{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:46:03Z","timestamp":1776303963849,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s10072-022-06573-z","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T20:02:45Z","timestamp":1671825765000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CSF neuron-specific enolase as a biomarker of neurovascular conflict severity in drug-resistant trigeminal neuralgia: a prospective study in patients submitted to microvascular decompression"],"prefix":"10.1007","volume":"44","author":[{"given":"Silvia","family":"Baroni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Rapisarda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Gentili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Burattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sarlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"D\u2019Ercole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Olivi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Urbani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-1950","authenticated-orcid":false,"given":"Nicola","family":"Montano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"6573_CR1","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.adaj.2016.02.014","volume":"147","author":"IP de Toledo","year":"2016","unstructured":"de Toledo IP, Conti R\u00e9us J, Fernandes M et al (2016) Prevalence of trigeminal neuralgia: a systematic review. J American Dental Association 147:570-576.e2","journal-title":"J American Dental Association"},{"key":"6573_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0733-8619(03)00094-X","volume":"22","author":"TD Rozen","year":"2004","unstructured":"Rozen TD (2004) Trigeminal neuralgia and glossopharyngeal neuralgia. Neurologic Clinics 22:185\u2013206","journal-title":"Neurologic Clinics"},{"key":"6573_CR3","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1227\/01.NEU.0000088806.11659.D8","volume":"53","author":"KJ Burchiel","year":"2003","unstructured":"Burchiel KJ, Hodge CJ, Kanpolat Y et al (2003) A new classification for facial pain. Neurosurgery 53:1164\u20131167","journal-title":"Neurosurgery"},{"key":"6573_CR4","doi-asserted-by":"crossref","unstructured":"Olesen J (2018) Headache Classification Committee of the International Headache Society (IHS) The international classification of headache disorders, 3rd edition. Cephalalgia 38 1\u2013211","DOI":"10.1177\/0333102417738202"},{"key":"6573_CR5","first-page":"754","volume":"383","author":"G Cruccu","year":"2020","unstructured":"Cruccu G, di Stefano G, Truini A (2020) Trigeminal neuralgia New England. J Med 383:754\u2013762","journal-title":"J Med"},{"key":"6573_CR6","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.mjafi.2017.11.007","volume":"75","author":"V Maurya","year":"2019","unstructured":"Maurya V, Sreedhar CM, Khera A et al (2019) Trigeminal neuralgia: when does neurovascular contact turn into a conflict? Med J Armed Forces India 75:134\u2013139","journal-title":"Med J Armed Forces India"},{"key":"6573_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/TCRM.S37592","volume":"11","author":"N Montano","year":"2015","unstructured":"Montano N, Conforti G, di Bonaventura R et al (2015) Advances in diagnosis and treatment of trigeminal neuralgia. Ther Clin Risk Manag 11:289\u2013299","journal-title":"Ther Clin Risk Manag"},{"key":"6573_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1139\/y91-092","volume":"69","author":"BJ Sessle","year":"1991","unstructured":"Sessle BJ, Hu JW (1991) Mechanisms of pain arising from articular tissues. Can J Physiol Pharmacol 69:617\u201326","journal-title":"Can J Physiol Pharmacol"},{"key":"6573_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0304-3959(87)90003-0","volume":"31","author":"R Dubner","year":"1987","unstructured":"Dubner R, Sharav Y, Gracely RH et al (1987) Idiopathic trigeminal neuralgia: sensory features and pain mechanisms. Pain 31:23\u201333","journal-title":"Pain"},{"key":"6573_CR10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.mehy.2009.09.056","volume":"74","author":"D Jia","year":"2010","unstructured":"Jia D, ze, Li G, (2010) Bioresonance hypothesis: a new mechanism on the pathogenesis of trigeminal neuralgia. Med Hypotheses 