{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:51:46Z","timestamp":1770839506439,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s10072-022-06309-z","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T14:08:48Z","timestamp":1659622128000},"page":"6487-6494","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Insomnia in primary care: a survey conducted on Italian patients older than 50\u00a0years\u2014results from the \u201cSonno e Salute\u201d study"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-3996","authenticated-orcid":false,"given":"Paola","family":"Proserpio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Biggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Girardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio Clemente","family":"Agostoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Manni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Minervino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Palagini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lino","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Arnaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"6309_CR1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S0140-6736(11)60750-2","volume":"379","author":"CM Morin","year":"2012","unstructured":"Morin CM, Benca R (2012) Chronic insomnia. The Lancet 379:1129\u20131141","journal-title":"The Lancet"},{"key":"6309_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1053\/smrv.2002.0186","volume":"6","author":"MM Ohayon","year":"2002","unstructured":"Ohayon MM (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6:97\u2013111. https:\/\/doi.org\/10.1053\/smrv.2002.0186","journal-title":"Sleep Med Rev"},{"key":"6309_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00406-003-0406-9","volume":"253","author":"C K\u00e4ppler","year":"2003","unstructured":"K\u00e4ppler C, Hohagen F (2003) Psychosocial aspects of insomnia. Results of a study in general practice. Eur Arch Psychiatry Clin Neurosci 253:49\u201352. https:\/\/doi.org\/10.1007\/s00406-003-0406-9","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"6309_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.sleep.2005.08.008","volume":"7","author":"CM Morin","year":"2006","unstructured":"Morin CM, LeBlanc M, Daley M et al (2006) Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med 7:123\u2013130. https:\/\/doi.org\/10.1016\/j.sleep.2005.08.008","journal-title":"Sleep Med"},{"issue":"Suppl 4","key":"6309_CR5","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1016\/S1389-9457(08)70004-2","volume":"8","author":"D Riemann","year":"2007","unstructured":"Riemann D (2007) Insomnia and comorbid psychiatric disorders. Sleep Med 8(Suppl 4):S15-20. https:\/\/doi.org\/10.1016\/S1389-9457(08)70004-2","journal-title":"Sleep Med"},{"key":"6309_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/sleep\/30.2.213","volume":"30","author":"DJ Taylor","year":"2007","unstructured":"Taylor DJ, Mallory LJ, Lichstein KL et al (2007) Comorbidity of chronic insomnia with medical problems. Sleep 30:213\u2013218","journal-title":"Sleep"},{"key":"6309_CR7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jad.2011.01.011","volume":"135","author":"C Baglioni","year":"2011","unstructured":"Baglioni C, Battagliese G, Feige B et al (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 135:10\u201319. https:\/\/doi.org\/10.1016\/j.jad.2011.01.011","journal-title":"J Affect Disord"},{"key":"6309_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.chest.2017.01.026","volume":"152","author":"S Javaheri","year":"2017","unstructured":"Javaheri S, Redline S (2017) Insomnia and risk of cardiovascular disease. Chest 152:435\u2013444. https:\/\/doi.org\/10.1016\/j.chest.2017.01.026","journal-title":"Chest"},{"key":"6309_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0167-4943(00)00075-3","volume":"31","author":"Asplund null,","year":"2000","unstructured":"Asplund null, (2000) Sleep and hypnotic use in relation to perceived somatic and mental health among the elderly. Arch Gerontol Geriatr 31:199\u2013205","journal-title":"Arch Gerontol Geriatr"},{"key":"6309_CR10","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/sleep\/14.5.386","volume":"14","author":"MA