{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:08:16Z","timestamp":1783807696279,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10072-021-05704-2","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T05:02:28Z","timestamp":1636088548000},"page":"2469-2480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral amyloid load determination in a clinical setting: interpretation of amyloid biomarker discordances aided by tau and neurodegeneration measurements"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-4748","authenticated-orcid":false,"given":"Matilde","family":"Nerattini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Arnone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Mazzeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Puccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"De Cristofaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pupi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sciagr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Berti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"issue":"4","key":"5704_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack","year":"2018","unstructured":"Jack CR, Bennett DA, Blennow K et al (2018) NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement 14(4):535\u2013562","journal-title":"Alzheimers Dement"},{"issue":"1","key":"5704_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13195-019-0532-x","volume":"11","author":"A De Wilde","year":"2019","unstructured":"De Wilde A, Reimand J, Teunissen CE et al (2019) Discordant amyloid-\u03b2 PET and CSF biomarkers and its clinical consequences. Alzheimers Res Ther 11(1):78 (Published 2019 Sep 12)","journal-title":"Alzheimers Res Ther"},{"issue":"9533","key":"5704_CR3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","volume":"368","author":"K Blennow","year":"2006","unstructured":"Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer\u2019s disease. Lancet 368(9533):387\u2013403","journal-title":"Lancet"},{"issue":"Pt 4","key":"5704_CR4","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1093\/brain\/aww015","volume":"139","author":"S Palmqvist","year":"2016","unstructured":"Palmqvist S, Mattsson N, Hansson O (2016) Cerebrospinal fluid analysis detects cerebral amyloid-\u03b2 accumulation earlier than positron emission tomography. Brain 139(Pt 4):1226\u20131236","journal-title":"Brain"},{"issue":"8","key":"5704_CR5","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S1474-4422(12)70142-4","volume":"11","author":"CM Clark","year":"2012","unstructured":"Clark CM, Pontecorvo MJ, Beach TG et al (2012) Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-\u03b2 plaques: a prospective cohort study. Lancet Neurol. 2012 Aug;11(8):658]. Lancet Neurol 11(8):669\u2013678","journal-title":"Lancet Neurol"},{"issue":"3","key":"5704_CR6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","volume":"7","author":"RA Sperling","year":"2011","unstructured":"Sperling RA, Aisen PS, Beckett LA et al (2011) Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7(3):280\u2013292","journal-title":"Alzheimers Dement"},{"issue":"6","key":"5704_CR7","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","volume":"13","author":"B Dubois","year":"2014","unstructured":"Dubois B, Feldman HH, Jacova C et al (2014) Advancing research diagnostic criteria for Alzheimer\u2019s disease: the IWG-2 criteria. Lancet Neurol. 13(6):614\u2013629 [published correction appears in Lancet Neurol. 2014 Aug;13(8):757]","journal-title":"Lancet Neurol."},{"issue":"3","key":"5704_CR8","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"MS Albert","year":"2011","unstructured":"Albert MS, DeKosky ST, Dickson D et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7(3):270\u2013279","journal-title":"Alzheimers Dement"},{"issue":"3","key":"5704_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7(3):263\u2013269","journal-title":"Alzheimers Dement"},{"issue":"5","key":"5704_CR10","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tips.2015.03.002","volume":"36","author":"K Blennow","year":"2015","unstructured":"Blennow K, Mattsson N, Sch\u00f6ll M, Hansson O, Zetterberg H (2015) Amyloid biomarkers in Alzheimer\u2019s disease. Trends Pharmacol Sci 36(5):297\u2013309","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"5704_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13195-019-0485-0","volume":"11","author":"O Hansson","year":"2019","unstructured":"Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P (2019) Advantages and disadvantages of the use of the CSF Amyloid \u03b2 (A\u03b2) 42\/40 ratio in the diagnosis of Alzheimer\u2019s Disease. Alzheimers Res Ther 11(1):34 (Published 2019 Apr 22)","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"5704_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/acn3.81","volume":"1","author":"N Mattsson","year":"2014","unstructured":"Mattsson N, Insel PS, Landau S et al (2014) Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer\u2019s disease. Ann Clin Transl Neurol 1(8):534\u2013543","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"5704_CR13","first-page":"826","volume":"74","author":"SM Landau","year":"2013","unstructured":"Landau SM, Lu M, Joshi AD et al (2013) Comparing positron emission tomography imaging and cerebrospinal fluid measurements of beta-amyloid. AnnNeurol 74(6):826\u2013836","journal-title":"AnnNeurol"},{"issue":"Pt 