{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:18:01Z","timestamp":1779167881292,"version":"3.51.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871018"],"award-info":[{"award-number":["81871018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575094"],"award-info":[{"award-number":["21575094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10072-023-06605-2","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T03:38:27Z","timestamp":1674185907000},"page":"2137-2148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications"],"prefix":"10.1007","volume":"44","author":[{"given":"Yifei","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-4906","authenticated-orcid":false,"given":"Zhining","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"4","key":"6605_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/epi.12550","volume":"55","author":"RS Fisher","year":"2014","unstructured":"Fisher RS et al (2014) ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55(4):475\u2013482","journal-title":"Epilepsia"},{"key":"6605_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.seizure.2017.02.006","volume":"49","author":"S Rizvi","year":"2017","unstructured":"Rizvi S et al (2017) Epidemiology of early stages of epilepsy: risk of seizure recurrence after a first seizure. Seizure 49:46\u201353","journal-title":"Seizure"},{"issue":"3","key":"6605_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","volume":"75","author":"Z Chen","year":"2018","unstructured":"Chen Z et al (2018) Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol 75(3):279\u2013286","journal-title":"JAMA Neurol"},{"issue":"12","key":"6605_CR4","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1111\/epi.14596","volume":"59","author":"L Kalilani","year":"2018","unstructured":"Kalilani L et al (2018) The epidemiology of drug-resistant epilepsy: a systematic review and meta-analysis. Epilepsia 59(12):2179\u20132193","journal-title":"Epilepsia"},{"issue":"4","key":"6605_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/epi.13671","volume":"58","author":"RS Fisher","year":"2017","unstructured":"Fisher RS et al (2017) Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 58(4):531\u2013542","journal-title":"Epilepsia"},{"issue":"4","key":"6605_CR6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/epi.13709","volume":"58","author":"IE Scheffer","year":"2017","unstructured":"Scheffer IE et al (2017) ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia 58(4):512\u2013521","journal-title":"Epilepsia"},{"issue":"4","key":"6605_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2165\/00023210-200418040-00001","volume":"18","author":"LM Specchio","year":"2004","unstructured":"Specchio LM, Beghi E (2004) Should antiepileptic drugs be withdrawn in seizure-free patients? CNS Drugs 18(4):201\u2013212","journal-title":"CNS Drugs"},{"issue":"2","key":"6605_CR8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00702-010-0527-z","volume":"118","author":"D Schmidt","year":"2011","unstructured":"Schmidt D (2011) AED discontinuation may be dangerous for seizure-free patients. J Neural Transm (Vienna) 118(2):183\u2013186","journal-title":"J Neural Transm (Vienna)"},{"issue":"Suppl 7","key":"6605_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/epi.12305","volume":"54","author":"E Beghi","year":"2013","unstructured":"Beghi E et al (2013) Withdrawal of antiepileptic drugs: guidelines of the Italian League Against Epilepsy. Epilepsia 54(Suppl 7):2\u201312","journal-title":"Epilepsia"},{"key":"6605_CR10","doi-asserted-by":"publisher","first-page":"9522","DOI":"10.1038\/srep09522","volume":"5","author":"J Wang","year":"2015","unstructured":"Wang J et al (2015) Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy. Sci Rep 5:9522","journal-title":"Sci Rep"},{"key":"6605_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.eplepsyres.2016.09.019","volume":"127","author":"N An","year":"2016","unstructured":"An N et al (2016) Elevated serum miR-106b and miR-146a in patients with focal and generalized epilepsy. Epilepsy Res 127:311\u2013316","journal-title":"Epilepsy Res"},{"key":"6605_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.eplepsyres.2016.07.003","volume":"126","author":"D Wang","year":"2016","unstructured":"Wang D et al (2016) GC-MS-Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures. Epilepsy Res 126:83\u201389","journal-title":"Epilepsy Res"},{"issue":"3","key":"6605_CR13","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.18632\/oncotarget.13744","volume":"8","author":"S Yan","year":"2017","unstructured":"Yan S et al (2017) Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis. Oncotarget 8(3):4136\u20134146","journal-title":"Oncotarget"},{"issue":"5\u20136","key":"6605_CR14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000512949","volume":"42","author":"R Li","year":"2020","unstructured":"Li R, Hu J, Cao S (2020) The clinical significance of miR-135b-5p and its role in the proliferation and