Quera-Salva","year":"1991","unstructured":"Quera-Salva MA, Orluc A, Goldenberg F, Guilleminault C (1991) Insomnia and use of hypnotics: study of a French population. Sleep 14:386\u2013391","journal-title":"Sleep"},{"key":"6309_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.5665\/sleep.3410","volume":"37","author":"SM Bertisch","year":"2014","unstructured":"Bertisch SM, Herzig SJ, Winkelman JW, Buettner C (2014) National use of prescription medications for insomnia: NHANES 1999\u20132010. Sleep 37:343\u2013349. https:\/\/doi.org\/10.5665\/sleep.3410","journal-title":"Sleep"},{"key":"6309_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/jsr.12594","volume":"26","author":"D Riemann","year":"2017","unstructured":"Riemann D, Baglioni C, Bassetti C et al (2017) European guideline for the diagnosis and treatment of insomnia. J Sleep Res 26:675\u2013700. https:\/\/doi.org\/10.1111\/jsr.12594","journal-title":"J Sleep Res"},{"key":"6309_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5664\/jcsm.6470","volume":"13","author":"MJ Sateia","year":"2017","unstructured":"Sateia MJ, Buysse DJ, Krystal AD et al (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med 13:307\u2013349. https:\/\/doi.org\/10.5664\/jcsm.6470","journal-title":"J Clin Sleep Med"},{"key":"6309_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fpsyt.2020.00558","volume":"11","author":"L Palagini","year":"2020","unstructured":"Palagini L (2020) Expert opinions and consensus recommendations for the evaluation and management of insomnia in clinical practice: joint statements of five Italian scientific societies. Front Psychiatry 11:13","journal-title":"Front Psychiatry"},{"key":"6309_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.sleep.2003.09.006","volume":"5","author":"MG Terzano","year":"2004","unstructured":"Terzano MG, Parrino L, Cirignotta F et al (2004) Studio Morfeo: insomnia in primary care, a survey conducted on the Italian population. Sleep Med 5:67\u201375. https:\/\/doi.org\/10.1016\/j.sleep.2003.09.006","journal-title":"Sleep Med"},{"key":"6309_CR16","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.sleep.2006.02.003","volume":"7","author":"MG Terzano","year":"2006","unstructured":"Terzano MG, Cirignotta F, Mondini S et al (2006) Studio Morfeo 2: survey on the management of insomnia by Italian general practitioners. Sleep Med 7:599\u2013606. https:\/\/doi.org\/10.1016\/j.sleep.2006.02.003","journal-title":"Sleep Med"},{"key":"6309_CR17","doi-asserted-by":"publisher","first-page":"e004183","DOI":"10.1136\/bmjopen-2013-004183","volume":"4","author":"CA Espie","year":"2014","unstructured":"Espie CA, Kyle SD, Hames P et al (2014) The Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder. BMJ Open 4:e004183. https:\/\/doi.org\/10.1136\/bmjopen-2013-004183","journal-title":"BMJ Open"},{"key":"6309_CR18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ijpsycho.2015.08.008","volume":"98","author":"L Palagini","year":"2015","unstructured":"Palagini L, Ragno G, Caccavale L et al (2015) Italian validation of the Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder according to DSM-5 criteria. Int J Psychophysiol Off J Int Organ Psychophysiol 98:435\u2013440. https:\/\/doi.org\/10.1016\/j.ijpsycho.2015.08.008","journal-title":"Int J Psychophysiol Off J Int Organ Psychophysiol"},{"key":"6309_CR19","unstructured":"American Academy of Sleep Medicine (2014) International classification of sleep disorders-third edition (ICSD-3)\u00a0American Academy of Sleep Medicine, Darien"},{"key":"6309_CR20","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/sleep\/24.8.926","volume":"24","author":"G Jean-Louis","year":"2001","unstructured":"Jean-Louis G, Magai CM, Cohen CI et al (2001) Ethnic differences in self-reported sleep problems in older adults. Sleep 24:926\u2013933","journal-title":"Sleep"},{"key":"6309_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/fampra\/cmw107","volume":"34","author":"B Bjorvatn","year":"2017","unstructured":"Bjorvatn B, Meland E, Flo E, Mildestvedt T (2017) High prevalence of insomnia and hypnotic use in patients visiting their general practitioner. Fam Pract 34:20\u201324. https:\/\/doi.org\/10.1093\/fampra\/cmw107","journal-title":"Fam