{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:14:49Z","timestamp":1793970889809,"version":"4.8.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s10072-023-06695-y","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T16:37:04Z","timestamp":1677170224000},"page":"2501-2507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Frequency of seizures in patients with metastatic brain tumors"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-8986","authenticated-orcid":false,"given":"Kristin","family":"Huntoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Musgrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Shaikhouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"issue":"1","key":"6695_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","volume":"5","author":"AS Achrol","year":"2019","unstructured":"Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L et al (2019) Brain metastases Nat Rev Dis Primers 5(1):5. https:\/\/doi.org\/10.1038\/s41572-018-0055-y","journal-title":"Brain metastases Nat Rev Dis Primers"},{"key":"6695_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.critrevonc.2019.07.012","volume":"142","author":"JW Rick","year":"2019","unstructured":"Rick JW, Shahin M, Chandra A, Dalle Ore C, Yue JK, Nguyen A et al (2019) Systemic therapy for brain metastases. Crit Rev Oncol Hematol 142:44\u201350. https:\/\/doi.org\/10.1016\/j.critrevonc.2019.07.012","journal-title":"Crit Rev Oncol Hematol"},{"issue":"5","key":"6695_CR3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1200\/JCO.21.02314","volume":"40","author":"MA Vogelbaum","year":"2022","unstructured":"Vogelbaum MA, Brown PD, Messersmith H, Brastionos PK, Burri S, Cahill D et al (2022) Treatment for brain metastasis: ASCO-SNO-ASTRO guideline. J Clin Oncol 40(5):492\u2013516. https:\/\/doi.org\/10.1200\/JCO.21.02314","journal-title":"J Clin Oncol"},{"issue":"8","key":"6695_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/s41571-020-0397-8","volume":"17","author":"D Killock","year":"2020","unstructured":"Killock D (2020) ICI for resected stage IV melanoma. Nat Rev Clin Oncol 17(8):450. https:\/\/doi.org\/10.1038\/s41571-020-0397-8","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"6695_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11940-020-0613-y","volume":"22","author":"R Rud\u00e0","year":"2020","unstructured":"Rud\u00e0 R, Mo F, Pellerino A (2020) Epilepsy in brain metastasis: an emerging entity. Curr Treat Options in Neurol 22(2):6. https:\/\/doi.org\/10.1007\/s11940-020-0613-y","journal-title":"Curr Treat Options in Neurol"},{"issue":"5","key":"6695_CR6","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1093\/neuonc\/noz172","volume":"22","author":"F Wolpert","year":"2020","unstructured":"Wolpert F, Lareida A, Terziev R, Grossenbacher B, Neidert MC, Roth P et al (2020) Risk factors for the development of epilepsy in patients with brain metastases. Neuro Oncol 22(5):718\u2013728. https:\/\/doi.org\/10.1093\/neuonc\/noz172","journal-title":"Neuro Oncol"},{"issue":"3","key":"6695_CR7","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s11060-016-2335-2","volume":"131","author":"V Chan","year":"2017","unstructured":"Chan V, Sahgal A, Egeto P, Schweizer T, Das S (2017) Incidence of seizure in adult patients with intracranial metastatic disease. J Neurooncol 131(3):619\u2013624. https:\/\/doi.org\/10.1007\/s11060-016-2335-2","journal-title":"J Neurooncol"},{"issue":"2","key":"6695_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2174\/157015912800604470","volume":"10","author":"M Maschio","year":"2012","unstructured":"Maschio M (2012) Brain tumor-related epilepsy. Curr Neuropharmacol 10(2):124\u2013133. https:\/\/doi.org\/10.2174\/157015912800604470","journal-title":"Curr Neuropharmacol"},{"issue":"7","key":"6695_CR9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.clineuro.2007.05.017","volume":"109","author":"LM Lynam","year":"2007","unstructured":"Lynam LM, Lyons MK, Drazkowski JF, Sirven JI, Noe KH, Zimmerman RS, Wilkens JA (2007) Frequency of seizures in patients with newly diagnosed brain tumors: a retrospective review. Clin Neurol Neurosurg 109(7):634\u2013638. https:\/\/doi.org\/10.1016\/j.clineuro.2007.05.017","journal-title":"Clin Neurol Neurosurg"},{"key":"6695_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.wneu.2017.05.028","volume":"104","author":"A Wu","year":"2017","unstructured":"Wu A, Weingart JD, Gallia GL, Lim M, Brem H, Bettegowda C, Chaichana KL (2017) Risk factors for preoperative seizures and loss of seizure control in patients undergoing surgery for metastatic brain tumors. World Neurosurg 104:120\u2013128. https:\/\/doi.org\/10.1016\/j.wneu.2017.05.028","journal-title":"World