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These features are the cardinal manifestations of Parkinson\u2019s disease, the most common cause of parkinsonism, and atypical parkinsonian disorders. However, parkinsonism can be a manifestation of complex neurological and neurodegenerative genetically determined disorders, which have a vast and heterogeneous motor and non-motor phenotypic features. Hereditary dementias, adult-onset ataxias and spastic paraplegias represent only few of this vast group of neurogenetic diseases. This review will provide an overview of parkinsonism\u2019s clinical features within adult-onset neurogenetic diseases which a neurologist could face with. Understanding parkinsonism and its characteristics in the context of the aforementioned neurological conditions may provide insights into pathophysiological mechanisms and have important clinical implications, including diagnostic and therapeutic aspects.<\/jats:p>","DOI":"10.1007\/s10072-023-07044-9","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T18:02:27Z","timestamp":1693418547000},"page":"3379-3388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias"],"prefix":"10.1007","volume":"44","author":[{"given":"Simone","family":"Aloisio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Satolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-3129","authenticated-orcid":false,"given":"Piervito","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"12","key":"7044_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/MDS.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB et al (2015) MDS clinical diagnostic criteria for Parkinson\u2019s disease. 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