apoptosis of hippocampus neurons in children with temporal lobe epilepsy. Dev Neurosci 42(5\u20136):187\u2013194","journal-title":"Dev Neurosci"},{"issue":"4","key":"6605_CR15","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/ene.14129","volume":"27","author":"R Martins-Ferreira","year":"2020","unstructured":"Martins-Ferreira R et al (2020) Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel. Eur J Neurol 27(4):660\u2013666","journal-title":"Eur J Neurol"},{"key":"6605_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ebiom.2018.10.068","volume":"38","author":"R Raoof","year":"2018","unstructured":"Raoof R et al (2018) Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy. EBioMedicine 38:127\u2013141","journal-title":"EBioMedicine"},{"issue":"9","key":"6605_CR17","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.3390\/cells10092444","volume":"10","author":"G Conte","year":"2021","unstructured":"Conte G et al (2021) Circulating P2X7 receptor signaling components as diagnostic biomarkers for temporal lobe epilepsy. Cells 10(9):2444","journal-title":"Cells"},{"issue":"8","key":"6605_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1097\/WNR.0000000000001252","volume":"30","author":"L Mo","year":"2019","unstructured":"Mo L et al (2019) Association of cerebrospinal fluid zinc-alpha2-glycoprotein and tau protein with temporal lobe epilepsy and related white matter impairment. NeuroReport 30(8):586\u2013591","journal-title":"NeuroReport"},{"issue":"11","key":"6605_CR19","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1007\/s00415-018-9026-1","volume":"265","author":"R Maiti","year":"2018","unstructured":"Maiti R et al (2018) Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial. J Neurol 265(11):2594\u20132601","journal-title":"J Neurol"},{"issue":"1","key":"6605_CR20","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/epi.17116","volume":"63","author":"LE Walker","year":"2022","unstructured":"Walker LE et al (2022) High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: a proof-of-concept study. Epilepsia 63(1):e1\u2013e6","journal-title":"Epilepsia"},{"key":"6605_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.yebeh.2018.11.023","volume":"90","author":"ECB Toscano","year":"2019","unstructured":"Toscano ECB et al (2019) Circulating levels of adipokines are altered in patients with temporal lobe epilepsy. Epilepsy Behav 90:137\u2013141","journal-title":"Epilepsy Behav"},{"key":"6605_CR22","doi-asserted-by":"publisher","first-page":"10201","DOI":"10.1038\/srep10201","volume":"5","author":"J Wang","year":"2015","unstructured":"Wang J et al (2015) Circulating microRNAs are promising novel biomarkers for drug-resistant epilepsy. Sci Rep 5:10201","journal-title":"Sci Rep"},{"issue":"5","key":"6605_CR23","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1097\/JCMA.0000000000000518","volume":"84","author":"X Niu","year":"2021","unstructured":"Niu X et al (2021) MiR-194-5p serves as a potential biomarker and regulates the proliferation and apoptosis of hippocampus neuron in children with temporal lobe epilepsy. J Chin Med Assoc 84(5):510\u2013516","journal-title":"J Chin Med Assoc"},{"key":"6605_CR24","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.eplepsyres.2016.09.016","volume":"127","author":"Y Sun","year":"2016","unstructured":"Sun Y et al (2016) Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy. Epilepsy Res 127:276\u2013283","journal-title":"Epilepsy Res"},{"issue":"4","key":"6605_CR25","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s11064-015-1773-0","volume":"41","author":"X Wang","year":"2016","unstructured":"Wang X et al (2016) Serum microRNA-4521 is a potential biomarker for focal cortical dysplasia with refractory epilepsy. Neurochem Res 41(4):905\u2013912","journal-title":"Neurochem Res"},{"issue":"4","key":"6605_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173060","volume":"12","author":"SH Avansini","year":"2017","unstructured":"Avansini SH et al (2017) MicroRNA hsa-miR-134 is a circulating biomarker for mesial temporal lobe epilepsy. PLoS ONE 12(4):e0173060","journal-title":"PLoS ONE"},{"issue":"2","key":"6605_CR27","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3390\/ijms22020702","volume":"22","author":"S De Benedittis","year":"2021","unstructured":"De Benedittis S et al (2021) Circulating microRNA: the potential novel diagnostic biomarkers to predict drug resistance in temporal lobe epilepsy, a pilot study. Int J Mol Sci 22(2):702","journal-title":"Int J Mol Sci"},{"key":"6605_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.eplepsyres.2019.04.010","volume":"154","author":"CH Shen","year":"2019","unstructured":"Shen CH et al (2019) Expression of plasma microRNA-145-5p and its correlation with clinical features in patients with refractory epilepsy. Epilepsy Res 154:21\u201325","journal-title":"Epilepsy Res"},{"issue":"1","key":"6605_CR29","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1038\/s41598-017-02969-6","volume":"7","author":"R