74:505\u2013507","journal-title":"Med Hypotheses"},{"key":"6573_CR11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","volume":"18","author":"M Devor","year":"2002","unstructured":"Devor M, Amir R, Rappaport ZH (2002) Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain 18:4\u201313","journal-title":"Clin J Pain"},{"key":"6573_CR12","doi-asserted-by":"publisher","first-page":"8489","DOI":"10.1523\/JNEUROSCI.2552-08.2008","volume":"28","author":"A Latr\u00e9moli\u00e8re","year":"2008","unstructured":"Latr\u00e9moli\u00e8re A, Mauborgne A, Masson J et al (2008) Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats. J Neurosci 28:8489\u20138501","journal-title":"J Neurosci"},{"key":"6573_CR13","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/j.pain.0000000000001122","volume":"159","author":"C Sommer","year":"2018","unstructured":"Sommer C, Leinders M, \u00dc\u00e7eyler N (2018) Inflammation in the pathophysiology of neuropathic pain. Pain 159:595\u2013602","journal-title":"Pain"},{"key":"6573_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1080\/01616412.2018.1564188","volume":"41","author":"MX Liu","year":"2019","unstructured":"Liu MX, Zhong J, Xia L et al (2019) A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. Neurol Res 41:335\u2013340","journal-title":"Neurol Res"},{"key":"6573_CR15","doi-asserted-by":"publisher","first-page":"e556","DOI":"10.1097\/SCS.0000000000005497","volume":"30","author":"B Chang","year":"2019","unstructured":"Chang B, Guan H, Zhu W et al (2019) Low uric acid indicates risk of incidence of trigeminal neuralgia. J Craniofacial Surg 30:e556\u2013e558","journal-title":"J Craniofacial Surg"},{"key":"6573_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1526-4610.1997.3704211.x","volume":"37","author":"M Strittmatter","year":"1997","unstructured":"Strittmatter M, Grauer M, Isenberg E et al (1997) Cerebrospinal fluid neuropeptides and monoaminergic transmitters in patients with trigeminal neuralgia. Headache 37:211\u2013216","journal-title":"Headache"},{"key":"6573_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.clineuro.2016.02.012","volume":"143","author":"ZL Qin","year":"2016","unstructured":"Qin ZL, Yang LQ, Li N et al (2016) Clinical study of cerebrospinal fluid neuropeptides in patients with primary trigeminal neuralgia. Clin Neurol Neurosurg 143:111\u2013115","journal-title":"Clin Neurol Neurosurg"},{"key":"6573_CR18","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1097\/j.pain.0000000000001649","volume":"160","author":"H Ericson","year":"2019","unstructured":"Ericson H, Hamdeh SA, Freyhult E et al (2019) Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression. Pain 160:2603\u20132611","journal-title":"Pain"},{"key":"6573_CR19","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.jpain.2020.03.002","volume":"21","author":"S Abu Hamdeh","year":"2020","unstructured":"Abu Hamdeh S, Khoonsari PE, Shevchenko G et al (2020) Increased CSF levels of apolipoproteins and complement factors in trigeminal neuralgia patients\u2013in depth proteomic analysis using mass spectrometry. J Pain 21:1075\u20131084","journal-title":"J Pain"},{"issue":"5","key":"6573_CR20","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/biomedicines10050998","volume":"10","author":"TS Svedung Wettervik","year":"2022","unstructured":"Svedung Wettervik TS, Folkvaljon D, Gordh T et al (2022) Cerebrospinal fluid in classical trigeminal neuralgia: an exploratory study on candidate biomarkers. Biomedicines 10(5):998","journal-title":"Biomedicines"},{"key":"6573_CR21","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1007\/s10072-022-05971-7","volume":"43","author":"A Rapisarda","year":"2022","unstructured":"Rapisarda A, Baroni S, Gentili V et al (2022) The role of biomarkers in drug-resistant trigeminal neuralgia: a prospective study in patients submitted to surgical treatment. Neurol Sci 43:4425\u20134430","journal-title":"Neurol Sci"},{"issue":"5","key":"6573_CR22","first-page":"E5","volume":"18","author":"PJ Jannetta","year":"2005","unstructured":"Jannetta PJ, McLaughlin MR, Casey KF (2005) Technique of microvascular decompression. Technical note. Neurosurg Focus 18(5):E5","journal-title":"Technical note. Neurosurg