Neurosurg"},{"issue":"21\u201322","key":"6695_CR11","first-page":"911","volume":"114","author":"S Oberndorfer","year":"2002","unstructured":"Oberndorfer S, Schmal T, Lahrmann H, Urbanits S, Lindner K, Grisold W (2002) The frequency of seizures in patients with primary brain tumors or cerebral metastases An evaluation from the Ludwig Boltzmann Institute of Neuro-Oncology and the Department of Neurology, Kaiser Franz Josef Hospital, Vienna. Wien Klin Wochenschr 114(21\u201322):911\u2013916 (article in German)","journal-title":"Wien Klin Wochenschr"},{"key":"6695_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/B978-0-12-802997-8.00016-5","volume":"134","author":"DJ Englot","year":"2016","unstructured":"Englot DJ, Chang EF, Vecht CJ (2016) Epilepsy and brain tumors. Handb Clin Neurol 134:267\u2013285. https:\/\/doi.org\/10.1016\/B978-0-12-802997-8.00016-5","journal-title":"Handb Clin Neurol"},{"issue":"6","key":"6695_CR13","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/CCO.0b013e32833de99d","volume":"22","author":"R Rud\u00e0","year":"2010","unstructured":"Rud\u00e0 R, Trevisan E, Soffietti R (2010) Epilepsy and brain tumors. Curr Opin Oncol 22(6):611\u2013620. https:\/\/doi.org\/10.1097\/CCO.0b013e32833de99d","journal-title":"Curr Opin Oncol"},{"issue":"2","key":"6695_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/WNP.0000000000000671","volume":"38","author":"S Ajinkya","year":"2021","unstructured":"Ajinkya S, Fox J, Houston P, Greenblatt A, Lekoubou A, Lindhorst S, Cachia D, Olar A, Kutluay E (2021) Seizures in patients with metastatic brain tumors: Prevalence, clinical characteristics, and features on EEG. J Clin Neurophysiol 38(2):143\u2013148. https:\/\/doi.org\/10.1097\/WNP.0000000000000671","journal-title":"J Clin Neurophysiol"},{"issue":"1","key":"6695_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11060-012-0802-y","volume":"108","author":"S Goldlust","year":"2012","unstructured":"Goldlust S, Hsu M, Lassman A, Panageas K, Avila E (2012) Seizure prophylaxis and melanoma brain metastases. J Neurooncol 108(1):109\u2013114. https:\/\/doi.org\/10.1007\/s11060-012-0802-y","journal-title":"J Neurooncol"},{"issue":"8","key":"6695_CR16","doi-asserted-by":"publisher","first-page":"e1237","DOI":"10.1212\/WNL.0000000000011459","volume":"96","author":"N Lamba","year":"2021","unstructured":"Lamba N, Catalano PJ, Cagney DN, Haas-Kogan DA, Bubrick EJ, Wen PY, Aizer AA (2021) Seizures among patients with brain metastases: a population-and institutional-level analysis. Neurology 96(8):e1237\u2013e1250. https:\/\/doi.org\/10.1212\/WNL.0000000000011459","journal-title":"Neurology"},{"issue":"15","key":"6695_CR17","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.2165\/00019053-200220150-00002","volume":"20","author":"P Berto","year":"2002","unstructured":"Berto P (2002) Quality of life in patients with epilepsy and impact of treatments. Pharmacoeconomics 20(15):1039\u20131059. https:\/\/doi.org\/10.2165\/00019053-200220150-00002","journal-title":"Pharmacoeconomics"},{"issue":"10","key":"6695_CR18","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s00415-002-0870-6","volume":"249","author":"R Soffietti","year":"2002","unstructured":"Soffietti R, Rud\u00e0 R, Mutani R (2002) Management of brain metastases. J Neurol 249(10):1357\u20131369. https:\/\/doi.org\/10.1007\/s00415-002-0870-6","journal-title":"J Neurol"},{"issue":"3","key":"6695_CR19","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3171\/jns.2002.96.3.0552","volume":"96","author":"AC Zacest","year":"2002","unstructured":"Zacest AC, Besser M, Stevens G, Thompson JF, McCarthy WH, Culjak G (2002) Surgical management of cerebral metastases from melanoma: outcome in 147 patients treated at a single institution over two decades. J Neurosurg 96(3):552\u2013558. https:\/\/doi.org\/10.3171\/jns.2002.96.3.0552","journal-title":"J Neurosurg"},{"issue":"2","key":"6695_CR20","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/brain\/awl318","volume":"130","author":"EA Van Vliet","year":"2007","unstructured":"Van Vliet EA, da Costa AS, Redeker S, Van Schaik R, Aronica E, Gorter J (2007) Blood\u2013brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130(2):521\u2013534. https:\/\/doi.org\/10.1093\/brain\/awl318","journal-title":"Brain"},{"issue":"2","key":"6695_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/brain\/awl317","volume":"130","author":"S Ivens","year":"2007","unstructured":"Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A (2007) TGF-\u03b2 receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain 