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With growing pharmacological options, polytherapy may increase the possibility of a patient-centered management of narcolepsy symptoms. The aims of our study are to describe a large cohort of Italian patients with narcolepsy who were candidates for pitolisant treatment and to compare patients\u2019 subgroups based on current drug prescription (drug-na\u00efve patients in whom pitolisant was the first-choice treatment, switching to pitolisant from other monotherapy treatments, and adding on in polytherapy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional survey based on Italian data from the inclusion visits of the Post Authorization Safety Study of pitolisant, a 5-year observational, multicenter, international study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred ninety-one patients were enrolled (76.4% with narcolepsy type 1 and 23.6% with narcolepsy type 2). Most patients (63.4%) presented at least one comorbidity, mainly cardiovascular and psychiatric. Pitolisant was prescribed as an add-on treatment in 120\/191 patients (62.8%), as switch from other therapies in 42\/191 (22.0%), and as a first-line treatment in 29\/191 (15.2%). Drug-naive patients presented more severe sleepiness, lower functional status, and a higher incidence of depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study presents the picture of a large cohort of Italian patients with narcolepsy who were prescribed with pitolisant, suggesting that polytherapy is highly frequent to tailor a patient-centered approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10072-022-06210-9","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T20:02:33Z","timestamp":1656100953000},"page":"5563-5574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix\u00ae 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Before enrollment, patients signed informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Isabelle Lecomte and Nora Blanchard are employees of Bioprojet. Tommaso Sacco is a consultant of Bioprojet and has received support for meeting attendance from Bioprojet. Valerio Brunetti has received support for meeting attendance from Bioprojet. Luigi Ferini-Strambi has received honoraria for lectures, presentations, or advisory board from Bioprojet, Jazz, Lundbeck, Sanofi, Italfarmaco, Valeas, and Angelini. Raffaele Ferri has received honoraria for lectures, presentations, or advisory board from Bioprojet and Elsevier. Rocco Liguori has received honoraria for lectures, presentations, or advisory board from Galen Symposion s.r.o., Planning Congressi s.r.l., P.T.S. s.r.l., LT3 s.r.l., PREX s.r.l., ARGENX BV, Alexion Pharma s.r.l., Amicus Therapeutics, and UCB. Lino Nobili has received honoraria for lectures from Bioprojet and consulting fees from Fidia Pharma, Eisai, and Roche. Fabio Pizza has received honoraria for presentation from Jazz and support for meeting attendance from Bioprojet. Giuseppe Plazzi has received honoraria for advisory board and consulting fees from Bioprojet, Jazz, Takeda, and Idorsia. Monica Puligheddu has received honoraria for educational events from Jazz and Livanova. Andrea Romigi has received honoraria for lectures, presentations, or advisory board from Bioprojet, Jazz, and Eisai. All other authors have no relevant conflict of interest to disclose related to the content of the current manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}