Focus"},{"key":"6573_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.wneu.2021.02.063","volume":"149","author":"FY Legninda Sop","year":"2021","unstructured":"Legninda Sop FY, D\u2019Ercole M, Izzo A et al (2021) The impact of neuronavigation on the surgical outcome of microvascular decompression for trigeminal neuralgia. World Neurosurg 149:80\u201385","journal-title":"World Neurosurg"},{"issue":"2","key":"6573_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/brainsci8020033","volume":"8","author":"A Haque","year":"2018","unstructured":"Haque A, Polcyn R, Matzelle D et al (2018) New insights into the role of neuron-specific enolase in neuro-inflammation, neurodegeneration, and neuroprotection. Brain Sci 8(2):33","journal-title":"Brain Sci"},{"key":"6573_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1159\/000087701","volume":"20","author":"N Anand","year":"2005","unstructured":"Anand N, Stead LG (2005) Neuron-specific enolase as a marker for acute ischemic stroke: a systematic review. Cerebrovascular Diseases 20:213\u2013219","journal-title":"Cerebrovascular Diseases"},{"key":"6573_CR26","doi-asserted-by":"publisher","first-page":"e434","DOI":"10.1016\/j.wneu.2017.09.202","volume":"109","author":"SW Song","year":"2018","unstructured":"Song SW, Kim YH, Kim JW et al (2018) Outcomes after transcranial and endoscopic endonasal approach for tuberculum meningiomas\u2014a retrospective comparison. World Neurosurg 109:e434\u2013e445","journal-title":"World Neurosurg"},{"key":"6573_CR27","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1097\/TA.0b013e318246887e","volume":"72","author":"SY Chabok","year":"2012","unstructured":"Chabok SY, Moghadam AD, Saneei Z et al (2012) Neuron-specific enolase and S100BB as outcome predictors in severe diffuse axonal injury. J Trauma Acute Care Surgery 72:1654\u20131657","journal-title":"J Trauma Acute Care Surgery"},{"key":"6573_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s11011-016-9801-6","volume":"31","author":"A Haque","year":"2016","unstructured":"Haque A, Ray SK, Cox A et al (2016) Neuron specific enolase: a promising therapeutic target in acute spinal cord injury. Metabolic Brain Disease 31:487\u2013495","journal-title":"Metabolic Brain Disease"},{"key":"6573_CR29","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1523\/JNEUROSCI.03-05-00915.1983","volume":"3","author":"T Kirino","year":"1983","unstructured":"Kirino T, Brightman MW, Oertel WH et al (1983) Neuron-specific enolase as an index of neuronal regeneration and reinnervation. J Neurosci 3:915\u201323","journal-title":"J Neurosci"},{"key":"6573_CR30","first-page":"125","volume-title":"Advances in experimental medicine and biology","author":"MA Isgr\u00f2","year":"2015","unstructured":"Isgr\u00f2 MA, Bottoni P, Scatena R (2015) Neuron-specific enolase as a biomarker: biochemical and clinical aspects. Advances in experimental medicine and biology. Springer, New York LLC, pp 125\u2013143"},{"key":"6573_CR31","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/j.1468-2982.2007.01508.x","volume":"28","author":"M Casmiro","year":"2008","unstructured":"Casmiro M, Scarpa E, Cortelli P et al (2008) Cerebrospinal fluid and serum neuron-specific enolase in acute benign headache. Cephalalgia 28:506\u2013509","journal-title":"Cephalalgia"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06573-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-022-06573-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-022-06573-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T17:05:49Z","timestamp":1679072749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-022-06573-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["6573"],"URL":"https:\/\/doi.org\/10.1007\/s10072-022-06573-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]},"assertion":[{"value":"25 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by Fondazione IRCCS Policlinico A. Gemelli\u2019s ethical committee and was conducted in accordance with the ethical standards reported in the 1964 Declaration of Helsinki;","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent to the study has been provided to all participants and authorization for anonymous publication of personal data was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}