{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:22:20Z","timestamp":1790706140210,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The early differential diagnosis among neurodegenerative parkinsonian disorders becomes essential to set up the correct clinical-therapeutic approach. The increased utilization of [<jats:sup>18<\/jats:sup>F] fluoro-deoxy-glucose positron emission tomography (FDG PET) and the pressure for cost-effectiveness request a systematic evaluation and a validation of its utility in clinical practice. This retrospective study aims to consider the contribution, in terms of increasing accuracy and increasing diagnostic confidence, of voxel-based FDG PET analyses in the differential diagnosis of these disorders, including Parkinson\u2019s disease, multiple system atrophy, progressive supranuclear palsy, and cortico-basal syndrome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Eighty-three subjects with a clinically confirmed diagnosis of degenerative parkinsonian disorders who underwent FDG brain PET\/CT were selected. A voxel-based analysis was set up using statistical parametric mapping (SPM) on MATLAB to produce maps of brain hypometabolism and relative hypermetabolism. Four nuclear physicians (two expert and two not expert), blinded to the patients\u2019 symptoms, other physicians\u2019 evaluations, and final clinical diagnosis, independently evaluated all data by visual assessment and by adopting metabolic maps.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In not-expert evaluators, the support of both hypometabolism and hypermetabolism maps results in a significant increase in diagnostic accuracy as well as clinical confidence. In expert evaluators, the increase in accuracy and in diagnostic confidence is mainly supported by hypometabolism maps alone.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this study, we demonstrated the additional value of combining voxel-based analyses with qualitative assessment of brain PET images. Moreover, maps of relative hypermetabolism can also make their contribution in clinical practice, particularly for less experienced evaluators.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-022-06166-w","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T03:39:21Z","timestamp":1655177961000},"page":"5333-5341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["FDG PET in the differential diagnosis of degenerative parkinsonian disorders: usefulness of voxel-based analysis in clinical practice"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-9264","authenticated-orcid":false,"given":"Annachiara","family":"Arnone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Allocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Di Dato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Puccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iashar","family":"Laghai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Nerattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ramat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"De Cristofaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Berti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"issue":"5","key":"6166_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/ene.13269","volume":"24","author":"SP Caminiti","year":"2017","unstructured":"Caminiti SP, Alongi P, Majno L, Volont\u00e8 MA, Cerami C, Gianolli L, Comi G, Perani D (2017) Evaluation of an optimized [18F]fluoro-deoxy-glucose positron emission tomography voxel-wise method to early support differential diagnosis in atypical Parkinsonian disorders. Eur J Neurol 24(5):687-e26. https:\/\/doi.org\/10.1111\/ene.13269","journal-title":"Eur J Neurol"},{"issue":"12","key":"6166_CR2","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov Disord 30(12):1591\u20131601. https:\/\/doi.org\/10.1002\/mds.26424","journal-title":"Mov Disord"},{"issue":"2","key":"6166_CR3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.mcna.2018.10.014","volume":"103","author":"SG Reich","year":"2019","unstructured":"Reich SG, Savitt JM (2019) Parkinson\u2019s disease. Med Clin North Am 103(2):337\u2013350. https:\/\/doi.org\/10.1016\/j.mcna.2018.10.014","journal-title":"Med Clin North Am"},{"key":"6166_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1749-6632.2011.06025.x","volume":"1228","author":"V Berti","year":"2011","unstructured":"Berti V, Pupi A, Mosconi L (2011) PET\/CT in diagnosis of movement disorders. Ann N Y Acad Sci 1228:93\u2013108. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06025.x","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"6166_CR5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/mds.25361","volume":"28","author":"LK Teune","year":"2013","unstructured":"Teune LK, Renken RJ, Mudali D, De Jong BM, Dierckx RA, Roerdink JBTM, Leenders KL (2013) Validation of parkinsonian disease-related metabolic brain patterns. Mov Disord 28(4):547\u2013551. https:\/\/doi.org\/10.1002\/mds.25361","journal-title":"Mov Disord"},{"issue":"9","key":"6166_CR6","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1007\/s00259-018-4031-2","volume":"45","author":"Z Walker","year":"2018","unstructured":"Walker Z, Gandolfo F, Orini S, Garibotto V, Agosta F, Arbizu J, Bouwman F, Drzezga A, Nestor P, Boccardi M, Altomare D, Festari C, Nobili F (2018) Clinical utility of FDG PET in Parkinson\u2019s disease and atypical parkinsonism associated with dementia. Eur J Nucl Med Mol Imaging 45(9):1534\u20131545. https:\/\/doi.org\/10.1007\/s00259-018-4031-2","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"6166_CR7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/ana.410330517","volume":"33","author":"D Eidelberg","year":"1993","unstructured":"Eidelberg D, Takikawa S, Moeller JR, Dhawan V, Redington K, Chaly T, Robeson W, Dahl JR, Margouleff D, Fazzini E, Przedborski S, Fahn S (1993) Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson\u2019s disease. Ann Neurol 33(5):518\u2013527. https:\/\/doi.org\/10.1002\/ana.410330517","journal-title":"Ann Neurol"},{"issue":"3","key":"6166_CR8","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.neuroimage.2005.03.012","volume":"26","author":"T Eckert","year":"2005","unstructured":"Eckert T, Barnes A, Dhawan V, Frucht S, Gordon MF, Feigin AS, Eidelberg D (2005) FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 26(3):912\u2013921. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.03.012","journal-title":"Neuroimage"},{"issue":"4","key":"6166_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00429-010-0246-0","volume":"214","author":"P Borghammer","year":"2010","unstructured":"Borghammer P, Chakravarty M, Jonsdottir KY, Sato N, Matsuda H, Ito K, Arahata Y, Kato T, Gjedde A (2010) Cortical hypometabolism and hypoperfusion in Parkinson\u2019s disease is extensive: probably even at early disease stages. Brain Struct Funct 214(4):303\u201317. https:\/\/doi.org\/10.1007\/s00429-010-0246-0","journal-title":"Brain Struct Funct"},{"key":"6166_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1749-6632.2011.06015.x.PET\/CT","volume":"1228","author":"V Berti","year":"2011","unstructured":"Berti V, Pupi A, Mosconi L (2011) PET-CT in diagnosis of dementia.pdf. Ann N Y Acad Sci 1228:81\u201392. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06015.x.PET\/CT","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"6166_CR11","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1468-1331.2007.01977.x","volume":"14","author":"SW Yong","year":"2007","unstructured":"Yong SW, Yoon JK, An YS, Lee PH (2007) A comparison of cerebral glucose metabolism in Parkinson\u2019s disease, Parkinson\u2019s disease dementia and dementia with Lewy bodies. Eur J Neurol 14(12):1357\u20131362. https:\/\/doi.org\/10.1111\/j.1468-1331.2007.01977.x","journal-title":"Eur J Neurol"},{"issue":"C","key":"6166_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1749-6632.2011.06025.x.PET\/CT","volume":"1228","author":"V Berti","year":"2011","unstructured":"Berti V, Pupi A, Mosconi L (2011) PET \/ CT in diagnosis of movement disorders Edited by Foxit Reader. Ann N Y Acad Sci 1228(C):93\u2013108. https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06025.x.PET\/CT","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"6166_CR13","doi-asserted-by":"publisher","first-page":"e1121","DOI":"10.1212\/WNL.0000000000007038","volume":"92","author":"M Pardini","year":"2019","unstructured":"Pardini M, Huey ED, Spina S, Kreisl WC, Morbelli S, Wassermann EM, Nobili F, Ghetti B, Grafman J (2019) FDG-PET patterns