Raoof","year":"2017","unstructured":"Raoof R et al (2017) Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Sci Rep 7(1):3328","journal-title":"Sci Rep"},{"issue":"7","key":"6605_CR30","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1172\/JCI126346","volume":"129","author":"MC Hogg","year":"2019","unstructured":"Hogg MC et al (2019) Elevation in plasma tRNA fragments precede seizures in human epilepsy. J Clin Invest 129(7):2946\u20132951","journal-title":"J Clin Invest"},{"issue":"5","key":"6605_CR31","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s12031-019-01477-8","volume":"70","author":"S Mirzajani","year":"2020","unstructured":"Mirzajani S et al (2020) Expression analysis of lncRNAs in refractory and non-refractory epileptic patients. J Mol Neurosci 70(5):689\u2013698","journal-title":"J Mol Neurosci"},{"key":"6605_CR32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jns.2016.06.031","volume":"367","author":"R Wang","year":"2016","unstructured":"Wang R et al (2016) Evaluation of serum matrix metalloproteinase-3 as a biomarker for diagnosis of epilepsy. J Neurol Sci 367:291\u2013297","journal-title":"J Neurol Sci"},{"key":"6605_CR33","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.eplepsyres.2016.02.009","volume":"122","author":"R Wang","year":"2016","unstructured":"Wang R et al (2016) Serum matrix metalloproteinase-2: a potential biomarker for diagnosis of epilepsy. Epilepsy Res 122:114\u2013119","journal-title":"Epilepsy Res"},{"key":"6605_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuint.2018.12.013","volume":"124","author":"H Zhang","year":"2019","unstructured":"Zhang H et al (2019) Chitinase-3-like protein 1 may be a potential biomarker in patients with drug-resistant epilepsy. Neurochem Int 124:62\u201367","journal-title":"Neurochem Int"},{"key":"6605_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.brainres.2018.09.028","volume":"1704","author":"M Asadollahi","year":"2019","unstructured":"Asadollahi M, Simani L (2019) The diagnostic value of serum UCHL-1 and S100-B levels in differentiate epileptic seizures from psychogenic attacks. Brain Res 1704:11\u201315","journal-title":"Brain Res"},{"issue":"2","key":"6605_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1515\/hmbci-2020-0060","volume":"42","author":"P Asia","year":"2021","unstructured":"Asia P et al (2021) The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study. Horm Mol Biol Clin Investig 42(2):183\u2013187","journal-title":"Horm Mol Biol Clin Investig"},{"key":"6605_CR37","doi-asserted-by":"publisher","first-page":"838389","DOI":"10.3389\/fimmu.2022.838389","volume":"13","author":"Q Lai","year":"2022","unstructured":"Lai Q et al (2022) GluR3B antibody was a biomarker for drug-resistant epilepsy in patients with focal to bilateral tonic-clonic seizures. Front Immunol 13:838389","journal-title":"Front Immunol"},{"issue":"4","key":"6605_CR38","doi-asserted-by":"publisher","first-page":"e0124663","DOI":"10.1371\/journal.pone.0124663","volume":"10","author":"B Stocklin","year":"2015","unstructured":"Stocklin B et al (2015) Copeptin as a serum biomarker of febrile seizures. PLoS ONE 10(4):e0124663","journal-title":"PLoS ONE"},{"issue":"2","key":"6605_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105475","volume":"30","author":"N Wang","year":"2021","unstructured":"Wang N et al (2021) Serum neuropeptide Y level is associated with post-ischemic stroke epilepsy. J Stroke Cerebrovasc Dis 30(2):105475","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"6605_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.seizure.2018.05.016","volume":"60","author":"M Kopczynska","year":"2018","unstructured":"Kopczynska M et al (2018) Complement system biomarkers in epilepsy. Seizure 60:1\u20137","journal-title":"Seizure"},{"issue":"1","key":"6605_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/ene.12232","volume":"21","author":"Z Hong","year":"2014","unstructured":"Hong Z et al (2014) Serum brain-derived neurotrophic factor levels in epilepsy. Eur J Neurol 21(1):57\u201364","journal-title":"Eur J Neurol"},{"issue":"1","key":"6605_CR42","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1038\/s41598-020-59259-x","volume":"10","author":"C Rawat","year":"2020","unstructured":"Rawat C et al (2020) Downregulation of peripheral PTGS2\/COX-2 in response to valproate treatment in patients with epilepsy. Sci Rep 10(1):2546","journal-title":"Sci Rep"},{"issue":"3","key":"6605_CR43","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","volume":"34","author":"VK Mootha","year":"2003","unstructured":"Mootha VK et al (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34(3):267\u2013273","journal-title":"Nat Genet"},{"issue":"43","key":"6605_CR44","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"6605_CR45","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","volume":"171","author":"A Subramanian","year":"2017","unstructured":"Subramanian A et al (2017) A next generation