{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:52:58Z","timestamp":1790790778830,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10072-024-07568-8","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T09:02:06Z","timestamp":1716282126000},"page":"4923-4930","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multimodal digital health treatments for Chronic Migraine associated with Medication Overuse Headache: a literature appraisal and results of a single-arm open trial (the BE-HOME program)"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-1109","authenticated-orcid":false,"given":"Licia","family":"Grazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-2045","authenticated-orcid":false,"given":"Danilo Antonio","family":"Montisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-9301","authenticated-orcid":false,"given":"Domenico","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5535","authenticated-orcid":false,"given":"Claudia","family":"Altamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-7779","authenticated-orcid":false,"given":"Alberto","family":"Raggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-3110","authenticated-orcid":false,"given":"Paul","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-1409","authenticated-orcid":false,"given":"Alessia","family":"Marcassoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"7568_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","volume":"38","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2018","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 38:1\u2013211. https:\/\/doi.org\/10.1177\/0333102417738202","journal-title":"Cephalalgia."},{"key":"7568_CR2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s10194-020-01111-8","volume":"21","author":"M Torres-Ferr\u00fas","year":"2020","unstructured":"Torres-Ferr\u00fas M, Ursitti F, Alpuente A et al (2020) From transformation to chronification of migraine: pathophysiological and clinical aspects. J Headache Pain 21:42. https:\/\/doi.org\/10.1186\/s10194-020-01111-8","journal-title":"J Headache Pain"},{"key":"7568_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41572-021-00328-4","volume":"8","author":"MD Ferrari","year":"2022","unstructured":"Ferrari MD, Goadsby PJ, Burstein R et al (2022) Migraine. Nat Rev Dis Primers 8:2. https:\/\/doi.org\/10.1038\/s41572-021-00328-4","journal-title":"Nat Rev Dis Primers"},{"key":"7568_CR4","doi-asserted-by":"publisher","first-page":"e067670","DOI":"10.1136\/bmj-2021-067670","volume":"379","author":"A Hovaguimian","year":"2022","unstructured":"Hovaguimian A, Roth J (2022) Management of chronic migraine. BMJ 379:e067670. https:\/\/doi.org\/10.1136\/bmj-2021-067670","journal-title":"BMJ"},{"key":"7568_CR5","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.3390\/ijerph18041503","volume":"18","author":"L Grazzi","year":"2021","unstructured":"Grazzi L, Toppo C, D\u2019Amico D et al (2021) Non-pharmacological approaches to headaches: non-invasive neuromodulation, nutraceuticals, and behavioral approaches. Int J Environ Res Public Health 18:1503. https:\/\/doi.org\/10.3390\/ijerph18041503","journal-title":"Int J Environ Res Public Health"},{"key":"7568_CR6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/head.13337","volume":"58","author":"A Raggi","year":"2018","unstructured":"Raggi A, Grignani E, Leonardi M et al (2018) Beavioral approaches for primary headaches: recent advances. Headache 58:913\u2013925. https:\/\/doi.org\/10.1111\/head.13337","journal-title":"Headache"},{"key":"7568_CR7","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3389\/fneur.2018.01009","volume":"9","author":"F Andrasik","year":"2018","unstructured":"Andrasik F, Grazzi L, Sansone E, D\u2019Amico D, Raggi A, Grignani E (2018) Non-pharmacological approaches for headaches in young age: an updated review. Front Neurol 9:1009. https:\/\/doi.org\/10.3389\/fneur.2018.01009","journal-title":"Front Neurol"},{"issue":"1","key":"7568_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s10194-021-01281-z","volume":"22","author":"V Caponnetto","year":"2021","unstructured":"Caponnetto V, Deodato M, Robotti M et al (2021) Comorbidities of primary headache disorders: a literature review with meta-analysis. J Headache Pain 22(1):71. https:\/\/doi.org\/10.1186\/s10194-021-01281-z","journal-title":"J Headache Pain"},{"key":"7568_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s10194-017-0728-z","volume":"18","author":"L Grazzi","year":"2017","unstructured":"Grazzi L, Sansone E, Raggi A et al (2017) Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up. J Headache Pain 18:15. https:\/\/doi.org\/10.1186\/s10194-017-0728-z","journal-title":"J