQ show a relation to the severity of cognitive impairment in PD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-021-05365-1","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T02:02:49Z","timestamp":1623290569000},"page":"1047-1054","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantifying activities of daily living impairment in Parkinson\u2019s disease using the Functional Activities Questionnaire"],"prefix":"10.1007","volume":"43","author":[{"given":"Sara","family":"Becker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lawton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Hipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bowring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Sulzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejko","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0875-892X","authenticated-orcid":false,"given":"Inga","family":"Liepelt-Scarfone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"issue":"6","key":"5365_CR1","first-page":"441","volume":"102","author":"JG Goldman","year":"2011","unstructured":"Goldman JG, Litvan I (2011) Mild cognitive impairment in Parkinson\u2019s disease. 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The ABC-PD study was approved by the local ethics committee of the University of T\u00fcbingen. The Luxembourg Parkinson\u2019s Study was approved by the the National Ethics Board and Data Protection Committee. The OPDC Discovery Cohort was approved by the Berkshire Research Ethics Committee. For all studies, procedures were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients gave written informed consent for respective study participation at each of the three study centers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}