{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:33:28Z","timestamp":1761294808802,"version":"3.40.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s10072-024-07975-x","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:35:45Z","timestamp":1735882545000},"page":"2303-2307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Many strokes from a single non-stenosing plaque: from the last event a light to the first one?"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-818X","authenticated-orcid":false,"given":"Marialuisa","family":"Zedde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-9298","authenticated-orcid":false,"given":"Rosario","family":"Pascarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"7975_CR1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","volume":"13","author":"RG Hart","year":"2014","unstructured":"Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O\u2019Donnell MJ et al (2014) Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol 13:429\u2013438. https:\/\/doi.org\/10.1016\/S1474-4422(13)70310-7","journal-title":"Lancet Neurol"},{"issue":"1","key":"7975_CR2","doi-asserted-by":"publisher","first-page":"e209535","DOI":"10.1212\/WNL.0000000000209535","volume":"103","author":"LA Sposato","year":"2024","unstructured":"Sposato LA, Sur NB, Katan M, Johansen MC, De Marchis GM, Caso V, Fischer U, Chaturvedi S (2024) Embolic stroke of undetermined source: New Data and New controversies on Cardiac Monitoring and Anticoagulation. Neurology 103(1):e209535. https:\/\/doi.org\/10.1212\/WNL.0000000000209535","journal-title":"Neurology"},{"issue":"18","key":"7975_CR3","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1093\/eurheartj\/ehaa218","volume":"42","author":"G Ntaios","year":"2021","unstructured":"Ntaios G, Wintermark M, Michel P (2021) Supracardiac atherosclerosis in embolic stroke of undetermined source: the underestimated source. Eur Heart J 42(18):1789\u20131796. https:\/\/doi.org\/10.1093\/eurheartj\/ehaa218","journal-title":"Eur Heart J"},{"issue":"1","key":"7975_CR4","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/STROKEAHA.119.027272","volume":"51","author":"J Kamtchum-Tatuene","year":"2020","unstructured":"Kamtchum-Tatuene J, Wilman A, Saqqur M, Shuaib A, Jickling GC (2020) Carotid plaque with high-risk features in Embolic Stroke of undetermined source: systematic review and Meta-analysis. Stroke 51(1):311\u2013314. https:\/\/doi.org\/10.1161\/STROKEAHA.119.027272","journal-title":"Stroke"},{"issue":"23","key":"7975_CR5","doi-asserted-by":"publisher","first-page":"e2644","DOI":"10.1212\/WNL.0000000000007611","volume":"92","author":"G Ntaios","year":"2019","unstructured":"Ntaios G, Perlepe K, Sirimarco G, Strambo D, Eskandari A, Karagkiozi E, Vemmou A, Koroboki E, Manios E, Makaritsis K, Michel P, Vemmos K (2019) Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source. Neurology 92(23):e2644\u2013e2652. https:\/\/doi.org\/10.1212\/WNL.0000000000007611","journal-title":"Neurology"},{"issue":"19","key":"7975_CR6","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.jacc.2020.09.532","volume":"76","author":"A Kopczak","year":"2020","unstructured":"Kopczak A, Schindler A, Bayer-Karpinska A, Koch ML, Sepp D, Zeller J, Strecker C, Hempel JM, Yuan C, Malik R, Wollenweber FA, Boeckh-Behrens T, Cyran CC, Helck A, Harloff A, Ziemann U, Poli S, Poppert H, Dichgans M, Saam T (2020) Complicated carotid artery plaques as a cause of Cryptogenic Stroke. J Am Coll Cardiol 76(19):2212\u20132222. https:\/\/doi.org\/10.1016\/j.jacc.2020.09.532","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"7975_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S1474-4422(19)30035-3","volume":"18","author":"L Saba","year":"2019","unstructured":"Saba L, Saam T, J\u00e4ger HR, Yuan C, Hatsukami TS, Saloner D, Wasserman BA, Bonati LH, Wintermark M (2019) Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol 18(6):559\u2013572. https:\/\/doi.org\/10.1016\/S1474-4422(19)30035-3","journal-title":"Lancet Neurol"},{"issue":"3","key":"7975_CR8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/svn-2022-001639","volume":"8","author":"D Dowlatshahi","year":"2023","unstructured":"Dowlatshahi D, Lum C, Menon BK, Bharatha A, Dave P, Puac-Polanco P, Blacquiere D, Stotts G, Shamy M, Momoli F, Thornhill R, Lun R, Torres C (2023) Aetiology of extracranial carotid free-floating thrombus in a prospective multicentre cohort. Stroke Vasc Neurol 8(3):194\u2013196. https:\/\/doi.org\/10.1136\/svn-2022-001639","journal-title":"Stroke Vasc Neurol"},{"issue":"1","key":"7975_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000352050","volume":"36","author":"P Amarenco","year":"2013","unstructured":"Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG (2013) The ASCOD phenotyping of ischemic stroke (updated ASCO phenotyping). Cerebrovasc Dis 36(1):1\u20135. https:\/\/doi.org\/10.1159\/000352050","journal-title":"Cerebrovasc Dis"},{"key":"7975_CR10","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0140-6736(04)15785-1","volume":"363","author":"PM Rothwell","year":"2004","unstructured":"Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJM (2004) Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363:915\u2013924. https:\/\/doi.org\/10.1016\/S0140-6736(04)15785-1","journal-title":"Lancet"},{"issue":"15","key":"7975_CR11","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1161\/01.CIR.0000144307.82502.32","volume":"110","author":"JK Lovett","year":"2004","unstructured":"Lovett JK, Gallagher PJ, Hands LJ, Walton J, Rothwell PM (2004) Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 110(15):2190\u20132197. https:\/\/doi.org\/10.1161\/01.CIR.0000144307.82502.32","journal-title":"Circulation"},{"key":"7975_CR12","doi-asserted-by":"publisher","unstructured":"Pakizer D, Kozel J, Elmers J, Feber J, Michel P, \u0160koloud\u00edk D, Sirimarco G (2024 Jul) Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in carotid arteries compared to histology: a systematic review. J Magn Reson Imaging 9. https:\/\/doi.org\/10.1002\/jmri.29522","DOI":"10.1002\/jmri.29522"},{"issue":"6","key":"7975_CR13","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/jmri.29013","volume":"59","author":"R El Sayed","year":"2024","unstructured":"El Sayed R, Park CC, Shah Z, Nahab FB, Haussen DC, Allen JW, Oshinski JN (2024) Assessment of Complex Flow patterns in patients with carotid webs, patients with carotid atherosclerosis, and healthy subjects using 4D Flow MRI. J Magn Reson Imaging 59(6):2001\u20132010. https:\/\/doi.org\/10.1002\/jmri.29013","journal-title":"J Magn Reson Imaging"},{"key":"7975_CR14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jcmg.2019.03.028","volume":"13","author":"A Schindler","year":"2020","unstructured":"Schindler A, Schinner R, Altaf N, Hosseini AA, Simpson RJ, Esposito-Bauer L et al (2020) Prediction of stroke risk by detection of hemorrhage in carotid plaques: meta-analysis of individual patient data. JACC Cardiovasc Imaging 13:395\u2013406. https:\/\/doi.org\/10.1016\/j.jcmg.2019.03.028","journal-title":"JACC Cardiovasc Imaging"},{"key":"7975_CR15","doi-asserted-by":"publisher","unstructured":"Kwee RM, van Oostenbrugge RJ, Mess WH, Prins MH, van der Geest RJ, ter, Berg JW et al (2013) MRI of carotid atherosclerosis to identify TIA and stroke patients who are at risk of a recurrence. J Magn Reson Imaging.;37:1189\u201394. https:\/\/doi.org\/10.1002\/jmri.23918","DOI":"10.1002\/jmri.23918"},{"key":"7975_CR16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/STROKEAHA.114.006286","volume":"46","author":"JS McNally","year":"2015","unstructured":"McNally JS, McLaughlin MS, Hinckley PJ, Treiman SM, Stoddard GJ, Parker DL et al (2015) Intraluminal thrombus, intraplaque hemorrhage, plaque thickness, and current smoking optimally predict carotid stroke. Stroke 46:84\u201390. https:\/\/doi.org\/10.1161\/STROKEAHA.114.006286","journal-title":"Stroke"},{"key":"7975_CR17","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3174\/ajnr.A2078","volume":"31","author":"M Eesa","year":"2010","unstructured":"Eesa M, Hill MD, Al-Khathaami A, Al-Zawahmah M, Sharma P, Menon BK et al (2010) Role of CT angiographic plaque morphologic characteristics in addition to stenosis in predicting the symptomatic side in carotid artery disease. AJNR Am J Neuroradiol 31:1254\u20131260. https:\/\/doi.org\/10.3174\/ajnr.A2078","journal-title":"AJNR Am J Neuroradiol"},{"key":"7975_CR18","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1161\/STROKEAHA.113.002551","volume":"44","author":"A Gupta","year":"2013","unstructured":"Gupta A, Baradaran H, Schweitzer AD, Kamel H, Pandya A, Delgado D et al (2013) Carotid plaque MRI and stroke risk: a systematic review and meta-analysis. Stroke 44:3071\u20133077. https:\/\/doi.org\/10.1161\/STROKEAHA.113.002551","journal-title":"Stroke"},{"key":"7975_CR19","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3174\/ajnr.A4765","volume":"37","author":"LB Eisenmenger","year":"2016","unstructured":"Eisenmenger LB, Aldred BW, Kim SE, Stoddard GJ, de Havenon A, Treiman GS et al (2016) Prediction of carotid intraplaque hemorrhage using adventitial calcification and plaque thickness on CTA. AJNR Am J Neuroradiol 37:1496\u20131503. https:\/\/doi.org\/10.3174\/ajnr.A4765","journal-title":"AJNR Am J Neuroradiol"},{"key":"7975_CR20","doi-asserted-by":"publisher","unstructured":"Jumah A, Aboul Nour H, Fana M, Choudhury O, Eltous L, Zoghoul S, Jumah F, Alsrouji OK, Alhajala H, Intikhab O, Marin H, Chebl A, Miller D (2022) The role of non-stenosing carotid artery plaques in embolic stroke of undetermined source, is it a silent offender? A review of literature. Interv Neuroradiol. https:\/\/doi.org\/10.1177\/15910199221143172","DOI":"10.1177\/15910199221143172"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07975-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-024-07975-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07975-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:56:59Z","timestamp":1744804619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-024-07975-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["7975"],"URL":"https:\/\/doi.org\/10.1007\/s10072-024-07975-x","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"20 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}