associated with underlying pathology in corticobasal syndrome. Neurology 92(10):e1121\u2013e1135. https:\/\/doi.org\/10.1212\/WNL.0000000000007038","journal-title":"Neurology"},{"issue":"10","key":"6166_CR14","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1002\/mds.21004","volume":"21","author":"S Klaffke","year":"2006","unstructured":"Klaffke S, Kuhn AA, Plotkin M, Amthauer H, Harnack D, Felix R, Kupsch A (2006) Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration. Mov Disord 21(10):1724\u20137. https:\/\/doi.org\/10.1002\/mds.21004","journal-title":"Mov Disord"},{"issue":"1\u20132","key":"6166_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neulet.2005.03.057","volume":"383","author":"R Juh","year":"2005","unstructured":"Juh R, Pae CU, Kim TS, Lee CU, Choe B, Suh T (2005) Cerebral glucose metabolism in corticobasal degeneration comparison with progressive supranuclear palsy using statistical mapping analysis. Neurosci Lett 383(1\u20132):22\u20137. https:\/\/doi.org\/10.1016\/j.neulet.2005.03.057","journal-title":"Neurosci Lett"},{"issue":"1863\u20131872","key":"6166_CR16","first-page":"16","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65(1863\u20131872):16","journal-title":"Neurology"},{"issue":"670\u2013676","key":"6166_CR17","first-page":"17","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(670\u2013676):17","journal-title":"Neurology"},{"key":"6166_CR18","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","volume":"80","author":"MJ Armstrong","year":"2013","unstructured":"Armstrong MJ, Litvan I, Lang AE et al (2013) Criteria for the diagnosis of corticobasal degeneration. Neurology 80:496\u2013503","journal-title":"Neurology"},{"key":"6166_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00234-012-1132-7","volume":"55","author":"M Tripathi","year":"2013","unstructured":"Tripathi M, Dhawan V, Peng S et al (2013) Differential diagnosis of parkinsonian syndromes using F-18 fluorodeoxyglucose positron emission tomography. Neuroradiology 55:483\u2013492","journal-title":"Neuroradiology"},{"issue":"2","key":"6166_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1474-4422(10)70002-8","volume":"9","author":"CC Tang","year":"2010","unstructured":"Tang CC, Poston KL, Eckert T, Feigin A, Frucht S, Gudesblatt M, Dhawan V, Lesser M, Vonsattel JP, Fahn S, Eidelberg D (2010) Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis. Lancet Neurol 9(2):149\u2013158. https:\/\/doi.org\/10.1016\/S1474-4422(10)70002-8","journal-title":"Lancet Neurol"},{"issue":"2","key":"6166_CR21","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s00259-021-05603-w","volume":"49","author":"E Guedj","year":"2022","unstructured":"Guedj E et al (2022) EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3. Eur J Nucl Med Mol Imaging. 49(2):632\u2013651","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"6166_CR22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.nicl.2014.10.009","volume":"6","author":"D Perani","year":"2014","unstructured":"Perani D, Della Rosa PA, Cerami C et al (2014) Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting. Neuroimage Clin 6:445\u2013454","journal-title":"Neuroimage Clin"},{"issue":"12","key":"6166_CR23","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.2967\/jnumed.116.186403","volume":"58","author":"PT Meyer","year":"2017","unstructured":"Meyer PT, Frings L, R\u00fccker G, Hellwig S (2017) 18F-FDG PET in Parkinsonism: differential diagnosis and evaluation of cognitive impairment. J Nucl Med 58(12):1888\u20131898. https:\/\/doi.org\/10.2967\/jnumed.116.186403","journal-title":"J Nucl Med"},{"issue":"3","key":"6166_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/mds.25314","volume":"28","author":"CF Lu","year":"2013","unstructured":"Lu CF, Soong BW, Wu HM, Teng S, Wang PS, Wu YT (2013) Disrupted cerebellar connectivity reduces whole-brain network efficiency in multiple system atrophy. Mov Disord 28(3):362\u2013369. https:\/\/doi.org\/10.1002\/mds.25314","journal-title":"Mov Disord"},{"issue":"7","key":"6166_CR25","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1007\/s00415-018-8874-z","volume":"265","author":"MJ Lee","year":"2018","unstructured":"Lee MJ, Kim TH, Mun CW, Shin HK, Son J, Lee JH (2018) Spatial correlation and segregation of