{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:52:05Z","timestamp":1782474725602,"version":"3.54.5"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi del Piemonte Orientale Amedeo Avogrado"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cognitive impairment (CI) is common in amyotrophic lateral sclerosis (ALS): a keystone is identifying factors that could potentially modify the CI course. In recent years, vitamin D is becoming a potential modificatory factor for CI in many neurological disorders. This study aimed to highlight if vitamin D deficiency correlated with CI and clinical features in a cohort of ALS patients. We included 55 ALS patients with a neuropsychological evaluation (classified with the Strong Criteria) and a vitamin D dosage at the diagnosis. We also reviewed medical records and completed data for medical history, physical and neurological examination, and functional scales. At the diagnosis, 30 patients (54%) had CI. Most patients (82%) displayed low vitamin D levels (19.87 \u00b1 9.80 ng\/ml). Comparing the vitamin D level between patients with and without CI, we observed significantly lower values in the first group (15.8 \u00b1 8.2 vs. 22.0 \u00b1 9.7 ng\/ml, <jats:italic>p<\/jats:italic>: 0.04). In the spinal female subgroup (<jats:italic>n<\/jats:italic> = 15), we found an inverse correlation between vitamin D and bizarreness score in the cognitive estimates test (<jats:italic>r<\/jats:italic> = 0.58; <jats:italic>p<\/jats:italic>: 0.04) and a positive correlation with the Corrected Raven\u2019s Standard Progressive Matrices (<jats:italic>r<\/jats:italic> = 0.53, <jats:italic>p<\/jats:italic>: 0.04). Conversely, in the bulbar female group, we observed a correlation with the corrected direct span (<jats:italic>r<\/jats:italic> = 0.84, <jats:italic>p<\/jats:italic>: 0.03). With the log-rank survival analysis, we found that the patients with vitamin D &lt; 10 ng\/ml had a shorter disease duration (Chi: 5.78, <jats:italic>p<\/jats:italic>: 0.02). Our results indicate that levels of vitamin D can influence the cognitive status of people living with ALS and that severe deficits might be an adverse prognostic survival factor.<\/jats:p>","DOI":"10.1007\/s10072-023-06751-7","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T01:02:15Z","timestamp":1679533335000},"page":"2795-2802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential role of vitamin D levels in amyotrophic lateral sclerosis cognitive impairment"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-1880","authenticated-orcid":false,"given":"Fabiola","family":"De Marchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Saraceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Sarnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Virgilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cantello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Mazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"issue":"5","key":"6751_CR1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/WCO.0000000000000730","volume":"32","author":"E Longinetti","year":"2019","unstructured":"Longinetti E, Fang F (2019) Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. 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