3","key":"5704_CR14","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/brain\/awu367","volume":"138","author":"N Mattsson","year":"2015","unstructured":"Mattsson N, Insel PS, Donohue M et al (2015) Independent information from cerebrospinal fluid amyloid-\u03b2 and florbetapir imaging in Alzheimer\u2019s disease. Brain 138(Pt 3):772\u2013783","journal-title":"Brain"},{"issue":"4","key":"5704_CR15","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1111\/j.1471-4159.2006.04404.x","volume":"101","author":"J Wiltfang","year":"2007","unstructured":"Wiltfang J, Esselmann H, Bibl M et al (2007) Amyloid \u03b2 peptide ratio 42\/40 but not A\u03b242 correlates with phospho-Tau in patients with low- and high-CSF A\u03b240 load. J Neurochem 101(4):1053\u20131059","journal-title":"J Neurochem"},{"issue":"3","key":"5704_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/acn3.274","volume":"3","author":"S Janelidze","year":"2016","unstructured":"Janelidze S, Zetterberg H, Mattsson N et al (2016) J CSF A\u03b242\/A\u03b240 and A\u03b242\/A\u03b238 ratios: better diagnostic markers of Alzheimer disease. Ann Clin Transl Neurol 3(3):154\u2013165","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"5704_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3233\/JAD-140771","volume":"43","author":"P Lewczuk","year":"2015","unstructured":"Lewczuk P, Lelental N, Spitzer P, Maler JM, Kornhuber J (2015) Amyloid-\u03b2 42\/40 cerebrospinal fluid concentration ratio in the diagnostics of Alzheimer\u2019s disease: validation of two novel assays. J Alzheimers Dis 43(1):183\u2013191","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"5704_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/jpm11010047","volume":"11","author":"G Giacomucci","year":"2021","unstructured":"Giacomucci G, Mazzeo S, Bagnoli S et al (2021) Matching clinical diagnosis and amyloid biomarkers in alzheimer\u2019s disease and frontotemporal dementia. J Pers Med 11(1):47","journal-title":"J Pers Med"},{"issue":"5","key":"5704_CR19","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1177\/1352458512460603","volume":"19","author":"K Augutis","year":"2013","unstructured":"Augutis K, Axelsson M, Portelius E et al (2013) Cerebrospinal fluid biomarkers of \u03b2-amyloid metabolism in multiple sclerosis. Mult Scler 19(5):543\u2013552","journal-title":"Mult Scler"},{"issue":"3","key":"5704_CR20","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3233\/JAD-132561","volume":"41","author":"M Zwan","year":"2014","unstructured":"Zwan M, van Harten A, Ossenkoppele R et al (2014) Concordance between cerebrospinal fluid biomarkers and [11C]PIB PET in a memory clinic cohort. J Alzheimers Dis 41(3):801\u2013807","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"5704_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/jon.12601","volume":"29","author":"P Alongi","year":"2019","unstructured":"Alongi P, Sardina DS, Coppola R et al (2019) 18F-Florbetaben PET\/CT to Assess Alzheimer\u2019s Disease: a new analysis method for regional amyloid quantification. J Neuroimaging 29(3):383\u2013393","journal-title":"J Neuroimaging"},{"key":"5704_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/bs.pmbts.2019.05.001","volume":"165","author":"PF Meyer","year":"2019","unstructured":"Meyer PF, McSweeney M, Gonneaud J, Villeneuve S (2019) AD molecular: PET amyloid imaging across the Alzheimer\u2019s disease spectrum: from disease mechanisms to prevention. Prog Mol Biol Transl Sci 165:63\u2013106","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"5704_CR23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3233\/JAD-200119","volume":"77","author":"G Lombardi","year":"2020","unstructured":"Lombardi G, Pupi A, Bessi V et al (2020) Challenges in Alzheimer\u2019s disease diagnostic work-up: amyloid biomarker incongruences. J Alzheimers Dis 77(1):203\u2013217","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"5704_CR24","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging. AJR Am J Roentgenol 149(2):351\u2013356","journal-title":"AJR Am J Roentgenol"},{"key":"5704_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.clinimag.2017.06.011","volume":"46","author":"S Rudilosso","year":"2017","unstructured":"Rudilosso S, San Rom\u00e1n L, Blasco J, Hern\u00e1ndez-P\u00e9rez M, Urra X, Chamorro \u00c1 (2017) Evaluation of white matter hypodensities on computed tomography in stroke patients using the Fazekas score. Clin Imaging 46:24\u201327","journal-title":"Clin Imaging"},{"key":"5704_CR26","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fnagi.2018.00253","volume":"10","author":"AL Kollhoff","year":"2018","unstructured":"Kollhoff AL, Howell JC, Hu WT (2018) Automation vs experience: measuring Alzheimer\u2019s beta-amyloid 1\u201342 peptide in the CSF. Front Aging Neurosci 10:253 (Published 2018 Aug 22)","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"5704_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/hbm.460020402","volume":"2","author":"KJ Friston","year":"1994","unstructured":"Friston KJ, Holmes AP, Worsley KJ, Poline J-P, Frith CD, Frackowiak RSJ (1994) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 2(4):189\u2013210","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"5704_CR28","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s12021-014-9235-4","volume":"12","author":"PA Della Rosa","year":"2014","unstructured":"Della Rosa PA, Cerami C, Gallivanone F et al (2014) A standardized [18F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia. Neuroinformatics 12(4):575\u2013593","journal-title":"Neuroinformatics"},{"issue":"6","key":"5704_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.nicl.2014.10.009","volume":"2014","author":"D Perani","year":"2014","unstructured":"Perani D, Della Rosa PA, Cerami C et al (2014) Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting. NeuroImage Clin 2014(6):445\u2013454","journal-title":"NeuroImage Clin"},{"key":"5704_CR30","doi-asserted-by":"publisher","first-page":"116189","DOI":"10.1016\/j.neuroimage.2019.116189","volume":"206","author":"ET Rolls","year":"2020","unstructured":"Rolls ET, Huang CC, Lin CP, Feng J, Joliot M (2020) Automated anatomical labelling atlas 3. Neuroimage. 