{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:19:52Z","timestamp":1786699192069,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s10072-022-05929-9","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:02:42Z","timestamp":1646704962000},"page":"4275-4279","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiological and clinical characteristics of patients with late-onset Creutzfeldt-Jakob disease"],"prefix":"10.1007","volume":"43","author":[{"given":"Iliya","family":"Trachtenbroit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren S.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joab","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Rosenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeev","family":"Nitsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kahana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-2183","authenticated-orcid":false,"given":"Shmuel","family":"Appel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"5929_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1021\/ar0301678","volume":"37","author":"GL Millhauser","year":"2004","unstructured":"Millhauser GL (2004) Copper binding in the prion protein. Acc Chem Res 37:79\u201385","journal-title":"Acc Chem Res"},{"key":"5929_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nn.2483","volume":"13","author":"J Bremer","year":"2010","unstructured":"Bremer J, Baumann F, Tiberi C et al (2010) Axonal prion protein is required for peripheral myelin maintenance. Nat Neurosci 13:310\u2013318","journal-title":"Nat Neurosci"},{"issue":"1","key":"5929_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12915-017-0375-5","volume":"15","author":"MA Wulf","year":"2017","unstructured":"Wulf MA, Senatore A, Aguzzi A (2017) The biological function of the cellular prion protein: an update. BMC Biol 15(1):34","journal-title":"BMC Biol"},{"key":"5929_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.ncl.2007.03.006","volume":"25","author":"E Eggenberger","year":"2007","unstructured":"Eggenberger E (2007) Prion disease. Neurol Clin 25:833\u201342.viii","journal-title":"Neurol Clin"},{"key":"5929_CR5","doi-asserted-by":"publisher","first-page":"i36","DOI":"10.1136\/jnnp.2004.036137","volume":"75","author":"RS Knight","year":"2004","unstructured":"Knight RS, Will RG (2004) Prion diseases. J Neurol Neurosurg Psychiatry 75:i36\u2013i42","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5929_CR6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/0140-6736(90)93443-S","volume":"336","author":"LG Goldfarb","year":"1990","unstructured":"Goldfarb LG, Korczyn AD, Brown P, Chapman J, Gajdusek DC (1990) Mutation in codon 200 of scrapie amyloid precursor gene linked to Creutzfeldt-Jakob disease in Sephardic Jews of Libyan and non-Libyan origin. Lancet 336:637\u2013638","journal-title":"Lancet"},{"key":"5929_CR7","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1056\/NEJM199104183241604","volume":"324","author":"K Hsiao","year":"1991","unstructured":"Hsiao K, Meiner Z, Kahana E et al (1991) Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease. N Engl J Med 324:1091\u20131097","journal-title":"N Engl J Med"},{"key":"5929_CR8","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/BF00143127","volume":"7","author":"AD Korczyn","year":"1991","unstructured":"Korczyn AD (1991) Creutzfeldt-Jakob disease among Libyan Jews. Eur J Epidemiol 7:490\u2013493","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"5929_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40478-017-0503-z","volume":"6","author":"I Cali","year":"2018","unstructured":"Cali I, Cohen ML, Haik S et al (2018) Iatrogenic Creutzfeldt-Jakob disease with amyloid-\u03b2 pathology: an international study. Acta Neuropathol Commun 6(1):5","journal-title":"Acta Neuropathol Commun"},{"key":"5929_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1023\/A:1024683119263","volume":"18","author":"EA Croes","year":"2003","unstructured":"Croes EA, van Duijn CM (2003) Variant Creutzfeldt-Jakob disease. Eur J Epidemiol 18:473\u2013477","journal-title":"Eur J Epidemiol"},{"key":"5929_CR11","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1136\/jnnp.65.6.836","volume":"65","author":"PO Lundberg","year":"1998","unstructured":"Lundberg PO (1998) Creutzfeldt-Jakob disease in Sweden. J Neurol Neurosurg Psychiatry 65:836\u2013841","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5929_CR12","doi-asserted-by":"publisher","first-page":"S1525","DOI":"10.1016\/j.jamda.2021.08.010","volume":"4","author":"Y Sun","year":"2021","unstructured":"Sun Y, Fan LY, Huang CT et al (2021) Prognostic Features of Sporadic Creutzfeldt-Jakob Disease: an analysis of Taiwan\u2019s Nationwide Surveillance. J Am Med Dir Assoc. 