Pract"},{"key":"6309_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3122\/jabfm.18.4.257","volume":"18","author":"JE Aikens","year":"2005","unstructured":"Aikens JE, Rouse ME (2005) Help-seeking for insomnia among adult patients in primary care. J Am Board Fam Pract 18:257\u2013261","journal-title":"J Am Board Fam Pract"},{"key":"6309_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.smrv.2009.06.001","volume":"14","author":"JA Shekleton","year":"2010","unstructured":"Shekleton JA, Rogers NL, Rajaratnam SMW (2010) Searching for the daytime impairments of primary insomnia. Sleep Med Rev 14:47\u201360. https:\/\/doi.org\/10.1016\/j.smrv.2009.06.001","journal-title":"Sleep Med Rev"},{"key":"6309_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11920-018-0940-9","volume":"20","author":"S Suh","year":"2018","unstructured":"Suh S, Cho N, Zhang J (2018) Sex differences in insomnia: from epidemiology and etiology to intervention. Curr Psychiatry Rep 20:69. https:\/\/doi.org\/10.1007\/s11920-018-0940-9","journal-title":"Curr Psychiatry Rep"},{"key":"6309_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/sleep\/23.1.1a","volume":"23","author":"K Kim","year":"2000","unstructured":"Kim K, Uchiyama M, Okawa M et al (2000) An epidemiological study of insomnia among the Japanese general population. Sleep 23:41\u201347","journal-title":"Sleep"},{"key":"6309_CR26","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s11325-018-1682-y","volume":"22","author":"B Yang","year":"2018","unstructured":"Yang B, Wang Y, Cui F et al (2018) Association between insomnia and job stress: a meta-analysis. Sleep Breath Schlaf Atm 22:1221\u20131231. https:\/\/doi.org\/10.1007\/s11325-018-1682-y","journal-title":"Sleep Breath Schlaf Atm"},{"key":"6309_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4137\/HACCE.S10596","volume":"4","author":"TH Monk","year":"2012","unstructured":"Monk TH, Buysse DJ, Schlarb JE, Beach SR (2012) Timing, duration and quality of sleep, and level of daytime sleepiness in 1166 retired seniors. Healthy Aging Clin Care Elder 4:33\u201340. https:\/\/doi.org\/10.4137\/HACCE.S10596","journal-title":"Healthy Aging Clin Care Elder"},{"key":"6309_CR28","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jsmc.2016.08.004","volume":"11","author":"MD Cheatle","year":"2016","unstructured":"Cheatle MD, Foster S, Pinkett A et al (2016) Assessing and managing sleep disturbance in patients with chronic pain. Sleep Med Clin 11:531\u2013541. https:\/\/doi.org\/10.1016\/j.jsmc.2016.08.004","journal-title":"Sleep Med Clin"},{"key":"6309_CR29","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3233\/JAD-180041","volume":"63","author":"P Proserpio","year":"2018","unstructured":"Proserpio P, Arnaldi D, Nobili F, Nobili L (2018) Integrating sleep and Alzheimer\u2019s disease pathophysiology: hints for sleep disorders management. J Alzheimers Dis 63:871\u2013886. https:\/\/doi.org\/10.3233\/JAD-180041","journal-title":"J Alzheimers Dis"},{"key":"6309_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.06.010","author":"L Shi","year":"2017","unstructured":"Shi L, Chen S-J, Ma M-Y et al (2017) Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev. https:\/\/doi.org\/10.1016\/j.smrv.2017.06.010","journal-title":"Sleep Med Rev"},{"key":"6309_CR31","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S1474-4422(18)30450-2","volume":"18","author":"MR Irwin","year":"2019","unstructured":"Irwin MR, Vitiello MV (2019) Implications of sleep disturbance and inflammation for Alzheimer\u2019s disease dementia. Lancet Neurol 18:296\u2013306. https:\/\/doi.org\/10.1016\/S1474-4422(18)30450-2","journal-title":"Lancet Neurol"},{"key":"6309_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.smrv.2015.08.005","volume":"28","author":"JM Krueger","year":"2016","unstructured":"Krueger JM, Frank MG, Wisor JP, Roy S (2016) Sleep function: toward elucidating an enigma. Sleep Med Rev 28:46\u201354. https:\/\/doi.org\/10.1016\/j.smrv.2015.08.005","journal-title":"Sleep Med Rev"},{"key":"6309_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.02.021","volume":"77","author":"KM de Almondes","year":"2016","unstructured":"de Almondes KM, Costa MV, Malloy-Diniz LF, Diniz BS (2016) Insomnia and risk of dementia in older adults: systematic review