multimodal MRI abnormalities in multiple system atrophy. J Neurol 265(7):1540\u20131547. https:\/\/doi.org\/10.1007\/s00415-018-8874-z","journal-title":"J Neurol"},{"issue":"3","key":"6166_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11910-018-0819-5","volume":"18","author":"MJ Armstrong","year":"2018","unstructured":"Armstrong MJ (2018) Progressive supranuclear palsy: an update. Curr Neurol Neurosci Rep 18(3):1\u20139. https:\/\/doi.org\/10.1007\/s11910-018-0819-5","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"2","key":"6166_CR27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3233\/JAD-200153","volume":"76","author":"C Cerami","year":"2020","unstructured":"Cerami C, Dodich A, Iannaccone S, Magnani G, Marcone A, Guglielmo P, Vanoli G, Cappa SF, Perani D (2020) Individual brain metabolic signatures in corticobasal syndrome. J Alzheimers Dis 76(2):517\u2013528. https:\/\/doi.org\/10.3233\/JAD-200153","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"6166_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.11477\/mf.1416200966","volume":"70","author":"H Watanabe","year":"2018","unstructured":"Watanabe H, Hara K, Ito M, Katsuno M, Sobue G (2018) New diagnostic criteria for Parkinson\u2019s disease: MDS-PD criteria. Brain Nerve 70(2):139\u2013146. https:\/\/doi.org\/10.11477\/mf.1416200966 (Japanese)","journal-title":"Brain Nerve"},{"issue":"8","key":"6166_CR29","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1136\/jnnp-2013-307035","volume":"85","author":"SK Alexander","year":"2014","unstructured":"Alexander SK, Rittman T, Xuereb JH, Bak TH, Hodges JR, Rowe JB (2014) Validation of the new consensus criteria for the diagnosis of corticobasal degeneration. J Neurol Neurosurg Psychiatry 85(8):925\u20139. https:\/\/doi.org\/10.1136\/jnnp-2013-307035","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"6166_CR30","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, D\u00fcrr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9):670\u20136. https:\/\/doi.org\/10.1212\/01.wnl.0000324625.00404.15","journal-title":"Neurology"},{"issue":"6","key":"6166_CR31","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.26987","volume":"32","author":"GU H\u00f6glinger","year":"2017","unstructured":"H\u00f6glinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, M\u00fcller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I (2017) Movement Disorder Society-endorsed PSP Study Group Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32(6):853\u2013864. https:\/\/doi.org\/10.1002\/mds.26987","journal-title":"Mov Disord"},{"issue":"4","key":"6166_CR32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s12021-014-9235-4","volume":"12","author":"PA Della Rosa","year":"2014","unstructured":"Della Rosa PA, Cerami C, Gallivanone F, Prestia A, Caroli A, Castiglioni I, Gilardi MC, Frisoni G, Friston K, Ashburner J, Perani D, EADC-PET Consortium (2014) A standardized [18F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia. Neuroinformatics 12(4):575\u201393. https:\/\/doi.org\/10.1007\/s12021-014-9235-4","journal-title":"Neuroinformatics"},{"key":"6166_CR33","doi-asserted-by":"publisher","unstructured":"Caminiti SP, Sala A, Presotto L, Chincarini A, Sestini S, Perani D; Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI), for the Associazione Italiana Medicina Nucleare (AIMN) datasets, The AIMN Neurology Study-Group collaborators:, Schillaci O, Berti V, Calcagni ML, Cistaro A, Morbelli S, Nobili F, Pappat\u00e0 S, Volterrani D, Gobbo CL (2021) Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps. Eur J Nucl Med Mol Imaging. 48(8):2486-2499https:\/\/doi.org\/10.1007\/s00259-020-05175-1","DOI":"10.1007\/s00259-020-05175-1"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06166-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-022-06166-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06166-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T04:13:14Z","timestamp":1660709594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-022-06166-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["6166"],"URL":"https:\/\/doi.org\/10.1007\/s10072-022-06166-w","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"assertion":[{"value":"16 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}