connectivity map: L1000 platform and the first 1,000,000 profiles. Cell 171(6):1437-1452 e17","journal-title":"Cell"},{"issue":"8","key":"6605_CR46","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1007\/s12264-022-00861-6","volume":"38","author":"X Dang","year":"2022","unstructured":"Dang X et al (2022) Correlation of ferroptosis and other types of cell death in neurodegenerative diseases. Neurosci Bull 38(8):938\u2013952","journal-title":"Neurosci Bull"},{"issue":"6","key":"6605_CR47","doi-asserted-by":"publisher","first-page":"508","DOI":"10.4161\/nucl.36360","volume":"5","author":"A Curinha","year":"2014","unstructured":"Curinha A et al (2014) Implications of polyadenylation in health and disease. Nucleus 5(6):508\u2013519","journal-title":"Nucleus"},{"issue":"7","key":"6605_CR48","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2017.05.031","volume":"169","author":"S Weis","year":"2017","unstructured":"Weis S et al (2017) Metabolic adaptation establishes disease tolerance to sepsis. Cell 169(7):1263-1275 e14","journal-title":"Cell"},{"key":"6605_CR49","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3389\/fnins.2019.01195","volume":"13","author":"BB Muhoberac","year":"2019","unstructured":"Muhoberac BB, Vidal R (2019) iron, ferritin, hereditary ferritinopathy, and neurodegeneration. Front Neurosci 13:1195","journal-title":"Front Neurosci"},{"key":"6605_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.609236","volume":"12","author":"E Akyuz","year":"2021","unstructured":"Akyuz E et al (2021) Myocardial iron overload in an experimental model of sudden unexpected death in epilepsy. Front Neurol 12:609236","journal-title":"Front Neurol"},{"key":"6605_CR51","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.freeradbiomed.2018.10.411","volume":"133","author":"CC Philpott","year":"2019","unstructured":"Philpott CC, Jadhav S (2019) The ins and outs of iron: escorting iron through the mammalian cytosol. Free Radic Biol Med 133:112\u2013117","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"6605_CR52","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/MOH.0000000000000417","volume":"25","author":"CC Philpott","year":"2018","unstructured":"Philpott CC (2018) The flux of iron through ferritin in erythrocyte development. Curr Opin Hematol 25(3):183\u2013188","journal-title":"Curr Opin Hematol"},{"key":"6605_CR53","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-030-62026-4_4","volume":"1301","author":"N Santana-Codina","year":"2021","unstructured":"Santana-Codina N, Gikandi A, Mancias JD (2021) The role of NCOA4-mediated ferritinophagy in ferroptosis. Adv Exp Med Biol 1301:41\u201357","journal-title":"Adv Exp Med Biol"},{"key":"6605_CR54","doi-asserted-by":"publisher","first-page":"696889","DOI":"10.3389\/fncel.2021.696889","volume":"15","author":"Y Cai","year":"2021","unstructured":"Cai Y, Yang Z (2021) Ferroptosis and its role in epilepsy. Front Cell Neurosci 15:696889","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"6605_CR55","doi-asserted-by":"publisher","first-page":"e0206239","DOI":"10.1371\/journal.pone.0206239","volume":"13","author":"C Sticht","year":"2018","unstructured":"Sticht C et al (2018) miRWalk: an online resource for prediction of microRNA binding sites. PLoS One 13(10):e0206239","journal-title":"PLoS One"},{"issue":"20","key":"6605_CR56","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1212\/WNL.0b013e3182563b19","volume":"78","author":"MJ Brodie","year":"2012","unstructured":"Brodie MJ et al (2012) Patterns of treatment response in newly diagnosed epilepsy. Neurology 78(20):1548\u20131554","journal-title":"Neurology"},{"issue":"4","key":"6605_CR57","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1111\/epi.13702","volume":"58","author":"J Gesche","year":"2017","unstructured":"Gesche J et al (2017) Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia 58(4):e64\u2013e69","journal-title":"Epilepsia"},{"key":"6605_CR58","doi-asserted-by":"publisher","first-page":"107966","DOI":"10.1016\/j.neuropharm.2020.107966","volume":"168","author":"GJ Sills","year":"2020","unstructured":"Sills GJ, Rogawski MA (2020) Mechanisms of action of currently used antiseizure drugs. Neuropharmacology 168:107966","journal-title":"Neuropharmacology"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06605-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-023-06605-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06605-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T04:07:41Z","timestamp":1683864461000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-023-06605-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["6605"],"URL":"https:\/\/doi.org\/10.1007\/s10072-023-06605-2","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"12 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not available.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No informed consent statement was not required for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}