and meta-analysis. J Psychiatr Res 77:109\u2013115. https:\/\/doi.org\/10.1016\/j.jpsychires.2016.02.021","journal-title":"J Psychiatr Res"},{"key":"6309_CR34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.7326\/M15-2175","volume":"165","author":"A Qaseem","year":"2016","unstructured":"Qaseem A, Kansagara D, Forciea MA et al (2016) Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med 165:125\u2013133. https:\/\/doi.org\/10.7326\/M15-2175","journal-title":"Ann Intern Med"},{"key":"6309_CR35","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/sleep\/22.3.371","volume":"22","author":"JK Walsh","year":"1999","unstructured":"Walsh JK, Schweitzer PK (1999) Ten-year trends in the pharmacological treatment of insomnia. Sleep 22:371\u2013375","journal-title":"Sleep"},{"key":"6309_CR36","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.2105\/AJPH.2010.300014","volume":"101","author":"ME Moloney","year":"2011","unstructured":"Moloney ME, Konrad TR, Zimmer CR (2011) The medicalization of sleeplessness: a public health concern. Am J Public Health 101:1429\u20131433","journal-title":"Am J Public Health"},{"key":"6309_CR37","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1192\/bjp.170.2.176","volume":"170","author":"M Balestrieri","year":"1997","unstructured":"Balestrieri M, Bortolomasi M, Galletta M, Bellantuono C (1997) Patterns of hypnotic drug prescription in Italy. A two-week community survey. Br J Psychiatry J Ment Sci 170:176\u2013180. https:\/\/doi.org\/10.1192\/bjp.170.2.176","journal-title":"Br J Psychiatry J Ment Sci"},{"key":"6309_CR38","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0531-5565(01)00120-6","volume":"36","author":"Y Touitou","year":"2001","unstructured":"Touitou Y (2001) Human aging and melatonin. Clinical relevance Exp Gerontol 36:1083\u20131100","journal-title":"Clinical relevance Exp Gerontol"},{"key":"6309_CR39","doi-asserted-by":"publisher","first-page":"e000850","DOI":"10.1136\/bmjopen-2012-000850","volume":"2","author":"DF Kripke","year":"2012","unstructured":"Kripke DF, Langer RD, Kline LE (2012) Hypnotics\u2019 association with mortality or cancer: a matched cohort study. BMJ Open 2:e000850. https:\/\/doi.org\/10.1136\/bmjopen-2012-000850","journal-title":"BMJ Open"},{"key":"6309_CR40","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14:540\u2013545. https:\/\/doi.org\/10.1093\/sleep\/14.6.540","journal-title":"Sleep"},{"key":"6309_CR41","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbi.2020.05.026","volume":"88","author":"S Pappa","year":"2020","unstructured":"Pappa S, Ntella V, Giannakas T et al (2020) Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis. Brain Behav Immun 88:901\u2013907. https:\/\/doi.org\/10.1016\/j.bbi.2020.05.026","journal-title":"Brain Behav Immun"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06309-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-022-06309-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06309-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:23:45Z","timestamp":1744205025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-022-06309-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["6309"],"URL":"https:\/\/doi.org\/10.1007\/s10072-022-06309-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]},"assertion":[{"value":"5 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethical Committee \u201cComitato Etico Regionale della Liguria\u201d (Register Number:\u00a0143\/2022_ DB id 12,253).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Paola Proserpio has received honoraria for advisory board from Italfarmaco and Jazz Pharmaceuticals. Raffaele Ferri has received consulting fee from Jazz Pharmaceutical. Raffaele Manni has received consulting fee from Fidia Pharma. Giuseppe Plazzi has received consulting fees from Jazz Pharmaceuticals, Takeda, Idorsia, and Bioprojet. Dario Arnaldi has received honoraria for lectures from Bruno Pharma, Fidia Pharma, and Jazz Pharmaceuticals. Lino Nobili has received honoraria for lectures from Bioprojet and consulting fees from Fidia Pharma, Eisai, and Roche. All other authors have no relevant conflict of interests to disclose related to the content of the current manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}