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The aim of this study is to demonstrate the presence of cardiac autonomic involvement in HD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Time and frequency domain parameters obtained from the 24-h Holter ECG(hECG) were compared between 20 HD patients and 20 healthy control subjects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fourteen HD patients had tachycardia, bradycardia, and extra beats. Interval between two heartbeats, normal-to-normal (NN), standard deviation of all normal-to-normal (SDNN), square root of the mean of the sum of the squares of the differences between consecutive N-N intervals in ms (rMSSD), and the ratio of the number of consecutive pairs of N-N intervals that differ by more than 50\u00a0ms to the total number of N-N intervals (pNN50) were all significantly higher in the patient group than in the control group during 24-h hECG monitoring. However, hECG monitoring showed that the patient group had significantly higher values of the frequency-domain metrics high frequency (HF) than the control group did (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Very low frequency (VLF) was lower in the patient group (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). There was no difference in low frequency (LF) in both groups. In comparison to the control group, LF\/HF was much reduced in the patient group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Cardiac disfunction increases, and autonomic functions change in HD, but more comprehensive studies are needed to distinguish sympathetic and parasympathetic involvement.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-024-07428-5","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T14:03:17Z","timestamp":1709560997000},"page":"3823-3828","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac autonomic involvement in Huntington\u2019s disease"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-7780","authenticated-orcid":false,"given":"Dilek","family":"\u0130\u015fcan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-6485","authenticated-orcid":false,"given":"Yakup","family":"\u00c7etinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"7428_CR1","doi-asserted-by":"publisher","unstructured":"Fang L, Monteys AM, D\u00fcrr A, Keizer M, Cheng C, Harapanahalli A et al (2023)Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing. 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