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Participants underwent physical, neurological, neuropsychological, and ophthalmological evaluations, including SD-OCT and OCTA. Logistic regression, adjusted for age, sex, and inter-eye correlation, was employed to identify retinal alterations in patients affected by DLB.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>OCTA revealed that DLB is associated with reduced superficial and deep vessel densities (SVD and DVD) in the macula (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), as well as decreased peripapillary vessel density (ppVD, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). SD-OCT parameters showed correlations with DLB, including reduced central macular thickness (CMT, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and thinning of the ganglion cell layer-inner plexiform layer (GCL-IPL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Logistic regression (R\u00b2=0.26) identified reduced ppVD as a significant predictor of DLB (<jats:italic>p<\/jats:italic>\u2009=\u20090.030).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Impairments in retinal capillaries, especially lower ppVD, might mirror cerebral hypoperfusion in DLB, potentially due to reduced Vascular Endothelial Growth Factor (VEGF) levels and increased \u03b1-synuclein. Further investigations are warranted to confirm the causal relationship between these observations, disease severity, and progression, as well as their potential role as biomarkers for DLB.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-024-07683-6","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T01:01:50Z","timestamp":1723856510000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroretinal and microvascular retinal features in dementia with Lewy body assessed by optical coherence tomography angiography"],"prefix":"10.1007","volume":"46","author":[{"given":"Giuseppe Maria","family":"Albanese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Gharbiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-433X","authenticated-orcid":false,"given":"Giacomo","family":"Visioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Panigutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Margarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvia","family":"Mastrogiuseppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Sepe-Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"D\u2019Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"7683_CR1","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/S0140-6736(15)00462-6","volume":"386","author":"Z Walker","year":"2015","unstructured":"Walker Z, Possin KL, Boeve BF, Aarsland D (2015) Lewy body dementias. 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