Headache Pain"},{"issue":"Suppl 1","key":"7568_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10072-017-2874-0","volume":"38","author":"L Grazzi","year":"2017","unstructured":"Grazzi L, D\u2019Amico D, Raggi A et al (2017) Mindfulness and pharmacological prophylaxis have comparable effect on biomarkers of inflammation and clinical indexes in chronic migraine with medication overuse: results at 12 months after withdrawal. Neurol Sci 38(Suppl 1):173\u2013175. https:\/\/doi.org\/10.1007\/s10072-017-2874-0","journal-title":"Neurol Sci"},{"key":"7568_CR11","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1177\/0333102418801584","volume":"39","author":"L Grazzi","year":"2019","unstructured":"Grazzi L, Raggi A, D\u2019Amico D et al (2019) A prospective pilot study of the effect on catecholamines of mindfulness training vs pharmacological prophylaxis in patients with chronic migraine and medication overuse headache. Cephalalgia 39:655\u2013664. https:\/\/doi.org\/10.1177\/0333102418801584","journal-title":"Cephalalgia"},{"key":"7568_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s10194-023-01630-0","volume":"24","author":"L Grazzi","year":"2023","unstructured":"Grazzi L, D\u2019Amico D, Guastafierro E et al (2023) Efficacy of mindfulness added to treatment as usual in patients with chronic migraine and medication overuse headache: a phase-III single-blind randomized-controlled trial (the MIND-CM study). J Headache Pain 24:86. https:\/\/doi.org\/10.1186\/s10194-023-01630-0","journal-title":"J Headache Pain"},{"key":"7568_CR13","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1111\/head.13657","volume":"59","author":"EK Seng","year":"2019","unstructured":"Seng EK, Singer AB, Metts C et al (2019) Does mindfulness-based cognitive therapy for migraine reduce migraine-related disability in people with episodic and chronic migraine? A phase 2b pilot randomized clinical trial. Headache 59:1448\u20131467. https:\/\/doi.org\/10.1111\/head.13657","journal-title":"Headache"},{"key":"7568_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1159\/000501425","volume":"27","author":"K Simsh\u00e4user","year":"2020","unstructured":"Simsh\u00e4user K, L\u00fcking M, Kaube H, Schultz C, Schmidt S (2020) Is Mindfulness-based stress reduction a promising and feasible intervention for patients suffering from migraine? A randomized controlled pilot trial. Complement Med Res 27:19\u201330. https:\/\/doi.org\/10.1159\/000501425","journal-title":"Complement Med Res"},{"key":"7568_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1001\/jamainternmed.2020.7090","volume":"181","author":"RE Wells","year":"2021","unstructured":"Wells RE, O\u2019Connell N, Pierce CR et al (2021) Effectiveness of mindfulness meditation vs headache education for adults with migraine: a randomized clinical trial. JAMA Intern Med 181:317\u2013328. https:\/\/doi.org\/10.1001\/jamainternmed.2020.7090","journal-title":"JAMA Intern Med"},{"key":"7568_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s10072-022-06585-9","volume":"44","author":"L Grazzi","year":"2023","unstructured":"Grazzi L, Rizzoli P, Raggi A (2023) How the COVID-19 emergency changed our modality to treat patients with migraine: a positive aspect of the pandemic. Neurol Sci 44:809\u2013810. https:\/\/doi.org\/10.1007\/s10072-022-06585-9","journal-title":"Neurol Sci"},{"key":"7568_CR17","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1007\/s10072-021-05836-5","volume":"43","author":"L Grazzi","year":"2022","unstructured":"Grazzi L, Telesca A, Rizzoli P (2022) Management of chronic migraine with medication overuse by web-based behavioral program during the COVID-19 emergency: results at 12 months. Neurol Sci 43:1583\u20131585. https:\/\/doi.org\/10.1007\/s10072-021-05836-5","journal-title":"Neurol Sci"},{"key":"7568_CR18","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3390\/brainsci13040699","volume":"13","author":"L Grazzi","year":"2023","unstructured":"Grazzi L, Montisano DA, Raggi A, Rizzoli P (2023) The Be-home kids program: an integrated approach for delivering behavioral therapies to adolescents with episodic and chronic migraine. Brain Sci 13:699. https:\/\/doi.org\/10.3390\/brainsci13040699","journal-title":"Brain Sci"},{"key":"7568_CR19","unstructured":"World Health Organization (2019) WHO guideline Recommendations on Digital Interventions for Health System Strengthening. World Health Organization, Geneva. Available at: www.ncbi.nlm.nih.gov\/books\/NBK541905\/ (Last accessed 13\/11\/2023)"},{"key":"7568_CR20","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1007\/s11136-013-0556-9","volume":"23","author":"A