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No definite indications have yet been elaborated to guide neurologists in Fabry disease diagnostics. In current practice, it is usually sought in case of cryptogenic strokes (while Fabry-related strokes can also occur by classical pathogenic mechanisms) or through screening programs in young cerebrovascular populations. Data on recurrence and secondary prevention of Fabry\u2019s stroke are scanty.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study had a prospective observational design involving 33 Italian neurological Stroke Units. Considering the incidence of TIA\/stroke in the European population aged\u2009&lt;\u200960\u00a0years and the frequency of Fabry disease in this category (as foreseen by a pilot study held at the Careggi University-Hospital, Florence), we planned to screen for Fabry disease a total of 1740\u2009&lt;\u200960-year-old individuals hospitalized for TIA, ischemic, or hemorrhagic stroke. We investigated TIA and stroke pathogenesis through internationally validated scales and we gathered information on possible early signs of Fabry disease among all cerebrovascular patients. Every patient was tested for Fabry disease through dried blood spot analysis. Patients who received Fabry disease diagnosis underwent a 12-month follow-up to monitor stroke recurrence and multi-system progression after the cerebrovascular event.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The potential implications of this study are as follows: (i) to add information about the yield of systematic screening for Fabry disease in a prospective large cohort of acute cerebrovascular patients; (ii) to deepen knowledge of clinical, pathophysiological, and prognostic characteristics of Fabry-related stroke.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-021-05615-2","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T17:07:28Z","timestamp":1633453648000},"page":"2433-2439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fabry-Stroke Italian Registry (FSIR): a nationwide, prospective, observational study about incidence and characteristics of Fabry-related stroke in young-adults. 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A written informed consent was required before enrollment. Due to the merely observational nature of the study, patients were expected to receive diagnostic procedures and therapies in agreement with Italian guidelines for stroke management and neurological FD recommendations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"IR received travel grants from Sanofi-Genzyme, Takeda\u2013Shire, and Amicus; PN received speaker\u2019s honoraria from Takeda-Shire, Sanofi-Genzyme, and Amicus, MZ received travel and consultation grants from Takeda-Shire, Sanofi-Genzyme, and Amicus, DI receives speaker\u2019s honoraria from Takeda-Shire. Other authors declared that they have no competing interests for FSIR study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests\/Competing interests"}}]}}