{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T22:48:04Z","timestamp":1774219684709,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10072-021-05619-y","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T01:02:15Z","timestamp":1632618135000},"page":"2405-2411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical features of Trousseau\u2019s syndrome with multiple acute ischemic strokes"],"prefix":"10.1007","volume":"43","author":[{"given":"Yitong","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinye","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-7545","authenticated-orcid":false,"given":"Jintao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"5619_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13256-018-1833-6","volume":"13","author":"KI Aoyama","year":"2019","unstructured":"Aoyama KI, Tamura M, Uchibori M, Nakanishi Y, Arai T, Aoki T, Osawa Y, Kaneko A, Ota Y (2019) Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report. J Med Case Rep 13:26","journal-title":"J Med Case Rep"},{"key":"5619_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/bc.bc_1_18","volume":"4","author":"W Chen","year":"2018","unstructured":"Chen W, He Y, Su Y (2018) Multifocal cerebral infarction as the first manifestation of occult malignancy: Case series of trousseau\u2019s syndrome and literature review. Brain Circ 4:65\u201372","journal-title":"Brain Circ"},{"key":"5619_CR3","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.3174\/ajnr.A4846","volume":"37","author":"PF Finelli","year":"2016","unstructured":"Finelli PF, Nouh A (2016) Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome). AJNR Am J Neuroradiol 37:2033\u20132036","journal-title":"AJNR Am J Neuroradiol"},{"key":"5619_CR4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/jjco\/hyv165","volume":"46","author":"S Ikushima","year":"2016","unstructured":"Ikushima S, Ono R, Fukuda K, Sakayori M, Awano N, Kondo K (2016) Trousseau\u2019s syndrome: cancer-associated thrombosis. Jpn J Clin Oncol 46:204\u2013208","journal-title":"Jpn J Clin Oncol"},{"key":"5619_CR5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3892\/mco.2016.888","volume":"5","author":"M Ishikawa","year":"2016","unstructured":"Ishikawa M, Nakayama K, Ishibashi T, Sato E, Nakamura K, Katagiri H, Kyo S (2016) Case series of cerebral infarction with Trousseau\u2019s syndrome associated with malignant gynecological tumors. Mol Clin Oncol 5:138\u2013142","journal-title":"Mol Clin Oncol"},{"key":"5619_CR6","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3389\/fneur.2018.00528","volume":"9","author":"S Ito","year":"2018","unstructured":"Ito S, Kikuchi K, Ueda A, Nagao R, Maeda T, Murate K, Shima S, Mizutani Y, Niimi Y, Mutoh T (2018) Changes in Serial D-Dimer Levels Predict the Prognoses of Trousseau\u2019s Syndrome Patients. Front Neurol 9:528","journal-title":"Front Neurol"},{"key":"5619_CR7","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1212\/01.WNL.0000163850.07976.63","volume":"11","author":"TG Jovin","year":"2005","unstructured":"Jovin TG, Boosupalli V, Zivkovic SA, Wechsler LR, Gebel\u00a0JM (2005) High titers of CA-125 may be associated with recurrent ischemic strokes in patients with cancer. Neurology 11:1944\u20131945","journal-title":"Neurology"},{"key":"5619_CR8","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.3892\/ol.2016.5152","volume":"12","author":"T Kato","year":"2016","unstructured":"Kato T, Yasuda K, Iida H, Watanabe A, Fujiuchi Y, Miwa S, Imura J, Komiya A (2016) Trousseau\u2019s syndrome caused by bladder cancer producing granulocyte colony-stimulating factor and parathyroid hormone-related protein: A case report. Oncol Lett 12:4214\u20134218","journal-title":"Oncol Lett"},{"key":"5619_CR9","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1161\/STROKEAHA.109.571356","volume":"41","author":"SG Kim","year":"2010","unstructured":"Kim SG, Hong JM, Kim HY, Lee J, Chung PW, Park KY, Kim GM, Lee KH, Chung CS, Bang OY (2010) Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. Stroke 41:798\u2013801","journal-title":"Stroke"},{"key":"5619_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1212\/CPJ.0000000000000603","volume":"9","author":"AM Nouh","year":"2019","unstructured":"Nouh AM, Staff I, Finelli PF (2019) Three Territory Sign: An MRI marker of malignancy-related ischemic stroke (Trousseau syndrome). Neurol Clin Pract 9:124\u2013128","journal-title":"Neurol Clin Pract"},{"key":"5619_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-197756010-00001","volume":"56","author":"GH Sack Jr","year":"1977","unstructured":"Sack GH Jr, Levin J, Bell WR (1977) Trousseau\u2019s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine 56:1\u201337","journal-title":"Medicine"},{"key":"5619_CR12","first-page":"623","volume":"4","author":"M Shoko","year":"2018","unstructured":"Shoko M (2018) Trousseau\u2019s Syndrome Causing Refractory Deep Venous Thrombosis. Intern Med 4:623\u2013626","journal-title":"Intern Med"},{"key":"5619_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.01.007","volume":"17","author":"FS Taccone","year":"2008","unstructured":"Taccone FS, Jeangette SM, Blecic SA (2008) First-ever stroke as initial presentation of systemic cancer. J Stroke Cerebrovasc Dis 17:169\u2013174","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"5619_CR14","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.12.005","volume":"27","author":"S Takeshita","year":"2018","unstructured":"Takeshita S, Ogata T, Mera H, Tsugawa J, Aoki M, Takeshita M, Tsuboi Y (2018) Multiple Thrombi in the Heart in Trousseau Syndrome Caused by Pancreatic Carcinoma. J Stroke Cerebrovasc Dis 27:e75\u2013e77","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"5619_CR15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1538-7836.2007.02369.x","volume":"5","author":"ME Tesselaar","year":"2007","unstructured":"Tesselaar ME, Romijn FP, Van Der Linden IK, Prins FA, Bertina RM, Osanto S (2007) Microparticle-associated tissue factor activity: a link between cancer and thrombosis? J Thromb Haemostasis 5:520\u2013527","journal-title":"J Thromb Haemostasis"},{"key":"5619_CR16","first-page":"654","volume":"3","author":"A Trousseau","year":"1865","unstructured":"Trousseau A (1865) Plegmasia alba dolens. Clin Med l\u2019Hotel-Dieu Paris 3:654\u2013712","journal-title":"Clin Med l\u2019Hotel-Dieu Paris"},{"key":"5619_CR17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1756-9966-28-30","volume":"28","author":"IV Tsimafeyeu","year":"2009","unstructured":"Tsimafeyeu IV, Demidov LV, Madzhuga AV, Somonova OV, Yelizarova AL (2009) Hypercoagulability as a prognostic factor for survival in patients with metastatic renal cell carcinoma. J Exp Clin Cancer Res 28:30","journal-title":"J Exp Clin Cancer Res"},{"key":"5619_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jocn.2017.04.014","volume":"42","author":"T Umemura","year":"2017","unstructured":"Umemura T, Yamamoto J, Akiba D, Nishizawa S (2017) Bilateral cerebral embolism as a characteristic feature of patients with Trousseau syndrome. J Clin Neurosci 42:155\u2013159","journal-title":"J Clin Neurosci"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05619-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-021-05619-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05619-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T02:08:44Z","timestamp":1647050924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-021-05619-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,26]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["5619"],"URL":"https:\/\/doi.org\/10.1007\/s10072-021-05619-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-50061\/v1","asserted-by":"object"}]},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,26]]},"assertion":[{"value":"4 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of Rizhao People`s Hospital. A written informed consent form was obtained from each study participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}