{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:27:18Z","timestamp":1791253638886,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-017"],"award-info":[{"award-number":["2022-PUMCH-B-017"]}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["CIFMS 2021-I2M-1-003"],"award-info":[{"award-number":["CIFMS 2021-I2M-1-003"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202158"],"award-info":[{"award-number":["7202158"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10072-023-06703-1","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T01:02:37Z","timestamp":1677805357000},"page":"1969-1978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Facial onset sensory and motor neuronopathy (FOSMN syndrome): Cases series and systematic review"],"prefix":"10.1007","volume":"44","author":[{"given":"Nan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunzhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-5345","authenticated-orcid":false,"given":"Mingsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"Pt 12","key":"6703_CR1","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1093\/brain\/awl258","volume":"129","author":"S Vucic","year":"2006","unstructured":"Vucic S et al (2006) Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology. Brain 129(Pt 12):3384\u20133390","journal-title":"Brain"},{"issue":"4","key":"6703_CR2","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/mus.24299","volume":"50","author":"I Karakis","year":"2014","unstructured":"Karakis I, Vucic S, Srinivasan J (2014) Facial onset sensory and motor neuronopathy (FOSMN) of childhood onset. Muscle Nerve 50(4):614\u2013615","journal-title":"Muscle Nerve"},{"issue":"4","key":"6703_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.neurol.2018.04.010","volume":"175","author":"W Pinto","year":"2019","unstructured":"Pinto W et al (2019) New findings in facial-onset sensory and motor neuronopathy (FOSMN) syndrome. Rev Neurol (Paris) 175(4):238\u2013246","journal-title":"Rev Neurol (Paris)"},{"issue":"2","key":"6703_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1212\/CPJ.0000000000000834","volume":"11","author":"EMJ de Boer","year":"2021","unstructured":"de Boer EMJ et al (2021) Facial onset sensory and motor neuronopathy: new cases, cognitive changes, and pathophysiology. Neurol Clin Pract 11(2):147\u2013157","journal-title":"Neurol Clin Pract"},{"issue":"11","key":"6703_CR5","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1007\/s10072-022-06339-7","volume":"43","author":"Z Liu","year":"2022","unstructured":"Liu Z et al (2022) Muscle and skin fibroblast TDP-43 expression, dynamic mutation analysis of NOTCH2NLC and C9orf72 in patients with FOSMN. Neurol Sci 43(11):6505\u20136510","journal-title":"Neurol Sci"},{"issue":"12","key":"6703_CR6","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1007\/s10072-016-2686-7","volume":"37","author":"Q Zheng","year":"2016","unstructured":"Zheng Q et al (2016) Facial onset sensory and motor neuronopathy. Neurol Sci 37(12):1905\u20131909","journal-title":"Neurol Sci"},{"issue":"7","key":"6703_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097","journal-title":"PLoS Med"},{"issue":"12","key":"6703_CR8","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1111\/cns.13755","volume":"27","author":"LX Chen","year":"2021","unstructured":"Chen LX et al (2021) Taste loss as the sole presenting symptom in Chinese patient with facial onset sensory and motor neuronopathy. CNS Neurosci Ther 27(12):1610\u20131613","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"6703_CR9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1186\/s13256-021-03212-7","volume":"15","author":"H Hanawa","year":"2021","unstructured":"Hanawa H et al (2021) Facial onset sensory and motor neuropathy in a pain clinic outpatient: a case report. J Med Case Rep 15(1):609","journal-title":"J Med Case Rep"},{"issue":"3","key":"6703_CR10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5603\/PJNNS.a2021.0018","volume":"55","author":"M Grudzi\u0144ska","year":"2021","unstructured":"Grudzi\u0144ska M et al (2021) Facial onset sensory and motor neuronopathy syndrome - a rare variant of motor neurone disease. Neurol Neurochir Pol 55(3):325\u2013327","journal-title":"Neurol Neurochir Pol"},{"issue":"5","key":"6703_CR11","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1212\/CPJ.0000000000000753","volume":"10","author":"G Agirre-Beitia","year":"2020","unstructured":"Agirre-Beitia G et al (2020) FOSMN: A possible TDP-43 proteinopathy to consider in a patient with facial sensory symptoms. Neurol Clin Pract 10(5):e47\u2013e50","journal-title":"Neurol Clin Pract"},{"issue":"1","key":"6703_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12883-020-01639-x","volume":"20","author":"N Ohashi","year":"2020","unstructured":"Ohashi N et al (2020) Taste disorder in facial onset sensory and motor neuronopathy: a case report. BMC Neurol 20(1):71","journal-title":"BMC Neurol"},{"issue":"4","key":"6703_CR13","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3988\/jcn.2020.16.4.729","volume":"16","author":"W Zhang","year":"2020","unstructured":"Zhang W et al (2020) Facial-onset sensory