Raggi","year":"2014","unstructured":"Raggi A, Giovannetti AM, Schiavolin S et al (2014) Validating the migraine-specific quality of life questionnaire v2.1 (MSQ) in Italian inpatients with chronic migraine with a history of medication overuse. Qual Life Res 23:1273\u20131277","journal-title":"Qual Life Res"},{"key":"7568_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s10194-022-01536-3","volume":"24","author":"E Troy","year":"2023","unstructured":"Troy E, Shrukalla AA, Buture A et al (2023) Medium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17\u201330 months. J Headache Pain 24:5","journal-title":"J Headache Pain"},{"key":"7568_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/ner.13465","volume":"25","author":"A Al-Kaisy","year":"2022","unstructured":"Al-Kaisy A, Palmisani S, Carganillo R et al (2022) Safety and efficacy of 10 kHz spinal cord stimulation for the treatment of refractory chronic migraine: a prospective long-term open-label study. Neuromodulation 25:103\u2013113","journal-title":"Neuromodulation"},{"key":"7568_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s40261-021-01115-5","volume":"42","author":"SJ Tepper","year":"2022","unstructured":"Tepper SJ, Ailani J, Ford JH et al (2022) Effects of galcanezumab on health-related quality of life and disability in patients with previous failure of 2\u20134 migraine preventive medication categories: results from a phase iiib randomized, placebo-controlled, multicenter clinical trial (CONQUER). Clin Drug Investig 42:263\u2013275","journal-title":"Clin Drug Investig"},{"key":"7568_CR24","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1023\/a:1026119331193","volume":"12","author":"M Kosinski","year":"2003","unstructured":"Kosinski M, Bayliss MS, Bjorner JB et al (2003) A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res 12:963\u2013974. https:\/\/doi.org\/10.1023\/a:1026119331193","journal-title":"Qual Life Res"},{"key":"7568_CR25","volume-title":"Beck Depression Inventory-II","author":"M Ghisi","year":"2006","unstructured":"Ghisi M, Flebus GB, Montano A, Sanavio E, Sica C (2006) Beck Depression Inventory-II. Organizzazioni Speciali, Firenze, Manuale Italiano"},{"key":"7568_CR26","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1027\/\/1015-5759.18.3.242","volume":"18","author":"U Scholz","year":"2002","unstructured":"Scholz U, Guti\u00e9rrez-Do\u00f1a B, Sud S, Schwarzer R (2002) Is general self-efficacy a universal construct? Psychometric findings from 25 countries. Eur J Psychol Assess 18:242\u20132517","journal-title":"Eur J Psychol Assess"},{"key":"7568_CR27","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jpain.2017.05.003","volume":"18","author":"BD Darnall","year":"2017","unstructured":"Darnall BD, Sturgeon JA, Cook KF et al (2017) Development and validation of a daily pain catastrophizing scale. J Pain 18:1139\u20131149","journal-title":"J Pain"},{"issue":"3","key":"7568_CR28","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/head.13215","volume":"58","author":"H Chu","year":"2018","unstructured":"Chu H, Te LCS, Lee JT et al (2018) Associations between depression\/anxiety and headache frequency in migraineurs: a cross-sectional study. Headache 58(3):407\u2013415","journal-title":"Headache"},{"key":"7568_CR29","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1111\/head.13946","volume":"60","author":"CR Houts","year":"2020","unstructured":"Houts CR, Wirth RJ, McGinley JS, Cady R, Lipton RB (2020) Determining thresholds for meaningful change for the headache impact test (HIT-6) total and item-specific scores in chronic migraine. Headache 60:2003\u20132013","journal-title":"Headache"},{"key":"7568_CR30","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/head.12597","volume":"55","author":"DS Bond","year":"2015","unstructured":"Bond DS, Buse DC, Lipton RB et al (2015) Clinical pain catastrophizing in women with migraine and obesity. Headache 55:923\u2013933","journal-title":"Headache"},{"key":"7568_CR31","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s10072-021-05453-2","volume":"43","author":"T Klonowski","year":"2022","unstructured":"Klonowski T, Kropp P, Straube A, Ruscheweyh R (2022) Psychological factors associated with headache frequency, intensity, and headache-related disability in migraine patients. Neurol Sci 43:1255\u20131266","journal-title":"Neurol Sci"},{"key":"7568_CR32","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/00002508-200103000-00008","volume":"17","author":"M Sullivan","year":"2001","unstructured":"Sullivan M, Thorn B, Haythornthwaite JA et al (2001) Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain 17:52\u201364","journal-title":"Clin J Pain"},{"key":"7568_CR33","doi-asserted-by":"publisher","first-page":"5741","DOI":"10.1007\/s10072-022-06225-2","volume":"43","author":"L Grazzi","year":"2022","unstructured":"Grazzi L, Montisano DA, Raggi A, Rizzoli P (2022) Feasibility and effect of mindfulness approach by web for chronic migraine and high-frequency episodic migraine without aura at in adolescents during and after COVID emergency: Preliminary findings. Neurol Sci 43:5741\u20135744","journal-title":"Neurol Sci"},{"key":"7568_CR34","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1037\/hea0000920","volume":"39","author":"SG Farris","year":"2020","unstructured":"Farris SG, Thomas JG, Kibbey MM, Pavlovic JM, Steffen KJ, Bond DS (2020) Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight\/obesity. Health Psychol 39:927\u2013933","journal-title":"Health Psychol"},{"key":"7568_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s10194-022-01436-6","volume":"23","author":"M Silvestro","year":"2022","unstructured":"Silvestro M, Tessitore A, Orologio I et al (2022) Galcanezumab effect on \u201cwhole pain burden\u201d and multidimensional outcomes in migraine patients with previous unsuccessful treatments: A real-world experience. J Headache Pain 23:69","journal-title":"J Headache Pain"},{"key":"7568_CR36","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/toxins15020086","volume":"15","author":"L Grazzi","year":"2023","unstructured":"Grazzi L, Montisano DA, Rizzoli P et al (2023) A single-group study on the effect of onabotulinumtoxina in patients with chronic migraine associated with medication overuse headache: pain catastrophizing plays a role. Toxins (Basel) 15:86","journal-title":"Toxins (Basel)"},{"key":"7568_CR37","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/ane.13475","volume":"144","author":"D D'Amico","year":"2021","unstructured":"D\u2019Amico D, Grazzi L, Guastafierro E, Sansone E, Leonardi M, Raggi A (2021) Withdrawal failure in patients with chronic migraine and medication overuse headache. Acta Neurol Scand 144:408\u2013417. https:\/\/doi.org\/10.1111\/ane.13475","journal-title":"Acta Neurol Scand"},{"issue":"Suppl 1","key":"7568_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10072-017-2894-9","volume":"38","author":"A Raggi","year":"2017","unstructured":"Raggi A, Grazzi L, Ayadi R et al (2017) Clinical and psychosocial features of frequent relapsers (FR) among patients with chronic migraine and medication overuse. Neurol Sci 38(Suppl 1):169\u2013171. https:\/\/doi.org\/10.1007\/s10072-017-2894-9","journal-title":"Neurol Sci"},{"key":"7568_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/ene.14034","volume":"27","author":"A Raggi","year":"2020","unstructured":"Raggi A, Leonardi M, Sansone E, Curone M, Grazzi L, D\u2019Amico D (2020) The cost and the value of treatment of medication overuse headache in Italy: a longitudinal study based on patient-derived data. Eur J Neurol 27:62-e1. https:\/\/doi.org\/10.1111\/ene.14034","journal-title":"Eur J Neurol"},{"key":"7568_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s10194-022-01492-y","volume":"23","author":"S Khanal","year":"2022","unstructured":"Khanal S, Underwood M, Naghdi S et al (2022) A systematic review of economic evaluations of pharmacological treatments for adults with chronic migraine. J Headache Pain 23:122. https:\/\/doi.org\/10.1186\/s10194-022-01492-y","journal-title":"J Headache Pain"},{"key":"7568_CR41","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s10194-023-01696-w","volume":"24","author":"S Naghdi","year":"2023","unstructured":"Naghdi S, Underwood M, Madan J et al (2023) (2023) Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis. J Headache Pain 24:164. https:\/\/doi.org\/10.1186\/s10194-023-01696-w","journal-title":"J Headache Pain"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07568-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-024-07568-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07568-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:25:40Z","timestamp":1727184340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-024-07568-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["7568"],"URL":"https:\/\/doi.org\/10.1007\/s10072-024-07568-8","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"26 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Fondazione IRCCS Istituto Neurologico Carlo Besta (approval no. 75.01\/2020).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"CA received travel grants and honoraria from Eli Lilly, TeVA, Abbvie, Lundbeck.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}