206:116189","journal-title":"Neuroimage."},{"issue":"14","key":"5704_CR31","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1212\/WNL.0000000000001991","volume":"85","author":"S Palmqvist","year":"2015","unstructured":"Palmqvist S, Zetterberg H, Mattsson N et al (2015) Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease. Neurology 85(14):1240\u20131249","journal-title":"Neurology"},{"issue":"10","key":"5704_CR32","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1111\/ene.13728","volume":"25","author":"F Nobili","year":"2018","unstructured":"Nobili F, Arbizu J, Bouwman F et al (2018) European Association of Nuclear Medicine and European Academy of Neurology recommendations for the use of brain 18 F-fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: Delphi consensus. Eur J Neurol 25(10):1201\u20131217","journal-title":"Eur J Neurol"},{"issue":"3","key":"5704_CR33","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s11682-009-9067-2","volume":"3","author":"MT Fodero-Tavoletti","year":"2009","unstructured":"Fodero-Tavoletti MT, Cappai R, McLean CA et al (2009) Amyloid imaging in Alzheimer\u2019s disease and other dementias. Brain Imaging Behav 3(3):246\u2013261","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"5704_CR34","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239\u2013259","journal-title":"Acta Neuropathol"},{"issue":"1","key":"5704_CR35","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","volume":"8","author":"S Palmqvist","year":"2017","unstructured":"Palmqvist S, Sch\u00f6ll M, Strandberg O et al (2017) Earliest accumulation of \u03b2-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nat Commun 8(1):1214","journal-title":"Nat Commun"},{"key":"5704_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1749-6632.2011.06015.x","volume":"1228","author":"V Berti","year":"2011","unstructured":"Berti V, Pupi A, Mosconi L (2011) PET\/CT in diagnosis of dementia. Ann N Y Acad Sci 1228:81\u201392","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"5704_CR37","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1097\/NEN.0b013e3181aacbe9","volume":"68","author":"PT Nelson","year":"2009","unstructured":"Nelson PT, Abner EL, Schmitt FA et al (2009) Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from alzheimer disease. J Neuropathol Exp Neurol 68(7):774\u2013784","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"5704_CR38","doi-asserted-by":"publisher","first-page":"fcz046","DOI":"10.1093\/braincomms\/fcz046","volume":"2","author":"AJ Weigand","year":"2020","unstructured":"Weigand AJ, Bangen KJ, Thomas KR et al (2020) Is tau in the absence of amyloid on the Alzheimer\u2019s continuum?: A study of discordant PET positivity. Brain Commun 2(1):fcz046","journal-title":"Brain Commun"},{"issue":"2","key":"5704_CR39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3233\/JAD-150229","volume":"48","author":"D Weise","year":"2015","unstructured":"Weise D, Tiepolt S, Awissus C et al (2015) Critical Comparison of Different Biomarkers for Alzheimer\u2019s Disease in a Clinical Setting. J Alzheimers Dis 48(2):425\u2013432","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"5704_CR40","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1006\/nimg.2002.1208","volume":"17","author":"K Herholz","year":"2002","unstructured":"Herholz K, Salmon E, Perani D et al (2002) Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 17(1):302\u2013316","journal-title":"Neuroimage"},{"issue":"12","key":"5704_CR41","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00234-007-0269-2","volume":"49","author":"G Karas","year":"2007","unstructured":"Karas G, Scheltens P, Rombouts S et al (2007) Precuneus atrophy in early-onset Alzheimer\u2019s disease: A morphometric structural MRI study. Neuroradiology 49(12):967\u2013976","journal-title":"Neuroradiology"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05704-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-021-05704-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-021-05704-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T15:47:39Z","timestamp":1675871259000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-021-05704-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["5704"],"URL":"https:\/\/doi.org\/10.1007\/s10072-021-05704-2","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"21 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Participants (or their caregivers) gave informed consent for all investigations, and study procedures were approved by the local Institutional Review Board (reference 15691_oss).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}