motor neuronopathy syndrome is not always facial onset. J Clin Neurol 16(4):729\u2013730","journal-title":"J Clin Neurol"},{"issue":"9","key":"6703_CR14","doi-asserted-by":"publisher","first-page":"e951","DOI":"10.1212\/WNL.0000000000007008","volume":"92","author":"AM Rossor","year":"2019","unstructured":"Rossor AM et al (2019) TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN. Neurology 92(9):e951\u2013e956","journal-title":"Neurology"},{"issue":"1","key":"6703_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10072-019-04033-9","volume":"41","author":"KS Lange","year":"2020","unstructured":"Lange KS, Maier A, Leithner C (2020) Elevated CSF neurofilament light chain concentration in a patient with facial onset sensory and motor neuronopathy. Neurol Sci 41(1):217\u2013219","journal-title":"Neurol Sci"},{"issue":"3\u20134","key":"6703_CR16","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1080\/21678421.2019.1582671","volume":"20","author":"JF V\u00e1zquez-Costa","year":"2019","unstructured":"V\u00e1zquez-Costa JF et al (2019) Facial onset sensory and motor neuronopathy: a motor neuron disease with an oligogenic origin? Amyotroph Lateral Scler Frontotemporal Degener 20(3\u20134):172\u2013175","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"1","key":"6703_CR17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/NRL.0000000000000201","volume":"24","author":"Q Zhang","year":"2019","unstructured":"Zhang Q et al (2019) Facial onset motor and sensory neuronopathy syndrome with a novel TARDBP mutation. Neurologist 24(1):22\u201325","journal-title":"Neurologist"},{"issue":"5","key":"6703_CR18","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1212\/WNL.0000000000001216","volume":"84","author":"A Truini","year":"2015","unstructured":"Truini A et al (2015) Differential trigeminal myelinated and unmyelinated nerve fiber involvement in FOSMN syndrome. Neurology 84(5):540\u2013542","journal-title":"Neurology"},{"issue":"9","key":"6703_CR19","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1136\/jnnp-2013-307416","volume":"85","author":"E Dalla Bella","year":"2014","unstructured":"Dalla Bella E et al (2014) Heterozygous D90A-SOD1 mutation in a patient with facial onset sensory motor neuronopathy (FOSMN) syndrome: a bridge to amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 85(9):1009\u20131011","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"6703_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000381944","volume":"7","author":"B Ziso","year":"2015","unstructured":"Ziso B et al (2015) Facial onset sensory and motor neuronopathy: further evidence for a TDP-43 proteinopathy. Case Rep Neurol 7(1):95\u2013100","journal-title":"Case Rep Neurol"},{"issue":"4","key":"6703_CR21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1136\/practneurol-2014-000984","volume":"15","author":"R Broad","year":"2015","unstructured":"Broad R, Leigh PN (2015) Recognising facial onset sensory motor neuronopathy syndrome: insight from six new cases. Pract Neurol 15(4):293\u2013297","journal-title":"Pract Neurol"},{"key":"6703_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12883-014-0248-2","volume":"14","author":"G Cruccu","year":"2014","unstructured":"Cruccu G et al (2014) Trigeminal isolated sensory neuropathy (TISN) and FOSMN syndrome: despite a dissimilar disease course do they share common pathophysiological mechanisms? BMC Neurol 14:248","journal-title":"BMC Neurol"},{"issue":"1\u20132","key":"6703_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jns.2013.06.027","volume":"332","author":"K Sonoda","year":"2013","unstructured":"Sonoda K et al (2013) TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: an autopsied case report and a review of the literature. J Neurol Sci 332(1\u20132):148\u2013153","journal-title":"J Neurol Sci"},{"issue":"1","key":"6703_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/CND.0b013e31825f82b3","volume":"14","author":"D Dobrev","year":"2012","unstructured":"Dobrev D et al (2012) Facial onset sensorimotor neuronopathy syndrome: a case series. J Clin Neuromuscul Dis 14(1):7\u201310","journal-title":"J Clin Neuromuscul Dis"},{"issue":"1","key":"6703_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1212\/WNL.0b013e31825dce13","volume":"79","author":"S Vucic","year":"2012","unstructured":"Vucic S et al (2012) FOSMN syndrome: novel insight into disease pathophysiology. Neurology 79(1):73\u201379","journal-title":"Neurology"},{"issue":"1","key":"6703_CR26","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/mus.21884","volume":"43","author":"F Fluchere","year":"2011","unstructured":"Fluchere F et al (2011) Clinical features and follow-up of four new cases of facial-onset sensory and motor neuronopathy. Muscle Nerve 43(1):136\u2013140","journal-title":"Muscle Nerve"},{"issue":"5","key":"6703_CR27","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/mus.20991","volume":"37","author":"G Isoardo","year":"2008","unstructured":"Isoardo G, Troni W (2008) Sporadic bulbospinal muscle atrophy with facial-onset sensory neuropathy. Muscle Nerve 37(5):659\u2013662","journal-title":"Muscle