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Recently, transcranial Alternating Current Stimulation (tACS) emerged as a tool to modulate brain oscillations implicated in various motor, perceptual, and cognitive functions. This study aims to investigate the influence of 20-Hz and 10-Hz tACS sessions on the primary motor cortex and their impact on blink reflex excitability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Fifteen healthy volunteers underwent 10-min tACS sessions (intensity 1\u00a0mA) with active\/reference electrodes placed over C4\/Pz, delivering 20-Hz, 10-Hz, and sham stimulation. The blink reflex recovery cycle (BRrc) was assessed using the R2 amplitude ratio at various interstimulus intervals (ISIs) before (T0), immediately after (T1), and 30\u00a0min post-tACS (T2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both 10-Hz and 20-Hz tACS sessions significantly increased R2 ratio at T1 (10-Hz: <jats:italic>p<\/jats:italic>\u2009=\u20090.02; 20-Hz: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and T2 (10-Hz: <jats:italic>p<\/jats:italic>\u2009=\u20090.01; 20-Hz: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to baseline (T0). Notably, 20-Hz tACS induced a significantly greater increase in blink reflex excitability compared to sham at both T1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and T2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study demonstrates the modulatory effect of tACS on trigemino-facial reflex circuits, with a lasting impact on BRrc. Beta-band frequency tACS exhibited a more pronounced effect than alpha-band frequency, highlighting the influential role of beta-band oscillations in the motor cortex on blink reflex excitability modulation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10072-024-07719-x","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T14:01:53Z","timestamp":1722693713000},"page":"401-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcranial alternating current stimulation can modulate the blink reflex excitability. Effects of a 10- and 20-Hz tACS session on the blink reflex recovery cycle in healthy subjects"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-0356","authenticated-orcid":false,"given":"Simona","family":"Maccora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierangelo","family":"Sardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Giglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Torrente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Brighina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"7719_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/brain\/96.1.87","volume":"96","author":"J Kimura","year":"1973","unstructured":"Kimura J (1973) Disorders of interneurons in parkinsonism. 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