130(2):535\u2013547. https:\/\/doi.org\/10.1093\/brain\/awl317","journal-title":"Brain"},{"issue":"1","key":"6695_CR22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11060-010-0214-9","volume":"101","author":"M Jung","year":"2011","unstructured":"Jung M, Ahn JB, Chang JH, Suh CO, Hong S, Roh JK, Shin SJ, Rha SY (2011) Brain metastases from colorectal carcinoma: prognostic factors and outcome. J Neurooncol 101(1):49\u201355. https:\/\/doi.org\/10.1007\/s11060-010-0214-9","journal-title":"J Neurooncol"},{"issue":"14","key":"6695_CR23","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","volume":"22","author":"JS Barnholtz-Sloan","year":"2004","unstructured":"Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE (2004) Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 22(14):2865\u20132872. https:\/\/doi.org\/10.1200\/JCO.2004.12.149","journal-title":"J Clin Oncol"},{"issue":"10","key":"6695_CR24","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1002\/cncr.10541","volume":"94","author":"LJ Schouten","year":"2002","unstructured":"Schouten LJ, Rutten J, Huveneers HA, Twijnstra A (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94(10):2698\u20132705. https:\/\/doi.org\/10.1002\/cncr.10541","journal-title":"Cancer"},{"issue":"1","key":"6695_CR25","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1038\/s41598-020-61354-y","volume":"10","author":"T Koo","year":"2020","unstructured":"Koo T, Kim K, Park HJ, Han SW, Kim TY, Jeong SY, Park KJ, Chie EK (2020) Prognostic factors for survival in colorectal cancer patients with brain metastases undergoing whole brain radiotherapy: Multicenter retrospective study. Sci Rep 10(1):4340. https:\/\/doi.org\/10.1038\/s41598-020-61354-y","journal-title":"Sci Rep"},{"issue":"2","key":"6695_CR26","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3816\/CCC.2009.n.016","volume":"8","author":"JP Mongan","year":"2009","unstructured":"Mongan JP, Fadul CE, Cole BF, Zaki BI, Suriawinata AA, Ripple GH, Tosteson TD, Pipas JM (2009) Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines. Clin Colorectal Cancer 8(2):100\u2013105. https:\/\/doi.org\/10.3816\/CCC.2009.n.016","journal-title":"Clin Colorectal Cancer"},{"issue":"4","key":"6695_CR27","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1093\/brain\/awr310","volume":"135","author":"M de Groot","year":"2012","unstructured":"de Groot M, Reijneveld JC, Aronica E, Heimans JJ (2012) Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain 135(4):1002\u20131016. https:\/\/doi.org\/10.1093\/brain\/awr310","journal-title":"Brain"},{"issue":"7","key":"6695_CR28","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1046\/j.1528-1157.2002.39501.x","volume":"43","author":"MM Zaatreh","year":"2002","unstructured":"Zaatreh MM, Spencer DD, Thompson JL, Blumenfeld H, Novotny EJ, Mattson RH, Spencer SS (2002) Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcome. Epilepsia 43(7):727\u2013733. https:\/\/doi.org\/10.1046\/j.1528-1157.2002.39501.x","journal-title":"Epilepsia"},{"issue":"1","key":"6695_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3171\/2022.3.JNS212285","volume":"138","author":"JH Garcia","year":"2022","unstructured":"Garcia JH, Morshed RA, Chung J, Chavez MAM, Sudhakar V, Saggi S et al (2022) Factors associated with preoperative and postoperative seizures in patients undergoing resection of brain metastases. J Neurosurg 138(1):19\u201326. https:\/\/doi.org\/10.3171\/2022.3.JNS212285","journal-title":"J Neurosurg"},{"issue":"3","key":"6695_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/NRL.0b013e31821733db","volume":"17","author":"R Bagla","year":"2011","unstructured":"Bagla R, Skidmore CT (2011) Frontal lobe seizures. Neurologist 17(3):125\u2013135. https:\/\/doi.org\/10.1097\/NRL.0b013e31821733db","journal-title":"Neurologist"},{"key":"6695_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/2162402X.2020.1851517","volume":"9","author":"H Urban","year":"2020","unstructured":"Urban H, Willems LM, Ronellenfitsch MW, Rosenow F, Steinbach JP, Strzelczyk A (2020) Increased occurrence of status epilepticus in patients with brain metastases and checkpoint inhibition. OncoImmunology 9:1. https:\/\/doi.org\/10.1080\/2162402X.2020.1851517","journal-title":"OncoImmunology"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-023-06695-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T04:04:09Z","timestamp":1686369849000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-023-06695-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["6695"],"URL":"https:\/\/doi.org\/10.1007\/s10072-023-06695-y","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]},"assertion":[{"value":"15 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}