Nerve"},{"issue":"1\u20132","key":"6703_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jns.2008.07.021","volume":"275","author":"T Hokonohara","year":"2008","unstructured":"Hokonohara T et al (2008) Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies. J Neurol Sci 275(1\u20132):157\u2013158","journal-title":"J Neurol Sci"},{"key":"6703_CR29","doi-asserted-by":"publisher","first-page":"17085","DOI":"10.1038\/nrdp.2017.85","volume":"3","author":"O Hardiman","year":"2017","unstructured":"Hardiman O et al (2017) Amyotrophic lateral sclerosis. Nat Rev Dis Primers 3:17085","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"6703_CR30","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1136\/jnnp-2021-326266","volume":"92","author":"P Corcia","year":"2021","unstructured":"Corcia P et al (2021) Split-hand and split-limb phenomena in amyotrophic lateral sclerosis: pathophysiology, electrophysiology and clinical manifestations. J Neurol Neurosurg Psychiatry 92(10):1126\u20131130","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"6703_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.clinph.2012.07.020","volume":"124","author":"M Mondelli","year":"2013","unstructured":"Mondelli M et al (2013) Sensory nerve action potential amplitude is rarely reduced in lumbosacral radiculopathy due to herniated disc. Clin Neurophysiol 124(2):405\u2013409","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"6703_CR32","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.clinph.2019.12.006","volume":"131","author":"G Siedler","year":"2020","unstructured":"Siedler G, Sommer C, \u00dc\u00e7eyler N (2020) Pain-related evoked potentials in patients with large, mixed, and small fiber neuropathy. Clin Neurophysiol 131(3):635\u2013641","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"6703_CR33","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1016\/j.clinph.2020.04.005","volume":"131","author":"JM Shefner","year":"2020","unstructured":"Shefner JM et al (2020) A proposal for new diagnostic criteria for ALS. Clin Neurophysiol 131(8):1975\u20131978","journal-title":"Clin Neurophysiol"},{"issue":"24","key":"6703_CR34","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1212\/01.wnl.0000286948.99150.16","volume":"69","author":"M Hammad","year":"2007","unstructured":"Hammad M et al (2007) Clinical, electrophysiologic, and pathologic evidence for sensory abnormalities in ALS. Neurology 69(24):2236\u20132242","journal-title":"Neurology"},{"issue":"5","key":"6703_CR35","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/acn3.51039","volume":"7","author":"P Menon","year":"2020","unstructured":"Menon P et al (2020) Cortical hyperexcitability evolves with disease progression in ALS. Ann Clin Transl Neurol 7(5):733\u2013741","journal-title":"Ann Clin Transl Neurol"},{"issue":"7","key":"6703_CR36","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1007\/s00415-018-8881-0","volume":"265","author":"N M\u00e9l\u00e9","year":"2018","unstructured":"M\u00e9l\u00e9 N et al (2018) Motor neuron disease of paraneoplastic origin: a rare but treatable condition. J Neurol 265(7):1590\u20131599","journal-title":"J Neurol"},{"issue":"3","key":"6703_CR37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jinf.2009.06.011","volume":"59","author":"G Thwaites","year":"2009","unstructured":"Thwaites G et al (2009) British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect 59(3):167\u2013187","journal-title":"J Infect"},{"issue":"2","key":"6703_CR38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0163-4453(87)91952-9","volume":"14","author":"IO Al-Orainey","year":"1987","unstructured":"Al-Orainey IO et al (1987) Brucella meningitis. J Infect 14(2):141\u2013145","journal-title":"J Infect"},{"issue":"1","key":"6703_CR39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/17482960701656940","volume":"9","author":"P Corcia","year":"2008","unstructured":"Corcia P et al (2008) Causes of death in a post-mortem series of ALS patients. Amyotroph Lateral Scler 9(1):59\u201362","journal-title":"Amyotroph Lateral Scler"},{"issue":"4","key":"6703_CR40","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bbadis.2014.08.010","volume":"1852","author":"S Ajroud-Driss","year":"2015","unstructured":"Ajroud-Driss S, Siddique T (2015) Sporadic and hereditary amyotrophic lateral sclerosis (ALS). Biochim Biophys Acta 1852(4):679\u2013684","journal-title":"Biochim Biophys Acta"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06703-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-023-06703-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-023-06703-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T03:52:41Z","timestamp":1683863561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-023-06703-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["6703"],"URL":"https:\/\/doi.org\/10.1007\/s10072-023-06703-1","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"assertion":[{"value":"30 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the PUMCH (Peking Union Medical\u00a0College Hospital).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All included patients were provided written, informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}}]}}