4:S1525-8610(21)00736\u20132. https:\/\/doi.org\/10.1016\/j.jamda.2021.08.010","journal-title":"J Am Med Dir Assoc."},{"key":"5929_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/bmb\/66.1.213","volume":"66","author":"P Gambetti","year":"2003","unstructured":"Gambetti P, Kong Q, Zou W, Parchi P, Chen SG (2003) Sporadic and familial CJD: classification and characterisation. Br Med Bull 66:213\u2013239","journal-title":"Br Med Bull"},{"issue":"2","key":"5929_CR14","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1212\/WNL.0000000000007745","volume":"93","author":"E Minikel","year":"2019","unstructured":"Minikel E, Vallabh S, Orseth M et al (2019) Age at onset in genetic prion disease and the design of preventive clinical trials. Neurology 93(2):e125\u2013e134","journal-title":"Neurology"},{"key":"5929_CR15","first-page":"87","volume":"108","author":"R Knight","year":"2002","unstructured":"Knight R (2002) Epidemiology of variant CJD. Dev Biol (Basel) 108:87\u201392","journal-title":"Dev Biol (Basel)"},{"key":"5929_CR16","first-page":"211","volume":"21","author":"M Corato","year":"2006","unstructured":"Corato M, Cereda C, Cova E, Ferrarese C, Ceroni M (2006) Young-onset CJD: age and disease phenotype in variant and sporadic forms. Funct Neurol 21:211\u2013215","journal-title":"Funct Neurol"},{"key":"5929_CR17","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/ana.20568","volume":"58","author":"C Boesenberg","year":"2005","unstructured":"Boesenberg C, Schulz-Schaeffer WJ, Meissner B et al (2005) Clinical course in young patients with sporadic Creutzfeldt-Jakob disease. Ann Neurol 58:533\u2013543","journal-title":"Ann Neurol"},{"key":"5929_CR18","unstructured":"WHO (1998) Global surveillance, diagnosis and therapy of human transmissible spongiform encephalopathies: report of the WHO consultation. In: World health organization: emerging and other communicable diseases, surveillance and control, Geneva, pp 9\u201311"},{"key":"5929_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1600-0404.1998.tb00617.x","volume":"97","author":"HC Hansen","year":"1998","unstructured":"Hansen HC, Zschocke S, Sturenburg HJ, Kunze K (1998) Clinical changes and EEG patterns preceding the onset of periodic sharp wave complexes in Creutzfeldt-Jakob disease. Acta Neurol Scand 97:99\u2013106","journal-title":"Acta Neurol Scand"},{"key":"5929_CR20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/jon.12098","volume":"25","author":"F Caobelli","year":"2015","unstructured":"Caobelli F, Cobelli M, Pizzocaro C, Pavia M, Magnaldi S, Guerra UP (2015) The role of neuroimaging in evaluating patients affected by Creutzfeldt-Jakob disease: a systematic review of the literature. J Neuroimaging. 25:2\u201313","journal-title":"J Neuroimaging."},{"key":"5929_CR21","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1093\/brain\/awq216","volume":"133","author":"I Nozaki","year":"2010","unstructured":"Nozaki I, Hamaguchi T, Sanjo N et al (2010) Prospective 10-year surveillance of human prion diseases in Japan. Brain 133:3043\u20133057","journal-title":"Brain"},{"key":"5929_CR22","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/j.1468-1331.2010.02948.x","volume":"17","author":"SA Appel","year":"2010","unstructured":"Appel SA, Chapman J, Kahana E et al (2010) Rapidly progressive Creutzfeldt-Jakob disease in patients with Familial Mediterranean Fever. Eur J Neurol 17:861\u2013865","journal-title":"Eur J Neurol"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-05929-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-022-05929-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-05929-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:08:01Z","timestamp":1655784481000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-022-05929-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["5929"],"URL":"https:\/\/doi.org\/10.1007\/s10072-022-05929-9","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"10 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}